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21. 发明公开

EP1453601A1 METHOD AND DEVICE FOR THE CONTINUOUS TESTING OF MATERIALS 审中-公开
标题翻译：方法和设备材料的不断审查
公开(公告)号：EP1453601A1
公开(公告)日：2004-09-08
申请号：EP02787710.9
申请日：2002-11-15
申请人： HTE Aktiengesellschaft The High Throughput Experimentation Company
发明人： SCHUNK, Stephan, Andreas , ZECH, Torsten , CROSS, Alexander , VIETZE, Uwe , KLEIN, Jens , SUNDERMANN, Andreas , STICHERT, Wolfram
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00326 , B01J2219/00328 , B01J2219/00416 , B01J2219/00418 , B01J2219/00459 , B01J2219/00461 , B01J2219/00468 , B01J2219/00495 , B01J2219/005 , B01J2219/00502 , B01J2219/00587 , B01J2219/0059 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00702 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , C40B60/14
摘要： The present invention relates to a method for testing building blocks, which are identical or different, of a library of materials, comprising at least two building blocks, for performance characteristics, comprising a sequence of the following steps: 4) testing of at least one library building block for at least one performance characteristic; 5) detecting at least one measurable quantity, to which at least one performance characteristic of the at least one library building block can be assigned by at least one sensor, wherein at least one of the steps (4) and (5) is performed continuously.

22. 发明公开

EP1239952A2 OLIGONUCLEOTIDE SYNTHESIZER USING CENTRIFUGAL FORCE 有权
标题翻译：合成设备，用于采用离心式的寡核苷酸
公开(公告)号：EP1239952A2
公开(公告)日：2002-09-18
申请号：EP00988097.2
申请日：2000-12-13
申请人： Illumina, Inc.
发明人： LEBL, Michal
IPC分类号： B01J19/00 , B04B5/04 , C07H21/00 , G01N35/10
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00295 , B01J2219/00308 , B01J2219/00315 , B01J2219/00326 , B01J2219/00328 , B01J2219/00369 , B01J2219/00389 , B01J2219/00412 , B01J2219/00421 , B01J2219/00423 , B01J2219/00454 , B01J2219/0049 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , C40B60/14 , G01N35/025 , G01N35/028 , G01N35/1067 , G01N2035/00504 , G01N2035/1037 , G01N2035/1069 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/2575
摘要： An apparatus for high-throughput combinatorial syntheses of organic molecules including a reaction vessel for containing a combinatorial-chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis of rotation. A method of combinatorial synthesis of organic molecules is also disclosed.

23. 发明公开

EP1230980A2 Vorrichtung zur Bereitstellung von Flüssigkeiten zur Beladung von Dispensionswerkzeugen 审中-公开
标题翻译： Vorrichtung zur Bereitstellung vonFlüssigkeitenzur Beladung von Dispensionswerkzeugen
公开(公告)号：EP1230980A2
公开(公告)日：2002-08-14
申请号：EP02090046.0
申请日：2002-02-04
申请人： Epigenomics AG
发明人： G-tig, David
IPC分类号： B01L9/06 , G01N35/04 , B01J19/00
CPC分类号： B01L9/06 , B01J19/0046 , B01J2219/00281 , B01J2219/00283 , B01J2219/00308 , B01J2219/00328 , B01J2219/00351 , B01J2219/00722 , C40B40/06 , C40B60/14 , G01N35/04 , G01N2035/0406
摘要： Beschrieben wird eine Vorrichtung zur Bereitstellung von Flüssigkeiten zur Beladung von Dispensionswerkzeugen zur Herstellung von Oligonukleotid-Chips.
Dabei handelt es sich um eine Vorrichtung zur beliebigen Anordnung nach oben offener Gefäße in einem rechtwinkligen Raster, wobei das Raster von Gefäßen an zwei gegenüber liegenden Seiten durch statische Seitenwände (B) begrenzt wird, zwischen denen es als ganzes mit den dazu senkrechten anderen beiden Seitenwänden (A) verschiebbar ist, und es mindestens eine Position gibt, an der die statischen Seitenwände an gegenüber liegenden Stellen durchbrochen sind und mindestens ein weiteres Gefäß mit einem Führungselement (C) in das Raster verschiebbar ist, welches gleichzeitig auf der gegenüber liegenden Seite zurück weicht, um das aus dem Raster herausgeschobene Gefäß aufzunehmen, und es bei Bedarf an anderer Stelle wieder in das Raster zu schieben, und somit die Gefäße sukzessiv zu permutieren.
摘要翻译：一种用于重排微量滴定板的装置，包括槽式侧轨（B），其中井安装在销上，端壁（A）允许它们向前和向后滑动，使得可以插入额外的井（C）或现有井可以重新排列。

24. 发明公开

EP1046823A2 Valve apparatus for adjusting parallel flows, method for manufacturing a valve member of said apparatus, method for adjusting said flows as well as method for washing said apparatus 审中-公开
标题翻译：用于这样的装置，用于调节这些流方法的阀构件的制备设定并行流，过程阀装置，以及用于这种装置的洗涤方法
公开(公告)号：EP1046823A2
公开(公告)日：2000-10-25
申请号：EP00660040.7
申请日：2000-03-03
申请人： FLUILOGIC SYSTEMS OY
发明人： Muukkonen, Kari
IPC分类号： F15C5/00 , B01J19/00
CPC分类号： F16K99/0011 , B01J19/0046 , B01J2219/00315 , B01J2219/00319 , B01J2219/00328 , B01J2219/00389 , B01J2219/00407 , B01L3/0241 , B01L99/00 , B01L2400/0622 , B01L2400/065 , C40B60/14 , F16K99/0001 , F16K2099/0076 , F16K2099/0084 , G01N35/1004 , G01N35/1074 , G01N2035/00247
摘要： The invention relates to a valve apparatus for adjusting parallel flows. Moreover, the invention comprises a method for manufacturing a valve member belonging to said apparatus, a method for adjusting parallel flows, a method for washing said apparatus and a dosing apparatus. The valve apparatus includes at least two valve members 1, la movable with respect to each other, in which members there are provided parallel channels 3 for said flows. The ends 4 of the channels are located on opposite sliding surfaces 2 belonging to the valve members, so that when the channel ends are matched, the flow paths are open, and when the channel ends are deviated, the flow paths are closed. Moreover, in at least one of the opposite sliding surfaces 2, there are made grooves 5 in between the channel ends 4. The grooves 5 can serve as washing channels in order to prevent contamination between parallel flows, in addition to which they serve, when manufacturing the valve member, as collectors of grinding dust and grinding paste. The grooves also make it possible to wash the sliding surfaces at a pressure that overcomes the force of the spring 19 charging the valve members, thus pushing the sliding surfaces apart. The flow adjustment according to the invention can be applied in simultaneously feeding small batches of liquid onto a microtiter plate 13 containing fluid positions 12 in a matrix-like fashion.
摘要翻译：阀装置（A）包括至少两个阀构件（1,1A），相对于彼此可移动的，并包括形成的具有阀的相对滑动面的端部的平行流路部件的通道。当通道结束的比赛中，流动路径确定，但否则就不是。在相对的滑动面中的至少一个，凹槽通道端部之间进行比较。独立权利要求中包括了以下内容：（1）生产（1，1），其包括形成流动通道和槽，研磨，收集膏并从表面之间放电期间磨削的光滑表面与研磨膏和，经由凹槽; （2）使用（A）调整并行流动，所以没有当流路是开放的，洗涤电路存在时，在较低的压力，其包括槽，以防止不同的流（3）洗涤（A）之间的污染哪所以没有当并行流被中断，洗涤以比弹簧力大的压力下进行，因此除了没有滑动面和阀构件下降，从而使洗涤液在所述滑动面的整个区域，（4）的计量分发包括装置（A），流体源被计量和泵用于以并行方式创建流动。

25. 发明授权

EP0734397B1 APPARATUS AND METHOD FOR POLYMER SYNTHESIS USING ARRAYS 失效
标题翻译：装置和方法与框架高分子合成
公开(公告)号：EP0734397B1
公开(公告)日：2000-08-23
申请号：EP94931933.9
申请日：1994-10-19
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： BRENNAN, Thomas, M.
IPC分类号： B01J19/00
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00286 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00328 , B01J2219/00364 , B01J2219/00369 , B01J2219/00414 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01J2219/00454 , B01J2219/00459 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07K1/04 , C07K1/045 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N35/1072
摘要： A polymer synthesis method and apparatus (20) is disclosed for building a polymer chain including a head assembly (21) having nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24), and a base assembly (25) having reaction wells (26). A gas inlet (70) into the common chamber (31), upstream from the nozzles (22), and a gas outlet (71) out of the common chamber (31), downstream from the nozzles (22), sweeps the common chamber (31) of toxic fumes emitted by the reagents. A pressure regulating device (82) is provided for controlling a pressure differential, between pressure exerted on the reaction well (26) and pressure exerted on an exit (80) of the orifice (74), such that upon the pressure differential exceeding a predetermined amount, the reagent solution (76) is expelled.

26. 发明公开

EP0734397A4 APPARATUS AND METHOD FOR POLYMER SYNTHESIS USING ARRAYS 失效
标题翻译：装置和方法与框架高分子合成
公开(公告)号：EP0734397A4
公开(公告)日：1997-04-02
申请号：EP94931933
申请日：1994-10-19
申请人： UNIV LELAND STANFORD JUNIOR
发明人： BRENNAN THOMAS M
IPC分类号： C12M1/00 , B01J19/00 , C07B61/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/02 , C07K1/04 , C08F2/00 , C08F2/04 , C08G85/00 , C12N15/09 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N35/10
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00286 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00328 , B01J2219/00364 , B01J2219/00369 , B01J2219/00414 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01J2219/00454 , B01J2219/00459 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07K1/04 , C07K1/045 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N35/1072
摘要： A polymer synthesis method and apparatus (20) is disclosed for building a polymer chain including a head assembly (21) having nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24), and a base assembly (25) having reaction wells (26). A gas inlet (70) into the common chamber (31), upstream from the nozzles (22), and a gas outlet (71) out of the common chamber (31), downstream from the nozzles (22), sweeps the common chamber (31) of toxic fumes emitted by the reagents. A pressure regulating device (82) is provided for controlling a pressure differential, between pressure exerted on the reaction well (26) and pressure exerted on an exit (80) of the orifice (74), such that upon the pressure differential exceeding a predetermined amount, the reagent solution (76) is expelled.

27. 发明公开

EP0734397A1 APPARATUS AND METHOD FOR POLYMER SYNTHESIS USING ARRAYS 失效
标题翻译：装置和方法与框架高分子合成
公开(公告)号：EP0734397A1
公开(公告)日：1996-10-02
申请号：EP94931933.0
申请日：1994-10-19
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： BRENNAN, Thomas, M.
IPC分类号： C12M1 , B01J19 , C07H21 , C07K1 , C08F2 , C08G85 , C12N15 , G01N35 , C07B61 , C40B40 , C40B50 , C40B60
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00286 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00328 , B01J2219/00364 , B01J2219/00369 , B01J2219/00414 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01J2219/00454 , B01J2219/00459 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07K1/04 , C07K1/045 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N35/1072
摘要： A polymer synthesis method and apparatus (20) is disclosed for building a polymer chain including a head assembly (21) having nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24), and a base assembly (25) having reaction wells (26). A gas inlet (70) into the common chamber (31), upstream from the nozzles (22), and a gas outlet (71) out of the common chamber (31), downstream from the nozzles (22), sweeps the common chamber (31) of toxic fumes emitted by the reagents. A pressure regulating device (82) is provided for controlling a pressure differential, between pressure exerted on the reaction well (26) and pressure exerted on an exit (80) of the orifice (74), such that upon the pressure differential exceeding a predetermined amount, the reagent solution (76) is expelled.

29. 发明授权

EP1499443B1 VORRICHTUNG ZUR PROTEINKRISTALLISATION 有权
标题翻译： DEVICE FOR蛋白质结晶
公开(公告)号：EP1499443B1
公开(公告)日：2012-06-13
申请号：EP03747428.5
申请日：2003-04-29
申请人： Greiner Bio-One GmbH
发明人： KNEBEL, Günther , D'ARCY, Allan , CUDNEY, Robert, Earl
IPC分类号： B01L3/00 , C30B7/00 , B01J19/00
CPC分类号： B01L3/5085 , B01J2219/00274 , B01J2219/00317 , B01J2219/00328 , B01J2219/00587 , B01J2219/00599 , B01J2219/00659 , B01J2219/00691 , B01J2219/00725 , B01J2219/00756 , B01L2200/025 , B01L2200/142 , B01L2200/18 , B01L2300/0618 , B01L2300/0829 , B01L2400/086 , C30B7/00 , C30B29/58 , C40B40/10 , C40B50/08 , C40B60/14
摘要： The invention relates to a container (1) containing a base body (2) consisting of a base plate (3) and lateral walls (4) that protrude from the latter at least in an approximately perpendicular manner, in addition to cells (5) arranged in said base body (2). The cells (5) are configured as depressions in the base plate (3) and the lateral walls (4) of the base plate (3) are positioned in a direction that is approximately opposite the depressions for receiving a volume.

30. 发明授权

EP1444497B1 AUTOMATED VERIFICATION AND INSPECTION DEVICE FOR SEQUENTIALLY INSPECTING MICROSCOPIC CRYSTALS 有权
标题翻译：自动验证和检查设备进行顺序EXAMINE微小晶体
公开(公告)号：EP1444497B1
公开(公告)日：2012-05-23
申请号：EP02780474.9
申请日：2002-10-17
申请人： Robodesign International, Inc.
发明人： GANZ, Brian, L. , JEWELL, David, W. , MICKLEY, Mandel, W. , MOULDS, John, Andrew , BROVOLD, Christopher, T. , ADAMS, John, A.
IPC分类号： G01N1/00 , B01L3/00 , G01N33/543 , B01L9/00 , G01N35/02 , C30B7/00
CPC分类号： B01L9/523 , B01J2219/00315 , B01J2219/00322 , B01J2219/00328 , B01J2219/00707 , B01J2219/00725 , B01J2219/00756 , B01L2300/0829 , C30B7/00 , G01N35/028
摘要： A method and device for inspecting and classifying a plurality of microscopic crystals. An indexing device (105, 115, 150 and 160) sequentially places microscopic crystals in cameraview of a camera (135, 155). The camera (135, 155) takes images of the microscopic crystals and then transfers the images to a computer (105) where they are received. The computer then classifies the images. The computer (105) is also programmed to control the indexing device and the camera. In a preferred embodiment, the microscopic crystals are protein crystals that have been grown in the wells of micro-well plates (125A-125F). Also, preferably, the computer is programmed to automatically classify the images.

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