专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP4328233A1 PRODUCTION METHOD OF FRAGMENTED EXTRACELLULAR MATRIX COMPONENT 审中-公开
公开(公告)号：EP4328233A1
公开(公告)日：2024-02-28
申请号：EP22841955.2
申请日：2022-06-29
申请人： TOPPAN INC. , OSAKA UNIVERSITY
发明人： YAMADA Asuka , KITANO Shiro , MATSUSAKI Michiya
IPC分类号： C07K1/02 , C07K1/14 , C07K5/09 , C12N5/071 , C12N1/00 , C07K14/78
摘要： One aspect of the present invention relates to a production method of a fragmented extracellular matrix component, the method including: a step of neutralizing a solution in which an extracellular matrix component is dissolved; a step of obtaining a mass containing the extracellular matrix component by removing the solvent through freeze-drying treatment after the neutralization step; a step of obtaining a liquid containing the fragmented extracellular matrix component by dispersing the mass in a solution containing a polar organic solvent and fragmenting the extracellular matrix component in the solution; and a step of removing a liquid component from the liquid containing the fragmented extracellular matrix component.

2. 发明公开

EP4310094A1 METHOD FOR PRODUCING AMINO ACID OR PEPTIDE, REAGENT FOR FORMING PROTECTING GROUP, AND COMPOUND 审中-公开
公开(公告)号：EP4310094A1
公开(公告)日：2024-01-24
申请号：EP22771542.2
申请日：2022-03-18
申请人： FUJIFILM Corporation
发明人： NAKAGAWA Daisuke , TSUYAMA Hiroaki
IPC分类号： C07K1/06 , C07D233/60 , C07K1/02
摘要： An object of the present invention is to provide a method for producing a peptide with high efficiency, which is capable of deprotecting a protective group in a side chain with a weak acid; a protective group-forming reagent having excellent deprotective properties; and a compound. According to the present invention, there is provided a method for producing a peptide, including a peptide chain extending step of reacting a first amino acid or peptide in which a side chain is protected with a first protective group represented by Formula (1) with a second amino acid or peptide to obtain a third amino acid or peptide, and a first deprotecting step of deprotecting the first protective group of the third amino acid or peptide, in which, in the first deprotecting step, the deprotection is performed using a deprotection solution having a trifluoroacetic acid content of 10% by mass or less. In the formula, R 11 is an aryl group having a substituent, R 21 and R 22 are each independently a hydrogen atom or a substituent, and n is an integer of 1 to 6.

3. 发明公开

EP4303224A1 PROTEIN FOLDING AGENT 审中-公开
公开(公告)号：EP4303224A1
公开(公告)日：2024-01-10
申请号：EP22763297.3
申请日：2022-03-02
申请人： Tohoku University
发明人： MURAOKA Takahiro , OKADA Shunsuke , MATSUMOTO Yosuke , OKUMURA Masaki , INABA Kenji , MATSUSAKI Motonori
IPC分类号： C07K1/02
摘要： Provided is a protein folding agent capable of folding a protein with high efficiency. A protein folding agent contains: as an active ingredient, at least one selected from compounds represented by formulas (1) to (14), salts thereof, and solvates thereof.

4. 发明授权

EP3704143B1 CHEMO-ENZYMATIC SYNTHESIS OF LIRAGLUTIDE, SEMAGLUTIDE AND GLP-1 有权
公开(公告)号：EP3704143B1
公开(公告)日：2023-10-18
申请号：EP19709061.6
申请日：2019-03-11
发明人： QUAEDFLIEG, Peter, Jan, Leonard, Mario , TOPLAK, Ana , NUIJENS, Timo
IPC分类号： C07K14/605 , C07K1/06 , C12P21/02 , C07K1/02 , C07K1/36 , C12N9/54 , C07K14/32

5. 发明授权

EP3778621B1 PEPTIDE SYNTHESIS METHOD 有权
公开(公告)号：EP3778621B1
公开(公告)日：2023-08-23
申请号：EP19785772.5
申请日：2019-04-13
发明人： SUZUKI, Hideaki , MUTO, Susumu , FUJITA, Shuji , KUBO, Daisuke
IPC分类号： C07K1/10 , C07K1/02 , C07K1/04 , C07K7/06

6. 发明公开

EP4146816A1 MOLECULAR TRANSPORT FOR VIRAL AGENTS 审中-实审
公开(公告)号：EP4146816A1
公开(公告)日：2023-03-15
申请号：EP21800601.3
申请日：2021-05-03
申请人： McMaster University
发明人： BULIR, David , CHONG, Sylvia
IPC分类号： C12Q1/6806 , A01N47/28 , A01N47/44 , A01P1/00 , C07K1/02 , C12N15/10 , G01N1/38

7. 发明公开

EP4116315A1 METHOD FOR PREPARING LIRAGLUTIDE USING ENVIRONMENT-FRIENDLY SOLVENT 审中-公开
公开(公告)号：EP4116315A1
公开(公告)日：2023-01-11
申请号：EP21809787.1
申请日：2021-05-17
申请人： Daebong LS Co., Ltd.
发明人： PARK, Eun Ju , KIM, Eun Teak , PARK, Jin Oh
IPC分类号： C07K1/10 , C07K1/02 , C07K14/605
摘要： The present invention relates to a novel method for preparing liraglutide by means of an ionic liquid and a eutectic solvent, which are environment-friendly solvents. More specifically, the present invention is characterized in that fractionated peptide 1 represented by the following formula (1) and fractionated peptide 2 represented by the following formula (2) are subjected to a coupling reaction in the presence of an ionic liquid or a eutectic solvent. In preparing GLP-1 analogues such as liraglutide, the present invention increases reactivity when producing liraglutide, which is an unprocessed reactant, by using an ionic liquid and a eutectic solvent as environment-friendly solvents instead of using organic solvents. Accordingly, through a relatively short and simple purification process, the present invention has advantages of reducing the formation of related substances, improving purity, improving yields, shortening reaction times, reducing production cost, and lowering the manufacturing cost.

[Formula 1] (Boc-His(Trt)-Ala-Glu(tBu)-Gly-Thr[PSI(Me,Me)Pro]-Phe-Thr[PSI(Me,Me)Pro]-Ser(tBu)-Asp(tBu)-Val-Ser[PSI(Me,Me)Pro]-Ser(tBu)-Tyr(tBu)-Leu-Glu(tBu)-Gly-OH)

[Formula 2] (NH 2 -Gln(Trt)-Ala-Ala-Lys(Pal-Glu-OtBu)-Glu(tBu)-Phe-Ile-Ala-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-Arg(Pbf)-Gly-linker-OH)

8. 发明公开

EP4100051A2 TREATMENT OF HPV-RELATED DISEASES 审中-公开
公开(公告)号：EP4100051A2
公开(公告)日：2022-12-14
申请号：EP21702684.8
申请日：2021-02-05
申请人： ISA Pharmaceuticals B.V.
发明人： BEENAKKER, Thomas, Johannes, Maria , MOOLHUIZEN, Gerben , MELIEF, Cornelis, Johannes, Maria , MOLENAAR, Miranda, Bernardina, Johanna , KOOI, Elvin, Irsan , VAN DUIN, Richard, Johannes , MORSCH, Thomas
IPC分类号： A61K39/12 , A61P31/20 , A61P35/00 , C07K1/02 , C07K14/025 , C12Q1/70

9. 发明公开

EP4059347A1 ORGANIC AMMONIUM SALT AND HYDROGEN BOND MATERIAL TREATING AGENT USING SAME 审中-公开
公开(公告)号：EP4059347A1
公开(公告)日：2022-09-21
申请号：EP20886807.5
申请日：2020-10-06
申请人： Miyoshi Oil & Fat Co., Ltd.
发明人： KANEKO Kotaro , KAWAI Koji
IPC分类号： A01N1/02 , C07C215/08 , C07C215/10 , C07C215/12 , C07H21/00 , C07K1/02 , C12N9/96
摘要： Provided are a novel compound and a hydrogen-bonding material treatment agent that are useful for treating various hydrogen-bonding materials such as biological samples. They are an organic ammonium salt and a hydrogen-bonding material treatment agent containing the same. The organic ammonium salt is solid at 25°C, and contains an anion and an ammonium cation represented by the following formula (I):

N + R n H 4 - n (I)

wherein R independently represents, for example, a hydroxyalkyl group in which there is at least one hydroxy group, an alkyl moiety is a linear or branched moiety having 1 to 10 carbon atoms, and the alkyl moiety may contain an oxygen atom(s), and n represents an integer of 0 to 4.

10. 发明公开

EP3904367A1 TETRAPEPTIDE COMPOUND, PREPARATION METHOD AND USE THEREOF 审中-公开
公开(公告)号：EP3904367A1
公开(公告)日：2021-11-03
申请号：EP19905086.5
申请日：2019-11-20
申请人： Lanzhou University , Hangzhou Yinfu Science & Technology Co., Ltd.
发明人： DA, Chaoshan , DU, Zhihong , QIN, Wenjuan , TAO, Baoxiu , BAI, Yanbing , LIN, Hang , ZHANG, Lianchun , YIN, Hanghua , YU, Jianxin , LIU, Xueyu , JIANG, Weilin , JIN, Wenjiu
IPC分类号： C07K5/103 , C07K5/097 , C07K1/06 , C07K1/02 , C12P17/10
摘要： The present invention discloses a tetrapeptide compound, a preparation method and a use thereof. The tetrapeptide compound of the present invention is TP represented by formula 1, the preparation method thereof is firstly preparing an intermediate compound, then adding the intermediate compound and catalysts Pd/C into a solvent, introducing hydrogen gas with the pressure being 1 to 30 Mpa for reaction, to obtain a final product of tetrapeptide compound TP. The compound of the present invention can be used for Aldol reaction of ketone and aromatic aldehyde, or can be used for catalyzing asymmetric conjugate addition reaction of fatty aldehyde and maleimide. The tetrapeptide compound of the present invention can be used for catalyzing the conjugate addition reaction of fatty aldehyde and maleimide at high efficiency in an asymmetric way, the reaction yield reaches 98%, the enantioselectivity is as high as 99%.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式