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1. 发明公开

EP2818046A1 Variably crosslinked tissue 审中-公开
标题翻译：变量Vernetzungsgewebe
公开(公告)号：EP2818046A1
公开(公告)日：2014-12-31
申请号：EP14002055.3
申请日：2007-02-22
申请人： BIOMEDICAL DESIGN, INC.
发明人： The designation of the inventor has not yet been filed
IPC分类号： A01N1/02 , A61K35/32 , A61K35/36 , A61L27/36 , A61K38/39
CPC分类号： A01N1/0215 , A61K35/32 , A61K35/36 , A61K38/39 , A61L27/3604 , A61L27/3687 , A61L27/50 , A61L2400/02 , A61L2430/40 , Y10S623/915 , Y10S623/918 , Y10S623/919
摘要： Non-glutaraldehyde fixation of an organ or a prosthesis for implantation in a mammal is based upon carbodiimide treatment. A solution containing a sterilizing agent, such as EDC, in combination with a coupling enhancer, such as Sulfo-NHS, and a high concentration of a diamine cross linking agent is used. As a result, only minimal surface reduction occurs during fixation, and the resultant products show a dramatic increase in resistance to calcification.
摘要翻译：用于植入哺乳动物的器官或假体的非戊二醛固定基于碳二亚胺处理。使用含有灭菌剂如EDC与偶联增强剂如磺基-NHS和高浓度二胺交联剂的溶液。结果，在固定期间仅发生最小的表面减少，并且所得产物显示出抗钙化的显着增加。

2. 发明授权

EP1738717B1 In vitro production of transplantable cartilage tissue 有权
标题翻译：在体外产生可移植的软骨组织的
公开(公告)号：EP1738717B1
公开(公告)日：2010-08-04
申请号：EP06015455.6
申请日：2000-02-29
申请人： RUSH UNIVERSITY MEDICAL CENTER
发明人： Masuda, Koichi , Thonar, Eugene , Hejna, Michael
IPC分类号： A61F2/28
CPC分类号： A61L27/3817 , A61F2/30756 , A61F2/3094 , A61F2310/00365 , A61K35/12 , A61L27/227 , A61L27/24 , A61L27/3633 , A61L27/3654 , A61L27/38 , A61L27/3852 , A61L27/3895 , A61L27/54 , A61L2430/06 , C12N5/0655 , C12N2500/38 , C12N2531/00 , C12N2533/74 , C12N2533/90 , Y10S623/915
摘要： The present invention is directed to a transplanter cartilage matrix (40), and a method for its in vitro production.

3. 发明授权

EP1027893B1 Alginate containing medicament and implant for treating fibrosis 失效
标题翻译：含藻酸盐的药物和植入物纤维化的治疗
公开(公告)号：EP1027893B1
公开(公告)日：2008-12-31
申请号：EP00201292.0
申请日：1992-05-29
申请人： Wright Medical Technology, Inc.
发明人： Roufa, Dikla , Harel, Adrian , Frederickson, Robert C.A.
IPC分类号： A61K31/734 , A61K38/39 , A61L15/28 , A61P41/00
CPC分类号： A61K31/734 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K38/1703 , A61K38/39 , A61L27/20 , A61L27/34 , A61L31/042 , Y10S530/857 , Y10S623/915 , Y10S623/924 , Y10S977/788 , Y10S977/793 , Y10S977/795 , Y10S977/908 , Y10S977/91 , A61K31/715 , A61K2300/00 , C08L5/00 , C08L5/02 , C08L5/04

4. 发明公开

EP1428869A4 CELL AND STRUCTURE INCUBATOR 审中-公开
标题翻译： ZELL- UND STRUKTURINKUBATOR
公开(公告)号：EP1428869A4
公开(公告)日：2008-08-06
申请号：EP02762902
申请日：2002-08-29
申请人： TAKAGI KOGYO KK
发明人： TAKAGI TAKAO , WATANABE SETSUO
IPC分类号： C12M1/36 , C12M1/42 , C12M3/00
CPC分类号： C12M35/04 , Y10S623/915 , Y10S623/92
摘要： A cell and structure incubator capable of promoting the cultivation of cultured matters such as cells and structures by providing a specified tensile stress thereto as a physical irritation, comprising a chamber (cultivation chamber (8)) for circulating culture solution (24), cultured matters (matrix (32)) installed in the chamber for cultivation, a stress generating means (electromagnetic stretcher (38), actuator (56)) for acting the tensile stress on the cultured matters from the outside of the chamber, and a control means (controllers (50), (60)) for applying or removing and gradually increasing or decreasing the tensile stress generated in the stress generating means, whereby the physical irritation required for the multiplication of the cultured matters can be provided to the cultured matters by extending or retracting the cultured matters by the application and removal of the tensile stress.
摘要翻译：一种细胞和结构培养箱，其能够通过向其提供特定的拉伸应力作为物理刺激来促进细胞和结构等培养物的培养，所述培养箱包括用于使培养液（24）循环的腔室（培养腔室（8）），培养物（矩阵（32）），用于从腔室的外部对培养物施加拉伸应力的应力产生装置（电磁拉伸器（38），致动器（56）），以及控制装置控制器（50），（60）），用于施加或去除并逐渐增加或减少应力发生装置中产生的拉伸应力，由此可以通过延长或增加培养物质的培养物的繁殖所需的物理刺激性通过施加回缩培养物并除去拉伸应力。

5. 发明公开

EP1428869A1 CELL AND STRUCTURE INCUBATOR 审中-公开
标题翻译：细胞和结构培养器
公开(公告)号：EP1428869A1
公开(公告)日：2004-06-16
申请号：EP02762902.1
申请日：2002-08-29
申请人： Takagi Industrial Co., Ltd.
发明人： TAKAGI, Takao c/o TAKAGI INDUSTRIAL CO., LTD. , WATANABE, Setsuo c/o TAKAGI INDUSTRIAL CO., LTD.
IPC分类号： C12M3/00
CPC分类号： C12M35/04 , Y10S623/915 , Y10S623/92
摘要： A cell/tissue culture apparatus for applying a desired tensile stress to a material to be cultivated such as a cell or tissue as a physical stimulation, thereby enhancing acceleration of culture of the material to be cultivated. The cell/tissue culture apparatus comprises a chamber (a culture chamber 8) for circulating a culture fluid (24), a material to be cultivated (a matrix 32) that is placed and cultivated in the chamber, stress generation means (an electromagnetic stretcher 38, an actuator 56) for causing a tensile stress to act on the material to be cultivated from an outside of the chamber, and control means (controllers 50, 60) for causing the tensile stress generated by the stress generation means to intermit as well as undergo gradual increase or gradual decrease. The material to be cultivated can be caused to undergo expansion or contraction by applying and relieving the tensile stress, thereby applying a physical stimulation necessary for the proliferation to the material to be cultivated.
摘要翻译：一种细胞/组织培养设备，用于对作为物理刺激的细胞或组织等要培养的材料施加所需的拉伸应力，从而加速待培养材料的培养。细胞/组织培养装置包括用于使培养液（24）循环的腔室（培养腔室8），在腔室中放置培养的培养基材（基质32），应力产生装置（电磁拉伸器 38，致动器56），用于使拉伸应力作用于从腔室的外部培养的材料;以及控制装置（控制器50,60），用于使由应力生成装置生成的拉伸应力也中断随着逐渐增加或逐渐减少。通过施加和缓解拉伸应力，可以使要栽培的材料发生膨胀或收缩，由此对待栽培的材料施加增殖所需的物理刺激。

6. 发明公开

EP1158930A1 PROTEOGLYCAN-REDUCED SOFT TISSUE XENOGRAFTS 审中-公开
标题翻译：蛋白多糖减少软组织异体移植
公开(公告)号：EP1158930A1
公开(公告)日：2001-12-05
申请号：EP00908532.5
申请日：2000-02-08
申请人： Crosscart Inc.
发明人： STONE, Kevin, R.
IPC分类号： A61F2/02
CPC分类号： A61L27/3691 , A61L27/3604 , A61L27/3687 , A61L2430/40 , Y10S623/915
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic soft tissue xenograft for implantation into humans. The invention further provides methods for preparing a soft tissue xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; and digesting the xenograft with a proteoglycan-depleting factor and/or glycosidase and optionally following with a capping treatment. The invention also provides an article of manufacture produced by the above-identified method of the invention. The invention further provides a soft tissue xenograft for implantation into a human including a portion of a soft tissue from a non-human animal, wherein the portion has extracellular components and substantially only dead cells. The extracellular components have reduced proteoglycan molecules. Each of the xenografts of the invention are substantially non-immunogenic and have substantially the same mechanical properties as a corresponding native soft tissue.
摘要翻译：本发明提供了一种制品，其包含用于植入人类的基本上非免疫原性的软组织异种移植物。本发明还提供了通过从非人类动物移除至少一部分软组织以提供异种移植物来制备软组织异种移植物的方法; 用盐水和酒精洗涤异种移植物; 使异种移植物经受细胞破裂治疗; 并用蛋白多糖消耗因子和/或糖苷酶消化异种移植物，并任选地进行封闭处理。本发明还提供了由本发明的上述方法生产的制品。本发明进一步提供了用于植入人类的软组织异种移植物，其包括来自非人类动物的软组织的一部分，其中该部分具有细胞外成分并且基本上仅具有死细胞。细胞外成分具有减少的蛋白聚糖分子。本发明的每个异种移植物基本上是非免疫原性的并且具有与相应的天然软组织基本相同的机械性质。

7. 发明授权

EP0804255B1 METHODS FOR TREATING IMPLANTABLE BIOLOGICAL TISSUES TO MITIGATE THE CALCIFICATION THEREOF 失效
标题翻译：方法植入式生物组织用于减少钙化治疗
公开(公告)号：EP0804255B1
公开(公告)日：2001-10-04
申请号：EP95931511.0
申请日：1995-07-25
申请人： Edwards Lifesciences Corporation
发明人： CARPENTIER, Sophie , CARPENTIER, Alain
IPC分类号： A61L27/00
CPC分类号： A61L27/3687 , A61L27/3604 , A61L2400/02 , Y10S623/915
摘要： A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutaraldehyde. Alternatively, methods other than heating (e.g., chemical or mechanical means), for effecting polymerization of the glutaraldehyde may also be utilized. Alternatively, the tissue may be heat treated prior to fixing thereof. Alternatively, methods other than glutaraldehyde may also be used for fixing the tissue. The biological tissue may be so treated at any time prior to implantation thereof in a mammalian body.

8. 发明授权

EP0744970B1 IMPROVED PROCESS FOR FIXATION OF CALCIFICATION-RESISTANT BIOLOGICAL TISSUE 失效
标题翻译：改进方法用于固定钙化BEST QUIT生物组织
公开(公告)号：EP0744970B1
公开(公告)日：2001-05-30
申请号：EP95912565.9
申请日：1995-02-16
申请人： BIOMEDICAL DESIGN, INC.
发明人： GIRARDOT, Jean-Marie , GIRARDOT, Marie-Nadia
IPC分类号： A61L27/00
CPC分类号： A61L27/3687 , A61L2400/02 , A61L2430/40 , Y10S623/915 , Y10S623/916 , Y10S977/702
摘要： Processes for the non-glutaraldehyde fixation of a prosthesis to be implanted in a mammal whereby the prosthesis is fixed by employing coupling agents and/or cross-linking agents to form amide linkages between and within the proteinaceous molecules of the prosthetic tissue. The disclosed processes prevent or retard calcification and result in a nontoxic product which does not cause inflammation, providing prostheses that are well-suited for implantation in a mammal.

9. 发明公开

EP0741550A4 MULTIPLE LAYER ALGINATE COATINGS OF BIOLOGICAL TISSUE FOR TRANSPLANTATION 失效
标题翻译：生物组织移植多层ALGINATBESCHICHTUNGEN
公开(公告)号：EP0741550A4
公开(公告)日：1998-09-09
申请号：EP95908081
申请日：1995-01-17
申请人： UNIV CALIFORNIA , METABOLEX INC
发明人： COCHRUM KENT C , DORIAN RANDEL E , JEMTRUD SUSAN A
IPC分类号： A01N1/02 , A61K9/00 , A61K9/16 , A61K9/50 , A61K35/12 , A61L27/20 , A61L27/34 , A61L27/36 , A61L27/38 , B01J2/00 , C12N5/00 , C12N5/071 , C12N11/04 , A61F2/02 , C12N5/08
CPC分类号： A61K9/0024 , A01N1/02 , A01N1/0205 , A01N1/0231 , A61K9/1652 , A61K9/5031 , A61K9/5073 , A61K9/5089 , A61K2035/128 , A61L27/20 , A61L27/34 , A61L27/36 , A61L27/3604 , A61L27/3687 , A61L27/38 , A61L27/3804 , A61L27/3839 , A61L2420/02 , A61L2420/08 , B01J2/003 , C12N5/0012 , C12N5/0677 , C12N11/04 , C12N2500/12 , C12N2533/74 , Y10S623/915 , C08L5/04
摘要： A method for multiple layer coating of biological tissue and cells for transplantation. The cell or tissue transplants are coated with multiple coatings of purified alginate. The method includes applying the first coat of sodium alginate gelled with divalent cations followed by optional treatment with strontium, barium or other divalent cation, resuspending the single coated droplets in sodium alginate and forming the halo layer around the first coating via exchange or diffusion of divalent cations from the single coating to the surrounding soluble alginate, removing the excess coating and gelling the remaining thin layer of soluble alginate with divalent cations. The coated transplants have distinct structure where biological tissue or cell core is covered with the first alginate coat, which is surrounded by an intermediate halo layer which is covered by the outer coating.

10. 发明公开

EP0819007A4 URINARY BLADDER SUBMUCOSA DERIVED TISSUE GRAFT 失效
标题翻译： GEWEBETRANSPLANTET从膀胱黏膜下层
公开(公告)号：EP0819007A4
公开(公告)日：1998-07-08
申请号：EP96907084
申请日：1996-02-22
申请人： PURDUE RESEARCH FOUNDATION
发明人： BADYLAK STEPHEN F , VOYTIK-HARBIN SHERRY L , BRIGHTMAN ANDREW O , WANINGER MATT
IPC分类号： C12N5/06 , A61K35/22 , A61L27/36 , A61P43/00 , C12N5/00
CPC分类号： A61L27/3683 , A61K35/22 , A61L27/3604 , A61L27/3645 , C12N5/0068 , C12N2533/92 , Y10S623/915
摘要： A tissue graft composition comprising bladder submucosal tissue delaminated from abluminal muscle layers and at least the luminal portion of the tunica mucosa of a segment of vertebrate urinary bladder is described. The graft composition can be implanted to replace or support damaged or diseased tissues.

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