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1. 发明公开

EP3177393A1 BENCHTOP NUCLEIC ACID LIBRARY PREPARATION DEVICE AND METHODS FOR USING THE SAME 审中-公开
标题翻译： BENCHTOP核酸酸库制备装置及其使用方法
公开(公告)号：EP3177393A1
公开(公告)日：2017-06-14
申请号：EP15750133.9
申请日：2015-08-03
申请人： Gencell Biosystems Limited
发明人： BARRETT, Brian , SIRR, Noel , CHAWKE, Brian , CURRAN, Kieran , DALY, John
IPC分类号： B01J19/00
CPC分类号： B01L7/52 , B01J19/0046 , B01J2219/00308 , B01J2219/00315 , B01J2219/00369 , B01J2219/00466 , B01J2219/00549 , B01J2219/00585 , B01J2219/00691 , B01J2219/00722 , B01L3/50851 , B01L3/50853 , B01L2300/021 , B01L2300/044 , C12Q1/6806
摘要： Complete nucleic acid library preparation devices are provided. Aspects of the devices include: a thermal chip module comprising multiple CLC reaction wells; one or more plate locations; a robotically controlled liquid handler configured to transfer liquid between the one or more plate locations and the thermal chip module; and a bulk reagent dispenser configured to access each CLC reaction well of the thermal chip module.
摘要翻译：提供完整的核酸文库制备装置。器件的方面包括：包含多个CLC反应孔的热芯片模块; 一个或多个板位置; 机器人控制的液体处理器，其被配置为在所述一个或多个板位置与所述热芯片模块之间传输液体; 以及配置成接近热芯片模块的每个CLC反应孔的批量试剂分配器。

2. 发明授权

EP1392428B1 SYSTEM SUITABLE FOR HIGH THROUGHPUT EXPERIMENTATION 有权
标题翻译：试验用于高通量系统的适当的
公开(公告)号：EP1392428B1
公开(公告)日：2012-11-07
申请号：EP02750927.2
申请日：2002-05-13
申请人： Avantium International B.V.
发明人： VAN DEN BRINK, Peter, John , BRACHT, Maarten , HARJI, Bashir, Husein
IPC分类号： B01J19/00 , G01N31/10
CPC分类号： B01L3/5025 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00308 , B01J2219/00313 , B01J2219/00331 , B01J2219/00333 , B01J2219/00351 , B01J2219/00423 , B01J2219/00495 , B01J2219/00585 , B01J2219/00702 , B01J2219/0072 , B01J2219/00745 , B01J2219/00747 , B01L2300/04 , B01L2300/0867 , C40B30/08 , C40B40/18 , C40B60/12 , C40B60/14 , G01N1/405 , G01N31/10

3. 发明授权

EP1765489B1 APPARATUS AND METHOD FOR ZIEGLER-NATTA RESEARCH 有权
标题翻译： DEVICE AND METHOD FOR齐格勒 - 纳塔研究
公开(公告)号：EP1765489B1
公开(公告)日：2009-11-11
申请号：EP05751063.8
申请日：2005-05-13
申请人： DOW GLOBAL TECHNOLOGIES INC.
发明人： CAMPBELL, Richard, E., Jr. , CASTILLE, Thomas, G. , CHEN, Linfeng , KILTY, Peter, A. , ROMER, Duane, R.
IPC分类号： B01J19/00 , C08F10/00 , C08F10/06
CPC分类号： B01J19/0046 , B01J27/135 , B01J31/0212 , B01J31/0272 , B01J31/128 , B01J31/143 , B01J31/38 , B01J37/24 , B01J2219/00283 , B01J2219/00286 , B01J2219/00308 , B01J2219/00315 , B01J2219/00322 , B01J2219/00353 , B01J2219/00369 , B01J2219/00423 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00689 , B01J2219/00691 , B01J2219/00704 , B01J2219/00707 , B01J2219/00747 , C08F10/00 , C08F110/06 , C08F4/6548 , C08F4/6465 , C08F4/651
摘要： A combinatorial method for identifying a catalyst composition for use in the heterogeneous Ziegler-Natta addition polymerization of an olefin monomer, said catalyst composition comprising a compound of a metal of Group 2 of the Periodic Table of the Elements.

4. 发明授权

EP1347829B1 MULTIPLE VESSEL ARRAY 有权
标题翻译：数组几个容器
公开(公告)号：EP1347829B1
公开(公告)日：2008-10-08
申请号：EP02710520.4
申请日：2002-01-02
申请人： Avantium International B.V.
发明人： VAN DEN BRINK, Peter, John , VAN DER WAAL, Jan, Cornelis , VAN LANGEN, Simon, Adrianus, Joseph , NAGY, Anton, John , HARJI, Bashir, Husein
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00333 , B01J2219/00335 , B01J2219/00479 , B01J2219/00481 , B01J2219/00486 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , C40B60/14
摘要： Apparatus for performing a multiplicity of physical and/or chemical operations comprises a plurality of reaction vessels (40), support means (30) for supporting said reaction vessels (40), and a closure member (20) adapted for movement relative to said support means (30) such that it can be urged towards a rim of each of the reaction vessels (40) to effect a fluid tight union between the reaction vessels (40) and the closure member (20). The reaction vessels (40) have a flange (42) at or adjacent to the rim and a seal associated with the flange (42).

5. 发明授权

EP1392429B1 A SYSTEM FOR PERFORMING EXPERIMENTS, IN PARTICULAR FOR HIGH THROUGHPUT EXPERIMENTATION 有权
标题翻译： SYSTEM FOR企图特别是对于具有高吞吐量的实验实现
公开(公告)号：EP1392429B1
公开(公告)日：2008-10-01
申请号：EP02769489.2
申请日：2002-05-13
申请人： Avantium International B.V.
发明人： VAN DEN BRINK, Peter John , BRACHT, Maarten
IPC分类号： B01J19/00 , B01J8/00 , B01J8/02 , G01N31/10
CPC分类号： B01L3/5025 , B01J8/0085 , B01J8/0285 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00308 , B01J2219/00423 , B01J2219/00479 , B01J2219/00495 , B01J2219/00585 , B01J2219/00587 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , B01J2219/00835 , B01J2219/00844 , B01J2219/00873 , B01L2300/04 , B01L2300/18 , C40B30/08 , C40B40/18 , C40B60/14 , G01N31/10
摘要： The system comprises a flow through reaction vessel having an inlet, an outlet and a reaction zone intermediate said inlet and outlet. The system further comprises reagent feed means for introducing one or more reagents into said vessel, said one or more reagents forming one or more reaction products in said reaction zone. Said reagent feed means at least include a liquid feed means for introducing a liquid into said inlet of said vessel. The vessel has a liquid evaporation zone intermediate said inlet and said reaction zone. Said liquid evaporation zone comprises an evaporation structure contacting said liquid and providing a liquid residence time in said liquid evaporation zone improving evaporation of said liquid.

6. 发明公开

EP1963015A1 AN OLIGO PEPTIDE SYNTHESIS APPARATUS 审中-公开
标题翻译：低聚肽合成装置
公开(公告)号：EP1963015A1
公开(公告)日：2008-09-03
申请号：EP06805554.0
申请日：2006-11-08
申请人： Alcorlab A/S
发明人： JEPSEN, Peter
IPC分类号： B01L3/02
CPC分类号： C40B60/08 , B01J19/0046 , B01J2219/00308 , B01J2219/00322 , B01J2219/00326 , B01J2219/00409 , B01J2219/00412 , B01J2219/00414 , B01J2219/00423 , B01J2219/00511 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00725
摘要： An oligo peptide synthesis apparatus comprises a housing and a drive motor mounted in the housing and having an output shaft. The oligo peptide synthesis apparatus further comprises an oligo peptide synthesis reaction holder defining a centre line and comprising a number of receptors for receiving a corresponding number of vessels. The receptors are located on a first circle having its centre on the centre line. The holder has a coupling for connecting the holder to the drive motor, the holder being journalled horizontally and rotatably relative to the housing for stepwise revolving around the centre line relative to the housing powered by the drive motor. The oligo peptide synthesis apparatus further comprises a number of synthesis material lines supported relatively to the housing, each of the lines communicating with a supply container and each of the lines defining a discharge end. The discharge ends are positioned on a second circle having its centre on the centre line for allowing a specific discharge end to be positioned above a specific vessel received in the holder.
摘要翻译：寡肽合成设备包括壳体和安装在壳体中并具有输出轴的驱动马达。寡肽合成装置还包含寡肽合成反应保持物，其限定中心线并且包含用于接收相应数量的血管的多个受体。受体位于以中心线为中心的第一个圆上。保持器具有用于将保持器连接到驱动电机的联接器，该保持器相对于壳体水平且可旋转地相对于由驱动电机供电的壳体相对于壳体围绕中心线逐步旋转。寡肽合成设备还包括相对于壳体支撑的多个合成材料线，每条线与供应容器连通并且每条线限定排出端。排出端位于以中心线为中心的第二圆上，以使特定的排出端位于容纳在夹持器中的特定容器的上方。

7. 发明公开

EP1789173A4 MULTIFUNCTIAL MULTIREACTOR CHEMICAL SYNTHESIS INSTRUMENT 审中-公开
标题翻译：多功能多核仪表化学合成
公开(公告)号：EP1789173A4
公开(公告)日：2008-04-23
申请号：EP05729265
申请日：2005-03-16
申请人： AKRIBIO CORP
发明人： YOUNG LI
IPC分类号： B01J19/00 , B01L3/00 , B32B5/02
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00344 , B01J2219/00353 , B01J2219/00389 , B01J2219/00416 , B01J2219/00481 , B01J2219/00493 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/0072
摘要： A stand alone instrument for enhancing chemical and physical reactions on the "bench" level by providing a single instrument capability of performing a variety of functions on a plurality of reaction vessels at the same time (in parallel), includes heating, cooling and five other functional capabilities, and more particularly to such instruments that provide the matrix of plural functions and plural reaction vessels, with the further ability of providing real time energy balance data on each reactor. Thus, the instruments provide for any or all of heating, cooling, reflux, inert gas blanketing, vacuuming, stirring and evaporation at each reactor. (The words "reactor", "microreactor", "reaction vessel" and "vessel" are used interchangeably herein, and generally refer to bench scale flasks, beakers and other reactors used by bench chemists, biochemists, physicists, biologists, research doctors, and the like.) In some embodiments, the instruments include cooling units which uniquely rely upon phase change coolant injections. In other embodiments, the instruments include cofinger stoppers, described below. The instruments may include both the phase change coolant systems and the cofinger stopper arrangements.

8. 发明公开

EP1830950A1 PREPARATION AND CHARACTERIZATION OF FORMULATIONS IN A HIGH THROUGHPUT MODE 审中-公开
标题翻译：制备和制剂的表征高通量模式
公开(公告)号：EP1830950A1
公开(公告)日：2007-09-12
申请号：EP04810792.4
申请日：2004-11-12
申请人： Syngenta Limited
发明人： BYSOUTH, Stephen R., c/o Mettler Toledo AutoChem , HITE, Sidney, Wilson , BOHARA, Amrish, c/o Procede Twente BV , NETTLETON-HAMMOND, John H., c/o Syngenta AG , BERGSTROM, Karin I. , LANDHAM, Rowena , LUKKARI, Ingrid, Gunborg
IPC分类号： B01J19/00 , G01N35/02
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00319 , B01J2219/00344 , B01J2219/00484 , B01J2219/00495 , B01J2219/00549 , B01J2219/00585 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00695 , B01J2219/00756 , B02C2017/065 , G01N35/0099 , G01N35/028 , G01N2035/00326
摘要： The invention is an automated robotic system for the production and testing of formulations at a very high throughput. It is an integrated system of hardware and software capable of preparing and evaluating hundreds of emulsions per day. The system can formulate aqueous solutions (SL), oil in water emulsions (EW), suspo-emulsions (SE), micro capsule suspensions (CS), micro-emulsions (ME), and suspension concentrates (SC) at the 1 ml to 25 ml scale. The system can process emulsions rapidly in an automated way and enable very flexible formulation recipes to be introduced. The system allows chemists to generate experimental samples of varying recipe and method to be conducted in parallel with projected throughput of up to 1200 formulations processed and characterized per day. Materials and consumables can be distributed from storage storage systems to the work stations where dispensing of ingredients in various states can be performed, including solids, liquids, gels, pastes, suspensions and waxes. The emulsions formed can be characterized using methods including phase diagnosis, turbidity analysis, viscosity and particle sizing using automated test equipment. An integrated module can also perform Tank Mix Compatibility testing in high throughput mode. The modular system allows future processes and tests to be added, either to a station, or as a new station. The software capability includes tracking of processes from start to finish and the integration of analytical data with the as-designed and as-formulated experimental results.

9. 发明公开

EP1761570A1 METHOD FOR IDENTIFYING ZIEGLER-NATTA COCATALYSTS 有权
标题翻译：检测方法的齐格勒 - 纳塔助催化剂
公开(公告)号：EP1761570A1
公开(公告)日：2007-03-14
申请号：EP05849080.6
申请日：2005-05-13
申请人： Dow Global Technologies Inc.
发明人： CAMPBELL, Richard, E., Jr. , ROMER, Duane, R. , DESJARDINS, Sylvie, Y. , HUSTAD, Phillip, D.
IPC分类号： C08F4/642 , C08F10/00 , B01J19/00
CPC分类号： B01J31/0272 , B01J19/0046 , B01J27/138 , B01J31/0212 , B01J31/128 , B01J31/143 , B01J31/26 , B01J2219/00283 , B01J2219/00286 , B01J2219/00308 , B01J2219/00315 , B01J2219/00322 , B01J2219/00353 , B01J2219/00369 , B01J2219/00423 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00689 , B01J2219/00691 , B01J2219/00704 , B01J2219/00707 , B01J2219/00736 , B01J2219/00738 , B01J2219/00747 , C08F210/16 , C08F4/6555 , C08F210/14 , C08F2500/12
摘要： A method for identifying a catalyst composition for use in the heterogeneous Ziegler-Natta addition polymerization of an olefin monomer, said catalyst composition comprising a procatalyst comprising a magnesium and titanium containing procatalyst and a cocatalyst said method comprising: a) providing a library comprising at least one procatalyst compound, b) forming a catalyst composition library by contacting the member of said procatalyst library with one or more cocatalysts and contacting the resulting mixture with an olefin monomer under olefin polymerization conditions thereby causing the polymerization reaction to take place, c) measuring at least one variable of interest during the polymerization, and d) selecting the catalyst composition of interest by reference to said measured variable.

10. 发明授权

EP1174185B1 High pressure parallel reactor 有权
标题翻译：高压并联反应器
公开(公告)号：EP1174185B1
公开(公告)日：2007-01-10
申请号：EP01117143.6
申请日：2001-07-13
申请人： Symyx Technologies, Inc.
发明人： Van Erden, Lynn , Turner, Howard , Lowe, David
IPC分类号： B01J19/00 , G01N35/02
CPC分类号： B01L3/5025 , B01J3/04 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00315 , B01J2219/00335 , B01J2219/00337 , B01J2219/00418 , B01J2219/00423 , B01J2219/00477 , B01J2219/00585 , B01J2219/00601 , B01J2219/00704 , B01J2219/0072 , B01J2219/00736 , G01N35/028

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