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1. 发明公开

EP0112152A3 Blood fractionation system and method 有权
$Blood fractionation system and method$
标题翻译：血液分离系统和方法
公开(公告)号：EP0112152A3
公开(公告)日：1986-02-12
申请号：EP83307577
申请日：1983-12-13
申请人： McLaughlin, William Francis
发明人： Fischel, Halbert
IPC分类号： A61M01/03 , B01D33/00 , B01D31/00
CPC分类号： B01D63/16 , A61M1/262 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0429 , A61M2202/0439 , A61M2205/3306 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3382 , A61M2205/3386 , A61M2205/3389 , B01D61/18 , B01D2315/02 , A61M2202/0035 , A61M2202/0071 , A61M2202/0042
摘要： Blood is passed from inlet 22 to outlet 34 axially along a shear gap between a stationary outer wall 24 and a cylindrical membrane 62 carried by a rotating spinner 50 and plasma is filtered off through the membrane and withdrawn through axial passge 76. The width of the gap and the rate of rotation of the spinner (greater than 1000 r.p.m.) are chosen such as to establish shear of from 1000 to 15,000 sec -1 across the gap and centrifugal force at the membrane of 50 gravity. The spinner 50 is driven by magnetic coupling 68, 74 from outside the housing 40, 12, 44 which thus forms a disposable unit. In a construction for separation of anti-freeze solution with white cells from frozen concentrated red cells, saline solution is introduced through a porous outer wall 12 and passes radially through the mixture to carry the anti-freeze and white cells through the membrane.
摘要翻译：血液从入口22到出口34沿着静止的外壁24和由旋转的旋转器50承载的圆柱形膜62之间的剪切间隙轴向流动，等离子体被滤过膜并通过轴向通过76取出。选择间隙和旋转器的旋转速度（大于1000rpm），以便跨越间隙和在50重力的膜处的离心力建立1000至15,000秒-1的剪切。旋转器50由壳体40,12,44的外部由磁耦合器68,74驱动，从而形成一次性单元。 ...在从冷冻浓缩红细胞中分离具有白细胞的防冻溶液的结构中，通过多孔外壁12引入盐水溶液，并径向通过混合物以携带抗冻和白细胞通过膜。

2. 发明公开

EP0126650A3 Technique and equipment for dialysis treatment 失效
标题翻译：用于DIALYSIS治疗的技术和设备
公开(公告)号：EP0126650A3
公开(公告)日：1985-08-21
申请号：EP84303439
申请日：1984-05-21
申请人： Japan Medical Supply Company Limited
发明人： Clark, Russell Donald, Dr. , Hua Su Ping, Andrew
IPC分类号： A61M01/03
CPC分类号： A61M39/18
摘要： A technique for connecting a catheter to a dialysis device is provided with the dialysis device comprising a dialysate solution bag, a connecting tube, one end of which is sealingly joined to the dialysate solution bag and the other end of which is sealingly connected into a flexible, substantially transparent sterilising bag containing a sterilising medium, the sterilising bag being additionally provided with a sealed opening through which the external end of an implanted catheter or the free end of an intermediate tube (the other end of which is connected to the external end of an implanted catheter) can penetrate into the sterilising bag to complete the connection from the dialysate solution bag to the patient. The technique and device help reduce the incidence of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis.

3. 发明公开

EP0102342A3 Improved percutaneous implant for peritoneal dialysis 有权
标题翻译：改善PERCUTANEOUS植入物进行腹膜透析
公开(公告)号：EP0102342A3
公开(公告)日：1985-01-09
申请号：EP83870082
申请日：1983-08-19
申请人： Renal Systems, Inc.
发明人： Klein, Elias , Ward, Richard A. , Wathen, Ronald L.
IPC分类号： A61M01/03
CPC分类号： A61M39/0247 , A61M1/285 , A61M2039/0282 , A61M2039/0288
摘要： @ An implant device for peritoneal dialysis which permits a flexible catheter (20) to be removed and replaced without invasive surgery. The catheter is passed through a substantially rigid tubular percutaneous device (10) and a flexible sleeve member (12) which together form a continuous conduit from the body exterior through the peritoneal wall (16). The catheter is associated with a percutaneous tubular device so as to be removable and replaceable through the sleeve member after implantation. The catheter preferably has a relatively weak memory which gives it a tendency to maintain a compact coiled configuration near the peritoneal wall. The catheter may extend through the percutaneous device or, more preferably, terminates within the interior cavity of the percutaneous device and is sealed from the environment by means of a septum closure within the device cavity.

4. 发明公开

EP0104897A3 Single needle alternating blood flow system 失效
标题翻译：单针替代血液流动系统
公开(公告)号：EP0104897A3
公开(公告)日：1984-10-03
申请号：EP83305637
申请日：1983-09-22
申请人： EXTRACORPOREAL MEDICAL SPECIALITIES INC.
发明人： Troutner, Vernon H.
IPC分类号： A61M01/03
CPC分类号： A61M1/30 , A61M1/302 , A61M1/303 , A61M1/306 , A61M1/308 , Y10S128/13
摘要： A two-pump single needle hemodialysis system is provided in which a flexible blood accumulator bag is located between the dialyzer and the second, venous blood pump. The accumulator bag is filled as the first, arterial blood pump is operated. Blood is pumped through the dialyzer and into the bag until the bag is full and taut. At this time, a rise in pressure is detected and the venous blood pump is activated to withdraw blood from the accumulator bag. The use of the accumulator bag assures that low blood pressures are maintained in the system.

5. 发明公开

EP0104895A3 Dual phase blood/flow system and method of operation 有权转让
标题翻译：双相血液/流动系统及其操作方法
公开(公告)号：EP0104895A3
公开(公告)日：1984-10-03
申请号：EP83305635
申请日：1983-09-22
申请人： EXTRACORPOREAL MEDICAL SPECIALITIES INC.
发明人： Troutner, Vernon H.
IPC分类号： A61M01/03
CPC分类号： A61M1/30 , A61M1/302 , A61M1/303 , A61M1/306 , A61M1/308 , Y10S128/03
摘要： A blood flow system for processing blood has two phases of operation, an arterial phase and a venous phase. During the arterial phase, the system is filled with blood through operation of an arterial blood pump. When a predetermined blood pressure level in the system has been attained, the arterial blood pump is inactivated and a venous blood pump removes blood from the system for a given number of pump turns.

6. 发明公开

EP0097432A3 Method and apparatus for peritoneal dialysis 失效
标题翻译：腹膜透析的方法和装置
公开(公告)号：EP0097432A3
公开(公告)日：1984-09-12
申请号：EP83303010
申请日：1983-05-25
申请人： Dadson, Joseph E. , Agarwal, Mahesh C.
发明人： Dadson, Joseph E.
IPC分类号： A61M01/03
CPC分类号： A61M1/28 , A61M1/1643 , A61M1/282 , A61M2205/3393
摘要： There is provided a dialysis apparatus which includes' first means for supplying dialysis fluid, second means for receiving, heating and weighing dialysis fluid, third means for receiving and weighing a quantity of dialysis fluid, a catheter, and structure which supports the first means above the second means, the second means above the catheter, and the third means below the catheter. A first flow path interconnects the first and second means, while a second flow path interconnects the second means in the catheter. A third flow path interconnects the catheter in the third means. Valve means are provided for selectively (i) blocking the first and third paths while leaving the second path open, (ii) blocking the second and third paths while leaving the first path open, and (iii) blocking the second path while leaving the first and third paths open. A timer/computer is provided which is able to maintain mode (i) until a preselected reduction in weight occurs at the second means, following which it switches to and maintains mode (ii), following which it switches to and maintains mode (iii).
摘要翻译：提供了一种透析装置，其包括用于提供透析液的第一装置，用于接收，加热和称重透析液的第二装置，用于接收和称量一定量的透析液的第三装置，导管和支撑第一装置上方的第一装置的结构第二装置，导管上方的第二装置，以及导管下方的第三装置。第一流动路径将第一和第二装置互连，而第二流动路径将导管中的第二装置相互连接。第三流动路径将第三装置中的导管相互连接。提供阀装置，用于选择性地（i）阻止第一和第三路径同时使第二路径打开，（ii）阻止第二路径和第三路径同时使第一路径断开，以及（iii）阻止第二路径同时离开第一路径和第三条路径打开。提供一种定时器/计算机，其能够维持模式（i），直到在第二装置处发生预定的权重减少，随后切换到并维持模式（ii），随后切换到并维持模式（iii）。

7. 发明公开

EP0088900A3 Device for purifying the blood from metabolism substances 有权
标题翻译：用于从代谢物质中净化血液的装置
公开(公告)号：EP0088900A3
公开(公告)日：1984-02-15
申请号：EP83101489
申请日：1983-02-16
申请人： FRESENIUS AG
发明人： Polaschegg, Hans-Dietrich, Dr. , Mathieu, Bernd, Dr.
IPC分类号： A61M01/03
CPC分类号： A61M1/30 , A61M1/1005 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1086 , A61M1/1087 , A61M1/1089 , A61M1/1096 , A61M1/302 , A61M1/308

8. 发明公开

EP0076355A3 Improved peritoneal dialysis solution 失效
标题翻译：改进的透析解决方案
公开(公告)号：EP0076355A3
公开(公告)日：1983-05-25
申请号：EP82101044
申请日：1982-02-12
申请人： ABBOTT LABORATORIES
发明人： Ramsay, Anne Barlow
IPC分类号： A61M01/03
CPC分类号： A61M1/287 , A61K31/715
摘要： An improved peritoneal dialysis solution comprises the conventional electrolyte combination of sodium, calcium, magnesium, chloride, lactate, and sodium hydroxide, the improvement comprising the use of a glucose polymer as the osmotic agent. In a preferred embodiment, the glucose polymer is found in a concentration of from 30 to 125 grams per liter. The large size of the glucose polymer molecules delays their passage through the peritoneum. In addition, the large glucose polymer molecules are slow to be metabolized in the blood. As a result, caloric intake is reduced and the length of time selective osmotic pressure may be applied is increased. Better B.U.N. (Blood Urea and Nitrogen) and creatinine clearances are thereby obtained, and the number of dialyses required can be reduced. Also disclosed is a method of use thereof.
摘要翻译：改进的腹膜透析溶液包括钠，钙，镁，氯化物，乳酸盐和氢氧化钠的常规电解质组合，改进包括使用葡萄糖聚合物作为渗透剂。在优选的实施方案中，发现葡萄糖聚合物的浓度为30至125克/升。葡萄糖聚合物分子的大尺寸延伸通过腹膜。另外，大的葡萄糖聚合物分子在血液中很慢被代谢。因此，可以减少热量摄取并且可以施加时间选择性渗透压的时间长度。更好B.U.N. （血液尿素和氮气）和肌酐清除率，可以减少所需的透析液数量。还公开了其使用方法。

9. 发明公开

EP0076665A3 Method and apparatus for plasmapheresis 有权
标题翻译：用于等离子体的方法和装置
公开(公告)号：EP0076665A3
公开(公告)日：1983-05-18
申请号：EP82305238
申请日：1982-10-01
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： Ramstack, Joseph Michael
IPC分类号： A61M01/03
CPC分类号： B01D61/147 , A61M1/10 , A61M1/1005 , A61M1/1006 , A61M1/1086 , A61M1/3496 , B01D61/22 , B01D65/08 , B01D2321/2066 , B01D2321/2083
摘要： Plasmapheresis by filtration can be carried out with high efficiency for long periods by conducting blood over a surface of a membrane and passing plasma at an accelerating rate until the threshold level is attained, maintaining the rate of passing plasma until the ceiling system transmembrane pressure difference is attained and then reducing the passing of plasma and the system transmembrane pressure difference and allowing the membrane to clear before repeating the cycle.

10. 发明公开

EP0044204A3 Sterile docking process, apparatus and system 有权
标题翻译：无菌对接过程，设备和系统
公开(公告)号：EP0044204A3
公开(公告)日：1982-04-28
申请号：EP81303157
申请日：1981-07-10
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： Spencer, Dudley Walter Cyril
IPC分类号： A61M01/03
CPC分类号： A61M39/146 , B29C65/2046 , B29C65/2061 , B29C65/2076 , B29C65/7802 , B29C65/7841 , B29C66/1142 , B29C66/5221 , B29C66/71 , B29C66/723 , B29C66/857 , B29L2023/22 , B29L2031/7148 , B29L2031/753 , B29K2023/06 , B29K2023/12 , B29K2027/06
摘要： A process, apparatus and system for making a sterile connection between two thermoplastic resin tubes is disclosed. The tubes are cut by a hot cutting means so as to form a molten interface between the tubes and the cutting means. The tubes are aligned with each other and slid off an edge of the cutting means while being urged together. As the thermoplastic resin cools a sterile weld is formed. The cutting means should either be thin or have a sharp edge where the aligned tubes are slid off and joined.
摘要翻译：公开了用于在两个热塑性树脂管之间进行无菌连接的过程，设备和系统。通过热切割装置切割管子，以在管子和切割装置之间形成熔化界面。这些管彼此对齐并从切割装置的边缘滑出，同时被压在一起。当热塑性树脂冷却时形成无菌焊缝。切割装置应该是薄的或者在对准的管子滑落和接合的地方具有尖锐的边缘。

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