专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2931259A4 METHOD FOR MAINTAINING HETEROGENEOUS CONCENTRATIONS OF MOLECULES IN EMULSION DROPLETS 审中-公开
标题翻译：方法用于维持分子的异质浓度乳滴
公开(公告)号：EP2931259A4
公开(公告)日：2016-07-13
申请号：EP13862508
申请日：2013-12-16
申请人： GNUBIO INC
发明人： HUNG TONY , BLOUWOLFF JOSHUA , KIANI SEPEHR
IPC分类号： A61K9/10 , B01J19/00 , C40B50/08
CPC分类号： B01J19/0046 , A61K9/107 , B01J2219/00599 , B01J2219/00722 , C40B50/08

2. 发明授权

EP2602018B1 Compartmentalised screening by microfluidic control 有权
标题翻译：细分调查通过微流体控制
公开(公告)号：EP2602018B1
公开(公告)日：2016-04-27
申请号：EP12195355.8
申请日：2005-10-12
申请人： Medical Research Council , President and Fellows of Harvard College
发明人： Griffiths, Andrew , Weitz, David , Link, Darren , Ahn, Kuenho , Bibette, Jerome
IPC分类号： B01F5/02
CPC分类号： G01N33/5432 , B01F3/0807 , B01F5/0256 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0062 , B01F13/0071 , B01F13/0076 , B01F2003/0834 , B01F2003/0842 , B01J19/0046 , B01J2219/00576 , B01J2219/00596 , B01J2219/00599 , B01J2219/00657 , B01J2219/00664 , B01J2219/00666 , B01J2219/00702 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12Q1/42 , C12Q2563/159 , C12Q2565/119 , C40B50/08 , G01N15/14 , G01N21/6428 , G01N33/5008 , G01N33/5044 , G01N33/573 , G01N2015/149 , G01N2021/6439 , G01N2333/916 , G01N2500/04 , G01N2500/10
摘要： The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

3. 发明公开

EP2647720A9 PEPTIDE LIBRARY PRODUCTION METHOD, PEPTIDE LIBRARY, AND SCREENING METHOD 有权
标题翻译：多肽库制作方法，肽库和筛选方法
公开(公告)号：EP2647720A9
公开(公告)日：2015-04-01
申请号：EP11845623.5
申请日：2011-12-05
申请人： The University of Tokyo
发明人： SUGA, Hiroaki , MORIMOTO, Jumpei
IPC分类号： C12P21/00 , C12N15/09 , C40B40/06 , C40B40/10 , G01N33/15 , G01N33/50 , G01N33/573 , C12Q1/34
CPC分类号： B01J19/0046 , B01J2219/00725 , C07K7/08 , C07K14/705 , C12N15/1062 , C12N15/67 , C12Q1/34 , C40B50/06 , C40B50/08
摘要： Object is to provide a method of constructing a library of peptides having, at a desired position in the random sequence of each peptide, an amino acid having a portion capable of binding to a target. The invention provides a method of producing a library of peptides having, at a designated position in the random sequence of each peptide, a special amino acid having a portion capable of binding to a target, including (i) preparing a library of mRNAs having, in the mRNA sequence coding for a random amino acid sequence, a base sequence having an altered codon encoding the special amino acid, (ii) preparing an aminoacyl tRNA with the special amino acid linked to a tRNA encoded by the altered codon, and (iii) translating the mRNAs by using a cell-free translation system containing the aminoacyl tRNA to obtain a library of peptides having, in the random sequence thereof, a predetermined special amino acid.
摘要翻译：目的是提供一种构建肽的文库的方法，所述肽文库在各肽的随机序列中的期望位置具有能够结合靶的部分的氨基酸。本发明提供了一种产生肽的文库的方法，所述肽文库在每个肽的随机序列中的指定位置具有能够与靶标结合的部分的特定氨基酸，包括（i）制备mRNA的文库，在编码随机氨基酸序列的mRNA序列中，具有编码特定氨基酸的改变密码子的碱基序列，（ii）制备具有与由改变密码子编码的tRNA连接的特殊氨基酸的氨酰基tRNA，和（iii ）通过使用含有氨酰基tRNA的无细胞翻译系统翻译mRNA以获得在其随机序列中具有预定特定氨基酸的肽文库。

4. 发明公开

EP2748319A1 VERFAHREN ZUR HERSTELLUNG EINER NUKLEINSÄURE- BIBLIOTHEK MIT MINDESTENS ZWEI BENACHBARTEN VARIABLEN CODON- TRIPLETTS 有权
标题翻译：制造方法的核酸库，至少两个相邻的可变密码子三联
公开(公告)号：EP2748319A1
公开(公告)日：2014-07-02
申请号：EP13704605.8
申请日：2013-02-14
申请人： Fuhrmann, Markus
发明人： Fuhrmann, Markus
IPC分类号： C12N15/10 , C12N15/66
CPC分类号： C12N15/1093 , C12N15/10 , C12N15/66 , C40B50/08
摘要： The invention relates to a method for producing a DNA sequence for a nucleic acid library having a plurality of elements. The synthesized DNA sequence comprises at least three regions. The first region and the third region in each element each have defined sequences (D1, D2) that are identical in each element of the nucleic acid library. In a middle second region, at least two adjacent variable codon triplets are arranged. The following method steps are carried out: First, oligonucleotides (O1-x) of a first oligonucleotide library (O1b) are hybridized with a first largely complementary oligonucleotide (O2) to form a first double-stranded DNA library (O1xO2). Furthermore, oligonucleotides (O3-x) of a second oligonucleotide library (O3b) are hybridized with a second largely complementary oligonucleotide (O4) to form a second double-stranded DNA library (O3xO4). Then the first double-stranded DNA library (O1xO2) and the second double-stranded DNA library (O3xO4) are ligated to form a double-stranded DNA ligation product (LPx). The double-stranded DNA ligation product comprises the following sub-regions: a defined first region (D1) of the nucleic acid library, at least one first variable codon triplet (Tv1), a spacer sequence (S), at least one second variable codon triplet (Tv2), and a defined second region (D2) of the nucleic acid library. After the spacer sequence (S) has been removed, a library of double-stranded DNA product (Px) comprising the following sub-regions is obtained: a defined first region (D1) of the nucleic acid library, at least one first variable codon triplet (Tv1), at least one second variable codon triplet (Tv2), and a defined second region (D2) of the nucleic acid library.

5. 发明公开

EP2364774A3 Microfluidic Devices And Methods Of Use In The Formation And Control Of Nanoreactors 审中-公开
标题翻译：微流体装置和用于在纳米反应器的形成和控制中使用的方法
公开(公告)号：EP2364774A3
公开(公告)日：2014-06-04
申请号：EP10196179.5
申请日：2006-06-01
申请人： Raindance Technologies, Inc.
发明人： LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
IPC分类号： B01J19/00 , G01N35/08 , B01L3/00
CPC分类号： C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label,; thereby identifying a single compound from a library of compounds.

6. 发明授权

EP1533608B1 Method for high-throughput screening with a calorimetric device 有权
标题翻译：高通量筛选方法用热量测定装置
公开(公告)号：EP1533608B1
公开(公告)日：2014-04-30
申请号：EP04025543.2
申请日：2004-10-27
申请人： Palo Alto Research Center Incorporated
发明人： Bruce, Richard H. , Torres, Francisco E. , Bell, Alan G. , Peeters, Eric
IPC分类号： G01N25/48 , B01J19/00
CPC分类号： G01N25/4866 , B01J2219/00599 , B01J2219/00702 , C40B50/08 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/2575

7. 发明公开

EP2647720A1 PEPTIDE LIBRARY PRODUCTION METHOD, PEPTIDE LIBRARY, AND SCREENING METHOD 有权
标题翻译： PEPTIDBIBLIOTHEK-HERSTELLUNGSVERFAHREN，PEPTIDBIBIIHEK UND SCREENING-VERFAHREN
公开(公告)号：EP2647720A1
公开(公告)日：2013-10-09
申请号：EP11845623.5
申请日：2011-12-05
申请人： The University of Tokyo
发明人： SUGA, Hiroaki , MORIMOTO, Jumpei
IPC分类号： C12P21/00 , C12N15/09 , C40B40/06 , C40B40/10 , G01N33/15 , G01N33/50 , G01N33/573 , C12Q1/34
CPC分类号： B01J19/0046 , B01J2219/00725 , C07K7/08 , C07K14/705 , C12N15/1062 , C12N15/67 , C12Q1/34 , C40B50/06 , C40B50/08
摘要： Object is to provide a method of constructing a library of peptides having, at a desired position in the random sequence of each peptide, an amino acid having a portion capable of binding to a target. The invention provides a method of producing a library of peptides having, at a designated position in the random sequence of each peptide, a special amino acid having a portion capable of binding to a target, including (i) preparing a library of mRNAs having, in the mRNA sequence coding for a random amino acid sequence, a base sequence having an altered codon encoding the special amino acid, (ii) preparing an aminoacyl tRNA with the special amino acid linked to a tRNA encoded by the altered codon, and (iii) translating the mRNAs by using a cell-free translation system containing the aminoacyl tRNA to obtain a library of peptides having, in the random sequence thereof, a predetermined special amino acid.
摘要翻译：目的是提供构建肽的文库的方法，其在每个肽的随机序列中的期望位置具有具有能够结合靶标的部分的氨基酸。本发明提供一种生产肽文库的方法，其在每个肽的随机序列中的指定位置具有具有能与靶标结合的部分的特殊氨基酸，包括（i）制备mRNA文库，在编码随机氨基酸序列的mRNA序列中，具有编码特殊氨基酸的改变的密码子的碱基序列，（ii）用与被改变的密码子编码的tRNA连接的特殊氨基酸制备氨酰基tRNA，和（iii ）通过使用含有氨酰基tRNA的无细胞翻译系统来翻译mRNA，以获得在其随机序列中具有预定的特殊氨基酸的肽文库。

8. 发明授权

EP1608976B1 SELECTION BY COMPARTMENTALISED SCREENING 有权
标题翻译：选择来筛选空间
公开(公告)号：EP1608976B1
公开(公告)日：2012-09-05
申请号：EP04724631.9
申请日：2004-03-31
申请人： MEDICAL RESEARCH COUNCIL
发明人： GRIFFITHS, Andrew David , ABELL, Chris, Department of Chemistry , HOLLFELDER, Florian , MASTROBATTISTA, Enrico
IPC分类号： G01N33/543
CPC分类号： G01N21/6428 , B01J2219/00596 , B01J2219/00599 , B01J2219/00702 , C40B50/08 , G01N21/6458 , G01N33/5432
摘要： The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in anyone microcapsule; and b) identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

9. 发明公开

EP2078077A2 NUCLEIC ACID LIBRARIES AND THEIR DESIGN AND ASSEMBLY 审中-公开
标题翻译： NUCLEIC库及其设计与制造
公开(公告)号：EP2078077A2
公开(公告)日：2009-07-15
申请号：EP07839344.4
申请日：2007-10-04
申请人： CODON DEVICES, INC
发明人： BAYNES, Brian M. , DANNER, John P. , LIPOVSEK, Dasa , BASU, Subhayu
IPC分类号： C12N15/10
CPC分类号： C12N15/1027 , C12N15/1034 , C12N15/1093 , C12N15/64 , C12N15/66 , C40B40/06 , C40B40/08 , C40B50/08
摘要： Aspects of the invention relate to the design and synthesis of nucleic acid libraries containing non-random mutations or variants. Aspects of the invention provide methods for assembling libraries containing high densities of predetermined variant sequences. Certain embodiments relate to the design and synthesis of nucleic acid libraries that express a predetermined polypeptide from a library of nucleic acids having silent sequence variants. Certain embodiments relate to the design and synthesis of nucleic acid libraries that express predetermined RNA variants that encode the same polypeptide sequence.

10. 发明公开

EP1670314A4 METHODS AND COMPOSITIONS COMPRISING DIAMINES AS NEW ANTI-TUBERCULAR THERAPEUTICS 审中-公开
标题翻译：方法和组合物含二胺作为新治疗结核病
公开(公告)号：EP1670314A4
公开(公告)日：2009-02-25
申请号：EP04809706
申请日：2004-09-07
申请人： SEQUELLA INC
发明人： BOGATCHEVA ELENA , PROTOPOPOVA MARINA , NIKONENKO BORIS
IPC分类号： A01N55/02 , A61K20060101 , C07D241/04 , C07D413/02
CPC分类号： A61K31/445 , A61K31/12 , A61K31/5375 , A61K45/06 , C07C211/20 , C07C211/27 , C07C211/36 , C07C211/38 , C07C211/49 , C07C211/53 , C07C217/10 , C07C217/58 , C07C217/62 , C07C323/32 , C07C2601/14 , C07C2601/16 , C07C2602/12 , C07C2602/28 , C07C2602/42 , C07C2603/74 , C40B40/04 , C40B50/08 , A61K2300/00
摘要： Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising novel diamine compositions for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式