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1. 发明授权

EP3259244B1 PROCÉDÉ DE PRODUCTION DE DIOLÉFINES À PARTIR D'UNE CHARGE DIOL DILUÉE 审中-公开
公开(公告)号：EP3259244B1
公开(公告)日：2018-12-26
申请号：EP16705127.5
申请日：2016-02-17
申请人： IFP Energies nouvelles , Compagnie Générale des Etablissements Michelin
发明人： RICHARD, Romain , JACQUIN, Marc
IPC分类号： C07C31/20 , C07C1/247 , C07C1/36 , C07C11/12 , C07C11/167
CPC分类号： C07D317/12 , C07C1/213 , C07C67/24 , C07C11/167 , C07C69/16

2. 发明授权

EP1753708B1 NOVEL SIRTUIN ACTIVATING COMPOUNDS AND METHODS FOR MAKING THE SAME 失效
标题翻译：新的SIRTUIN激活化合物及其制备方法
公开(公告)号：EP1753708B1
公开(公告)日：2018-02-21
申请号：EP05711939.8
申请日：2005-01-19
申请人： Brigham Young University
发明人： ANDRUS, Merritt, B. , LIU, Jing
IPC分类号： C07C67/08 , C07C67/14 , C07C67/287 , C07C67/29 , C07C67/293 , C07C69/017 , C07C69/16 , C07C69/18 , C07C69/63 , C07C69/716
CPC分类号： C07C69/017 , C07C67/08 , C07C67/14 , C07C67/287 , C07C67/29 , C07C67/293 , Y02P20/55 , C07C69/716 , C07C69/63 , C07C69/18 , C07C69/16
摘要： The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from 2 to 6 carbon atoms and cycloalkyl of from 3 to 8 carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.

3. 发明公开

EP3246304A2 DIPHENYL DERIVATIVE AND USES THEREOF 审中-公开
标题翻译：二苯基衍生物及其用途
公开(公告)号：EP3246304A2
公开(公告)日：2017-11-22
申请号：EP16737100.4
申请日：2016-03-11
申请人： Xi'an Libang Pharmaceutical Co., Ltd
发明人： WANG, Rutao , CHEN, Tao , AN, Long , ZHAO, Yi , WANG, Weijiao , GUO, Shupan , XIAO, Sa , PANG, Jinghua , HU, Huijing
IPC分类号： C07C69/16 , C07C69/40 , C07C65/105 , C07C229/08 , C07C39/15 , A61K31/222 , A61K31/192 , A61K31/223 , A61K31/05 , A61P25/28
CPC分类号： C07C229/08 , A61K31/05 , A61K31/192 , A61K31/222 , A61K31/223 , A61P25/28 , C07C39/15 , C07C65/105 , C07C69/16 , C07C69/40
摘要： The present invention relates to a biphenyl derivative and use thereof, and the biphenyl derivative has a structure represented by the formula (I) as defined in the specification. The use refers the use of the biphenyl derivative or a pharmaceutically acceptable salt or solvate thereof, or a pharmaceutical composition comprising the biphenyl derivative or a pharmaceutically acceptable salt or solvate thereof in the preparation of a medicament for the treatment and/or prevention of ischemic stroke.
摘要翻译：联苯衍生物及其用途本发明涉及联苯衍生物及其用途，联苯衍生物具有如说明书中所定义的式（I）所示的结构。该用途是指联苯衍生物或其药学上可接受的盐或溶剂化物或包含联苯衍生物或其药学上可接受的盐或溶剂化物的药物组合物在制备用于治疗和/或预防缺血性中风的药物中的用途。

4. 发明公开

EP3094321A4 METHODS OF SUSTAINING DIETARY KETOSIS AND ITS EFFECTS ON LIPID PROFILE 有权
标题翻译： VERFAHREN ZUR ERHALTUNG VON DIAMETKERCHER KETOSE UND AUSWIRKUNGEN AUF DEN LIPIDSPIEGEL
公开(公告)号：EP3094321A4
公开(公告)日：2017-05-24
申请号：EP15776261
申请日：2015-01-13
申请人： UNIV SOUTH FLORIDA
发明人： D'AGOSTINO DOMINIC PAUL , KESL SHANNON
IPC分类号： C07C31/20 , A61K31/22 , A61K31/225 , A61P3/04 , C07C69/16 , C07C69/34
CPC分类号： A61K31/225 , A61K31/22 , C07B2200/07 , C07C31/207 , C07C69/16 , C07C69/34
摘要： The ketogenic diet (KD) has therapeutic implications in many disease states. It was hypothesized ketone precursor supplementation would elevate blood ketone levels to therapeutic ranges (2-7 mM) without need for dietary restriction. The effects of ketogenic agents were tested on blood glucose, ketones, and lipids with a 28-day dose escalation study in male Sprague-Dawley rats: R,S-1,3-Butandiol (BD), acetoacetate ketone ester (KE), and control (H2O) (n≧8). Days 1-28, rats received a daily 5 g/kg intragastric gavage, based on previous toxicology studies. Once weekly, whole blood samples (10 μl) were acquired for analysis of glucose and βHB at 0, 0.5, 1, 4, 8, and 12 hours after test substance administration, or until βHB returned to baseline. At day 1 and 28, 10 μL of whole blood were collected to measure triglycerides, total cholesterol, and HDL concentration. Significant elevation of blood ketone was observed with a significant inverse relationship with blood glucose for the duration of the experiment. There were no significant changes in the lipid panel for any of the substances. There were significant reductions in body weight when animals were treated with either BD or KE as compared to control.
摘要翻译：生酮饮食（KD）在许多疾病状态中具有治疗意义。假设酮前体补充剂将血液酮水平提高到治疗范围（2-7mM）而不需要饮食限制。通过在雄性Sprague-Dawley大鼠中进行28天剂量递增研究，测试生酮剂对血糖，酮和脂质的影响：R，S-1,3-丁二醇（BD），乙酰乙酸酯酮（KE），和控制（H 2 O）（n≥8）。基于先前的毒理学研究，在第1-28天，大鼠每天接受5g / kg胃内灌胃。每周一次，在测试物质施用后0,0.5,1,4,8和12小时获取全血样品（10μl）以分析葡萄糖和βHB，或直到βHB回到基线。在第1天和第28天，收集10μL全血以测量甘油三酯，总胆固醇和HDL浓度。观察到血酮的显着升高，并且在实验期间与血糖有显着的负相关。对于任何物质，脂质组没有显着变化。与对照相比，用BD或KE处理动物时体重显着降低。

5. 发明公开

EP3098214A4 HEXAHYDROCOLUPULONE MONOESTER, INNER COMPLEX SALT OR MONOESTER SALT, AND APPLICATION THEREOF AS ANIMAL FEED ADDITIVE 有权
标题翻译： HEXAHYDROCOLUPULONMONOESTER在复杂的盐或单酯盐及其用途用作动物饲料附加
公开(公告)号：EP3098214A4
公开(公告)日：2017-01-04
申请号：EP14882819
申请日：2014-03-19
申请人： GUANGZHOU INSIGHTER BIOTECHNOLOGY CO LTD
发明人： PENG XIANFENG , QIN ZONGHUA , HUANG JIJUN
IPC分类号： C07C45/77 , A23K20/121 , C07C49/713 , C07C67/28 , C07C69/16 , C07C69/28
CPC分类号： C07C69/12 , A23K20/10 , A23K20/121 , C07C49/713 , C07C69/16 , C07C69/28 , C07C2601/16 , C07F1/08 , C07F3/003 , C07F3/02 , C07F3/06 , C07F13/005 , C07F15/025 , C07F15/065
摘要： The invention discloses monoesters, inner complex salts or monoester salts of hexahydro-²-acid, and application thereof as animal feed additives. The compounds of the present invention as shown in formula (I), (II) and (III) show low toxicity or non-toxicity to animals, and have higher stability and better growth promotion effects than those disclosed in other patents, which make them more suitable to be applied as growth promoters used in feed and have a very good application prospect in cultivation industry.

6. 发明公开

EP3098214A1 HEXAHYDROCOLUPULONE MONOESTER, INNER COMPLEX SALT OR MONOESTER SALT, AND APPLICATION THEREOF AS ANIMAL FEED ADDITIVE 有权
标题翻译： HEXAHYDROCOLUPULONMONOESTER，INNENKOMPLEXSALZ ODER MONOESTERSALZ UND ANWENDUNG DAVON ALS TIERFUTTERZUSATZ
公开(公告)号：EP3098214A1
公开(公告)日：2016-11-30
申请号：EP14882819.7
申请日：2014-03-19
申请人： Guangzhou Insighter Biotechnology Co., Ltd
发明人： PENG, Xianfeng , QIN, Zonghua , HUANG, Jijun
IPC分类号： C07C45/77 , C07C49/713 , C07C67/28 , C07C69/16 , C07C69/28
CPC分类号： C07C69/12 , A23K20/10 , A23K20/121 , C07C49/713 , C07C69/16 , C07C69/28 , C07C2601/16 , C07F1/08 , C07F3/003 , C07F3/02 , C07F3/06 , C07F13/005 , C07F15/025 , C07F15/065
摘要： The invention discloses monoesters, inner complex salts or monoester salts of hexahydro-β-acid, and application thereof as animal feed additives. The compounds of the present invention as shown in formula (I), (II) and (III) show low toxicity or non-toxicity to animals, and have higher stability and better growth promotion effects than those disclosed in other patents, which make them more suitable to be applied as growth promoters used in feed and have a very good application prospect in cultivation industry.
摘要翻译：本发明公开了六氢²酸的单酯，内复合盐或单酯盐及其作为动物饲料添加剂的应用。式（I），（II）和（III）所示的本发明化合物对动物显示低毒性或无毒性，并且具有比其他专利中公开的那些更高的稳定性和更好的生长促进效果，这使得它们更适合用作饲料中生长促进剂，在栽培行业具有很好的应用前景。

7. 发明公开

EP3045445A1 1,5-DIPHENYL-PENTA-1,4-DIEN-3-ONE COMPOUNDS 审中-公开
标题翻译： 1,5-二苯基 - 戊-1,4-二烯-3-酮化合物
公开(公告)号：EP3045445A1
公开(公告)日：2016-07-20
申请号：EP16152929.2
申请日：2011-08-16
申请人： THE UNIVERSITY OF TOKYO , AndroScience Corporation
发明人： SHIH, Charles C-Y , KITUMURA, Toshio , SHI, Qian , KAWASHIMA, Toshiyuki , WANG, Hui-Kang
IPC分类号： C07C49/248 , C07C309/67 , C07D211/06 , A61K31/121 , A61P35/00
CPC分类号： C07C49/248 , C07C49/235 , C07C49/255 , C07C69/16 , C07C217/22 , C07C217/60 , C07C235/82 , C07C307/02 , C07C309/65 , C07C309/66 , C07C309/73 , C07C317/24 , C07C2601/14 , C07C2601/16 , C07D213/68 , C07D295/112 , C07D295/13 , C07F9/06 , C07F9/09 , C07F9/12 , C07F9/32 , C07F9/3282
摘要： This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.

8. 发明公开

EP2885310A1 NOVEL METAL COMPLEXES, ESPECIALLY THE RUTHENIUM COMPLEXES, AND USE THEREOF 有权
标题翻译： NEUE METALLKOMPLEXE，INSBESONDERE RUTHENIUMKOMPLEXE，UND VERWENDUNG DAVON
公开(公告)号：EP2885310A1
公开(公告)日：2015-06-24
申请号：EP13759147.5
申请日：2013-08-14
申请人： Apeiron Synthesis S.A.
发明人： GRELA, Karol , TORBORG, Christian , SZCZEPANIAK, Grzegorz , ZIELINSKI, Adam
IPC分类号： C07F15/00 , B01J31/22 , C07C6/02
CPC分类号： B01J31/2295 , B01J31/2273 , B01J31/2278 , B01J2231/54 , B01J2531/821 , B01J2531/825 , C07B2200/09 , C07C6/04 , C07C67/333 , C07C2531/22 , C07C2531/24 , C07C2601/10 , C07D207/48 , C07D209/30 , C07D211/96 , C07D307/28 , C07F7/1852 , C07F7/1892 , C07F15/0046 , C08F132/08 , C07C11/02 , C07C69/74 , C07C69/16
摘要： The object of the invention is a novel metal complex of the formula (1), the parameters of which are as defined in the description of the invention, as well as use of the metal complex of the formula (1) in the olefin metathesis reactions.
摘要翻译：本文描述了由式（1）表示的新型金属络合物，特别是钌络合物：其中L1是N-杂环卡宾配体，L2是中性膦配体，优选三环己基膦，以及催化烯烃复分解反应的方法，特别是四取代烯烃复分解反应。

9. 发明授权

EP2364287B1 PROCESS FOR THE PREPARATION OF NON-GENOTOXIC DIACETYLRHEIN (DIACEREIN) AND FORMULATIONS COMPRISING NON-GENOTOXIC DIACETYLRHEIN 有权
标题翻译：过程对非遗传毒性DIACETHYLRHEIN（DIACARHEIN）的制备和制剂不具有遗传毒性DIACETHYLRHEIN
公开(公告)号：EP2364287B1
公开(公告)日：2014-04-02
申请号：EP09751880.7
申请日：2009-11-03
申请人： Evultis S.A.
发明人： MAZZOLA, Alessandro , MOIANA, Silvia
IPC分类号： C07C51/47 , C07C66/02 , C07C69/157
CPC分类号： C07C51/47 , C07C51/412 , C07C67/56 , C07C66/02 , C07C69/017 , C07C69/16

10. 发明公开

EP2606021A2 1,5-DIPHENYL-PENTA-1,4-DIEN-3-ONE COMPOUNDS 审中-公开
标题翻译： 1,5-二苯基 - 戊-1,4-二烯-3- ON-VERBINDUNGEN
公开(公告)号：EP2606021A2
公开(公告)日：2013-06-26
申请号：EP11818654.3
申请日：2011-08-16
申请人： The University of Tokyo , AndroScience Corporation
发明人： SHIH, Charles C-Y , KITUMURA, Toshio , SHI, Qian , KAWASHIMA, Toshiyuki , WANG, Hui-Kang
IPC分类号： C07C49/248 , C07C309/67 , C07D211/06 , A61K31/121 , A61P35/00
CPC分类号： C07C49/248 , C07C49/235 , C07C49/255 , C07C69/16 , C07C217/22 , C07C217/60 , C07C235/82 , C07C307/02 , C07C309/65 , C07C309/66 , C07C309/73 , C07C317/24 , C07C2601/14 , C07C2601/16 , C07D213/68 , C07D295/112 , C07D295/13 , C07F9/06 , C07F9/09 , C07F9/12 , C07F9/32 , C07F9/3282
摘要： This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.
摘要翻译：本发明涉及说明书中所示的含有1,5-二苯基戊-1,4-二烯-3-酮骨架的式（I），（II）或（III）的化合物。这些化合物可用于治疗癌症，炎性疾病或自身免疫性疾病。

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