专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP4216957A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS 审中-实审
公开(公告)号：EP4216957A1
公开(公告)日：2023-08-02
申请号：EP21873238.6
申请日：2021-09-20
申请人： Merck Sharp & Dohme LLC , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人： BODDEY, Justin, A. , OLSEN, David, B. , STEEL, Ryan
IPC分类号： A61K31/505 , A61K31/506 , A61K31/5585 , C07C13/44 , C07D239/20 , C07D239/22

2. 发明公开

EP3952998A1 PYRIMIDINONE DERIVATIVES AS SHP2 ANTAGONISTS 审中-实审
公开(公告)号：EP3952998A1
公开(公告)日：2022-02-16
申请号：EP20721371.1
申请日：2020-04-08
申请人： Merck Patent GmbH
发明人： JORAND-LEBRUN, Catherine , BOIVIN, Roch , JOHNSON, Theresa , WANG, Yanping , XIAO, Yufang , CHEN, Xiaoling , LINDE, Nina , MUSCH, Doreen , KUMAR, Deepak
IPC分类号： A61P35/00 , C07D239/22 , C07D401/04 , C07D403/04 , C07D491/107 , A61K31/506

3. 发明授权

EP2643416B1 THE USE OF ARYL OR HETEROARYL SUBSTITUTED DITHIOLENE METAL COMPLEXES AS IR ABSORBERS 有权
公开(公告)号：EP2643416B1
公开(公告)日：2019-08-07
申请号：EP11785701.1
申请日：2011-11-23
申请人： BASF SE
发明人： REICHELT, Helmut , GEßNER, Thomas , HEIZLER, Daniel , LEHMANN, Urs
IPC分类号： C09D11/03 , C09D11/02 , B41M3/14 , C07D233/84 , C07D233/88 , C07D239/22

4. 发明授权

EP2638900B1 DRUG FOR TREATING LIVER LESIONS CAUSED BY THE ACTION OF CHEMICAL OR BIOLOGICAL AGENTS 有权
公开(公告)号：EP2638900B1
公开(公告)日：2019-05-15
申请号：EP11839641.5
申请日：2011-10-10
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： KRASNOV, Konstantin Andreevich
IPC分类号： A61K31/513 , A61P1/16 , C07D239/22

5. 发明公开

EP3191449A1 NOVEL COMPOUNDS AS REARRANGED DURING TRANSFECTION (RET) INHIBITORS 有权
标题翻译：在转运（RET）抑制剂过程中重新配制的新化合物
公开(公告)号：EP3191449A1
公开(公告)日：2017-07-19
申请号：EP15840612.4
申请日：2015-09-10
申请人： GlaxoSmithKline Intellectual Property Development Limited
发明人： CHEUNG, Mui , DEMARTINO, Michael P. , EIDAM, Hilary Schenck , GUAN, Huiping Amy , QIN, Donghui , WU, Chengde , GONG, Zhen , YANG, Haiying , YU, Haiyu , ZHANG, Zhiliu
IPC分类号： C07D211/94 , C07D217/24 , C07D239/22 , A61K31/4412 , A61K31/4427 , A61P35/00 , A61P1/00 , A61P43/00
CPC分类号： C07D491/048 , C07B2200/13 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/75 , C07D217/24 , C07D221/00 , C07D221/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D471/04
摘要： This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.
摘要翻译：本发明涉及作为转染期间重排（RET）激酶抑制剂的新化合物，含有它们的药物组合物，其制备方法，以及它们单独或组合用于胃肠敏感性正常化的用途，（RET）功能障碍相关疾病相关的动力和/或分泌和/或腹部病症或疾病和/或治疗，或者RET活性的调节可能具有治疗益处，包括但不限于肠易激综合征（IBS）的所有分类，包括腹泻 - 功能性腹胀，功能性腹泻，非特异性功能性肠病，功能性腹痛综合征，慢性特发性便秘，功能性食管疾病，功能性胃十二指肠疾病，功能性肛门直肠疼痛，炎症性肠病，增殖性疾病疾病等如非小细胞肺癌，肝细胞癌，结直肠癌，甲状腺髓样癌，甲状腺滤泡癌，甲状腺未分化癌，乳头状甲状腺癌，脑肿瘤，腹腔癌，实体瘤，其他肺癌，头颈部癌，神经胶质瘤，神经母细胞瘤，Von Hippel-Lindau综合征和肾肿瘤，乳腺癌，输卵管癌，卵巢癌，移行细胞癌，前列腺癌，食管癌和胃食管连接癌，胆管癌，腺癌和RET激酶活性增加的任何恶性肿瘤。

6. 发明授权

EP2683694B1 ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF 有权转让
标题翻译：雄激素受体拮抗剂及其用途
公开(公告)号：EP2683694B1
公开(公告)日：2016-04-27
申请号：EP12755126.5
申请日：2012-03-08
申请人： Suzhou Kintor Pharmaceuticals, Inc.
发明人： TONG, Youzhi
IPC分类号： C07D233/42 , C07D233/86 , C07D233/66 , C07D233/84 , C07D401/04 , C07D401/14 , C07D403/10 , C07D417/14 , A61K31/4164 , A61K31/4178 , A61P5/28 , A61P35/00 , C07D413/10 , C07D239/22 , C07D413/14 , C07D235/02 , C07D401/10
CPC分类号： C07D239/22 , C07D233/86 , C07D235/02 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/10 , C07D413/14 , C07D417/14

7. 发明授权

EP1546114B1 TETRAHYDROPYRIMIDINE-2-ONE DERIVATIVES AND THEIR USES 失效转让
标题翻译：四氢-2-酮衍生物及其应用
公开(公告)号：EP1546114B1
公开(公告)日：2015-09-30
申请号：EP03797254.4
申请日：2003-08-26
申请人： Unilever PLC , Unilever NV
发明人： FOSTER, Alison , VAN DER LOGT, C. P. E., Unilever R & D Vlaardingen , TAREILUS, Erwin Werner, Unilever R & D Vlaardingen
IPC分类号： A61Q11/00 , A61Q19/00 , C07D239/22
CPC分类号： C07D239/22 , A23L27/204 , A23L27/2054 , A61K8/4953 , A61K2800/244 , A61Q11/00 , A61Q19/00

8. 发明公开

EP2377854A1 N-phenyl-dioxo-hydropyrimidines useful as hepatitis C virus (HCV) inhibitors 审中-公开
标题翻译： Als丙型肝炎 - Hemmer verwendbare N-苯基 - 二氧代 - 氢嘧啶
公开(公告)号：EP2377854A1
公开(公告)日：2011-10-19
申请号：EP11163527.2
申请日：2008-09-17
申请人： Abbott Laboratories
发明人： Donner, Pamela L , Randolph, John T , Krueger, Allan C , Betebenner, David A , Hutchinson, Douglas K , Liu, Dachun , Liu, Yaya , Longenecker, Kenton L , Maring, Clarence J , Pratt, John K , Rockway, Todd W , Stewart, Kent D , Wagner, Rolf , Barnes, David M , Chen, Shuang , Franczyk II, Thaddeus S , Gao, Yi , Haight, Anthony R , Hengeveld, John E , Henry, Rodger F , Kotecki, Brian J , Lou, Xiachun , Zhang, Geoff G Z
IPC分类号： C07D239/22 , C07D239/54 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D239/553 , A61K31/513 , A61K31/506 , A61P31/14
CPC分类号： C07D239/22 , A61K31/513 , C07D239/54 , C07D239/553 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions. The compounds are useful in the treatment of hepatitis C and are of the following general structure: Formula (I)
摘要翻译：本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备此类中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。该化合物可用于丙型肝炎的治疗，具有以下一般结构：式（I）

9. 发明公开

EP2368882A1 ANTI-INFECTIVE PYRIMIDINES AND USES THEREOF 有权转让
标题翻译：抗生素PYRIMIDINE UND DEREN VERWENDUNG
公开(公告)号：EP2368882A1
公开(公告)日：2011-09-28
申请号：EP11171399.6
申请日：2008-09-17
申请人： ABBOTT LABORATORIES
发明人： Flentge, Charles, A , Hutchinson, Douglas K , Betebenner, David A , Degoey, David A , Donner, Pamela L , Kati, Warren M , Krueger, Allan C , Liu, Dachun , Liu, Yaya , Longenecker, Kenton L , Maring, Clarence J , Motter, Christopher E , Pratt, John K , Randolph, John T , Rockway, Todd W , Stewart, Kent D , Wagner, Rolf , Barnes, David M , Chen, Shuang , Franczyk II, Thaddeus S , Gao, Yi , Haight, Anthony R , Hengeveld, John E , Kotecki, Brian J , Lou, Xiaochun , Zhang, Geoff G Z
IPC分类号： C07D239/22 , C07D239/54 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K31/513 , A61P31/12
CPC分类号： C07D239/54 , A61K31/513 , A61K45/06 , C07D239/22 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K2300/00
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia , inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
摘要翻译：本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备此类中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

10. 发明授权

EP2203431B1 ANTI-INFECTIVE PYRIMIDINES AND USES THEREOF 有权转让
标题翻译：抗感染性嘧啶类及其应用
公开(公告)号：EP2203431B1
公开(公告)日：2011-08-10
申请号：EP08832330.8
申请日：2008-09-17
申请人： Abbott Laboratories
发明人： FLENTGE, Charles, A. , HUTCHINSON, Douglas, K. , BETEBENNER, David, A. , DEGOEY, David, A. , DONNER, Pamela, L. , KATI, Warren, M. , KRUEGER, Allan, C. , LIU, Dachun , LIU, Yaya , LONGENECKER, Kenton, L. , MARING, Clarence, J. , MOTTER, Christopher, E. , PRATT, John, K. , RANDOLPH, John, T. , ROCKWAY, Todd, W. , STEWART, Kent, D. , WAGNER, Rolf , BARNES, David, M. , CHEN, Shuang , FRANCZYK, Thaddeus, S., II , GAO, Yi , HAIGHT, Anthony, R. , HENGEVELD, John, E. , KOTECKI, Brian, J. , LOU, Xiaochun , ZHANG, Geoff, G., Z.
IPC分类号： C07D239/22 , C07D239/54 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K31/513 , A61P31/12
CPC分类号： C07D239/54 , A61K31/513 , A61K45/06 , C07D239/22 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K2300/00
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式