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1. 发明授权

EP2871481B1 Bewegungsvorrichtung mit kombiniertem Individual- und Blockbewegungsantrieb für mehrere gemeinsam geführte Bewegungseinheiten 有权
标题翻译：联合个人动机和阻塞几个共同控制移动单元的电动机驱动
公开(公告)号：EP2871481B1
公开(公告)日：2016-07-06
申请号：EP14188093.0
申请日：2014-10-08
申请人： Hamilton Bonaduz AG
发明人： Nawrocki, Eduard
IPC分类号： G01N35/00 , G01N35/04
CPC分类号： F16H19/06 , A47B21/03 , A47B57/58 , A47B63/06 , F16H19/003 , G01N35/1067 , G01N35/1074 , G01N35/1081 , G01N2035/1069 , Y10T74/18832

3. 发明公开

EP1759215A1 VORRICHTUNG UND VERFAHREN ZUM ANORDNEN VON PIPETTEN- ODER DISPENSER-SPITZEN IN EINEM SYSTEM ZUM MANIPULIEREN VON FLÜSSIGKEITSPROBEN 有权转让
标题翻译：装置和方法为系统中的操纵液体样品的移液管或分配器TIPS配售
公开(公告)号：EP1759215A1
公开(公告)日：2007-03-07
申请号：EP05742111.7
申请日：2005-05-30
申请人： Tecan Trading AG
发明人： WIGGLI, Markus , SCHINZEL, Fred , FORSTER, Bronwen
IPC分类号： G01N35/10
CPC分类号： G01N35/1067 , Y10T436/2575
摘要： Disclosed are devices (1) and methods for disposing pipette syringes or dispenser syringes (2) in a system (3) used for manipulating liquid samples (4). One inventive device (1) comprises: a robot (5) for orienting pipette syringes or dispenser syringes (2) relative to sample receptacles (6) located in or on the system (3) in an X direction and in a Y direction that extends substantially at a right angle thereto; pipette syringes or dispenser syringes (2) which extend essentially in a vertical direction and can be raised and lowered in a Z direction running substantially perpendicular to the X and Y directions; drive units for moving the robot (5); and processors for controlling the movements and actions of the robot (5) and the pipette syringes and dispenser syringes (2). The inventive device (1) is characterized in that the same comprises at least two blocks (8, 9) which are arranged on a robot (5) arm (7) and on which at least two pipette syringes or dispenser syringes (2) are placed at an axial distance (10) from each other. The axial distance (10) essentially corresponds to the grid space of wells (19) of a microplate (18). At least one of said blocks (8, 9) is configured so as to be individually movable in the X direction and Y direction in order to alternately orient the pipette syringes or dispenser syringes (2) of the two blocks (8, 9) in a staggered manner along a common line (12). The disclosed method makes it possible to re-pipette liquid sample (4) in a time-saving fashion between several sample receptacles, e.g. between small sample tubes and microplates (18) encompassing 24, 96, 384, or 1536 wells.

4. 发明公开

EP1541236A3 Apparatus and method for spotting a substrate 审中-公开
标题翻译：用于在基板上的液滴的电荷的方法和装置
公开(公告)号：EP1541236A3
公开(公告)日：2007-01-17
申请号：EP05004387.6
申请日：2000-03-09
申请人： Applera Corporation
发明人： Bryning, Zbigniew , Vann, Charles S.
IPC分类号： B01L3/02
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00369 , B01J2219/00376 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01L3/0251 , B01L3/0262 , B01L2300/0819 , B01L2300/0838 , B01L2400/028 , B01L2400/0406 , C40B60/14 , G01N35/1016 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1034 , G01N2035/1037 , G01N2035/1039 , G01N2035/1069 , Y10T436/25 , Y10T436/2575
摘要： The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongate fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.

5. 发明公开

EP1597082A2 IMPROVED PRINTING METHOD AND APPARATUS 有权转让
标题翻译：改进的压力的方法和装置
公开(公告)号：EP1597082A2
公开(公告)日：2005-11-23
申请号：EP03786130.9
申请日：2003-12-16
申请人： Arrayjet Limited
发明人： MANNING, Howard, John , MITCHELL, Benjamin, Bruce
IPC分类号： B41J2/21 , B01J19/00 , G01N35/10
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00362 , B01J2219/00378 , B01J2219/00385 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00722 , B41J2/2132 , C40B40/06 , C40B50/14 , C40B60/14 , G01N35/1067
摘要： A printing method and apparatus is disclosed wherein the printhead (10) has a linear array (14) of nozzles (12N1, 126) oriented in an axis, and drops of a liquid are printed at a particular location from first and second nozzles of the printhead at a first location. In an embodiment, the nozzles are arranged in groups, each group of nozzles being used to superpose spots of a particular liquid at a different location. A further method is described wherein the printhead is triggered by transferring printing triggers from a processing module to a printhead at print intervals representative of a plurality of fixed units of spatial displacement of the printhead. The present invention is particularly advantageous for the cycling of print nozzles, superposition of spots in linear arrays and fine control of spot positioning. The invention has particular application in the field of printing DNA microarrays.

6. 发明授权

EP1132136B1 Microarray, method for producing the same, and method for correcting inter-pin spotting amount error of the same 有权
标题翻译：微阵列和适于该任务的制造和销间隔的校正方法
公开(公告)号：EP1132136B1
公开(公告)日：2004-09-22
申请号：EP01104785.9
申请日：2001-02-27
申请人： Hitachi Software Engineering Co., Ltd.
发明人： Yamamoto, Tomoyuki , Tamura, Takuro
IPC分类号： B01L3/02 , B01J19/00 , G01N21/88 , G01N35/10
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00621 , B01J2219/00659 , B01J2219/00695 , B01J2219/00698 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N2035/1037 , G01N2035/1069

7. 发明公开

EP1352971A3 DNA diagnostics based on mass spectrometry 失效
标题翻译： DNA-Diagnostik mittels Massenspektrometrie
公开(公告)号：EP1352971A3
公开(公告)日：2004-02-18
申请号：EP03002612.4
申请日：1996-03-18
申请人： SEQUENOM, INC.
发明人： Köster, Hubert
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6872 , C12Q1/6816 , C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/686 , C12Q1/6862 , C12Q1/6883 , C12Q1/706 , G01N35/1067 , H01J49/00 , Y10T436/143333 , Y10T436/24 , C12Q2565/627 , C12Q2537/113 , C12Q2535/113 , C12Q2521/325 , C12Q2535/131 , C12Q2525/107 , C12Q2523/107 , C12Q2523/319 , C12Q2565/625 , C12Q2535/125
摘要： The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.
摘要翻译：本发明提供了用于检测生物样品中特定核酸序列的基于快速和高精度的基于质谱仪的方法。根据待检测的序列，可以使用例如诊断遗传病或染色体异常的方法; 疾病或病症的倾向，病原体感染，或确定身份或遗传。

8. 发明公开

EP1132136A3 Microarray, method for producing the same, and method for correcting inter-pin spotting amount error of the same 有权
标题翻译：微阵列和适于该任务的制造和销间隔的校正方法
公开(公告)号：EP1132136A3
公开(公告)日：2003-07-02
申请号：EP01104785.9
申请日：2001-02-27
申请人： Hitachi Software Engineering Co., Ltd.
发明人： Yamamoto, Tomoyuki , Tamura, Takuro
IPC分类号： B01L3/02 , B01J19/00 , G01N21/88 , G01N35/10
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00621 , B01J2219/00659 , B01J2219/00695 , B01J2219/00698 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N2035/1037 , G01N2035/1069
摘要： The present invention has an objective of obtaining more accurate data of microarray experiments by correcting an inter-pin spotting amount error caused upon microarray production using a plurality of pins. Upon microarray production, samples are immobilized on a microarray support using all pins as controls for correcting the inter-pin spotting amount errors. After the microarray experiments, luminescent intensities of the samples used as control spots for correcting the inter-pin spotting amount errors are measured and used to obtain correction parameters for the inter-pin spotting amount errors of respective pins. These parameters are used to correct luminescent intensities of other samples.

9. 发明授权

EP0815261B1 DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY 失效
标题翻译： DNA诊断，以通过MASS
公开(公告)号：EP0815261B1
公开(公告)日：2003-02-12
申请号：EP96910464.5
申请日：1996-03-18
申请人： SEQUENOM, INC.
发明人： KÖSTER, Hubert , TANG, Kai , FU, Dong-Jing , SIEGIRT, Carsten W. , LITTLE, Daniel P. , HIGGINGS, G.Scott , BRAUN, Andreas , DARNHOFER-DEMAR, Brigitte , JURINKE, Christian
IPC分类号： C12Q1/68 , G01N30/72
CPC分类号： C12Q1/6872 , C12Q1/6816 , C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/686 , C12Q1/6862 , C12Q1/6883 , C12Q1/706 , G01N35/1067 , H01J49/00 , Y10T436/143333 , Y10T436/24 , C12Q2565/627 , C12Q2537/113 , C12Q2535/113 , C12Q2521/325 , C12Q2535/131 , C12Q2525/107 , C12Q2523/107 , C12Q2523/319 , C12Q2565/625 , C12Q2535/125
摘要： The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

10. 发明公开

EP1262564A2 Dna sequencing by mass spectrometry 失效
标题翻译： Dns-Sequenzierung durch Massenspektrometrie
公开(公告)号：EP1262564A2
公开(公告)日：2002-12-04
申请号：EP02016384.6
申请日：1994-01-06
申请人： SEQUENOM, INC.
发明人： Köster, Hubert
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6816 , C12Q1/6872 , G01N35/1067 , Y10S435/81 , Y10T436/143333 , Y10T436/24 , Y10T436/25 , C12Q2565/627 , C12Q2563/167 , C12Q2537/113 , C12Q2537/143
摘要： The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts due to the complete absence of an electrophoretic step, and no costly reagents involving various substitutions with stable isotopes. The invention utilizes the Sanger sequencing strategy and assembles the sequence information by analysis of the nested fragments obtained by base-specific chain termination via their different molecular masses using mass spectrometry, as for example, MALDI or ES mass spectrometry. A further increase in throughput can be obtained by introducing mass-modifications in the oligonucleotide primer, chain-terminating nucleoside triphosphates and/or in the chain-elongating nucleoside triphosphates, as well as using integrated tag sequences which allow multiplexing by hybridization of tag specific probes with mass-differentiated molecular weights.
摘要翻译：本发明描述了一种新的DNA序列化方法。由于完全不存在电泳步骤，现有DNA测序技术的改进是高速度，高通量，无电泳和凝胶读数伪像，并且没有昂贵的试剂涉及具有稳定同位素的各种取代。本发明利用Sanger测序策略，并通过使用质谱法，例如MALDI或ES质谱法，通过分析通过其不同分子量通过碱基特异性链终止获得的嵌套片段来组装序列信息。通过在寡核苷酸引物，链终止的三磷酸核苷和/或在延伸链的三磷酸的链中引入质量修饰，以及使用允许通过标签特异性探针的杂交进行多重复合的整合的标签序列，可以获得通量的进一步增加具有质量分化的分子量。

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