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61. 发明公开

EP2173698A2 PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF RENIN INHIBITORS SUCH AS ALISKIREN 审中-公开
标题翻译：方法肾素抑制剂的合成中间体，如阿利吉仑
公开(公告)号：EP2173698A2
公开(公告)日：2010-04-14
申请号：EP08761132.3
申请日：2008-06-18
申请人： Novartis AG
发明人： DOMINGUEZ, Beatriz , DYKE, Alan , HEMS, William , MATHES, Christian , O'SULLIVAN, Anthony Cornelius , SEDELMEIER, Gottfried
IPC分类号： C07C51/00
CPC分类号： C07C57/13 , C07C51/09 , C07C51/353 , C07C51/36 , C07C67/475 , C07C69/593 , C07C69/602 , C07D321/00
摘要： The present invention relates to olefin metathesis processes for the manufacture of a compound of the formula (I) which is a novel useful intermediate in the synthesis of pharmaceutically active compounds, in particular renin inhibitors.

62. 发明公开

EP2157076A1 Verfahren zur Herstellung von ungesättigten alpha, omega Dicarbonsäurediestern 审中-公开
标题翻译：阿尔法，欧米茄Dicarbonsaurediestern，Verfahren zur Herstellung vonungesättigten
公开(公告)号：EP2157076A1
公开(公告)日：2010-02-24
申请号：EP08014838.0
申请日：2008-08-21
申请人： Cognis IP Management GmbH
发明人： Samorski, Markus , Dierker, Markus
IPC分类号： C07C67/475 , C07C69/593 , C07C6/04 , C07C11/02 , C07C51/353 , C07C57/13 , C11C3/00
CPC分类号： C11C3/00 , C07C67/475 , C07C2531/22 , C07C2531/24 , C07C69/593
摘要： Verfahren zur Herstellung von ungesättigten alpha, omega Dicarbonsäurediestern, bei dem man ungesättigte Fettsäuren und/oder Ester ungesättigter Fettsäuren in Gegenwart des Katalysators (1) und/oder (2)

umzetzt.
摘要翻译：不饱和α，ω-二羧酸二酯的制备包括在催化剂存在下转化不饱和脂肪酸和/或不饱和脂肪酸酯，所述催化剂包含二氯 - [1,3-双（均三甲基）-2-咪唑烷亚基] - （3-苯基 - （三环己基膦）钌（II）和/或[1,3-双（2,4,6-三甲基苯基）-2-咪唑烷亚基] - [2 - [[（4-甲基苯基）亚氨基 ]甲基] -4-硝基苯甲酰基] - [3-苯基-1H-茚-1-亚基]氯化钌（II）。

63. 发明授权

EP1810960B1 Procédé de co-production d'oléfines et de diesters ou de diacides à partir de corps gras insaturés 有权
标题翻译：过程从不饱和脂肪酸的物质同时生产烯烃和二酯或二酸的
公开(公告)号：EP1810960B1
公开(公告)日：2009-11-18
申请号：EP07290061.6
申请日：2007-01-16
申请人： Institut Français du Pétrole
发明人： Olivier-Bourbigou, Hélène , Vallee, Christophe , Hillion, Gérard
IPC分类号： C07C67/475 , C07C67/333 , C07C51/347 , C07C69/593 , C07C69/533 , C07C6/04 , C07C11/04 , C07C11/02 , C07C57/13
CPC分类号： C07C51/347 , C07C1/213 , C07C6/04 , C07C67/333 , C07C67/475 , C07C2531/24 , C07C11/04 , C07C11/02 , C07C57/13 , C07C69/533 , C07C69/593

64. 发明授权

EP1673328B1 AN IMPROVED PROCESS FOR THE SYNTHESIS OF UNSATURATED ALCOHOLS 有权
标题翻译：改进方法合成的不饱和醇的
公开(公告)号：EP1673328B1
公开(公告)日：2008-07-09
申请号：EP04788745.0
申请日：2004-09-14
申请人： Dow Global Technologies Inc.
发明人： MAUGHON, Bob, R. , BURDETT, Kenneth, A. , LYSENKO, zenon
IPC分类号： C07C29/32
CPC分类号： C07C29/095 , C07C67/293 , C07C67/333 , C07C67/475 , C07C69/007 , C07C69/533 , C07C69/593 , C07C69/145 , C07C33/03 , C07C33/035
摘要： A process of preparing an unsaturated alcohol (olefin alcohol), such as, a homo-allylic mono-alcohol or homo-allylic polyol, involving protecting a hydroxy-substituted unsaturated fatty acid or fatty acid ester, such as methyl ricinoleate, derived from a seed oil, to form a hydroxy-protected unsaturated fatty acid or fatty acid ester; homo-metathesizing or cross-metathesizing the hydroxy-protected unsaturated fatty acid or fatty acid ester to produce a product mixture containing a hydroxy-protected unsaturated metathesis product; and deprotecting the hydroxy-protected unsaturated metathesis product under conditions sufficient to prepare the unsaturated alcohol. Preferably, methyl ricinoleate is converted by cross-metathesis or homo-metathesis into the homo-allylic mono-alcohol 1-decene-4-ol or the homo-allylic polyol 9-octadecene-7,12-diol, respectively.

65. 发明公开

EP1810960A1 Procédé de co-production d'oléfines et de diesters ou de diacides à partir de corps gras insaturés 有权
标题翻译：过程从不饱和脂肪酸的物质同时生产烯烃和二酯或二酸的
公开(公告)号：EP1810960A1
公开(公告)日：2007-07-25
申请号：EP07290061.6
申请日：2007-01-16
申请人： Institut Français du Pétrole
发明人： Olivier-Bourbigou, Hélène , Vallee, Christophe , Hillion, Gérard
IPC分类号： C07C67/475 , C07C67/333 , C07C51/347 , C07C69/593 , C07C69/533 , C07C6/04 , C07C11/04 , C07C11/02 , C07C57/13
CPC分类号： C07C51/347 , C07C1/213 , C07C6/04 , C07C67/333 , C07C67/475 , C07C2531/24 , C07C11/04 , C07C11/02 , C07C57/13 , C07C69/533 , C07C69/593
摘要： Pour produire à la fois une fraction oléfinique et une composition de diacides ou diesters de corps gras, on met en oeuvre un procédé qui comprend successivement :
a) la métathèse d'un corps gras insaturé avec de l'éthylène, en présence d'au moins un liquide ionique non-aqueux ;
b) la séparation et le recyclage du liquide ionique utilisé dans la première étape ;
c) la séparation, par distillation, de la fraction oléfinique (fraction A) de la fraction mono-esters ou mono-acides de corps gras insaturés (fraction B) formées dans l'étape (a) ;
d) l'homométathèse de la coupe esters ou acides de corps gras mono-insaturés (fraction B) qui permet de co-produire les diesters ou les diacides de corps gras insaturés (fraction C) et de l'éthylène qui est recyclé à la première étape de métathèse du procédé ; et
e) éventuellement le recyclage du liquide ionique contenant le catalyseur utilisé dans l'étape (d). Appliqué plus particulièrement à une huile de tournesol oléique, à une huile de colza oléique ou à un mélange d'esters de monoalcool desdites huiles, le procédé permet de produire à la fois une fraction oléfinique (majoritairement composée de décène-1) et une composition de diesters ou diacides dont en général plus de la moitié des chaînes est constituée de chaînes insaturées en C18 (majoritairement composée de diacide ou de diester-1,18 de l'octadécène-9) et de recycler l'éthylène mis en jeu.
摘要翻译：的同时准备烯烃馏分和二酯/二酸的组合物的方法，包括：具有在催化剂的存在下和非水性一个12-22个碳的单羧酸或其酯和不饱和乙烯链的脂肪物质的复分解反应离子液体; 分离和含催化剂的离子液体的再循环; 烯烃馏分和单酯的分离/非饱和脂肪物质的一元酸; 和单酯的反应homometathesis /中在催化剂的存在下使液相一元酸。一个独立的claimsoft被包括用于在组件用于上述方法包括五个区域，即，（I），用于所述复分解反应包括引入所述不饱和脂肪酸的物质，乙烯，从homometathesis反应，区域区催化剂与流出物的功能（ II）用于分离和离子液体，其包括引入的流出物从以前的步骤中，所述离子液体中的条目中的回收和有机相含的烯烃馏分和不饱和的出口所得的的功能的再循环脂肪酯/酸，用于分离包括引入前一步骤，烯烃馏分的输出不饱和脂肪酸酯/丙烯酸和输出的流出物的功能的区域（III），和（IV）用于homometathesis反应包括区引入来自先前步骤的流出物的功能，流出物的出口主要含有长链不饱和二酯/二酸的SEPA 副产物，乙烯分离，引入乙烯进入区域（I）的乙烯和引入催化剂的比。

66. 发明公开

EP1664067A2 A NEW ROUTE TO alpha-TOCOPHEROL, alpha-TOCOPHERYL ALKANOATES AND PRECURSORS THEREOF 审中-公开
标题翻译：新航线α-生育酚，α-TOCOPHERYLALKANOATEN及其前体
公开(公告)号：EP1664067A2
公开(公告)日：2006-06-07
申请号：EP04786906.0
申请日：2004-09-02
申请人： DSM IP Assets B.V.
发明人： BONRATH, Werner , BREUNINGER, Manfred , MALAISE, Gregory , NETSCHER, Thomas
IPC分类号： C07F7/18 , C07D311/72
CPC分类号： C07D311/72 , C07C67/293 , C07C67/475 , C07C69/017 , C07C69/16
摘要： The present invention is concerned with a novel process for the manufacture of (E/Z)-4-alkanoyloxy-3,5,6-trimethyl-2-phytylphenyI esters and silyl ethers, precursors of α- tocopherol and α-tocopheryl alkanoates, by cross-metathesis reaction of 2-alkenyl-3,5,6-trimethylhydroquinone dialkanoates or 4-alkanoyloxy-2-alkenyl-3,5,6-trimethylphenyI silylethers with 2,6,10,14-tetramethylpentadecene or a phytol derivative, e.g. phytyl acetate, in the presence of a cross-metathesis catalyst. As the cross-metathesis catalyst especially ruthenium metal carbene complexes are suitable which possess (a) ruthenium metal center(s), have an electron count of 16 or 18 and are penta- or hexa- coordinated. A further object of the invention is a process for the manufacture of α-tocopherol and α-tocopheryl alkanoates comprising this reaction.

67. 发明公开

EP1322418A2 TRÄGERFIXIERTE RHENIUM-ALKYLIDEN-KATALYSATOREN FÜR DIE OLEFIN-METATHESE 审中-公开
标题翻译：支持固定铼亚催化剂上烯烃复分解
公开(公告)号：EP1322418A2
公开(公告)日：2003-07-02
申请号：EP01976225.1
申请日：2001-09-14
申请人： BASF AKTIENGESELLSCHAFT
发明人： BASSET, Jean-Marie , CHABANAS, Mathieu , COPERET, Christophe
IPC分类号： B01J31/22 , B01J31/26 , B01J37/02 , C07C6/04 , C07F13/00
CPC分类号： B01J31/1625 , B01J31/2265 , B01J2231/543 , B01J2231/74 , C07C6/04 , C07C67/475 , C07C2531/12 , C07C69/593
摘要： The invention relates to a novel, heterogeneous catalyst which is especially suitable for the metathesis of olefins, in addition to the production and corresponding use of the same. Said catalyst is fixed on an inorganic carrier and contains at least one active rhenium compound having at least one carbene group and optionally other functional groups. The rhenium compound is bonded to the material used as the carrier by a chemical bond. Preferably, a catalyst is used, which corresponds to formula (III) wherein S is a suitable carrier, preferably SiO2, and R?1, R2 and R3¿ independently represent a linear or branched C¿1?-C5 alkyl group, preferably a tert-butyl group.

68. 发明公开

EP1251135A2 High activity ruthenium or osmium metal carbene complexes for olefin metathesis reactions and synthesis thereof 失效
标题翻译： Hochwirksame Ruthenium- und Osmium-Metall-Carbenkomplexefürdie Olefinmetathesereaktionen，und deren Herstellung
公开(公告)号：EP1251135A2
公开(公告)日：2002-10-23
申请号：EP02016470.3
申请日：1995-07-28
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Grubbs, Robert H. , Nguyen, Sonbinh T. , Johnson, Lynda K. , Hillmyer, Marc A., Dept. of Chem.Eng. and Material , Fu, Gregory C.
IPC分类号： C07F15/02 , C07F15/04
CPC分类号： B01J31/2265 , B01J23/462 , B01J23/466 , B01J31/24 , B01J31/2404 , B01J2231/14 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07C51/353 , C07C67/333 , C07C67/475 , C07C2601/10 , C07F15/002 , C07F15/0046 , C08C19/08 , C08C2019/09 , C08F8/50 , C08F10/00 , C08F32/00 , C08F210/02 , C08G61/08 , C08G61/128 , Y10S525/938 , C07C57/13 , C07C69/74 , C07C69/533 , C07C69/593 , C08F4/80 , C08F220/00 , C08F110/14
摘要： A method of preparing a catalyst of the formula
comprising:

reacting a compound of the formula (XX 1 ML n L 1 m ) p with a phosphorane of the formula
wherein:
M is Os or Ru;
R and R 1 are either the same or different and are

(a) hydrogen,
(b) a group selected from C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, C 1 -C 20 alkyl, aryl, C 1 -C 20 carboxylate, C 2 -C 20 alkoxy, C 2 -C 20 alkenyloxy, C 2 -C 20 alkynyloxy, aryloxy, C 2 -C 20 alkoxycarbonyl, C 1 -C 20 alkylthio, C 1 -C 20 alkylsulfonyl, or C 1 -C 20 alkylsulfinyl, or
(c) one of the groups listed in (b) substituted with C 1 -C 5 alkyl, halogen, C 1 -C 5 alkoxy, unsubstituted phenyl, halogen substituted phenyl, C 1 -C 5 alkyl substituted phenyl, or C 1 -C 5 alkoxy substituted phenyl;

R 4 , R 5 , and R 6 are either the same or different and are each unsubstituted or substituted hydrocarbon wherein the hydrocarbon is selected from the group consisting of aryl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, and phenoxy and the hydrocarbon substitution is selected from the group consisting of halogen, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, unsubstituted phenyl, halogen substituted phenyl, C 1 -C 5 alkyl substituted phenyl, and C 1 -C 5 alkoxy substituted phenyl;
X and X 1 are either the same or different and are any anionic ligand;
L is any neutral electron donor;
L 1 is a trialkylphosphine ligand where at least one of the alkyl groups is a secondary alkyl or a cycloalkyl;
n and m are independently 0-4, provided n+m=2, 3 or 4; and
p is an integer equal to or greater than 1.
摘要翻译：制备式CHEM的催化剂的方法，包括：使式（XX1）MLnL1 m）p的化合物与式（CHEM）的正膦反应，其中：M是Os或Ru; R和R 1可以相同或不同，为（a）氢，（b）选自C 2 -C 20烯基，C 2 -C 20炔基，C 1 -C 20烷基，芳基，C 1 -C 20羧酸酯， C20烷氧基，C2-C20链烯氧基，C2-C20炔氧基，芳氧基，C2-C20烷氧基羰基，C1-C20烷硫基，C1-C20烷基磺酰基或C1-C20烷基亚磺酰基，或（c）（b）与C 1 -C 5烷基，卤素，C 1 -C 5烷氧基，未取代的苯基，卤素取代的苯基，C 1 -C 5烷基取代的苯基或C 1 -C 5烷氧基取代的苯基; R 4，R 5和R 6可以相同或不同，并且各自为未取代或取代的烃，其中烃选自芳基，C 1 -C 6烷基，C 1 -C 6烷氧基，苯氧基和烃取代选自卤素，C 1 -C 3烷基，C 1 -C 3烷氧基，未取代的苯基，卤素取代的苯基，C 1 -C 5烷基取代的苯基和C 1 -C 5烷氧基取代的苯基; X和X 1可以相同或不同，并且是任何阴离子配体; L是任何中性电子给体; L 1是三烷基膦配体，其中至少一个烷基是仲烷基或环烷基; n和m独立地为0-4，条件是n + m = 2,3或4; 并且p是等于或大于1的整数。

69. 发明公开

EP0773948A4 HIGH ACTIVITY RUTHENIUM OR OSMIUM METAL CARBENE COMPLEXES FOR OLEFIN METATHESIS REACTIONS AND SYNTHESIS THEREOF 失效
标题翻译：高活性钌或锇金属卡宾络合物FOR烯烃复分解反应，并合成
公开(公告)号：EP0773948A4
公开(公告)日：1998-09-02
申请号：EP95929340
申请日：1995-07-28
申请人： CALIFORNIA INST OF TECHN
发明人： GRUBBS ROBERT H , NGUYEN SONBINH T , JOHNSON LYNDA K , HILLMYER MARC , FU GREGORY C
IPC分类号： B01J23/46 , B01J31/22 , C07C51/353 , C07C67/475 , C07F15/00 , C08F4/80 , C08F8/50 , C08F10/00 , C08F32/00 , C08F210/02 , C08G61/08 , C08G61/12 , C08F32/04 , C08F32/08
CPC分类号： B01J31/2265 , B01J23/462 , B01J23/466 , B01J31/24 , B01J31/2404 , B01J2231/14 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07C51/353 , C07C67/333 , C07C67/475 , C07C2601/10 , C07F15/002 , C07F15/0046 , C08C19/08 , C08C2019/09 , C08F8/50 , C08F10/00 , C08F32/00 , C08F210/02 , C08G61/08 , C08G61/128 , Y10S525/938 , C07C57/13 , C07C69/74 , C07C69/533 , C07C69/593 , C08F4/80 , C08F220/00 , C08F110/14
摘要： Ruthenium and osmium carbene compounds which are stable in the presence of a variety of functional groups and which can be used to catalyze olefin metathesis reactions are discussed. Methods for synthesizing these carbene compounds are also disclosed. Specifically, the present invention relates to carbene compounds of formula (I) wherein: M is Os or Ru; R and R1 are independently selected from hydrogen; C¿2?-C20 alkenyl, C2-C20 alkynyl, C1-C20 alkyl, aryl, C1-C20 carboxylate, C2-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl or C1-C20 alkylsulfinyl; each optionally substituted with C1-C5 alkyl, halogen, C1-C5 alkoxy or with a phenyl group optionally substituted with halogen, C1-C5 alkyl or C1-C5 alkoxy; X and X?1¿ are independently selected from any anionic ligand; and L and L1 are each trialkyl phosphine ligands where at least one of the alkyl groups on the phosphine is a secondary alkyl or a cycloalkyl. In a preferred embodiment, all of the alkyl groups of the trialkyl phosphine are either a secondary alkyl or a cycloalkyl. In a more preferred embodiment, the alkyl groups are either isopropyl, isobutyl, sec-butyl, neopentyl, neophenyl, cyclopentyl or cyclohexyl.

70. 发明公开

EP0808824A3 Process for preparing optically active 2-halogeno-3-hydroxypropionic acid ester 失效
标题翻译：一种用于2-卤代-3-羟基丙酸的光学活性酯的制备过程
公开(公告)号：EP0808824A3
公开(公告)日：1998-04-08
申请号：EP97303508.2
申请日：1997-05-22
申请人： TANABE SEIYAKU CO., LTD.
发明人： Kuroda, Tooru , Yamanaka, Takeshi , Yamagishi, Masafumi , Ozaki, Yasuhiko , Imashiro, Ritsuo
IPC分类号： C07C69/732 , C07C67/475 , C07C69/734 , C07C69/675 , C07D303/48 , C07D281/10
CPC分类号： C07D317/20 , C07C67/475 , C07C69/732 , C07C69/734 , C07D281/10 , C07D301/24 , C07D303/48
摘要： A novel process for preparing optically active 2-halogeno-3-hydroxypropionic acid ester compound (III), which comprises reacting the aldehyde compound (I) with the silylketene acetal compound (II) in the presence of a chiral Lewis acid, as illustrated below.
wherein R is aryl, cycloalkyl, etc., one of X 1 and X 2 is H, and the other is Cl or Br, or both are Cl or Br, R 1 , R 2 and R 3 are the same or different, and are lower alkyl or aryl, R 4 is lower alkyl or aryl, and * is asymmetric carbon atom. The compound (III) is very useful as an intermediate for preparing medicament such as diltiazem hydrochloride.

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