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    • 1. 发明公开
      EP0178381A3 Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents 失效
    • Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents
    • 苯乙烯胺作为抗过敏剂，抗哮喘药和抗炎药物
    • EP0178381A3
    • 1987-03-18
    • EP85106617
    • 1985-05-29
    • USV PHARMACEUTICAL CORPORATION
    • Stevenson, David , Liu, Robert C. , Ho, Laurence L. , Jones, Howard , Coutts, Stephen
    • C07C103/76 , C07C149/243 , C07D209/20 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/40
    • C07D209/20
    • Compounds of the structure:
      and pharmaceutically acceptable salts thereof, wherein
      R 7 is H or halogen; R, and R 2 are independently OH, lower alkyl, lower alkoxy, aryloxy, heteroaryloxy, heteroaryl lower alkoxy, aryl, heteroaryl, aryl lower alkyl, aryl lower alkoxy, halogenated aryl lower alkoxy, lower alkenyl, lower alkynyl, lower alkenoxy, lower alkynoxy, halogen, trifluoromethyl, cyclopropy-Imethoxy or cyclohexenoxy; A is H, aryl, lower alkyl, aryl lower alkyl or heteroaryl; and B is
      or
      is an amino acid, N-lower alkyl amino acid, N-aryl lower alkyl amino acid or N-heteroaryl amino acid, or lower alkyl esters or amides thereof; n = 0-6;
      M is H, lower alkyl, or CH 2 OR 5 ; R 5 is H, lower alkyl, aryl, aryl lower alkyl or heteroaryl; R 6 is lower alkyl, aryl, aryl lower alkyl or heteroaryl; E is OH, lower alkyl, aryl or heteroaryl; F is
      and G is OH, lower alkyl, lower alkoxy, aryloxy, heteroaryl, aryl lower alkyl, aryl lower alkoxy, halogenated aryl lower alko xy, lower alkenyl, lower alkynyl, lower alkenoxy, lower alkynoxy, halogen or trifluoromethyl.
    • 结构化合物及其药学上可接受的盐，其中：R 1和R 2独立地为H，OH，低级烷基，低级烷氧基，芳氧基，杂芳氧基，杂芳基低级烷氧基，芳基，杂芳基，芳基 - 低级烷基， 烷氧基，卤代芳基 - 低级烷氧基，低级烯基，低级炔基，低级链烯氧基，低级炔氧基，卤素或三氟甲基; A是H，芳基，低级烷基，芳基 - 低级烷基或杂芳基; 并且B是N = 0-6，其中D是H，CONR 3 R 4，CO 2 H，CO 2 R 5，CH 2 OH或CH 2 OR 6，其中R 3，R 4，R 5和R 6独立地是H，低级烷基，芳基，芳基 - 低级烷基或杂芳基 ; E是H，OH，低级烷基，芳基或杂芳基; 且F为，其中G与R1和R2相同，可用于治疗过敏，哮喘和炎性病症。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 2. 发明公开
      EP0200101A2 Aryl and heteroaryl ethers as agents for the treatment of hypersensitive aliments 失效
    • Aryl and heteroaryl ethers as agents for the treatment of hypersensitive aliments
    • 芳基和杂芳基醚作为治疗过敏性食物的试剂
    • EP0200101A2
    • 1986-12-10
    • EP86105287.6
    • 1986-04-16
    • USV PHARMACEUTICAL CORPORATION
    • Youssefyeh, Raymond , Chakraborty, Utpal , Magnien, Ernest , Desai, Rohit
    • A61K31/47 , A61K31/35 , A61K31/41 , A61K31/085 , C07D215/14 , C07D405/12 , C07D401/12 , C07D309/22 , C07D257/04 , C07C43/23
    • The present invention is concerned with the therapeutic composition comprising as an active ingredient a compound of the formula:
      and salts thereof; wherein

      Ar and Ar, are independently phenyl, naphthyl or a nitrogen, oxygen, or sulfur heterocyclic ring;
      R,, R 2 and R 3 are independently H, lower alkyl, lower alkoxy, hydroxy, halo, trihalomethyl, hydroxy-lower alkyl, alkyl carboxy, carboxy, formyl, lower alkyl carbonyl, aryl, aryloxy, benzyloxy, lower alkylamino, diloweralkylamino, cyano, lower alkanoyloxy, carbamoyl, lower alkoxy-lower alkoxy, lower carbalkoxy-lower alkoxy, nitro, amino, tetrahydropyranylmethyl, tetrazole, tetrazole lower alkyl, formyl amino or lower alkanoylamino;
      R, is independently H, lower alkyl, lower alkoxy, hydroxy, halo, trihalomethyl, hydroxy-lower alkyl, alkyl carboxy, carboxy, formyl, lower alkyl carbonyl, aryl, aryloxy, benzyloxy, lower alkylamino, diloweralkylamino, cyano, lower alkanoyloxy, carbamoyl, lower alkoxy-lower alkoxy, lower carbalkoxy-lower alkoxy, nitro, amino, tetrahydropyranylmethyl, or tetrazole, or tetrazole lower alkyl or R s ;
      R s is lower alkoxy, phenyl, OH, CO 2 R 6 cyclic or heterocyclic structures.
    • 本发明涉及包含作为活性成分的下式化合物及其盐的治疗组合物： 其中Ar和Ar独立地为苯基，萘基或氮，氧或硫杂环; 低级烷基，低级烷氧基，羟基，卤素，三卤代甲基，羟基 - 低级烷基，烷基羧基，羧基，甲酰基，低级烷基羰基，芳基，芳氧基，苄氧基，低级烷基氨基，二低级烷基氨基，氰基 氨基甲酰基，低级烷氧基 - 低级烷氧基，低级烷氧基 - 低级烷氧基，硝基，氨基，四氢吡喃基甲基，四唑，四唑低级烷基，甲酰基氨基或低级烷酰基氨基; 低级烷基，低级烷氧基，羟基，卤素，三卤代甲基，羟基 - 低级烷基，烷基羧基，羧基，甲酰基，低级烷基羰基，芳基，芳氧基，苄氧基，低级烷基氨基，二低级烷基氨基，氰基， 氨基甲酰基，低级烷氧基 - 低级烷氧基，低级烷氧羰基 - 低级烷氧基，硝基，氨基，四氢吡喃基甲基或四唑或四唑低级烷基或R; R5是低级烷氧基，苯基，OH，CO2R6环或杂环结构。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 3. 发明公开
      EP0185383A2 Bag clamping arrangement 失效
    • Bag clamping arrangement
    • Sackklemmvorrichtung。
    • EP0185383A2
    • 1986-06-25
    • EP85116304.8
    • 1985-12-20
    • USV PHARMACEUTICAL CORPORATION
    • Lavender, Ardis , Vrrany, George
    • A61F5/44 , A61J1/00
    • A61J1/16 , A61F5/44
    • A bag clamping arrangement, such as an arrangement for automatically controlling the filling volume and overflow of a liquid conducted into a flexible bag which is clamped in the arrangement. The bag clamping arrangement is essentially constituted of a rigid upwardly open receptacle of substantially rectangular or a relatively large upper compartment, and wherein a narrow compartment which in open communication with the upper compartment depends downwardly from the bottom of the upper compartment so as to extend longitudinally and generally centrally across the full width of the receptacle. The lower compartment includes opposite parallel sidewalls which are down so as to form a reducing compartment width therebetween. Towards the lower end of the compartment is a plate-like clamping arrangement essentially constituted of a flat plate member which may be manually engaged through an elongate slot and gripping portion proximate its upper horizontal edge. The plate member is provided along its lower edge on both sides thereof with sideways projecting resilient clamping components which, upon being inserted into the lower compartment of the receptacle, are biased towards the plate member and are dimensioned to clampingly engage between the sides of the clamping plate and the contiguous sidewalls of the lower compartment. A flexible bag is positioned on either one side, or two bags each respectively on the opposite sides of the clamping plate member prior to insertion of the latter into the receptacle, with the lower end portion of the bag or bags extending between the respective resilient clamping component and the facing surface of the clamping plate member such that, upon introduction of the clamping plate member downwardly into the lower compartment, the applicable resilient clamping component upon being biased towards the plate member, will clamp the lower bag portion against the facing surface of the clamping plate member, thereby ensuring the secure clamping of the bag.
    • 袋夹紧装置，例如用于自动控制填充体积的装置，以及被传导到柔性袋中的液体的溢出，该柔性袋被夹持在该装置中。 袋夹紧装置基本上由基本为矩形或相对较大的上隔室的刚性向上开口的容器构成，并且其中与上隔室开放连通的狭窄隔室从上隔室的底部向下从顶部向下延伸，以便纵向延伸 并且通常在容器的整个宽度上居中。 下隔室包括向下的相对的平行侧壁，以便在它们之间形成减小隔间宽度。 朝向隔室的下端是板状夹持装置，其基本上由平板构件构成，平板构件可以通过细长的槽和靠近其上部水平边缘的夹紧部分手动接合。 板构件沿着其下边缘在其两侧设置有侧向突出的弹性夹紧部件，其在插入到容器的下隔室中时被朝向板构件偏置，并且尺寸被设计成夹紧地夹紧在夹紧件的侧面之间 板和下隔室的连续侧壁。 一个柔性袋在将其插入到容器中之前分别位于夹板构件的相对侧上的一侧或两个袋上，其中袋或袋的下端部分在相应的弹性夹紧 夹紧板构件的面向表面和夹紧板构件的相对表面，使得当夹紧板构件向下进入下隔室时，适用的弹性夹紧构件被朝向板构件偏置时，将下袋部分夹紧在 夹紧板构件，从而确保袋的牢固夹紧。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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