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1. 发明授权

EP1221491B1 SUSPENSION SYSTEM FOR SEQUENCING GENETIC SUBSTANCE, METHOD OF SEQUENCING GENETIC SUBSTANCE BY USING THE SUSPENSION SYSTEM, AND METHOD OF HIGH-SPEED SNPs SCORING BY USING THE SUSPENSION SYSTEM 有权
标题翻译：序列遗传物质的悬浮系统，使用悬浮系统测序遗传物质的方法，以及使用悬浮系统进行高速SNP评分的方法
公开(公告)号：EP1221491B1
公开(公告)日：2007-06-27
申请号：EP00966410.3
申请日：2000-10-11
申请人： PRECISION SYSTEM SCIENCE CO., LTD. , Itakura, Mitsuo
发明人： ITAKURA, Mitsuo , TAJIMA, Hideji, Precision System Science Co., Ltd.
IPC分类号： C07H21/00 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2561/125
摘要： The base sequence of a target genetic substance is determined by using a suspension system comprising a first group of encoded oligonucleotides having one base sequence consisting of a definite number of bases and being encoded in such a manner as to discriminate this base sequence, a second group of encoded oligonucleotides, and an enzyme, which makes deoxyriboses (i.e., saccharides of terminal nucleotides) to bind specifically to each other exclusively in case where two encoded oligonucleotides are hybridized with a single-stranded genetic substance and the terminal nucleotides are adjacent directly to each other and the base sequences of the above-described encoded oligonucleotides have a definite relation with the base sequence of the genetic substance, suspended in a liquid in a container.
摘要翻译：目标遗传物质的碱基序列通过使用包含第一组编码寡核苷酸的悬浮系统来确定，所述第一组编码寡核苷酸具有由确定数目的碱基组成的一个碱基序列并且以区分该碱基序列的方式编码，第二组编码的寡核苷酸，和一种仅在两个编码的寡核苷酸与单链遗传物质杂交并且末端核苷酸直接与各自相邻的情况下使得脱氧核糖（即，末端核苷酸的糖）彼此特异性结合的酶上述编码的寡核苷酸的碱基序列与遗传物质的碱基序列有明确的关系，悬浮在容器内的液体中。

2. 发明公开

EP1760149A1 METHOD OF CONSTRUCTING MODIFIED PROTEIN 审中-公开
标题翻译：构建修饰蛋白的方法
公开(公告)号：EP1760149A1
公开(公告)日：2007-03-07
申请号：EP05737205.4
申请日：2005-05-06
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： TAJIMA, Hideji, PRECISION SYSTEM SCIENCE CO., LTD , TAKAHASHI, Masaaki PRECISION SYSTEM SCIENCE CO LTD , MIYASHITA, Yukiko, PRECISION SYSTEM SCIENCE CO LTD
IPC分类号： C12N15/00 , C12N9/00 , C12P21/02 , G01N33/15 , G01N33/50 , C07K1/00
CPC分类号： C12N15/1034 , C12N15/10 , C12N15/102 , C12P21/02
摘要： DNA derived from a microorganism is prepared from a sample containing the microorganism, degenerate primers are prepared based on an amino acid sequence conserved among known proteins nos. 1 through N all having the same type of function, PCR is performed using the degenerate primers in the presence of the DNA derived from the microorganism, the nucleotide sequence of DNA fragment amplified by the PCR is determined and the amino acid sequence coded for by the DNA fragment is also determined, homology between the amino acid sequence coded for by the DNA fragment and amino acid sequences of known proteins is evaluated, a known protein is discovered which has an amino acid sequence having homology with the amino acid sequence coded for by the DNA fragment, the region of the DNA coding for the discovered known protein which codes for the amino acid sequence having the homology is replaced by the DNA fragment to produce a modified DNA, and the modified DNA is expressed to produce a modified protein, thereby achieving high-throughput and efficient functional analysis and screening of a modified protein.
摘要翻译：从含有微生物的样品制备来自微生物的DNA，根据已知蛋白质中保守的氨基酸序列制备简并引物。 1至N都具有相同类型的功能，在来自微生物的DNA的存在下使用简并引物进行PCR，测定通过PCR扩增的DNA片段的核苷酸序列，并确定由该编码的氨基酸序列也测定DNA片段，评估由该DNA片段编码的氨基酸序列与已知蛋白质的氨基酸序列之间的同源性，发现一种已知的蛋白质，其具有与由该氨基酸序列编码的氨基酸序列具有同源性的氨基酸序列 DNA片段中，编码发现的已知蛋白质的编码具有同源性的氨基酸序列的DNA的区域被DNA片段置换以产生修饰的DNA，并且修饰的DNA被表达以产生修饰的蛋白质，从而实现高通量和高效的功能分析和筛选改性蛋白。

3. 发明公开

EP1671703A2 Method for making substances in carriers 审中-公开
标题翻译：德尔格恩的Verfahren zur Herstellung von Substanzen
公开(公告)号：EP1671703A2
公开(公告)日：2006-06-21
申请号：EP06004271.0
申请日：1999-03-18
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： Tajima, Hideji
IPC分类号： B03C1/00 , C12M1/00 , B01J19/00 , G01N35/00
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00286 , B01J2219/0029 , B01J2219/00292 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/00369 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00686 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01L3/0231 , B01L3/5025 , B01L2300/0829 , B03C1/025 , B03C1/033 , B03C1/035 , B03C1/284 , B03C1/288 , B03C2201/18 , B03C2201/26 , C40B40/06 , C40B60/14 , G01N35/0098 , G01N35/028 , G01N35/1065 , G01N35/1074 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A method for making any combined substances in carriers by arbitrarily combining with plural elements of substances, comprising the steps of:
dispensing each liquid incorporating each element of substances into one or more groups of containing parts arranged by plural containing parts in a matrix in which the containing parts accommodating said carriers are arranged in rows or columns having a predetermined number width in a way so as to be included in said matrix, according to the structure of the specified combined substances or the utilized kinds of containing parts, and
mixing the dispensed elements of substances into the group of the containing parts accommodating the carriers, with the elements of substances arranged in rows or columns having a predetermined number width, in such a manner that row-like or column-like arrangements of the dispensed elements of substances are positioned against row-like or column-like arrangements of the elements of substances in a state of transposition or non-transposition.
摘要翻译：一种用于通过任意组合物质的多种元素来形成载体中的任何组合物质的方法，包括以下步骤：将包含每个物质元素的每种液体分配到一组或多组由多个包含部分排列的容纳部分中，容纳所述载体的容纳部件以具有预定数量宽度的行或列布置，以便包括在所述矩阵中，根据指定的组合物质的结构或所使用的容纳部分的种类，并将分配的元件的物质进入容纳载体的容纳部分的组中，其中以具有预定数量宽度的行或列排列的物质元素以这样的方式排列物质的分配元素的行状或柱状布置针对排列状态的物质元素的排列或列状排列游戏或非转置。

4. 发明授权

EP0866336B1 LIQUID SUCTION EXAMINATION METHOD AND DISPENSATION APPARATUS DRIVING-CONTROLLED BY THE SAME 失效
标题翻译：流体吸入和在这个过程中控制的供给单位测试程序
公开(公告)号：EP0866336B1
公开(公告)日：2006-01-04
申请号：EP96909340.0
申请日：1996-04-11
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： TAJIMA, Hideji Precision System Science Co., Ltd.
IPC分类号： G01N35/10 , G01F23/28 , G01F23/292
CPC分类号： G01N35/1016 , G01F23/292 , G01F23/2928 , G01N2035/1018 , G01N2035/1025 , G01N2035/1062 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： The variation condition of the light obtained by a liquid (10) held in a liquid vessel (9) is detected by a nozzle (2) adapted to suck the liquid (10), whereby the surface of extraneous matter mixed in, and an interface of a liquid, the color of which is different from that of the liquid sucked by the nozzle (2) are determined. This invention provides a novel liquid suction examination method capable of detecting the surface of extraneous matter mixed in, and an interface of a liquid, the color of which is different from that of a liquid with a very high sensitivity without being influenced by the waving of the surface of the liquid, by monitoring lower end openings of a dispensation tip (8) and a cleaning tip from the side of the nozzle (2) in such a manner as to visually recognize one opening of a tunnel from the other opening; and a dispensation apparatus driving-controlled by this method.

5. 发明公开

EP1519196A3 Liquid processing method making use of pipette device and apparatus for same 失效
标题翻译：通过移液管的装置的方法和设备用于液体处理
公开(公告)号：EP1519196A3
公开(公告)日：2005-07-20
申请号：EP04031057.5
申请日：1996-03-19
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： Tajima, Hideji
IPC分类号： G01N35/10 , B01L7/00
CPC分类号： G01N35/1065 , B01L3/0275 , B01L3/0279 , B01L7/52 , B01L2300/0681 , B01L2300/087 , B03C1/01 , B03C1/0332 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N35/0098 , G01N35/10 , G01N35/1079 , G01N2035/0405 , G01N2035/103 , G01N2035/1053 , G01N2035/1055
摘要： Technological preposition of the present invention is a liquid processing method making use of a pipette device which sucks a liquid containing a target high molecular substance from inside of a vessel through a chip detachably set on a sucking port or a discharging port of a liquid sucking/discharging line and transfers this liquid or target high molecular substance to the next target processing position for the purpose to execute such works as quantifying, separating, taking out, pipetting, cleaning, condensing, and diluting a liquid or a target high molecular substance contained in a liquid and also such works as extracting, recovering, and isolating the target high molecular substance by means of sucking and discharging a liquid with a pipette device, and the chip can isolate the target high molecular substance by having the substance with a filter set on each chip.

6. 发明公开

EP1541668A1 REACTION VESSEL AND REACTION PRODUCT EXTRACTING DEVICE 审中-公开
标题翻译： REAKTIONSGEFûSSUND REAKTIONSPRODUKT-EXTRAKTIONSVORRICHTUNG
公开(公告)号：EP1541668A1
公开(公告)日：2005-06-15
申请号：EP02736134.4
申请日：2002-06-17
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： TAJIMA, H.; c/o Precision System Science Co., Ltd , ASANO, T.; c/o Precision System Science Co., Ltd
IPC分类号： C12M1/00 , C12N15/09 , C12Q1/68 , G01N35/02 , B01J19/00
CPC分类号： B01L7/52 , B01J2219/00283 , B01J2219/00693 , B01J2219/00704 , B01L3/0275 , B01L3/502 , B01L2200/026 , B01L2200/0642 , B01L2200/141 , B01L2300/042 , B01L2300/046 , B01L2300/0654 , B01L2300/0681 , B01L2300/0832 , B01L2300/087 , B01L2300/1805 , B01L2300/1822 , B01L2400/0478 , B01L2400/0683 , G01N21/03 , G01N21/0303 , G01N21/0332 , G01N21/645 , G01N35/1079 , G01N2021/0389 , G01N2021/6482
摘要： An object is to provide a reaction vessel in which, after a reaction has been conducted in the state with a cover member mounted on a reaction vessel main body, the reaction product contained in the reaction solution within the reaction vessel can be acquired without removing the cover member from the reaction vessel main body, and in order to achieve this object, the reaction vessel of the present invention is characterized in that : a nozzle tip fitting space, in which a nozzle tip mounted on a nozzle that can take in and discharge liquid can be fitted, is formed in the cover member; a nozzle tip fitting hole leading to the nozzle tip space is formed such that the nozzle tip can be fitted in the nozzle tip fitting space in the state with the cover member mounted on the reaction vessel main body; and in the state with the cover member mounted on the reaction vessel main body, a through-hole, which causes the exterior of the reaction vessel to communicate with the reaction solution holding space and the nozzle tip fitting space, can be formed in the reaction vessel main body and the cover member by a puncture needle provided exterior to the reaction vessel.
摘要翻译：本发明的目的是提供一种反应容器，其中在反应容器主体上安装有盖构件的状态下进行反应后，可以获得反应容器内的反应溶液中所含的反应产物，而不会除去反应容器为了达到上述目的，本发明的反应容器的特征在于：喷嘴头嵌合空间，其中安装在能够吸收和排出的喷嘴上的喷嘴头部液体可以安装在盖构件上; 形成通向喷嘴前端空间的喷嘴头嵌合孔，使得喷嘴头能够以安装在反应容器主体上的盖部件的状态装配在喷嘴头装配空间中; 并且在安装在反应容器主体上的盖部件的状态下，能够在反应中形成使反应容器的外部与反应液保持空间和喷嘴头嵌合空间连通的通孔通过设置在反应容器外部的穿刺针将容器主体和盖构件。

7. 发明授权

EP0926496B1 MAGNETIC CARRIER FOR HOLDING MICROSUBSTANCES AND METHOD OF CONTROLLING ITS POSITION 失效
标题翻译：磁性载体TO BE REPLACED微物质和方法用于控制的车辆位置
公开(公告)号：EP0926496B1
公开(公告)日：2005-03-09
申请号：EP97925298.8
申请日：1997-06-09
申请人： PRECISION SYSTEM SCIENCE CO., LTD. , Okami, Yoshiro
发明人： OKAMI, Yoshiro , TAJIMA, Hideji
IPC分类号： G01N33/543 , G01N33/553 , C12M1/00 , C12N11/00 , C12Q1/68 , C12Q1/70
CPC分类号： C12M33/04 , G01N33/54313 , G01N33/5434 , G01N35/0098 , G01N2446/10 , Y10S436/80 , Y10S436/808 , Y10S436/819 , Y10S436/822 , Y10S436/828 , Y10T428/2982
摘要： A fine substance hold-back carrier, a suspension system for the same, a fine substance manipulating apparatus, and a method of controlling the position of a fine substance, which are used to carry out the examination of various kinds of object substances efficiently, inexpensively, easily and reliably. A carrier on the surface of which a remote control member capable of controlling the position of a fine substance by a remote operation and a fine substance including a substance to be examinated are supported, the carrier being formed so that the position of the object substance is controlled by a remote operation directed to the supported remote control member.

8. 发明公开

EP1416041A1 REACTION CONTAINER AND REACTION DEVICE 审中-公开
标题翻译：反应容器和反应装置
公开(公告)号：EP1416041A1
公开(公告)日：2004-05-06
申请号：EP02743841.5
申请日：2002-07-05
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： TAJIMA, H., c/o Precision System Science Co., Ltd. , ASANO, T., c/o Precision System Science Co., Ltd.
IPC分类号： C12M1/00 , C12N15/09 , C12Q1/68 , B01J19/00 , G01N33/50
CPC分类号： G01N21/03 , B01J2219/00283 , B01J2219/00693 , B01J2219/00704 , B01L3/50 , B01L3/508 , B01L7/52 , B01L2200/026 , B01L2200/0642 , B01L2300/042 , B01L2300/046 , B01L2300/0654 , B01L2300/0672 , B01L2300/0832 , B01L2300/1805 , B01L2300/1822 , G01N21/0303 , G01N21/0332 , G01N21/645 , G01N2021/0389 , G01N2021/6482 , G01N2035/1053
摘要： In order to attain an object to provide a reaction vessel, reaction apparatus, and method with which a reaction can be automated without requiring centrifugation when a reaction solution is held in a reaction chamber, the temperature of the reaction solution held in the reaction chamber can be rapidly controlled, the reaction can proceed even when just a tiny amount of reaction solution is held in the reaction chamber, and the reaction occurring in the reaction chamber can be monitored in real time, temperature control of a reaction solution 4a held in a tightly closed space S1a is performed through a bottom plate 22a constituting a reaction vessel main body 2a and a pressing part 32a constituting a cover member 3a, and the irradiation of the reaction solution 4a with excitation light and the detection of fluorescent light emitted from the reaction solution 4a are performed through a first side plate 23a constituting the reaction vessel main body 2a.
摘要翻译：为了达到提供反应容器，反应装置和方法，当反应溶液被保持在反应室中时，反应可以自动化而无需离心，反应室中保持的反应溶液的温度可以即使在反应室内仅保持极少量的反应溶液的情况下也能够迅速进行反应，能够实时地监视在反应室内发生的反应，能够将反应液4a的温度控制紧密地保持封闭空间S1a通过构成反应容器主体2a的底板22a和构成盖部件3a的按压部32a进行，通过激发光照射反应溶液4a，检测反应液放出的荧光 4a通过构成反应容器主体2a的第一侧板23a进行。

9. 发明公开

EP1300462A1 REACTION VESSEL, REACTION DEVICE AND TEMPERATURE CONTROL METHOD FOR REACTION LIQUID 审中-公开
标题翻译：反应容器，反应装置和反应液的温度控制方法
公开(公告)号：EP1300462A1
公开(公告)日：2003-04-09
申请号：EP01945682.1
申请日：2001-06-28
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： TAJIMA, Hideji
IPC分类号： C12M1/20 , C12M1/38 , C12Q1/68 , B01J19/00
CPC分类号： B01L3/50851 , B01J19/0013 , B01J19/004 , B01J19/0093 , B01J2219/00162 , B01J2219/00783 , B01J2219/00788 , B01J2219/00869 , B01J2219/00873 , B01L3/50853 , B01L7/52 , B01L2300/042 , B01L2300/0829 , B01L2300/1805 , C12Q1/686
摘要： It is an object of the present invention to provide a reaction vessel which makes it possible to control the temperature of the reaction solution accommodated in the reaction chamber with a quick response, without any need for centrifuging when the reaction solution is accommodated in the reaction chamber, and which also makes it possible to cause the reaction to proceed even when the amount of reaction solution accommodated in the reaction chamber is extremely small. The present invention provides a reaction vessel comprising a reaction vessel main body which has a reaction chamber that has an opening part in the upper end and that can accommodate a reaction solution, and a cover member which can seal the opening part of the abovementioned reaction chamber, wherein the abovementioned cover member has a pressing part that can press the reaction solution accommodated in the abovementioned reaction chamber.
摘要翻译：本发明的一个目的是提供一种反应容器，其能够快速响应地控制容纳在反应室中的反应溶液的温度，而当反应溶液容纳在反应室中时不需要离心即使容纳在反应室内的反应液的量极少，也可以使反应进行。本发明提供一种反应容器，该反应容器包括：反应容器主体，该反应容器主体具有反应室，该反应室在上端具有开口部并且能够容纳反应溶液;以及盖构件，其能够密封上述反应室的开口部其中，上述盖部件具有能够按压收纳在上述反应室内的反应液的按压部。

10. 发明公开

EP0866336A1 LIQUID SUCTION EXAMINATION METHOD AND DISPENSATION APPARATUS DRIVING-CONTROLLED BY THE SAME 失效
标题翻译： ÜEN EN EN T T T T T T T T T T T T T T T T T T T T T T T T T T T
公开(公告)号：EP0866336A1
公开(公告)日：1998-09-23
申请号：EP96909340.0
申请日：1996-04-11
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： TAJIMA, Hideji Precision System Science Co., Ltd.
IPC分类号： G01N35/06 , G01F23/28
CPC分类号： G01N35/1016 , G01F23/292 , G01F23/2928 , G01N2035/1018 , G01N2035/1025 , G01N2035/1062 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： There are provided an entire new method for sucking/determining a liquid and a pipetting device driven and controlled by the method in which a liquid level of a liquid sucked by a nozzle, contamination of a liquid with foreign matters, or an interface of a liquid with another liquid having different color are determined by detecting fluctuation of a light obtained from a liquid accommodated in a vessel with a nozzle provided in the nozzle for sucking the liquid, and a liquid level, contamination of a liquid with foreign matters, or an interface of a liquid with another liquid having a different color can be detected with extremely high-sensitivity without being affected by a wavy liquid level by monitoring a pipetting chip or an opening section at a tip of a chip in a cleaning system as if to visually check the other opening section of a tunnel from one side thereof.
摘要翻译：提供了用于吸取/确定液体的全新方法和由喷嘴吸入的液体的液面，异物的液体或液体的界面的驱动和控制的移液装置具有不同颜色的另一种液体通过检测从容纳在容器中的液体中获得的光的波动来确定，其中喷嘴设置在喷嘴中用于吸取液体，液面，液体与异物的污染或界面可以以非常高的灵敏度检测具有不同颜色的液体的液体，而不受波形液位的影响，通过在清洁系统中监测移液芯片或芯片的尖端处的开口部分，如同目视检查一样隧道的一侧的另一个开口部分。

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