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1. 发明公开

EP1362239A2 CHARACTERIZING BIOLOGICAL STIMULI BY RESPONSE CURVES 审中-公开
标题翻译：生物REIZEN由浓度曲线表征
公开(公告)号：EP1362239A2
公开(公告)日：2003-11-19
申请号：EP02742492.8
申请日：2002-02-20
申请人： Cytokinetics, Inc.
发明人： ADAMS, Cynthia, L. , OESTREICHER, Donald, R. , VAISBERG, Eugeni, A.
IPC分类号： G01N33/50
CPC分类号： G06K9/6253 , G06F19/70 , G06K9/00127
摘要： A method for generating stimulus response curves (e.g., dose response curves) shows how the phenotype of one or more cells change in response to varying levels of the stimulus. Each 'point' on the curve represents quantitative phenotype for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The quantitative phenotypes are multivariate phenotypic representations of the cell(s). They include various features of the cell(s) obtained by image analysis. Such features often include basic parameters obtained from images (e.g., cell shape, nucleus area, Golgi texture) and/or biological characterizations derived from the basic parameters (e.g., cell cycle state, mitotic index, etc.). The stimulus response curves may be compared to allow classification of stimuli and identify subtle differences in related stimuli. To facilitate the comparison, it may be desirable to present the response curves in a principal component space.

2. 发明公开

EP1675834A1 COMPOUNDS, COMPOSITIONS, AND METHODS 审中-公开
标题翻译：化合物，组合物和方法
公开(公告)号：EP1675834A1
公开(公告)日：2006-07-05
申请号：EP04795136.3
申请日：2004-10-15
申请人： Cytokinetics, Inc.
发明人： RAMCHANDANI, Shyamlal , NORMAN DE LA ROSA, Reginald , ADAMS, Cynthia, L. , BERGNES, Gustave , MORGANS, David, J., Jr. , TRAUTMAN, Jay, K.
IPC分类号： C07D239/22 , A61K31/505 , A61K31/506 , A61P35/00 , A61P37/00 , A61P9/04
CPC分类号： C07D239/22 , C07D403/04
摘要： Compounds useful for treating cellular proliferative diseases are disclosed.
摘要翻译：公开了用于治疗细胞增殖性疾病的化合物。

3. 发明公开

EP1188139A2 METHOD AND APPARATUS FOR PREDICTIVE CELLULAR BIOINFORMATICS 审中-公开
标题翻译：方法和装置用于蜂窝预测生物信息学
公开(公告)号：EP1188139A2
公开(公告)日：2002-03-20
申请号：EP00930696.0
申请日：2000-05-12
申请人： Cytokinetics, Inc.
发明人： SABRY, James, H. , ADAMS, Cynthia, L. , VAISBERG, Eugeni, A. , CROMPTON, Anne, M. , BLUM, Robert, I. , OESTREICHER, Donald, R. , SIGAL, Nolan, H.
IPC分类号： G06F19/00
摘要： Techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, techniques for determining information about the properties of substances based upon information about structure of living or non-living cells exposed to substances are provided. A method according to the present invention enables researchers and/or scientists to identify promising candidates in the search for new and better medicines or treatments using, for example, a cellular informatics database. The present invention further teaches a system for acquiring knowledge from cellular information. The system has a database 1012 comprising a database management module ('DBMS'). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.

4. 发明公开

EP1814554A1 CERTAIN COMPOUNDS, COMPOSITIONS, AND METHODS 审中-公开
标题翻译：某些化合物，组成和方法
公开(公告)号：EP1814554A1
公开(公告)日：2007-08-08
申请号：EP05812392.8
申请日：2005-10-24
申请人： Cytokinetics, Inc.
发明人： RAMCHANDANI, Shyamlal , DE LA ROSA, Reginald, Norman , ADAMS, Cynthia, L. , BERGNES, Gustave , MORGANS, David J. Jr. , TRAUTMAN, Jay K.
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4709 , C07D417/02
CPC分类号： C07D215/54 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/12
摘要： Compounds useful for treating cellular proliferative diseases are disclosed.

5. 发明公开

EP1322788A2 IMAGE ANALYSIS FOR PHENOTYPING SETS OF MUTANT CELLS 审中-公开
标题翻译：图像分析方法来突变的细胞群的表型
公开(公告)号：EP1322788A2
公开(公告)日：2003-07-02
申请号：EP01948675.2
申请日：2001-06-22
申请人： Cytokinetics, Inc.
发明人： NISLOW, Corey, E. , SIGAL, Nolan, H. , DRUBIN, David, G. , ADAMS, Cynthia, L.
IPC分类号： C12R1/865
CPC分类号： C12N15/1079 , C12N15/1034
摘要： A method described herein phenotypes a set of mutant strains in a quantitative manner. Specifically, the method characterizes a cellular and subcellular architecture of mutant alleles grown in a variety of conditions using various morphological and molecular markers, combined with automated image acquisition and analysis. Phenotypic features may include the cytoskeleton, organelles, cell morphology, DNA replication state, the relationship of these features to each other, etc. From these features a quantitative 'fingerprint' can be generated for each phenotype. This quantitative phenotypic information is made available in a database that links geneotype to phenotype. Genes characterized in this manner may be clustered into functional categories, pathways, higher order protein assemblies, and the like.

6. 发明公开

EP1309848A2 METHOD AND APPARATUS FOR PREDICTIVE CELLULAR BIOINFORMATICS 审中-公开
标题翻译：方法和设备的预测ZELLBIOINFORMATIK
公开(公告)号：EP1309848A2
公开(公告)日：2003-05-14
申请号：EP01932627.1
申请日：2001-04-24
申请人： Cytokinetics, Inc.
发明人： OESTREICHER, Donald, R. , SABRY, James, H. , ADAMS, Cynthia, L. , VAISBERG, Eugeni, A. , CROMPTON, Anne, M.
IPC分类号： G01N15/14
CPC分类号： C12M41/46 , B01J2219/00315 , B01J2219/00689 , B01J2219/00695 , B01J2219/00707 , B01J2219/0072 , C40B60/14 , G01N15/1475 , G01N2015/1477
摘要： Techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, techniques for determining information about the properties of substances based upon information about structure of living or non-living cells exposed to substances are provided. A method according to the present invention enables researchers and/or scientists to identify promising candidates in the search for new and better medicines or treatments using, for example, a multiple biological descriptors derived from a single cell component or marker. The method employs image analysis to extract a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database.

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