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1. 发明公开

EP4410822A1 ESTERIFIED PROTEIN AND PRODUCTION METHOD THEREOF 审中-实审
公开(公告)号：EP4410822A1
公开(公告)日：2024-08-07
申请号：EP22889984.5
申请日：2022-11-02
申请人： Spiber Inc.
发明人： SAKATA Kazuki , SHIRAKAWA Seiji , KITAHARA Nao , NIWA Takahiro
IPC分类号： C07K14/00 , C07K1/02 , C08G69/48
CPC分类号： C07K14/00 , C08G69/48 , C07K1/02
摘要： The present invention provides a β-ketoester of a protein containing an amino acid having a hydroxyl group, wherein the hydroxyl group forms an ester bond with a group represented by Formula (1) wherein R represents a C1-6 alkyl group or an optionally substituted aryl group.

2. 发明公开

EP4396194A1 VERFAHREN ZUR ZELLFREIEN HERSTELLUNG VON UNSPEZIFISCHEN PEROXYGENASEN 审中-实审
公开(公告)号：EP4396194A1
公开(公告)日：2024-07-10
申请号：EP22776894.2
申请日：2022-09-05
申请人： Brandenburgische Technische Universität Cottbus-Senftenberg
发明人： SCHEIBNER, Katrin , SCHMIDTKE, Kai-Uwe , SCHRAMM, Marina
IPC分类号： C07K1/02
CPC分类号： C12Y111/02001 , C12N9/0065

3. 发明公开

EP4328233A1 PRODUCTION METHOD OF FRAGMENTED EXTRACELLULAR MATRIX COMPONENT 审中-实审
公开(公告)号：EP4328233A1
公开(公告)日：2024-02-28
申请号：EP22841955.2
申请日：2022-06-29
申请人： TOPPAN INC. , OSAKA UNIVERSITY
发明人： YAMADA Asuka , KITANO Shiro , MATSUSAKI Michiya
IPC分类号： C07K1/02 , C07K1/14 , C07K5/09 , C12N5/071 , C12N1/00 , C07K14/78
摘要： One aspect of the present invention relates to a production method of a fragmented extracellular matrix component, the method including: a step of neutralizing a solution in which an extracellular matrix component is dissolved; a step of obtaining a mass containing the extracellular matrix component by removing the solvent through freeze-drying treatment after the neutralization step; a step of obtaining a liquid containing the fragmented extracellular matrix component by dispersing the mass in a solution containing a polar organic solvent and fragmenting the extracellular matrix component in the solution; and a step of removing a liquid component from the liquid containing the fragmented extracellular matrix component.

4. 发明公开

EP4310094A1 METHOD FOR PRODUCING AMINO ACID OR PEPTIDE, REAGENT FOR FORMING PROTECTING GROUP, AND COMPOUND 审中-实审
公开(公告)号：EP4310094A1
公开(公告)日：2024-01-24
申请号：EP22771542.2
申请日：2022-03-18
申请人： FUJIFILM Corporation
发明人： NAKAGAWA Daisuke , TSUYAMA Hiroaki
IPC分类号： C07K1/06 , C07D233/60 , C07K1/02
摘要： An object of the present invention is to provide a method for producing a peptide with high efficiency, which is capable of deprotecting a protective group in a side chain with a weak acid; a protective group-forming reagent having excellent deprotective properties; and a compound. According to the present invention, there is provided a method for producing a peptide, including a peptide chain extending step of reacting a first amino acid or peptide in which a side chain is protected with a first protective group represented by Formula (1) with a second amino acid or peptide to obtain a third amino acid or peptide, and a first deprotecting step of deprotecting the first protective group of the third amino acid or peptide, in which, in the first deprotecting step, the deprotection is performed using a deprotection solution having a trifluoroacetic acid content of 10% by mass or less. In the formula, R 11 is an aryl group having a substituent, R 21 and R 22 are each independently a hydrogen atom or a substituent, and n is an integer of 1 to 6.

5. 发明公开

EP4303224A1 PROTEIN FOLDING AGENT 审中-实审
公开(公告)号：EP4303224A1
公开(公告)日：2024-01-10
申请号：EP22763297.3
申请日：2022-03-02
申请人： Tohoku University
发明人： MURAOKA Takahiro , OKADA Shunsuke , MATSUMOTO Yosuke , OKUMURA Masaki , INABA Kenji , MATSUSAKI Motonori
IPC分类号： C07K1/02
摘要： Provided is a protein folding agent capable of folding a protein with high efficiency. A protein folding agent contains: as an active ingredient, at least one selected from compounds represented by formulas (1) to (14), salts thereof, and solvates thereof.

6. 发明授权

EP3704143B1 CHEMO-ENZYMATIC SYNTHESIS OF LIRAGLUTIDE, SEMAGLUTIDE AND GLP-1 有权转让
公开(公告)号：EP3704143B1
公开(公告)日：2023-10-18
申请号：EP19709061.6
申请日：2019-03-11
发明人： QUAEDFLIEG, Peter, Jan, Leonard, Mario , TOPLAK, Ana , NUIJENS, Timo
IPC分类号： C07K14/605 , C07K1/06 , C12P21/02 , C07K1/02 , C07K1/36 , C12N9/54 , C07K14/32

7. 发明授权

EP3778621B1 PEPTIDE SYNTHESIS METHOD 有权
公开(公告)号：EP3778621B1
公开(公告)日：2023-08-23
申请号：EP19785772.5
申请日：2019-04-13
发明人： SUZUKI, Hideaki , MUTO, Susumu , FUJITA, Shuji , KUBO, Daisuke
IPC分类号： C07K1/10 , C07K1/02 , C07K1/04 , C07K7/06

8. 发明公开

EP4146816A1 MOLECULAR TRANSPORT FOR VIRAL AGENTS 审中-实审
公开(公告)号：EP4146816A1
公开(公告)日：2023-03-15
申请号：EP21800601.3
申请日：2021-05-03
申请人： McMaster University
发明人： BULIR, David , CHONG, Sylvia
IPC分类号： C12Q1/6806 , A01N47/28 , A01N47/44 , A01P1/00 , C07K1/02 , C12N15/10 , G01N1/38

9. 发明公开

EP4116315A1 METHOD FOR PREPARING LIRAGLUTIDE USING ENVIRONMENT-FRIENDLY SOLVENT 审中-实审
公开(公告)号：EP4116315A1
公开(公告)日：2023-01-11
申请号：EP21809787.1
申请日：2021-05-17
申请人： Daebong LS Co., Ltd.
发明人： PARK, Eun Ju , KIM, Eun Teak , PARK, Jin Oh
IPC分类号： C07K1/10 , C07K1/02 , C07K14/605
摘要： The present invention relates to a novel method for preparing liraglutide by means of an ionic liquid and a eutectic solvent, which are environment-friendly solvents. More specifically, the present invention is characterized in that fractionated peptide 1 represented by the following formula (1) and fractionated peptide 2 represented by the following formula (2) are subjected to a coupling reaction in the presence of an ionic liquid or a eutectic solvent. In preparing GLP-1 analogues such as liraglutide, the present invention increases reactivity when producing liraglutide, which is an unprocessed reactant, by using an ionic liquid and a eutectic solvent as environment-friendly solvents instead of using organic solvents. Accordingly, through a relatively short and simple purification process, the present invention has advantages of reducing the formation of related substances, improving purity, improving yields, shortening reaction times, reducing production cost, and lowering the manufacturing cost.

[Formula 1] (Boc-His(Trt)-Ala-Glu(tBu)-Gly-Thr[PSI(Me,Me)Pro]-Phe-Thr[PSI(Me,Me)Pro]-Ser(tBu)-Asp(tBu)-Val-Ser[PSI(Me,Me)Pro]-Ser(tBu)-Tyr(tBu)-Leu-Glu(tBu)-Gly-OH)

[Formula 2] (NH 2 -Gln(Trt)-Ala-Ala-Lys(Pal-Glu-OtBu)-Glu(tBu)-Phe-Ile-Ala-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-Arg(Pbf)-Gly-linker-OH)

10. 发明公开

EP4100051A2 TREATMENT OF HPV-RELATED DISEASES 审中-公开
公开(公告)号：EP4100051A2
公开(公告)日：2022-12-14
申请号：EP21702684.8
申请日：2021-02-05
申请人： ISA Pharmaceuticals B.V.
发明人： BEENAKKER, Thomas, Johannes, Maria , MOOLHUIZEN, Gerben , MELIEF, Cornelis, Johannes, Maria , MOLENAAR, Miranda, Bernardina, Johanna , KOOI, Elvin, Irsan , VAN DUIN, Richard, Johannes , MORSCH, Thomas
IPC分类号： A61K39/12 , A61P31/20 , A61P35/00 , C07K1/02 , C07K14/025 , C12Q1/70

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