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1. 发明授权

EP1250165B1 BIOACTIVE COATINGS TO PREVENT TISSUE OVERGROWTH ON ARTIFICIAL HEART VALVES 有权
标题翻译：生物活性涂层以减少组织增长对人工心脏瓣膜的风险
公开(公告)号：EP1250165B1
公开(公告)日：2009-05-13
申请号：EP01906708.1
申请日：2001-01-25
申请人： Edwards Lifesciences Corporation
发明人： HELMUS, Michael, N. , CUNANAN, Crystal , TREMBLE, Patrice , KAFESJIAN, Ralph
IPC分类号： A61L27/54 , A61L33/00
CPC分类号： A61L27/507 , A61L27/54 , A61L33/0011 , A61L2300/114 , A61L2300/222 , A61L2300/236 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/434 , A61L2300/602
摘要： The present invention provides a prosthetic heart valve that includes biologically active agents that retard or prevent the infiltration of fibrous tissue ("pannus") from the host into the structure of the prosthetic valve. Preventing or decreasing the overgrowth of the prosthetic valve by pannus reduces the complications associated with the implantation and use of prosthetic heart valves.

2. 发明公开

EP1098670A1 CROSSLINKING OF BIOPROSTHETIC MATERIAL TO MITIGATE POST-IMPLANTATION CALCIFICATION 有权
标题翻译：链接到BIOPROTHESEMATERIAL KALZIFIKATIONSVERMINDERUNG植入后
公开(公告)号：EP1098670A1
公开(公告)日：2001-05-16
申请号：EP99948339.9
申请日：1999-09-20
申请人： Edwards Lifesciences Corporation
发明人： CUNANAN, Crystal, M. , QUINTERO, Lillian , HELMUS, Michael, N. , LOSHBAUGH, Christine , SARNER, Chris, H.
IPC分类号： A61L27/24 , A61L33/12
CPC分类号： A61L27/3691 , A61L2/0088 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L33/12 , A61L2400/02 , A61L2430/40 , Y10S623/901 , Y10S623/915 , Y10S623/917 , Y10S623/92
摘要： A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of: A) fixing the tissue; B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a cross-linking agent; C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto); and D) subjecting the bioprosthesis to terminal sterilization.

3. 发明授权

EP1250166B1 DELIVERY SYSTEMS FOR TREATMENT OF RESTENOSIS AND ANASTOMOTIC INTIMAL HYPERPLASIA 有权
标题翻译：释放系统用于治疗和再狭窄的吻合口内膜增生
公开(公告)号：EP1250166B1
公开(公告)日：2010-03-17
申请号：EP01905081.4
申请日：2001-01-25
申请人： Edwards Lifesciences Corporation
发明人： HELMUS, Michael, N. , CUNANAN, Crystal , TREMBLE, Patrice
IPC分类号： A61L31/16 , A61L31/14 , A61L31/04 , A61L27/22 , A61L27/54
CPC分类号： A61L27/52 , A61L27/225 , A61L27/54 , A61L31/04 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/622
摘要： The invention provides methods for treating injuries to one or more internal structures of a subject by administering a drug delivery vehicle to an external surface of the injured structure. The drug delivery vehicle substantially adheres to the site of administration and provides for the release of a bioactive agent that reduces or prevents further injury to the internal structure by disease processes, such as hyperplasia.

4. 发明授权

EP1098670B1 CROSSLINKING OF BIOPROSTHETIC MATERIAL TO MITIGATE POST-IMPLANTATION CALCIFICATION 有权
标题翻译：交联生物材料以减轻植入后的钙化
公开(公告)号：EP1098670B1
公开(公告)日：2003-06-25
申请号：EP99948339.9
申请日：1999-09-20
申请人： Edwards Lifesciences Corporation
发明人： CUNANAN, Crystal, M. , QUINTERO, Lillian , HELMUS, Michael, N. , LOSHBAUGH, Christine , SARNER, Chris, H.
IPC分类号： A61L27/24 , A61L33/12 , A61P19/00
CPC分类号： A61L27/3691 , A61L2/0088 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L33/12 , A61L2400/02 , A61L2430/40 , Y10S623/901 , Y10S623/915 , Y10S623/917 , Y10S623/92
摘要： A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of: A) fixing the tissue; B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a cross-linking agent; C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto); and D) subjecting the bioprosthesis to terminal sterilization.
摘要翻译：一种固定生物组织的方法，以及通过这种方法制备的生物假体装置。该方法通常包括以下步骤：A）固定组织; B）用i）变性剂，ii）表面活性剂和iii）交联剂的混合物处理组织; C）制造或形成生物假体（例如，形成组织并将任何非生物组分附着于其上）; 和D）对生物假体进行最终灭菌。

5. 发明授权

EP1239795B1 ENHANCED VISUALIZATION OF MEDICAL IMPLANTS 有权
标题翻译：知名度的提高的医学植入物
公开(公告)号：EP1239795B1
公开(公告)日：2006-12-06
申请号：EP00988113.7
申请日：2000-12-15
申请人： Edwards Lifesciences Corporation
发明人： BESSLER, Anita, B. , HELMUS, Michael, N.
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61B17/0469 , A61B90/39 , A61B2090/3941 , A61F2/2409 , A61F2/2448 , A61F2220/0075 , A61F2250/0097
摘要： Medical implants, installation tools, and methods of installation for minimally-invasive surgery wherein the implants, tools, and/or implantation site are marked with structure having enhanced visibility. The enhanced visibility markers may be highly reflective or luminescent; that is, the markers may be fluorescent, luminescent, or chemiluminescent. Metallic markers, such as gold, platinum, or stainless-steel may be used. The implant may be for cardiovascular surgery, and may have fabric thereon on which the enhanced visibility marker is provided. For example, the marker may be provided on a sewing ring of a heart valve, or on the exterior of an annuloplasty ring. A marker may be placed at anatomical location at the implantation site for better visualization thereof. An enhanced visibility marker on the implant may then be registered with the marker at the anatomical location. Sutures for attaching the implant to the host tissue, or for attaching an installation tool to the implant, may be made of a material, or treated, so as to have enhanced visibility.

6. 发明授权

EP1014896B1 SEWING RING HAVING INCREASED ANNULAR COAPTATION 失效
标题翻译：圆具有增加住宿EQUIPPED缝纫环
公开(公告)号：EP1014896B1
公开(公告)日：2005-11-02
申请号：EP98936861.8
申请日：1998-07-16
申请人： Edwards Lifesciences Corporation
发明人： STARR, Albert , STOBIE, Robert , HELMUS, Michael, N.
IPC分类号： A61F2/24
CPC分类号： A61F2/2409
摘要： A sewing ring for implantation of prosthetic heart valves has a compliant ring member made of a plurality of cells. The ring member may be silicon rubber and the cells defined within outer walls and inner ribs. A biocompatible fabric covering surrounds at least an outer portion of the ring member, and the assembly mounts to a mechanical or tissue-type prosthetic heart valve. The ring member has a radial dimension and cross-sectional area sufficient to ensure a large coaptation area between the sewing ring and the annulus tissue so as to enable adequate attachment of the valve without load distributing devices such as pledgets. A version of the sewing ring for attachment to the mitral annulus includes a curved coaptation edge, while another embodiment for attachment to the aortic annulus has a tapered outer edge with increased radial and axial dimensions. The sewing ring eliminates the need for pledgets, reduces the number of sutures required, lessens the potential for decubitous ulceration, and provides a better seal against perivalvular leakage. Moreover, the aortic valve sewing ring is sufficiently flexible and large to be able to be placed intra- or supra-annularly, as the surgeons deem best for the patient.

7. 发明公开

EP1239795A1 ENHANCED VISUALIZATION OF MEDICAL IMPLANTS 有权
标题翻译：知名度的提高的医学植入物
公开(公告)号：EP1239795A1
公开(公告)日：2002-09-18
申请号：EP00988113.7
申请日：2000-12-15
申请人： Edwards Lifesciences Corporation
发明人： BESSLER, Anita, B. , HELMUS, Michael, N.
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61B17/0469 , A61B90/39 , A61B2090/3941 , A61F2/2409 , A61F2/2448 , A61F2220/0075 , A61F2250/0097
摘要： Medical implants, installation tools, and methods of installation for minimally-invasive surgery wherein the implants, tools, and/or implantation site are marked with structure having enhanced visibility. The enhanced visibility markers may be highly reflective or luminescent; that is, the markers may be fluorescent, luminescent, or chemiluminescent. Metallic markers, such as gold, platinum, or stainless-steel may be used. The implant may be for cardiovascular surgery, and may have fabric thereon on which the enhanced visibility marker is provided. For example, the marker may be provided on a sewing ring of a heart valve, or on the exterior of an annuloplasty ring. A marker may be placed at anatomical location at the implantation site for better visualization thereof. An enhanced visibility marker on the implant may then be registered with the marker at the anatomical location. Sutures for attaching the implant to the host tissue, or for attaching an installation tool to the implant, may be made of a material, or treated, so as to have enhanced visibility.

8. 发明公开

EP1250166A1 DELIVERY SYSTEMS FOR TREATMENT OF RESTENOSIS AND ANASTOMOTIC INTIMAL HYPERPLASIA 有权
标题翻译：释放系统用于治疗和再狭窄的吻合口内膜增生
公开(公告)号：EP1250166A1
公开(公告)日：2002-10-23
申请号：EP01905081.4
申请日：2001-01-25
申请人： Edwards Lifesciences Corporation
发明人： HELMUS, Michael, N. , CUNANAN, Crystal , TREMBLE, Patrice
IPC分类号： A61L31/16 , A61L31/14 , A61L31/04 , A61L27/22 , A61L27/54
CPC分类号： A61L27/52 , A61L27/225 , A61L27/54 , A61L31/04 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/622
摘要： The invention provides methods for treating injuries to one or more internal structures of a subject by administering a drug delivery vehicle to an external surface of the injured structure. The drug delivery vehicle substantially adheres to the site of administration and provides for the release of a bioactive agent that reduces or prevents further injury to the internal structure by disease processes, such as hyperplasia.

9. 发明公开

EP1250165A2 BIOACTIVE COATINGS TO PREVENT TISSUE OVERGROWTH ON ARTIFICIAL HEART VALVES 有权
标题翻译：生物活性涂层以减少组织增长对人工心脏瓣膜的风险
公开(公告)号：EP1250165A2
公开(公告)日：2002-10-23
申请号：EP01906708.1
申请日：2001-01-25
申请人： Edwards Lifesciences Corporation
发明人： HELMUS, Michael, N. , CUNANAN, Crystal , TREMBLE, Patrice , KAFESJIAN, Ralph
IPC分类号： A61L27/54 , A61L33/00
CPC分类号： A61L27/507 , A61L27/54 , A61L33/0011 , A61L2300/114 , A61L2300/222 , A61L2300/236 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/434 , A61L2300/602
摘要： The present invention provides a prosthetic heart valve that includes biologically active agents that retard or prevent the infiltration of fibrous tissue ('pannus') from the host into the structure of the prosthetic valve. Preventing or decreasing the overgrowth of the prosthetic valve by pannus reduces the complications associated with the implantation and use of prosthetic heart valves.

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