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1. 发明授权

EP2166353B1 REAGENT AND REAGENT KIT FOR ANALYSIS OF PRIMITIVE LEUKOCYTE 有权
公开(公告)号：EP2166353B1
公开(公告)日：2018-08-08
申请号：EP08777588.8
申请日：2008-06-25
申请人： Sysmex Corporation
发明人： KATAOKA, Yukiko , TSUJI, Tomohiro , OGUNI, Shinichiro , YOSHIDA, Ayumu , ABE, Masaki
IPC分类号： G01N33/49 , G01N33/48
CPC分类号： G01N33/56972 , G01N15/1459 , G01N2015/1006 , G01N2015/1402 , G01N2015/1477 , Y10T436/100833 , Y10T436/101666 , Y10T436/107497 , Y10T436/25125
摘要： The present invention provides a reagent for analysis of immature leukocytes comprising: a surfactant which can damage cell membranes of erythrocytes and mature leukocytes, a solubilizing agent which can shrink the damaged blood cells and a dye for staining nucleic acid, wherein the reagent has an osmotic pressure of not lower than 10 mOsm/kg and lower than 150 mOsm/kg.

2. 发明授权

EP2997365B1 ANALYSEVERFAHREN ZUR KLASSIFIKATIONSUNTERSTÜTZUNG 有权
公开(公告)号：EP2997365B1
公开(公告)日：2018-05-23
申请号：EP14752580.2
申请日：2014-08-05
申请人： Siemens Healthcare Diagnostics Products GmbH
发明人： KAVSEK, Barbara , LEDERER, Peter , TAAL, Peter , VAN DEN BOOGAART, Jan
IPC分类号： G01N33/49 , G01N21/49 , G01N15/14
CPC分类号： G01N15/1456 , G01N21/49 , G01N33/49 , G01N2015/0073 , G01N2015/1006 , G01N2015/1477 , G01N2015/1488 , G01N2015/1497 , G01N2021/4702 , G01N2021/4769 , G01N2800/22 , G01N2800/26

3. 发明授权

EP2951722B1 PROCESS FOR IDENTIFYING RARE EVENTS 有权
标题翻译：识别稀有事件的过程
公开(公告)号：EP2951722B1
公开(公告)日：2018-05-16
申请号：EP14701802.2
申请日：2014-01-31
申请人： UNIVERSITE DE MONTPELLIER , Centre Hospitalier Universitaire de Montpellier , INRIA - Institut National de Recherche en Informatique et en Automatique , Institut National de Recherche en Sciences et Technologies pour l'Environnement et l'Agriculture (IRSTEA)
发明人： CEZAR, Renaud , IENCO, Dino , MAS, André , MASSEGLIA, Florent , PONCELET, Pascal , PUDLO, Pierre , SZEKELY, Eniko , TEISSEIRE, Maguelonne , VENDRELL, Jean-Pierre
IPC分类号： G06F17/18 , G01N15/14 , G01N33/569 , G06F19/24
CPC分类号： G06F19/24 , G01N15/1459 , G01N33/569 , G01N2015/1477 , G01N2015/1488 , G06F17/18
摘要： A method for identifying a subpopulation of specific cells among a large population of cells, includes: a step of exposing the cells of the large population to n-reagents; a step of detecting the n-reagents; a step of grouping the cells by clusterization into k different clusters; and a step of eliminating cells that are not rare cells.

4. 发明授权

EP2811032B1 Bacteria analyzing method and specimen analyzer 有权
标题翻译：细菌分析方法和标本分析仪
公开(公告)号：EP2811032B1
公开(公告)日：2018-04-04
申请号：EP14170754.7
申请日：2014-06-02
申请人： SYSMEX CORPORATION
发明人： Tanaka, Masamichi , Tateyama, Shota , Fukuda, Masakazu
IPC分类号： C12Q1/04 , G01N15/14 , G01N33/493
CPC分类号： C12Q1/02 , C12Q1/04 , G01N15/1459 , G01N2015/1006 , G01N2015/1402 , G01N2015/1477
摘要： Disclosed is a bacteria analyzing method comprising: irradiating with light a measurement sample prepared by mixing a specimen and a reagent; obtaining two types of optical information from each of at least some particles contained in the measurement sample; and generating a measurement result of the specimen with a flag representing morphological characteristics of bacteria contained in the specimen, characterized in that the flag is generated based on both of: (i) information indicative of a characteristic of a distribution pattern of particles plotted in a first region of a coordinate space including at least two axes, wherein the two types of optical information are scalable along the respective axes, and (ii) information representing a number of particles plotted in a second region being a part of the first region.

5. 发明公开

EP3274688A1 APPAREIL HYDROFOCUS A SOLUTION D'ANALYSE UNIQUE 有权
标题翻译：具有单分析解决方案的液氦锅炉设备
公开(公告)号：EP3274688A1
公开(公告)日：2018-01-31
申请号：EP16716500.0
申请日：2016-03-25
申请人： BIT Group France
发明人： CHAMPSEIX, Henri , LEVEAU, Maxime , MAGNIN, Olivier
IPC分类号： G01N15/14 , G01N15/06
CPC分类号： G01N15/1404 , G01N2015/0693 , G01N2015/1413 , G01N2015/1477
摘要： The present invention relates to an apparatus for analysing a blood sample contained in an analysis solution. This apparatus includes a dilution and analysis tray capable of containing the analysis solution. This tray is directly connected to a circulation vessel comprising a sleeve active so that the analysis solution used to measure the haemoglobin content is also used to measure the leukocyte sub-populations of white blood cells, at a predefined dilution rate having a ratio of less than 1/160. The apparatus also includes a hydraulic system which, together with the circulation vessel, is designed to generate a flow of the analysis solution having a diameter of 70 to 90 pm so as to have enough cells for the optical measurement.

6. 发明公开

EP2149081A4 GRAPHICAL USER INTERFACE FOR ANALYSIS AND COMPARISON OF LOCATION-SPECIFIC MULTIPARAMETER DATA SETS 有权转让
公开(公告)号：EP2149081A4
公开(公告)日：2017-11-15
申请号：EP08746006
申请日：2008-04-16
申请人： EMD MILLIPORE CORP
发明人： CAPPIONE AMEDEO JOSEPH , LEFEBVRE RAY , KILCOIN NEIL , KING DAVID ANDREW , DIXON GEORGE J
IPC分类号： G06F3/048
CPC分类号： G06F19/26 , G01N35/00722 , G01N2015/1402 , G01N2015/1477 , G01N2035/0091 , G06F3/04817
摘要： A graphical user interface on a computer provides for the analysis of location specific data and the presentation of analysis results for visual comparison by a user. Results of the analysis are visually presented as icons subdivided into regions and arranged in such a way that the user is able to associate each icon with a data location. A visual presentation of results in the icons and regions allows a user to visually compare the analysis results in two or more data sets according to location. The graphical user interface further provides for the definition and adjustment of an analysis through the interaction of a user with a graphical representation of the analysis. In some cases, the visual presentation of results tracks the analysis adjustments so the user can visually observe the effects that the adjustments have on the results. A method of interacting with the interface to define an analysis and represent results and a method of presenting two or more data sets using the interface are described. The interface can be used to analyze and visually compare the results of location specific data from a number of sources and is illustrated in a flow cytometry application.

7. 发明授权

EP1922695B1 METHOD OF, AND APPARATUS AND COMPUTER SOFTWARE FOR, PERFORMING IMAGE PROCESSING 有权转让
标题翻译：用于执行图像处理的方法和设备以及计算机软件
公开(公告)号：EP1922695B1
公开(公告)日：2017-10-04
申请号：EP06765317.0
申请日：2006-08-19
申请人： GE Healthcare Limited
发明人： ALEXANDROV, Yuriy , BYE, Iain , KALUSCHE, Geert
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G01N15/1475 , G01N2015/1477 , G06K9/00147 , G06K9/6228 , G06T2207/30024

8. 发明公开

EP3213080A2 REAGENTS, METHODS AND KITS FOR DIAGNOSING PRIMARY IMMUNODEFICIENCIES 有权
标题翻译：用于诊断主要免疫缺陷的试剂，方法和试剂盒
公开(公告)号：EP3213080A2
公开(公告)日：2017-09-06
申请号：EP15823036.7
申请日：2015-10-30
申请人： Erasmus University Medical Center Rotterdam
发明人： VAN DONGEN, Jacobus Johannes Maria , ORFAO DE MATOS CORREIA E VALE, José Alberto , VAN DER BURG, Mirjam , PÉREZ-ANDRÉS, Martín , VAN ZELM, Menno Cornelis , KALINA, Tomás , VLKOVÁ, Marcela , LÓPEZ-GRANADOS, Eduardo , BLANCO ÁLVAREZ, Elena , KIENZLER, Anne-Kathrin
IPC分类号： G01N33/569 , C07K16/00 , G01N15/14
CPC分类号： G01N33/56972 , G01N15/1459 , G01N2015/008 , G01N2015/1006 , G01N2015/1402 , G01N2015/1477 , G01N2015/1488 , G01N2800/24
摘要： This invention relates to the field of primary immunodeficiencies (PID), more specifically to means and method for the diagnosis of PID of the lymphoid system. Provided are unique reagent compositions for the flow cytometric immunophenotyping of leukocytes comprising fluorochrome-conjugated antibodies directed against various specific combinations of markers. Also provided are kits comprising the reagent compositions, and methods using the same.
摘要翻译：本发明涉及初级免疫缺陷（PID）领域，更具体地涉及用于诊断淋巴系统的PID的手段和方法。提供了用于白细胞流式细胞术免疫分型的独特试剂组合物，其包含针对各种特定标记组合的荧光染料缀合抗体。还提供了包含试剂组合物的试剂盒和使用其的方法。

9. 发明公开

EP3204756A1 PARTICLE ANALYSIS AND SORTING APPARATUS AND METHODS 有权
标题翻译：粒子分析和分选设备和方法
公开(公告)号：EP3204756A1
公开(公告)日：2017-08-16
申请号：EP15848958.3
申请日：2015-10-09
申请人： Kinetic River Corp.
发明人： VACCA, Giacomo
IPC分类号： G01N21/64
CPC分类号： G01N15/14 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G01N15/147 , G01N2015/1006 , G01N2015/1477 , G01N2015/1488 , G01N2015/149
摘要： A particle analyzer, comprising a source of a beam of pulsed optical energy; a detector comprising a number of spectral detection channels to detect optical signals resulting from interactions between the beam and particles in a sample (such as, e.g., fluorescence signals), and to convert the optical signals into respective electrical signals; optical paths from the source to the sample and from the sample to the detector; a flowcell connected with the optical paths and with a flow path for a suspension of particles; a signal processing module capable of: receiving the electrical signals from the detector; mathematically combining individual decay curves in the signals into a decay supercurve; allocating individual components of the supercurve to discrete bins of predetermined time constants; and quantifying the relative contribution of individual components to the supercurve; a particle sorting actuator; an actuator driver; and at least one particle collection receptacle.
摘要翻译：一种粒子分析仪，包括脉冲光能束的源; 包括多个光谱检测通道的检测器，用于检测由光束和样本中的粒子之间的相互作用（诸如例如荧光信号）产生的光信号，并将光信号转换为相应的电信号; 从光源到样品和从样品到检测器的光路; 与光路连接并且具有用于悬浮颗粒的流动路径的流动池; 信号处理模块，其能够：从所述检测器接收所述电信号; 将信号中的各个衰减曲线数学地组合成衰减超曲线; 将超曲线的各个分量分配给预定时间常数的离散区间; 并量化单个组件对超曲线的相对贡献; 颗粒分选致动器; 致动器驱动器; 和至少一个颗粒收集容器。

10. 发明公开

EP2647976A4 3D DATA ANALYSIS DEVICE, 3D DATA ANALYSIS METHOD, AND 3D DATA ANALYSIS PROGRAM 审中-公开
标题翻译： 3D-DATANANALYSEVORRICHTUNG，3D-DATANANALYSEVERFAHREN UND 3D-DATANANALYSEPROGRAMM
公开(公告)号：EP2647976A4
公开(公告)日：2017-08-09
申请号：EP11844939
申请日：2011-11-25
申请人： SONY CORP
发明人： SUZUKI SHUNSUKE , FUJIMAKI ATSUO , SHODA KENJI
IPC分类号： G01N15/00 , G01N35/00 , G06T15/00 , G06T19/00 , H04N13/02
CPC分类号： G06T15/00 , G01N15/14 , G01N2015/1006 , G01N2015/1477 , G06T3/40 , G06T3/60 , G06T11/206 , G06T2200/04 , G06T2200/08 , G06T2210/56 , H04N13/0203 , H04N13/0275 , H04N13/0282 , H04N13/0409 , H04N13/0436 , H04N13/0447
摘要： The present invention provides a 3D data analysis apparatus, a 3D data analysis method, and a 3D data analysis program capable of easily and instinctively specifying microparticles and microparticle small populations to be analyzed without referring to a large number of histograms or cytograms or imaging a 3D distribution chart. Provided is a 3D data analysis apparatus including a data storage unit that stores measurement data of microparticles, an input unit that selects three kinds of variables independent of the measurement data, a data processing unit that calculates positions and graphics in a coordinate space with the three kinds of variables being coordinate axes and creates a 3D stereoscopic image that represents a characteristic distribution of the microparticles, and a display unit that displays the 3D stereoscopic image.
摘要翻译：本发明提供了一种3D数据分析装置，3D数据分析方法和3D数据分析程序，其能够容易地且本能地指定待分析的微粒和微粒小群体而不参考大量的直方图或细胞图或3D 分布图。提供了一种3D数据分析装置，包括：数据存储单元，存储微粒的测量数据;输入单元，用于选择与测量数据无关的三种变量;数据处理单元，用于计算三个坐标空间中的位置和图形作为坐标轴的变量，生成表示微粒的特征分布的3D立体图像，显示3D立体图像的显示部。

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