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1. 发明公开

EP3971171A1 OXAZOLINE COMPOUND, SYNTHESIS METHOD THEREFOR AND APPLICATION THEREOF 有权
公开(公告)号：EP3971171A1
公开(公告)日：2022-03-23
申请号：EP20867265.9
申请日：2020-09-24
申请人： Nankai University
发明人： WANG, Qingmin , LIU, Yuxiu , WANG, Ziwen , SONG, Hongjian , LI, Yongqiang , CHEN, Shilin , ZHANG, Yu
IPC分类号： C07D263/10 , C07D263/14 , A01N43/90 , A01N43/76 , A01P7/04 , A01P7/02
摘要： The present invention relates to the field of agricultural protection. Disclosed are an oxazoline compound, a synthesis method therefor and an application thereof. The oxazoline compound has a structure represented by formula (I), wherein in the formula (I), R is selected from groups represented by formula (1-1), formula (1-2), and formula (1-3). According to the present invention, an oxazoline derivative having a novel molecular structure is obtained by introducing a nitrogen heterocycle, an ether bond or a sulfonate structure into the oxazoline compound. The oxazoline derivative has higher acaricidal activity than etoxazole, can inhibit the synthesis of chitin from mites, and can effectively control the embryogenesis and development of eggs of Tetranychus cinnabarinus, as well as the ecdysis process from larvae to adults, and therefore has a significant effect in killing mite eggs and larvae.

2. 发明公开

EP3191456A1 A ONE POT PROCESS FOR SYNTHESIS OF OXAZOLINE AND IMIDAZOLE COMPOUNDS FROM GLYCEROL 有权
标题翻译：从甘油中合成恶唑啉和咪唑类化合物的一步法
公开(公告)号：EP3191456A1
公开(公告)日：2017-07-19
申请号：EP15787030.4
申请日：2015-09-11
申请人： Council of Scientific and Industrial Research
发明人： RODE, Chandrashekhar Vasant , PANDYA, Rajan , MANE, Rasika Bharat
IPC分类号： C07D233/58 , C07D263/14
CPC分类号： C07D263/14 , C07D233/58 , Y02P20/127
摘要： The present invention disclose a single step one pot process for synthesis of oxazoline and imidazole derivatives from glycerol using solid acid metal catalyst with improved yield.
摘要翻译：本发明公开了一种使用固体酸金属催化剂由甘油合成恶唑啉和咪唑衍生物的单步一锅法，其产率得到提高。

3. 发明授权

EP1958940B1 CONDENSATION REACTION BY METAL CATALYST 有权
标题翻译：缩合反应金属催化剂
公开(公告)号：EP1958940B1
公开(公告)日：2013-06-26
申请号：EP06833933.2
申请日：2006-12-04
申请人： Takasago International Corporation
发明人： MASHIMA, Kazushi , OHSHIMA, Takashi , IWASAKI, Takanori , MAEDA, Hironori , ISHIDA, Kenya
IPC分类号： C07D263/10 , C07D263/12 , C07D263/14 , C07D263/52 , C07D413/06 , C07C53/18 , C07C231/02 , C07C233/11 , C07C233/69 , C07C253/30 , C07C255/18 , B01J31/12 , C07F3/06 , C07K1/08
CPC分类号： C07D263/12 , B01J31/2226 , B01J2531/26 , C07C53/18 , C07C231/02 , C07C253/30 , C07D263/10 , C07D263/14 , C07D263/52 , C07D413/06 , C07F3/003 , C07F7/1892 , C07F9/5022 , C07K1/088 , C07K1/10

5. 发明授权

EP1802593B1 POLYMER-FILLER COUPLING ADDITIVES 有权
标题翻译：连接附件用于聚合物填料
公开(公告)号：EP1802593B1
公开(公告)日：2013-04-24
申请号：EP05815966.6
申请日：2005-10-20
申请人： Bridgestone Corporation
发明人： FUKUSHIMA, Yasuo , HERGENROTHER, William , KOCH, Russell , ARAKI, Sunji
IPC分类号： C07D263/14 , C07D277/10 , C08K5/32 , C08K5/3415 , C08L21/00
CPC分类号： C08K5/353 , C07D263/14 , C07D277/10 , C08K5/32 , C08L21/00

6. 发明公开

EP2566854A2 DESAZADESFERROTHIOCIN AND DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS 审中-公开
标题翻译： DESAZADESFERROTHIOCIN和DESAZADESFERROTHIOCIN聚醚类似物作为金属螯合剂
公开(公告)号：EP2566854A2
公开(公告)日：2013-03-13
申请号：EP11778269.8
申请日：2011-05-04
申请人： Shire LLC
发明人： MALECHA, James, W.
IPC分类号： C07D263/16 , C07D263/14 , C07D233/22 , C07D231/14 , A61K31/421 , A61K31/4164 , A61P3/10 , A61P31/12
CPC分类号： C07D263/16 , C07D231/14 , C07D233/28 , C07D277/12 , C07D277/56
摘要： Disclosed herein are new compounds of desazadesferrothiocin polyether (DADFT- PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.
摘要翻译：本发明公开了脱氮脱铁螺菌素聚醚（DADFT-PE）类似物的新化合物，以及包含它们的药物组合物及其作为用于治疗疾病的金属螯合剂的应用。还提供了人或动物受试者中铁和其他金属螯合的方法用于治疗金属超载和毒性。

7. 发明公开

EP1988071A4 METHOD OF PRODUCING OPTICALLY ACTIVE ALCOHOL 审中-公开
标题翻译：工艺生产光学活性醇
公开(公告)号：EP1988071A4
公开(公告)日：2011-10-12
申请号：EP07714428
申请日：2007-02-13
申请人： KOTOBUKI PHARMACEUTICAL CO LTD
发明人： TOMIYAMA HIROSHI , YOKOTA MASAYUKI
IPC分类号： C07C29/143 , C07B53/00 , C07B61/00 , C07C33/22 , C07C67/31 , C07C69/65 , C07D205/08 , C07D263/14
CPC分类号： C07D263/14 , C07B53/00 , C07B2200/07 , C07C67/31 , C07D205/08 , C07C69/732

8. 发明公开

EP2292628A2 Compounds for preparing immunological adjuvant 审中-公开
标题翻译： Verbindungen zur Herstellung eines immunologischen Ajduvans
公开(公告)号：EP2292628A2
公开(公告)日：2011-03-09
申请号：EP10012396.7
申请日：2006-06-30
申请人： Eisai R&D Management Co., Ltd.
发明人： Fang, Francis G. , Foy, James E. , Hawkins, Lynn , Lemelin, Charles , Lescarbeau, Andre , Niu, Xiang , Wu, Kuo-ming
IPC分类号： C07F9/09 , C07F9/24 , C07F9/141 , C07D263/14 , C07C271/16 , C07C217/28
CPC分类号： C07D263/14 , C07C217/28 , C07C271/16 , C07F9/091 , C07F9/1411 , C07F9/2408
摘要： The present invention provides methods for preparing TLR-4 receptor agonist E6020:

and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
摘要翻译：本发明提供了制备TLR-4受体激动剂E6020及其立体异构体的方法，当与抗原如用于细菌和病毒疾病的疫苗共同施用时，该化合物可用作免疫佐剂。还提供了合成中间体。

9. 发明授权

EP1366816B1 Complexes organométalliques comportant des ligands chelatants bidentes associant un hétérocycle azoté avec un alcool et leur utilisation pour catalyser l'oligomérisation des oléfines 有权
标题翻译：有机金属络合物具有由组N杂环，并且醇Bidentatchelatliganden，以及它们在烯烃低聚使用
公开(公告)号：EP1366816B1
公开(公告)日：2009-08-05
申请号：EP03291105.9
申请日：2003-05-09
申请人： Institut Français du Pétrole
发明人： Speiser, Fredy , Braunstein, Pierre , Saussine, Lucien
IPC分类号： B01J31/18 , C07F15/04 , C08F10/00 , C07C2/32 , C07D213/30 , C07D233/64 , C07D263/14
CPC分类号： C07C2/22 , B01J31/14 , B01J31/143 , B01J31/181 , B01J2231/20 , B01J2531/847 , C07C2531/14 , C07C2531/22 , C07F15/045 , C08F10/02 , C07C11/02 , C08F4/70

10. 发明公开

EP1958940A1 CONDENSATION REACTION BY METAL CATALYST 有权
标题翻译：漏电探测器金属探测器
公开(公告)号：EP1958940A1
公开(公告)日：2008-08-20
申请号：EP06833933.2
申请日：2006-12-04
申请人： Takasago International Corporation
发明人： MASHIMA, Kazushi , OHSHIMA, Takashi , IWASAKI, Takanori , MAEDA, Hironori , ISHIDA, Kenya
IPC分类号： C07D263/10 , C07D263/12 , C07D263/14 , C07D263/52 , C07D413/06 , C07C53/18 , C07C231/02 , C07C233/11 , C07C233/69 , C07C253/30 , C07C255/18 , C07F7/18 , C07K5/027 , C07B61/00 , C07F3/06
CPC分类号： C07D263/12 , B01J31/2226 , B01J2531/26 , C07C53/18 , C07C231/02 , C07C253/30 , C07D263/10 , C07D263/14 , C07D263/52 , C07D413/06 , C07F3/003 , C07F7/1892 , C07F9/5022 , C07K1/088 , C07K1/10
摘要： The invention relates to a method for producing an azoline compound represented by the general formula (3):

wherein R 1 represents an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; R 3 , R 4 , R 5 and R 6 may be the same or different and each represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; two arbitrary groups selected from R 3 , R 4 , R 5 and R 6 may bond to each other to form a ring; and Z 1 represents an oxygen atom, a sulfur atom or a selenium atom;
comprising reacting a carboxylic acid or a carboxylic acid derivative represented by the general formula (1):

R 1 CO 2 R 2 (1)

wherein R 1 is as defined above; R 2 represents a hydrogen atom, an optionally substituted alkyl group or an optionally substituted aryl group; and R 1 and R 2 may bond to each other to form a ring;
with an aminochalcogenide represented by the general formula (2):

wherein R 3 , R 4 , R 5 , R 6 and Z 1 are as defined above;
in the presence of a compound containing a group 12 metal element in the periodic table.
摘要翻译：本发明涉及一种制备由通式（3）表示的唑啉化合物的方法：其中R 1表示任选取代的烃基，任选取代的烷氧基，任选取代的烷氧基羰基，卤素原子，取代的氨基取代的氨基甲酰基或任选取代的杂环基; R 3，R 4，R 5和R 6可以相同或不同，各自表示氢原子，任选取代的烃基，任选取代的烷氧基，任选取代的烷氧基羰基，卤素原子，取代的氨基取代的氨基甲酰基或任选取代的杂环基; 选自R 3，R 4，R 5和R 6中的两个任意基团可以彼此键合形成环; Z 1表示氧原子，硫原子或硒原子; 包括使由通式（1）表示的羧酸或羧酸衍生物反应：ƒ€ƒ€ƒ€ƒ€ƒ€ƒR1 CO 2 R 2€ƒ€ƒ€ƒ€ƒ （1）其中R 1如上所定义; R 2表示氢原子，任选取代的烷基或任选取代的芳基; 并且R 1和R 2可以彼此键合形成环; 与通式（2）表示的氨基硫族化物：其中R 3，R 4，R 5，R 6和Z 1如上所定义; 在含有周期表中第12族金属元素的化合物存在下进行。

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