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1. 发明公开

EP3357902A1 METHOD FOR PRODUCING ACID HALIDE SOLUTION, MIXED SOLUTION, AND METHOD FOR PRODUCING MONOESTER COMPOUND 审中-公开
公开(公告)号：EP3357902A1
公开(公告)日：2018-08-08
申请号：EP16850679.8
申请日：2016-09-29
申请人： Zeon Corporation
发明人： OKUYAMA, Kumi , SAKAMOTO, Kei , SANUKI, Kanako , IWAKI, Hiroki
IPC分类号： C07C51/60 , C07C61/15 , C07C67/14 , C07C69/54 , C07B61/00
CPC分类号： C07C67/14 , C07B61/00 , C07C51/60 , C07C61/15 , C07C69/54 , C07C2601/14
摘要： The present disclosure provides a method for producing an acid halide solution that is useful as a production intermediate or the like that allows industrially advantageous production of a polymerizable liquid crystal compound. The method for producing an acid halide solution of the present disclosure includes a step α of reacting a halogenating agent and a dicarboxylic acid compound in a water-immiscible organic solvent in the presence of a tetraalkylammonium salt to obtain a water-immiscible organic solvent solution including an acid halide, and a step β of concentrating the obtained water-immiscible organic solvent solution.

2. 发明公开

EP3133057A4 PRODUCTION METHOD FATTY ACID CHLORIDE AND FATTY ACID CHLORIDE 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VONFETTSÄURECHLORIDUNDFETTSÄURECHLORID
公开(公告)号：EP3133057A4
公开(公告)日：2017-08-30
申请号：EP15780158
申请日：2015-04-14
申请人： NOF CORP
发明人： FUJITA HIROYA , OHARA SHINJI , MARUYAMA KEI-ICHI , IWATA TOMOKI
IPC分类号： C07C51/60 , C07C53/42 , C07C57/66
CPC分类号： C07C51/60 , C07C53/42 , C07C57/66
摘要： Provided is a fatty acid chloride which is manufactured by a simple method, which does not cloud and which has stable color over time. A fatty acid chloride is produced by causing a fatty acid with a carbon number of 8-22 and phosphorous trichloride in a proportion of one-third to two-thirds with respect to the fatty acid to react and removing phosphorous acid that appears as a byproduct to obtain a reaction product. Next, the reaction product is treated at a temperature of 10-60°C, a nitrogen flow rate of 1.0 × 10 -4 to 1.0 × 10 -2 m 3 /kg·hr, and a pressure of 133.3 X 10 -2 to 133.3 × 10 2 Pa, the unreacted phosphorous trichloride is caused to react with the fatty acid and the fatty acid chloride to produce an organic phosphorous compound, and the unreacted phosphorous trichloride is distilled to obtain the fatty acid chloride.
摘要翻译：本发明提供一种通过简便的方法制造的不会变色且随着时间的推移色彩稳定的脂肪酰氯。通过使相对于脂肪酸的碳原子数为8〜22的脂肪酸和三氯化磷的比例为三分之一至三分之二以反应并除去作为副产物出现的亚磷酸而生成脂肪酸氯化物得到反应产物。接着，在10〜60℃的温度，1.0×10 -4〜1.0×10 -2 m 3 / kg·hr的氮气流量，133.3×10 -2〜 133.3×10 2 Pa，使未反应的三氯化磷与脂肪酸和脂肪酰氯反应生成有机磷化合物，蒸馏未反应的三氯化磷得到脂肪酰氯。

3. 发明公开

EP3045440A4 METHOD FOR THE PREPARATION OF TRICHLOROMETHYL-GROUP-SUBSTITUTED BENZENE 有权转让
标题翻译：过程与三氯甲基取代苯生产
公开(公告)号：EP3045440A4
公开(公告)日：2017-03-01
申请号：EP14843701
申请日：2014-09-12
申请人： SHANGHAI FANGLUN NEW MAT TECH CO LTD , WANG NONGYUE
发明人： WANG NONGYUE , QU XIONGWEI , LI GUOHUA , ZHAO QUANZHONG , SHAO JIANMING , WEN GUOQIANG
IPC分类号： C07C17/14 , B01J19/12 , C07C17/10 , C07C17/12 , C07C17/38 , C07C22/04 , C07C51/60 , C07C53/44
CPC分类号： C07C17/08 , C07C17/093 , C07C17/12 , C07C17/14 , C07C17/383 , C07C51/60 , C07C25/125 , C07C53/44 , C07C22/04 , C07C22/06
摘要： The present application relates to a method for photochlorination, and specifically to photochlorination by a photochemical reaction of an aromatic compound with gaseous chlorine so as to prepare a trichloromethyl-substituted benzene, and to a method using bis-(trichloromethyl)-benzene as the trichloromethyl-substituted benzene to prepare by further reaction bis-(chloroformyl)-benzene. Through the control of temperature, illuminance and consumption of gaseous chlorine, the method of this application can greatly improve the purity of trichloromethyl-substituted benzene and further prepare polymer-grade bis-(chloroformyl)-benzene with low cost. The present application also relates to a method for purifying trichloromethyl-substituted benzene, and specifically to a method for purifying trichloromethyl-substituted benzene via molecular distillation. The present application further relates to a photochlorination reactor for use in photochlorination reactions (such as those of the present application).

4. 发明公开

EP3023410A4 5-BROMINE-2-(alpha-HYDROXYPENTYL)BENZOIC ACID SODIUM SALTS IN DIFFERENT CRYSTAL FORMS, AND PREPARATION METHOD THEREOF 有权
标题翻译： 5-BROMIN-2-（ALPHA-HYDROXYPENTYL）BENZOESUREURE NATRIUMSALZE IN VERSCHIEDENEN KRISTALLFORMEN UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP3023410A4
公开(公告)日：2017-02-08
申请号：EP14826150
申请日：2014-07-10
申请人： ZHEJIANG AUSUN PHARMACEUTICAL CO LTD
发明人： CHANG JUNBIAO , SONG CHUANJUN
IPC分类号： C07C65/03 , A61K31/192 , C07C51/09
CPC分类号： C07C63/70 , C07B2200/13 , C07C51/09 , C07C51/60 , C07C65/03
摘要： The present invention discloses 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt in different crystal forms and the preparation methods thereof, and belongs to the field of pharmaceutical chemistry. Said different crystal forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt include: amorphous 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt, crystal form A of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt, and crystal form B of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt. The different crystal forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt obtained according to the present invention have better stability and water-solubility than the mixed forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt, thus is advantageous for pharmaceutical use. Moreover, the different crystal forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt possess much better therapeutic effect than 5-bromo-2-(±-hydroxypentyl)benzoic acid potassium salt.
摘要翻译：本发明公开了不同晶型的5-溴-2-（± - 羟基戊基）苯甲酸钠盐及其制备方法，属于药物化学领域。所述不同晶型的5-溴-2-（± - 羟基戊基）苯甲酸钠盐包括：无定形5-溴-2-（± - 羟基戊基）苯甲酸钠盐，5-溴-2-（ ± - 羟基戊基）苯甲酸钠盐和5-溴-2-（± - 羟基戊基）苯甲酸钠盐的晶型B. 根据本发明获得的5-溴-2-（± - 羟基戊基）苯甲酸钠盐的不同晶体形式比5-溴-2-（± - 羟基戊基）苯甲酸的混合形式具有更好的稳定性和水溶性酸性钠盐，因此对于药物使用是有利的。此外，5-溴-2-（± - 羟基戊基）苯甲酸钠盐的不同晶体形式具有比5-溴-2-（± - 羟基戊基）苯甲酸钾盐好得多的治疗效果。

5. 发明授权

EP2006274B1 METHOD FOR PRODUCING 3,3,3-TRIFLUOROPROPIONIC ACID CHLORIDE 有权
标题翻译：生产3,3,3-三氟丙酸氯化物的方法
公开(公告)号：EP2006274B1
公开(公告)日：2016-12-21
申请号：EP07740262.6
申请日：2007-03-29
申请人： CENTRAL GLASS COMPANY, LIMITED
发明人： KOMATA, Takeo , HOSOI, Kenji , AKIBA, Shinya
IPC分类号： C07C51/60 , C07C53/50
CPC分类号： C07C51/60 , C07C53/50

6. 发明授权

EP2640711B1 IMPROVED PROCESS FOR THE PREPARATION OF RUFINAMIDE 有权
标题翻译：改进方法，卢非酰胺PRODUCING
公开(公告)号：EP2640711B1
公开(公告)日：2015-10-14
申请号：EP11819524.7
申请日：2011-08-23
申请人： Davuluri, Ramamohan Rao
发明人： PONNAIAH, Ravi , DEHURY, Sanjay Kumar , KARUPPANNAN, Selvaraju , VPSS, Deepthi , NAIDU, Dhanunjaya. S
IPC分类号： C07D249/04 , C07D249/06 , C07C69/653
CPC分类号： C07D249/06 , C07C51/60 , C07C67/307 , C07D249/04

7. 发明授权

EP2731923B1 VERFAHREN ZUR HERSTELLUNG VON CYCLOHEPTEN 有权
标题翻译：用于生产庚烯
公开(公告)号：EP2731923B1
公开(公告)日：2015-09-09
申请号：EP12733089.2
申请日：2012-07-03
申请人： BASF SE
发明人： TELES, Joaquim Henrique , LIMBACH, Michael , DEHN, Richard , DEUERLEIN, Stephan , DANZ, Manuel
IPC分类号： C07C6/06 , C07C13/24
CPC分类号： C07C6/04 , C07C1/2078 , C07C45/50 , C07C51/353 , C07C51/60 , C07C209/26 , C07C2531/22 , C07C2531/24 , C07C2601/18 , Y02P20/127 , C07C13/24 , C07C11/02 , C07C211/35 , C07C47/43 , C07C61/10

8. 发明公开

EP2731923A1 VERFAHREN ZUR HERSTELLUNG VON CYCLOHEPTEN 有权
公开(公告)号：EP2731923A1
公开(公告)日：2014-05-21
申请号：EP12733089.2
申请日：2012-07-03
申请人： BASF SE
发明人： TELES, Joaquim Henrique , LIMBACH, Michael , DEHN, Richard , DEUERLEIN, Stephan , DANZ, Manuel
IPC分类号： C07C6/06 , C07C13/24
CPC分类号： C07C6/04 , C07C1/2078 , C07C45/50 , C07C51/353 , C07C51/60 , C07C209/26 , C07C2531/22 , C07C2531/24 , C07C2601/18 , Y02P20/127 , C07C13/24 , C07C11/02 , C07C211/35 , C07C47/43 , C07C61/10
摘要： The present invention provides a process for preparing cycloheptene and derivatives thereof by ring-closure metathesis of asymmetric 1,8-dienes whose C-C double bond in position 8 is not terminal. Cycloheptene and also its derivatives cycloheptanone, cycloheptylamine, cycloheptanecarbaldehyde, cycloheptanecarboxylic acid and cycloheptanecarbonyl chloride, and also their derivatives, are important synthetic building blocks for active compounds. The ring-closure metathesis is performed preferably as a reactive distillation. The asymmetric 1,8-dienes for the ring-closure metathesis can be obtained by catalytic decarbonylation or oxidative decarboxylation of the corresponding unsaturated carboxylic acids and/or carboxylic acid derivatives.
摘要翻译：本发明提供了通过不对称1,8-二烯的闭环复分解制备环庚烯及其衍生物的方法，其中位置8的C-C双键不是末端。环庚烯及其衍生物环庚酮，环庚胺，环庚烷甲醛，环庚烷羧酸和环庚烷碳酰氯及其衍生物是活性化合物的重要合成结构单元。闭环复分解优选作为反应性蒸馏进行。用于闭环复分解的不对称1,8-二烯可以通过相应的不饱和羧酸和/或羧酸衍生物的催化脱羰或氧化脱羧获得。

9. 发明公开

EP2651868A2 PROCESS FOR THE PREPARATION OF ATOVAQUONE 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON ATOVAQUON
公开(公告)号：EP2651868A2
公开(公告)日：2013-10-23
申请号：EP11805451.9
申请日：2011-12-13
申请人： Glaxo Group Limited
发明人： DWYER, Andrew Neil , GORDON, Andrew , URQUHART, Michael
IPC分类号： C07C46/00
CPC分类号： C07C46/00 , C07C45/41 , C07C51/60 , C07C69/76 , C07C69/78 , C07C2601/14 , C07D307/89 , C07D311/76 , C07C50/32 , C07C61/40 , C07C47/457
摘要： Disclosed herein is novel process for preparation of atovaquone, which process includes reacting 1H-2-benzopyran-1,4(3H)-dione with 4-(4-chlorophenyl)cyclohexanecarbaldehyde. The invention further discloses novel intermediates useful in the preparation of atovaquone.
摘要翻译：本文公开了一种制备阿托伐醌的新方法，该方法包括使1H-2-苯并吡喃-1,4（3H） - 二酮与4-（4-氯苯基）环己烷甲醛反应。本发明还公开了可用于制备阿托瓦醌的新型中间体。

10. 发明公开

EP2640711A2 IMPROVED PROCESS FOR THE PREPARATION OF RUFINAMIDE 有权
标题翻译：改进方法，卢非酰胺PRODUCING
公开(公告)号：EP2640711A2
公开(公告)日：2013-09-25
申请号：EP11819524.7
申请日：2011-08-23
申请人： Davuluri, Ramamohan Rao
发明人： PONNAIAH, Ravi , DEHURY, Sanjay Kumar , K, Selvaraju , VPSS, Deepthi , NAIDU, Dhanunjaya. S
IPC分类号： C07D249/04 , C07D249/06 , C07C69/653
CPC分类号： C07D249/06 , C07C51/60 , C07C67/307 , C07D249/04
摘要： The invention relates to a novel, industrially viable, cost effective process for the preparation of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide commonly known as Rufinamide and intermediates thereof.

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