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1. 发明授权

EP0114067B1 Compounds for treating hypertension 有权
标题翻译：用于治疗高血压的化合物
公开(公告)号：EP0114067B1
公开(公告)日：1987-04-29
申请号：EP84100300.7
申请日：1984-01-12
申请人： USV PHARMACEUTICAL CORPORATION
发明人： Huang, Fu-chih , Jones, Howard , Lin, Clara J. , Loev, Bernard
IPC分类号： C07K5/06 , C07C83/10 , C07D295/08 , A61K37/02
CPC分类号： C07K5/022 , A61K38/00 , Y10S530/80

2. 发明授权

EP0108822B1 Antiglaucoma compounds 失效
标题翻译：抗肿瘤化合物
公开(公告)号：EP0108822B1
公开(公告)日：1986-08-13
申请号：EP82110433.8
申请日：1982-11-11
申请人： USV PHARMACEUTICAL CORPORATION
发明人： Loev, Bernard , Lee, Daw-Yuan , Youssefyeh, Raymond
IPC分类号： C07C93/26 , A61K31/135 , A61K31/22
CPC分类号： A61K31/215

3. 发明公开

EP0127066A2 Composition for treating asthma 失效
标题翻译： Zusammensetzung zur Behandlung von哮喘。
公开(公告)号：EP0127066A2
公开(公告)日：1984-12-05
申请号：EP84105521.3
申请日：1984-05-15
申请人： USV PHARMACEUTICAL CORPORATION
发明人： Loev, Bernard , Brown, Richard E. , Huang, Fu-chih , Jones, Howard
IPC分类号： A61K31/42 , C07D263/58
CPC分类号： C07D263/58 , Y10S514/826
摘要： A new method of treating asthma is provided. The method is the administration of an effective dose of a Benzoxazole-2-carboxylic acid amide.
摘要翻译：提供了治疗哮喘的新方法。该方法是施用有效剂量的苯并恶唑-2-羧酸酰胺。

4. 发明授权

EP0040332B1 Antihypertensive lactams 有权
标题翻译：抗生素LACTAMS
公开(公告)号：EP0040332B1
公开(公告)日：1986-09-17
申请号：EP81103073.3
申请日：1981-04-23
申请人： USV PHARMACEUTICAL CORPORATION
发明人： Suh, John Taiyoung , Williams, Bruce Earl , Skiles, Jerry Wallace , Loev, Bernard
IPC分类号： C07D417/14 , C07D417/04 , C07D281/00 , C07D513/04 , A61K31/54 , C07D279/12 , A61K31/55
CPC分类号： C07D513/04 , C07D277/06 , C07D279/12 , C07D281/06

5. 发明公开

EP0137155A3 Derivatives of Alpha-alkyl polyolefinic compounds useful in the treatment of psoriasis 失效
标题翻译：用于治疗PSORIASIS的ALPHA-ALKYL POLYOLEFINIC化合物的衍生物
公开(公告)号：EP0137155A3
公开(公告)日：1985-12-18
申请号：EP84108432
申请日：1984-07-17
申请人： USV PHARMACEUTICAL CORPORATION
发明人： Loev, Bernard , Jones, Howard , Chan, Wan-kit
IPC分类号： C07C175/00 , A61K31/07
CPC分类号： C07C403/16 , C07C43/23 , C07C403/02 , C07C403/08 , C07C403/10 , C07C403/12 , C07C403/18 , C07C403/22 , C07C2601/16
摘要： The present invention relates to novel a-alkyl polyolefinic compounds and to pharmaceuticals containing said compounds. The pharmaceuticals are useful for the treatment of psoriasis. The a-alkyl polyolefinic compounds have the structure
wherein
n is 0 to 3; R, and R 4 are each independently hydrogen or an alkyl group of from 1 to 5 carbon atoms; R 2 is an alkyl group of from 1 to 5 carbon atoms; R 3 is H, C 1 -C 5 alkyl, cyclo C 3 -C 7 alkyl, C 2 -C 5 alkenyl, cyclo C 3 -C 7 alkenyl, aryl, hydroxy, C 1 -C 5 alkoxy, aryloxy, arylalkoxy, formyl, C 1 -C 6 alkylcarbonyl, C 2 -C 5 alkenylcarbonyl, arylcarbonyl, aryl C 1 -C 5 alkylcarbonyl, aryl C 2 -C 5 alkenylcarbonyl, NR 6 R 5 , SR 5 ,
retinyloxy, retinoyl, retinoyloxy, or
R 6 is H, C 1 -C 20 alkyl, aryl, aralkyl; and Z is a cycloalkyl, cycloalkenyl or cycloalkadienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group, or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof; and the pharmaceutically- acceptable salts thereof.
摘要翻译：本发明涉及新的α-烷基聚烯烃化合物和含有所述化合物的药物。这些药物可用于治疗牛皮癣。 α-烷基聚烯烃化合物具有以下结构：其中... n为0至3; R 1至R 4各自独立地为氢或1至5个碳原子的烷基; R 2为 1至5个碳原子; R3是H，C1-C5烷基，环C3-C7烷基，C2-C5烯基，环C3-C7链烯基，芳基，羟基，C1-C5烷氧基，芳氧基，芳基烷氧基，甲酰基，C1- C6烷基羰基，C2-C5烯基羰基，芳基羰基，芳基C1-C5烷基羰基，芳基C2-C5烯基羰基，NR5R5，SR5，...... -O-@-R5，...视黄酰基，视黄酰氧基或... H，C 1 -C 20烷基，芳基，芳烷基; Z是被0-5个烷基，酮基或羟基取代的环烷基，环烯基或环二烯基，或被0至4个羟基，烷氧基，烷基或三氟甲基或卤素原子取代的苯基或其组合; 及其药学上可接受的盐。

6. 发明公开

EP0039919A1 Benzoxazole and benzothiazole derivatives with anti-allergic activity 有权
标题翻译：苯并恶唑和苯并噻唑衍生物抗逆转录酶Wirkung。
公开(公告)号：EP0039919A1
公开(公告)日：1981-11-18
申请号：EP81103497.4
申请日：1981-05-07
申请人： USV PHARMACEUTICAL CORPORATION
发明人： Brown, Richard E. , Georgiev, Vasil St. , Loev, Bernard
IPC分类号： A61K31/42 , A61K31/425 , C07D263/58 , C07D277/68 , C07D413/12 , C07D498/04 , C07D513/04
CPC分类号： C07D263/58 , C07D265/36 , C07D277/68
摘要： An anti-allergic compound of the formula:
wherein,

X is S or O R 1 and R 2 are each H, R 3 , OR 4 , halogen, cyano, COOR 4 , methanesulfonyl, nitro, trifluoromethyl or taken together, methylenedioxy, wherein R 3 is loweralkyl orcycloalkyl of 3 to 7 carbon atoms and R 4 is hydrogen or lower alkyl; and
R is -Z-O-R 3 ; -Z-N(R 5 R 6 ); Z 1 -O-Z 2 -N(R 5 R 6 ); -Z- heterocycle; -Z 1 -O-Z 2 -heterocycle; or-Z-O-C 6 H 4 R 1 wherein each of R 5 and R 6 are hydrogen or lower alkyl, or when taken together with the nitrogen to which they are attached R 5 and R 6 form a nitrogen-heterocyclic ring, R 1 and R 3 have the meaning hereinbefore described, and Z,Z 1 and Z 2 are each branched or unbranched alkylene chain containing from 2 to about 6 carbon atoms in the principal chain and a total of up to about 12 carbon atoms; Z 1 and Z 2 when taken together with a hetero atom form a saturated heterocyclic ring; and heterocycle represents a heterocyclic ring containing one or more of the hetero atoms, oxygen, nitrogen and sulfur and acid addition and conjugate salts thereof.
摘要翻译：一种下式的抗过敏化合物：其中，... X为S或O ... R 1和R 2各自为H，R 3，OR 4，卤素，氰基，COOR 4，甲磺酰基，硝基，三氟甲基或一起取代亚甲二氧基其中R3是3-7个碳原子的低级烷基或环烷基，R4是氢或低级烷基; 和... R是-Z-O-R3; -Z-N（R 5 R 6）; ž<1> -O-Z <2> -N（R 5 R 6）; -Z-杂环; -Z <1> -O-Z <2> - 杂环; 或-ZO-C 6 H 4 R 1，其中R 5和R 6各自为氢或低级烷基，或者当与其连接的氮一起连接时，R 5和R 6形成氮杂环，R 1和R 3具有上述含义，Z Z 1和Z 2分别是在主链中含有2至约6个碳原子且总共至多约12个碳原子的支链或非支链亚烷基链; Z 1和Z 2与杂原子一起形成饱和杂环; 杂环表示含有一个或多个杂原子，氧，氮和硫及其酸加成和共轭盐的杂环。

7. 发明公开

EP0127066A3 Composition for treating asthma 失效
标题翻译：用于治疗哮喘的组合物
公开(公告)号：EP0127066A3
公开(公告)日：1987-12-16
申请号：EP84105521
申请日：1984-05-15
申请人： USV PHARMACEUTICAL CORPORATION
发明人： Loev, Bernard , Brown, Richard E. , Huang, Fu-chih , Jones, Howard
IPC分类号： A61K31/42 , C07D263/58
CPC分类号： C07D263/58 , Y10S514/826
摘要： A new method of treating asthma is provided. The method is the administration of an effective dose of a Benzoxazole-2-carboxylic acid amide.
摘要翻译：提供了一种治疗哮喘的新方法。该方法是施用有效剂量的苯并恶唑-2-羧酸酰胺。

8. 发明公开

EP0100433A3 Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis 有权转让
标题翻译：用于治疗牛皮癣的α-烷基聚烯酸羧酸及其衍生物
公开(公告)号：EP0100433A3
公开(公告)日：1985-06-26
申请号：EP83106298
申请日：1983-06-28
申请人： USV PHARMACEUTICAL CORPORATION
发明人： Loev, Bernard , Chan, Wan-kit , Jones, Howard
IPC分类号： C07C175/00 , A61K31/20 , A61K31/23 , A61K31/16
CPC分类号： A61K31/23 , A61K31/16 , A61K31/20 , C07C403/20 , C07C2601/16 , Y10S424/04 , Y10S514/863
摘要： Polyolefinic compounds, useful in the treatment of psoriasis, are disclosed. The compounds are represented by the general formula
in which R and R, are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R 2 is an alkyl group of from 1 to 5 carbon atoms; R 3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH 2 ,NHR 2 or NR 2 R 2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis.
摘要翻译：公开了用于治疗牛皮癣的聚烯烃化合物。所述化合物由通式表示，其中R和R 1各自为氢或具有1至5个碳原子的烷基; R2是1至5个碳原子的烷基; R 3是羟基，1至5个碳原子的烷氧基，NH 2，NHR 2或NR 2 R 2，Z是被0至5个烷基，酮基或羟基取代的环烷基，环烯基或环烷二烯基， 0至4个羟基，烷氧基，烷基或三氟甲基或卤素原子或其组合及其药学上可接受的盐。已经发现上述化合物在银屑病的治疗中是有效的。

9. 发明公开

EP0137155A2 Derivatives of Alpha-alkyl polyolefinic compounds useful in the treatment of psoriasis 失效
标题翻译： α-烷基 - 聚烯烃衍生的银屑病银屑病。
公开(公告)号：EP0137155A2
公开(公告)日：1985-04-17
申请号：EP84108432.0
申请日：1984-07-17
申请人： USV PHARMACEUTICAL CORPORATION
发明人： Loev, Bernard , Jones, Howard , Chan, Wan-kit
IPC分类号： C07C175/00 , A61K31/07
CPC分类号： C07C403/16 , C07C43/23 , C07C403/02 , C07C403/08 , C07C403/10 , C07C403/12 , C07C403/18 , C07C403/22 , C07C2601/16
摘要： The present invention relates to novel a-alkyl polyolefinic compounds and to pharmaceuticals containing said compounds. The pharmaceuticals are useful for the treatment of psoriasis. The a-alkyl polyolefinic compounds have the structure
wherein

n is 0 to 3;
R, and R 4 are each independently hydrogen or an alkyl group of from 1 to 5 carbon atoms;
R 2 is an alkyl group of from 1 to 5 carbon atoms;
R 3 is H, C 1 -C 5 alkyl, cyclo C 3 -C 7 alkyl, C 2 -C 5 alkenyl, cyclo C 3 -C 7 alkenyl, aryl, hydroxy, C 1 -C 5 alkoxy, aryloxy, arylalkoxy, formyl, C 1 -C 6 alkylcarbonyl, C 2 -C 5 alkenylcarbonyl, arylcarbonyl, aryl C 1 -C 5 alkylcarbonyl, aryl C 2 -C 5 alkenylcarbonyl, NR 6 R 5 , SR 5 ,
retinyloxy, retinoyl, retinoyloxy, or

R 6 is H, C 1 -C 20 alkyl, aryl, aralkyl; and
Z is a cycloalkyl, cycloalkenyl or cycloalkadienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group, or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof; and the pharmaceutically- acceptable salts thereof.
摘要翻译：本发明涉及新的α-烷基聚烯烃化合物和含有所述化合物的药物。这些药物可用于治疗牛皮癣。 α-烷基聚烯烃化合物具有以下结构：其中... n为0至3; R 1至R 4各自独立地为氢或1至5个碳原子的烷基; R 2为 1至5个碳原子; R3是H，C1-C5烷基，环C3-C7烷基，C2-C5烯基，环C3-C7链烯基，芳基，羟基，C1-C5烷氧基，芳氧基，芳基烷氧基，甲酰基，C1- C6烷基羰基，C2-C5烯基羰基，芳基羰基，芳基C1-C5烷基羰基，芳基C2-C5烯基羰基，NR5R5，SR5，...... -O-@-R5，...视黄酰基，视黄酰氧基或... H，C 1 -C 20烷基，芳基，芳烷基; Z为被0-5个烷基，酮基或羟基取代的环烷基，环烯基或环二烯基，或被0至4个羟基，烷氧基，烷基或三氟甲基或卤素原子取代的苯基或其组合; 及其药学上可接受的盐。

10. 发明授权

EP0039920B1 Triazaloquinoxalin-1,4-diones 有权
标题翻译： Triazaloquinoxalin -1,4-二酮
公开(公告)号：EP0039920B1
公开(公告)日：1984-07-25
申请号：EP81103498.2
申请日：1981-05-07
申请人： USV PHARMACEUTICAL CORPORATION
发明人： Brown, Richard E. , Georgiev, Vasil St. , Kropp, Philip , Loev, Bernard
IPC分类号： C07D487/04 , C07D471/14 , A61K31/495
CPC分类号： C07D471/04 , C07D241/44 , C07D471/14 , C07D487/04

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