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1. 发明公开

EP1188139A2 METHOD AND APPARATUS FOR PREDICTIVE CELLULAR BIOINFORMATICS 审中-公开
标题翻译：方法和装置用于蜂窝预测生物信息学
公开(公告)号：EP1188139A2
公开(公告)日：2002-03-20
申请号：EP00930696.0
申请日：2000-05-12
申请人： Cytokinetics, Inc.
发明人： SABRY, James, H. , ADAMS, Cynthia, L. , VAISBERG, Eugeni, A. , CROMPTON, Anne, M. , BLUM, Robert, I. , OESTREICHER, Donald, R. , SIGAL, Nolan, H.
IPC分类号： G06F19/00
摘要： Techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, techniques for determining information about the properties of substances based upon information about structure of living or non-living cells exposed to substances are provided. A method according to the present invention enables researchers and/or scientists to identify promising candidates in the search for new and better medicines or treatments using, for example, a cellular informatics database. The present invention further teaches a system for acquiring knowledge from cellular information. The system has a database 1012 comprising a database management module ('DBMS'). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.

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