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31. 发明公开

EP3992174A1 METAL-ORGANIC FRAMEWORK HAVING TEREPHTHALIC ACID BASED LIGAND 审中-实审转让
公开(公告)号：EP3992174A1
公开(公告)日：2022-05-04
申请号：EP20830682.9
申请日：2020-06-24
申请人： Rikkyo Educational Corporation , Nippon Soda Co., Ltd.
发明人： MINOURA, Mao , SUGAMATA, Koh , YANAGISAWA, Daichi , KOBAYASHI, Sho , IIHAMA, Teruyuki
IPC分类号： C07C63/331 , C07C63/49 , C07C63/72 , C07C65/24 , C07C229/62 , C07C323/62 , C07D333/24 , C07F1/08 , C07F3/06 , C07F15/04 , C01B3/00 , C07F7/00 , C07F7/08 , C07D213/55 , C07D213/68 , B01J20/22 , C07D307/54
摘要： Despite the fact that the amount and type of gas to be stored may vary in accordance with the type of substituent, metal-organic frameworks only using a terephthalic acid having substituents within the limited range have been produced conventionally. An object of the present invention is to provide a novel metal-organic framework using a 2,5-disubstituted terephthalic acid. A metal-organic framework comprising a carboxylate ion of formula (I) and a multivalent metal ion bound to each other is a novel metal-organic framework, enabling a gas such as hydrogen and nitrogen to be store efficiently. (wherein in formula (I),
X is an unsubstituted or substituted cycloalkyl group, an unsubstituted or substituted aryl group, an unsubstituted or substituted heterocyclyl group or -Si(R 1 )(R 2 )(R 3 ) ; and Y is a single bond, an alkylene group, -O-, -S-, -S(O)-, - SO 2 -, -N(R 4 )- or a group formed by a combination thereof; provided that X-Y- is a phenyl group, a benzyloxy group, a pyrazol-1-yl group or a group of formula (II) except for a case where m is 3, 6, 8, 9, 10, 11 and 12).

32. 发明公开

EP2426102A4 PROCESS FOR PRODUCING PHTHALIC ACID COMPOUND INCLUDING CHLORINATED AROMATIC RING 审中-公开
标题翻译：一种用于生产邻苯二甲酸与氯化芳族环
公开(公告)号：EP2426102A4
公开(公告)日：2013-01-02
申请号：EP10769850
申请日：2010-04-23
申请人： SUMITOMO CHEMICAL CO
发明人： SOUDA HIROSHI , HAGIYA KOJI
IPC分类号： C07C51/62 , C07B61/00 , C07C63/68 , C07C63/72
CPC分类号： C07C51/62 , C07C63/68

33. 发明公开

EP2192087A4 ALKALI METAL FLUORIDE DISPERSION, AND PROCESS FOR PRODUCTION OF FLUORINATED ORGANIC COMPOUND USING THE SAME 审中-公开
标题翻译：碱金属氟化物分散液及其制备方法具有氟化有机结合
公开(公告)号：EP2192087A4
公开(公告)日：2012-05-02
申请号：EP08828723
申请日：2008-08-27
申请人： SUMITOMO CHEMICAL CO
发明人： HAGIYA KOJI
IPC分类号： C01D3/02 , C07B39/00 , C07C17/20 , C07C22/08 , C07C51/00 , C07C51/58 , C07C51/60 , C07C63/72 , C07C67/14 , C07C69/82 , C07C201/12 , C07C205/11 , C07C205/12
CPC分类号： C07B39/00 , C01D3/02 , C07C17/208 , C07C51/00 , C07C51/58 , C07C51/60 , C07C67/14 , C07C201/12 , C07C63/30 , C07C69/76 , C07C205/12

34. 发明公开

EP2192087A1 ALKALI METAL FLUORIDE DISPERSION, AND PROCESS FOR PRODUCTION OF FLUORINATED ORGANIC COMPOUND USING THE SAME 审中-公开
标题翻译：碱金属氟化物分散液及其制备方法具有氟化有机结合
公开(公告)号：EP2192087A1
公开(公告)日：2010-06-02
申请号：EP08828723.0
申请日：2008-08-27
申请人： Sumitomo Chemical Company, Limited
发明人： HAGIYA, Koji
IPC分类号： C01D3/02 , C07B39/00 , C07C17/20 , C07C22/08 , C07C51/58 , C07C63/72 , C07C67/14 , C07C69/82 , C07C201/12 , C07C205/11
CPC分类号： C07B39/00 , C01D3/02 , C07C17/208 , C07C51/00 , C07C51/58 , C07C51/60 , C07C67/14 , C07C201/12 , C07C63/30 , C07C69/76 , C07C205/12
摘要： An alkali metal fluoride dispersion essentially consisting of an alkali metal fluoride and an aprotic organic solvent obtainable by conducting the following Step (A), subsequently conducting the following Step (B) at least once, and then conducting the following Step(C);
Step (A) : a step of separating a liquid phase from an alkali metal fluoride dispersion comprising at least one alcohol solvent selected from the group consisting of methanol, ethanol and isopropanol and an alkali metal fluoride, and mixing the separated liquid phase with an aprotic organic solvent having a boiling point of 85°C or higher at normal pressure to obtain a mixture containing the alkali metal fluoride;
Step (B) : a step of obtaining a mixture containing the alkali metal fluoride comprising the following Steps (b1) to (b3);
Step (b1) : a step of concentrating the mixture containing the alkali metal fluoride obtained in Step (A) or Step (b3) to obtain a concentrated fraction and a concentrated residue;
Step (b2) : a step of mixing a residue of the alkali metal fluoride dispersion obtained by separating the liquid phase in Step (A) or a residue of the mixture obtained by separating a liquid phase in Step (b3) with the concentrated fraction obtained in Step (b1) to obtain a mixture containing an alkali metal fluoride; and
Step (b3) : a step of separating a liquid phase from the mixture containing an alkali metal fluoride obtained in Step (b2) and mixing the separated liquid phase with the concentrated residue obtained in Step (b1) to obtain a mixture containing an alkali metal fluoride; and

Step (C) : a step of removing the alcohol solvent fromthemixture containing the alkali metal fluoride, which is obtained in Step (B), to obtain the alkali metal fluoride dispersion essentially consisting of the alkali metal fluoride and the aprotic organic solvent.
摘要翻译：碱金属氟化物分散液实质上通过进行下述工序（A）中，随后进行下面的工序（B）至少一次，然后进行随后的步骤（C）由以下组成的碱金属氟化物和非质子性有机溶剂而得到的A; 步骤（A）：从在碱金属氟化物分散液，其包含至少一种醇中分离出液相的步骤选自甲醇，乙醇和异丙醇以及碱金属氟化物的由......组成选择的溶剂，并且所述分离的液相与在非质子传递混合在常压下的85℃或更高的沸点，得到含有碱金属氟化物的混合物中有机溶剂中; 步骤（B）：得到含有碱金属氟化物，包括以下步骤（b1）至混合物的步骤（B3）; 工序（b1）：含有碱金属氟化物的工序（A）或工序（b3）中得到以获得浓缩馏分和浓缩的残留物浓缩混合物的步骤; 步骤（b2）：获得与浓缩馏分混合通过分离在步骤（A）的液相得到的碱金属氟化物分散液的残基或通过分离在步骤（b3）中的液相中获得的混合物的残基的一个步骤在工序（b1），以获得的碱金属氟化物包含的混合物; 和工序（b3）：分离从含有超过碱金属氟化物在步骤（b2）中得到的混合物的液相，并与在步骤（b1）中得到的浓缩残余物中分离出的液相混合的步骤，得到含有经碱的混合物金属氟化物; 和步骤（C）：除去醇溶剂fromthemixture含有碱金属氟化物，所有这些都在步骤（B）得到的步骤，以获得碱金属氟化物分散液基本上由碱金属氟化物和非质子性有机溶剂。

35. 发明公开

EP1500641A4 HIGH-PURITY (FLUOROALKYL)BENZENE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：荷兰（FLUORALKYL）BENZOLDERIVATE UND VERFAHREN ZU DEREN HERSTELLUNG
公开(公告)号：EP1500641A4
公开(公告)日：2006-05-31
申请号：EP03723191
申请日：2003-04-24
申请人： MITSUBISHI GAS CHEMICAL CO
发明人： HIDAKA T , FUSHIMI N , YOSHIMURA T , KAWAI T
IPC分类号： C07C29/136 , C07B39/00 , C07B61/00 , C07C29/147 , C07C29/62 , C07C33/46 , C07C37/56 , C07C39/24 , C07C45/41 , C07C45/45 , C07C45/63 , C07C45/67 , C07C47/55 , C07C49/80 , C07C51/04 , C07C51/363 , C07C51/62 , C07C63/70 , C07C67/14 , C07C67/307 , C07C69/76 , C07C209/26 , C07C211/29 , C07C231/02 , C07C233/65 , C07C253/20 , C07C255/49 , C07C255/50 , C07C37/62 , C07C63/72 , C07C209/68 , C07C211/52 , C07C231/12 , C07C253/30
CPC分类号： C07C45/41 , C07B39/00 , C07C29/147 , C07C39/24 , C07C45/45 , C07C45/63 , C07C47/55 , C07C49/80 , C07C51/04 , C07C51/62 , C07C67/307 , C07C211/29 , C07C233/65 , C07C255/50 , C07C63/72 , C07C63/70 , C07C69/76 , C07C33/46
摘要： The process for producing a (fluoroalkyl)benzene derivative according to the present invention comprises a step of reducing the total content of group 3 to group 12 transition metals in an alkylbenzene derivative to 500 ppm or less in terms of metal atoms; a step of halogenating the branched alkyl group of the purified alkylbenzene derivative by a photohalogenation to obtain a (haloalkyl)benzene derivative; and a step of subjecting the (haloalkyl)benzene derivative to a halogen-fluorine exchange using HF in an amount of 10 mol or higher per one mole of the (haloalkyl)benzene derivative. The (fluoroalkyl)benzene derivative produced by the process is reduced in the content of impurities such as residual halogens and residual metals, and is useful as intermediates for functional chemical products for use in applications such as medicines and electronic materials.
摘要翻译：本发明的（氟代烷基）苯衍生物的制造方法包括使烷基苯衍生物中的第1族过渡金属的组3的含量以金属原子计降低至500ppm以下的步骤; 通过光卤代化将纯化的烷基苯衍生物的支链烷基卤化以获得（卤代烷基）苯衍生物的步骤; 以及使用每10摩尔（卤代烷基）苯衍生物的10摩尔以上的量使用（卤代烷基）苯衍生物进行卤代氟交换的工序。通过该方法制备的（氟代烷基）苯衍生物的残留卤素和残余金属等杂质含量降低，可用作药物和电子材料等应用中的功能性化学产品的中间体。

36. 发明公开

EP1497274A2 DERIVES DE TERPHENYLE, LEUR PREPARATION, LES COMPOSITIONS PHARMACEUTIQUES EN CONTENANT 有权
标题翻译： TERPHENYLDERIVATE，DEREN HERSTELLUNG UND ZUSAMMENSETZUNGEN，DIEE ENTHALTEN
公开(公告)号：EP1497274A2
公开(公告)日：2005-01-19
申请号：EP03745842.9
申请日：2003-04-10
申请人： Sanofi-Aventis
发明人： BARTH, Francis , MARTINEZ, Serge , RINALDI-CARMONA, Murielle
IPC分类号： C07D295/22 , C07C233/65 , C07C69/76 , C07C63/72 , C07C63/331 , C07C65/24 , A61K31/165 , A61K31/445 , A61P25/00
CPC分类号： C07D295/32 , C07C69/76 , C07C233/65 , C07C233/69 , C07C233/78 , C07C2602/22 , C07D209/16 , C07D211/16 , C07D211/98
摘要： The invention concerns terphenyl derivatives of formula (I) and their preparations as well as pharmaceutical compositions containing them. Said compounds have a cannabinoid CB1 receptor antagonist activity.
摘要翻译：本发明涉及式的三联苯衍生物及其制备方法以及包含它们的药物组合物。这些化合物相对于CB1大麻素受体表现出拮抗剂活性。

37. 发明公开

EP1346975A4 AROMATIC CARBOXYLIC ACIDS, ACID HALIDES THEREOF AND PROCESSES FOR PREPARING BOTH 审中-公开
标题翻译：芳族羧酸，制备这些化合物的酰卤和方法
公开(公告)号：EP1346975A4
公开(公告)日：2004-03-31
申请号：EP01997472
申请日：2001-11-26
申请人： SUMITOMO BAKELITE CO
发明人： OKANUMA MASAKO , ISHIDA YUICHI , HASE YOKO , HIGASHIDA NOBUHIRO , ENOKI TAKASHI
IPC分类号： C07C63/64 , C07C65/28 , C07C63/15 , C07C51/09 , C07C51/60 , C07C63/331 , C07C63/66 , C07C63/72 , C07C63/74
CPC分类号： C07C63/64 , C07C65/28
摘要： A novel aromatic carboxylic acid useful as a material for macromolecular compounds and, in particular, for polycondensed macromolecular compounds exhibiting excellent heat resistance, an acid halide derivative thereof and a process for producing these compounds are disclosed. The aromatic carboxylic acid and the acid halide derivative thereof have structures represented general formulae (1) and (2), respectively, and can be efficiently produced from a dialkyl ester derivative of isophthalic acid and an acetylene derivative in accordance with the disclosed process comprising specific steps. In the above formulae, A represents: - C IDENTICAL C-R or (R represents hydrogen atom, an alkyl group or an aromatic group, R represents an alkyl group or an aromatic group) and X represents a halogen atom.

38. 发明公开

EP0983991A3 Compounds having selectivity for retinoid x receptors 失效
标题翻译：与视黄醇X受体选择性的化合物
公开(公告)号：EP0983991A3
公开(公告)日：2001-01-17
申请号：EP99118827.7
申请日：1993-04-22
申请人： LIGAND PHARMACEUTICALS, INC.
发明人： Boehm, Marcus F. , Heyman, Richard A. , Zhi, Lin
IPC分类号： C07C63/49 , A61K31/19 , A61K31/44 , C07C63/72 , C07C65/40 , C07C69/76 , C07C235/84 , C07D307/68 , C07D333/38 , C07D213/80 , C07D213/79 , C07D405/04 , C07D213/48
CPC分类号： C07D213/79 , C07C57/26 , C07C57/48 , C07C57/50 , C07C63/49 , C07C63/66 , C07C63/72 , C07C63/74 , C07C65/17 , C07C65/19 , C07C65/36 , C07C65/40 , C07C69/76 , C07C233/66 , C07C233/75 , C07C233/81 , C07C235/84 , C07C2601/02 , C07C2601/08 , C07C2602/08 , C07C2602/10 , C07D213/80 , C07D257/04 , C07D303/38 , C07D307/68 , C07D311/58 , C07D333/38 , C07D405/04
摘要： Compounds, compositions, and method for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass of Retinoic Acid Receptors (RARs). Examples of such compounds are bicyclic benzyl, pyridinyl, thiophene, furanyl, and pyrrole derivatives. The disclosed methods employ compounds for modulating processes selectively mediated by Retinoid X Receptors.

39. 发明公开

EP0627433A4 PROCESS FOR PRODUCING IMIDAZOPYRIDINE DERIVATIVE AND INTERMEDIATE. 失效
标题翻译：工艺用于生产和中间体咪唑衍生物。
公开(公告)号：EP0627433A4
公开(公告)日：1995-04-12
申请号：EP94901045
申请日：1993-12-07
申请人： EISAI CO LTD , EISAI KAGAKU KK
发明人： URAWA YOSHIO-KONOIKE OHKARYO , FURUKAWA KEN RESIDENCE HIRO , SHIMIZU TOSHIKAZU KONOIKE OHKA , YAMAGISHI YOJI , TSURUGI TOMIO-TOYOSATODAI , ICHINO TOMIO-KYUCHU
IPC分类号： C07C63/72 , C07C65/105 , C07C69/732 , C07C69/76 , C07D213/73 , C07D213/75 , C07D263/10 , C07D263/12 , C07D263/14 , C07D309/12 , C07D413/12 , C07D471/04 , C07C63/06 , C07C309/65 , C07C309/73 , C07D213/76 , C07F7/18
CPC分类号： C07D213/73 , C07C63/72 , C07C65/105 , C07C69/732 , C07C69/76 , C07D213/75 , C07D263/10 , C07D263/12 , C07D263/14 , C07D309/12 , C07D413/12 , C07D471/04 , Y02P20/55
摘要： The invention provides an industrially excellent process for producing a 2-alkyl-3-(biphenyl-4-yl)-methyl-3H-imidazo[4.5-b]pyridine derivative represented by general formula (II), serving as a precursor of the angiotensin II receptor antagonist useful as an antihypertensive, a biphenyl derivative serving as a precursor of the substituent of the imidazopyridine derivative, a process for producing the biphenyl derivative, and an intermediate useful for producing the biphenyl derivative. The imidazopyridine derivative (II) can be produced in a high yield according to the process of the invention by subjecting a 2-amino-5-halogeno-3-nitropyridine derivative to amidation, N-alkylation and reductive cyclization. This process is industrially excellent, because the halogen atom introduced into the 5-position as a protective group in the nitration step can be eliminated simultaneously in the subsequent step. The above biphenyl derivative is excellent in reactivity and product purity, thus being an intermediate suitable for industrial production.

40. 发明公开

EP0549021A3 Flame retardant compounds 失效
标题翻译：阻燃化合物
公开(公告)号：EP0549021A3
公开(公告)日：1993-12-08
申请号：EP92203770.0
申请日：1992-12-04
申请人： FMC CORPORATION (UK) LIMITED
发明人： Schneider, Michael James , Gainer, James
IPC分类号： C07C63/72 , C08K5/15 , C07C63/74 , C08K5/37 , C08K5/42
CPC分类号： C08K5/1539 , C07C63/72 , C07C63/74
摘要： The invention provides
A compound of general formula I

in which X represents a direct bond or a

-CH=CH- , -CH₂--CHBr-CHBr-

or -S-
group.

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