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1. 发明授权

EP2554251B1 PIPE TYPE CIRCULATION-BASED REACTION APPARATUS 有权
公开(公告)号：EP2554251B1
公开(公告)日：2018-11-14
申请号：EP11765220.6
申请日：2011-04-01
申请人： Nisso Engineering Co., Ltd.
发明人： KOBAYASHI, Eiichiro
IPC分类号： B01J19/24 , B01F5/00 , B01J4/00
CPC分类号： B01J19/244 , B01F5/0057 , B01F13/0059 , B01F15/0202 , B01F15/066 , B01F2015/061 , B01J4/002 , B01J19/0013 , B01J19/0093 , B01J2219/00094 , B01J2219/00788 , B01J2219/00797 , B01J2219/00889 , B01J2219/00894 , B01J2219/0286 , B01J2219/029
摘要： A tubular flow reactor comprises at least two fluid feed channels made of a multi-walled tube for feeding at least two kinds of fluids to be used in a reaction, a reaction channel having an annular cross section that can cause the fluids to react while flowing the same therethrough, and a fluid discharge channel for discharging a reaction product. The fluid feed channels are so connected as to communicate with an inlet of the reaction channel along a peripheral tangential direction or along a direction perpendicular to a peripheral surface of the annular reaction channel, and the fluid discharge channel is so connected as to communicate with an outlet of the reaction channel.

2. 发明授权

EP1251949B2 METHOD FOR THE CATALYTIC STEAM REFORMING OF A HYDROCARBON 有权
标题翻译：一种烃类催化蒸汽重整的方法
公开(公告)号：EP1251949B2
公开(公告)日：2018-02-21
申请号：EP01906687.7
申请日：2001-01-24
申请人： BATTELLE MEMORIAL INSTITUTE
发明人： TONKOVICH, Anna, Lee, Y. , WANG, Yong , WEGENG, Robert, S. , GAO, Yufei
IPC分类号： B01J8/02 , B01J12/00 , C01B3/38 , B01J19/00 , F28D7/00
CPC分类号： B01J19/0093 , B01J8/0285 , B01J8/067 , B01J12/007 , B01J19/249 , B01J2208/00194 , B01J2208/00212 , B01J2208/00309 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00835 , B01J2219/0086 , B01J2219/00873 , B01J2219/00984 , B01J2219/2453 , B01J2219/2454 , B01J2219/2458 , B01J2219/2465 , B01J2219/2481 , B01J2219/2497 , C01B3/16 , C01B3/38 , C01B3/384 , C01B3/48 , C01B2203/0233 , C01B2203/0283 , C01B2203/0495 , C01B2203/066 , C01B2203/0811 , C01B2203/0833 , C01B2203/1005 , C01B2203/1023 , C01B2203/1029 , C01B2203/1041 , C01B2203/1047 , C01B2203/1058 , C01B2203/1064 , C01B2203/1082 , C01B2203/1241 , C01B2203/1247 , C01B2203/1288 , C01B2203/1619 , C01B2203/1633 , C01B2203/1652 , C01B2203/1676 , C01B2203/169 , F28D7/00 , Y02P20/52
摘要： The present invention relates to a method and apparatus for thermal chemical reactions. The method and apparatus can provide an enhanced reaction rates for thermal chemical reactions. A microchannel apparatus comprising: a header; at least two flow microchannels, at least two orifices; wherein an orifice connects said header with each flow microchannel; and wherein the ratio of the cross-sectional area of each of said at least two orifices to the cross-sectional area of the flow microchannels connected to said orifices is between 0.0005 and 0.1.

3. 发明公开

EP2480258A4 CHEMICAL PRODUCTION MODULE AND DOSE SYNTHESIS CARD FOR PET BIOMARKER PRODUCTION SYSTEM 有权转让
标题翻译： CHEMISCHES PRODUKTIONSMODUL UNDISISYYTHESEKARTEFÜREIN HAUSTIER-BIOMARKER-PRODUKTIONSSYSTEM
公开(公告)号：EP2480258A4
公开(公告)日：2017-03-22
申请号：EP10819146
申请日：2010-09-21
申请人： ABT MOLECULAR IMAGING INC
发明人： NUTT RONALD , GIAMIS ANTHONY M , MCFARLAND AARON
IPC分类号： A61K51/00 , A61M3/00 , A61M36/14 , B01J19/00
CPC分类号： A61K51/0491 , B01J19/004 , B01J19/0093 , B01J2219/00788 , B01J2219/00873 , B01J2219/00891 , B01J2219/00905
摘要： A microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, one (1) unit dose of a radiopharmaceutical biomarker for use in positron emission tomography (PET). The radiopharmaceutical production system includes a reaction vessel that receives a radioisotope from an accelerator or other radioisotope generator. Organic and aqueous reagents are introduced into the reaction vessel, and the mixture is heated to synthesize a solution of a pre-selected radiopharmaceutical. The radiopharmaceutical solution is purified by passing the solution through a solid phase extraction column and a filter. The synthesis process produces per run a quantity of radiopharmaceutical approximately equal to, but not less than, one (1) unit dose of a radiopharmaceutical, reducing waste and allowing for the production of radiopharmaceutical on an as-needed basis. The synthesis process allows for the production of biomarker radiopharmaceuticals on site and close to the location where the unit dose will be administered to the patient. On-site, as-needed production of radiopharmaceuticals in small doses reduces the time between the synthesis of the radiopharmaceutical and the administration of that radiopharmaceutical, thereby minimizing the loss of active isotopes through decay and allowing the production of lesser amounts of radioisotopes overall.
摘要翻译：一种微流体放射性药物生产系统和用于在正电子发射断层摄影（PET）中使用的放射性药物生物标志物的大约一个但不少于一个单位剂量的合成的方法。放射性药物生产系统包括从加速器或其它放射性同位素发生器接收放射性同位素的反应容器。将有机和水性试剂引入反应容器中，并加热混合物以合成预先选择的放射性药物的溶液。通过使溶液通过固相萃取柱和过滤器来纯化放射性药物溶液。合成过程每次运行一定量的放射性药物，大约等于但不小于一（1）个单位剂量的放射性药物，减少浪费并允许根据需要生产放射性药物。合成过程允许在现场生产标记放射性药物并且靠近给予患者的单位剂量的位置。现场按需要以小剂量生产放射性药物可以减少放射性药物的合成和放射性药物的施用之间的时间，从而通过衰变最大程度地减少活性同位素的损失，并允许总体生产较少量的放射性同位素。

4. 发明公开

EP2821134A1 A system and a method for the implementation of chemical, biological or physical reactions 审中-公开
标题翻译：系统和方法，用于化学的表演，生物或物理反应
公开(公告)号：EP2821134A1
公开(公告)日：2015-01-07
申请号：EP13003400.2
申请日：2013-07-04
申请人： Technische Universität Kaiserslautern
发明人： Ulber, Roland , Tippkötter, Nils , Al-Kaidy, Huschyar
IPC分类号： B01J19/00
CPC分类号： B01J19/0093 , B01J2219/00788 , B01J2219/00822 , B01J2219/0084 , B01J2219/00846 , B01J2219/00873 , B01J2219/00889 , B01J2219/00903 , B01J2219/0093 , B01J2219/0097 , B01L3/50 , B01L3/502792 , B01L2200/0647 , B01L2200/0668 , B01L2300/0819 , B01L2300/1822 , B01L2300/1861 , B01L2400/043
摘要： The invention relates to a system for the implementation of chemical, biological or physical reactions, consisting of
- one or more magnetic micro-reactors (13), each comprising a shell (3) made of hydrophobic magnetic nanoparticles encapsulating an aqueous core (2),
- a plane platform (1) comprising a surface (12) to receive the micro-reactors (13),
- a source (14) that generates a magnetic field above or underneath the platform (1) for manipulating the one or more hydrophobic magnetic micro-reactors (13), or for moving them along the surface (12) of the platform (1) from one position to another position, characterized in that the aqueous core (2) of the one or more magnetic micro-reactors (13) contains a reaction solution or buffer, and wherein the magnetic field generated by the source (14) correlates to a defined position on the surface of the platform (1).
摘要翻译：本发明涉及一种系统，用于化学，生物或物理反应的实施，由......组成 - 一个或多个磁性微反应器（13），每个包括一个外壳（3）由疏水性的磁性纳米颗粒在wässrige芯封装（2）的 - 一个平面的平台（1）包括一个表面（12）以接收所述微反应器（13）， - 源极（14），其产生上述或平台（1），用于操纵一个或多个疏水下方的磁场磁性微反应器（13），或者用于沿着所述平台（1）的表面（12）从一个位置移动到另一个位置，在DASS特点死wässrige芯（2）的一个或多个磁性微反应器的（ 13）含有一个反应溶液或缓冲液，并通过worin（14）关联到所述平台（1）的表面上的限定位置的源所产生的磁场。

5. 发明公开

EP2344135A4 A PROCESS FOR MAKING PARTICLES FOR DELIVERY OF DRUG NANOPARTICLES 审中-公开
标题翻译：用于生产颗粒以释放活性，纳米
公开(公告)号：EP2344135A4
公开(公告)日：2013-09-18
申请号：EP09816538
申请日：2009-09-24
申请人： NANOMATERIALS TECH PTE LTD
发明人： SHEN ZHIGANG , YUN JIMMY SUNG LAI , HU JUN , JUGADE NITAL ARVIND , ZHANG JIYAO , CHEN WENHAO , WANG ZHE , GAO LINGYAN , GLOVER WILLIAM , CHEN JIAN FENG
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , B01J2/06 , B01J14/00 , B01J19/00
CPC分类号： A61K9/14 , A61K9/1623 , A61K9/1652 , A61K9/1694 , A61K9/2077 , B01J2/06 , B01J19/0093 , B01J2219/00788 , B01J2219/00889

6. 发明公开

EP2627442A2 PROCÉDÉ ET DISPOSITIF DE TRANSFORMATION CHIMIQUE PAR RÉACTION ÉQUILIBRÉE ENTRE DES RÉACTIFS, AINSI QUE PROCÉDÉ DE DÉTERMINATION D'AU MOINS UN PARAMÈTRE D'UNE TELLE TRANSFORMATION CHIMIQUE 审中-公开
标题翻译：用于确定至少一个这样的化学转化性能参数的方法和装置之间的反应的反应物和方法的平衡化学转换装置
公开(公告)号：EP2627442A2
公开(公告)日：2013-08-21
申请号：EP11832106.6
申请日：2011-10-13
申请人： Rhodia Operations
发明人： GUILLOT, Pierre , VASCONCELOS, Inès
IPC分类号： B01J19/00 , C08G63/78 , B01D17/00 , B01D53/22 , B81B3/00
CPC分类号： B01J19/0093 , B01D1/14 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01J2219/00907 , B01J2219/00952 , B01J2219/00957 , B01J2219/00986 , C08G63/785
摘要： The invention relates to a chemical conversion method which can be used to controllably force the evolution of an equilibrium chemical reaction between reactants, particularly in a milli-fluidic system. According to the method, a single-phase liquid reaction flow stream containing the reactants is obtained and then segmented to form a two-phase gas-liquid flow stream, such as to extract a co-product of the reaction in the gas phase of the two-phase flow stream from the liquid phase from said two-phase flow stream. Subsequently, at least one fraction of the gas phase is separated from the two-phase flow stream by means of gas permeation of the co-product.

7. 发明公开

EP2585211A2 VORRICHTUNG UND VERFAHREN ZUR HERSTELLUNG RADIOCHEMISCHER VERBINDUNGEN 审中-公开
公开(公告)号：EP2585211A2
公开(公告)日：2013-05-01
申请号：EP11828159.1
申请日：2011-06-20
申请人： ABX Advanced Biochemical Compounds GmbH , GeSIM Gesellschaft für Silizium-Mikrosysteme mbH
发明人： MÜLLER, Marco , HOWITZ, Steffen
IPC分类号： B01J19/00 , C07B59/00
CPC分类号： C07B59/005 , B01J19/004 , B01J19/0046 , B01J19/0093 , B01J2219/00038 , B01J2219/0004 , B01J2219/00094 , B01J2219/00132 , B01J2219/00141 , B01J2219/00283 , B01J2219/00333 , B01J2219/00364 , B01J2219/00585 , B01J2219/00599 , B01J2219/00704 , B01J2219/0072 , B01J2219/00731 , B01J2219/00788 , B01J2219/0081 , B01J2219/00882 , B01J2219/00889 , B01J2219/00916 , B01J2219/00941 , C07B59/00 , C07B2200/05 , C07H5/02
摘要： The invention relates to a device for producing radiochemical compounds. Said device comprises at least a reaction module, a dosing module, and a supply module. The reaction module has at least one reaction vessel that includes a closeable opening through which substances needed for the production of a predefined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the produced radiochemical compound can be removed from the reaction vessel of the reaction module. The dosing module has at least one pipetting head which can be moved relative to the supply module and the reaction module in the x, y, and z directions and also has at least one dosing unit. At least one storage tank for one of the substances needed for the production of the respective radiochemical substance is formed in the supply module.
摘要翻译：该装置包括反应模块（2），计量模块，供应模块和分配模块，其中反应模块包括具有可闭合的开口的反应容器（3），通过该开闭开口将产生预定放射化学化合物所需的物质引入反应容器。将产生的放射化学化合物从反应模块的反应容器中除去。给药模块包括移液头（9），其相对移动到供应和反应模块并且包括剂量单位（10a，10b，10c，12）。该装置包括反应模块（2），计量模块，供应模块和分配模块，其中反应模块包括具有可闭合的开口的反应容器（3），通过该开闭开口将产生预定放射化学化合物所需的物质引入反应容器。将产生的放射化学化合物从反应模块的反应容器中除去。给药模块包括移液头（9），其相对移动到供应和反应模块并且包括剂量单位（10a，10b，10c，12）。在供给模块中形成有用于制备各放射化学化合物的储存器。反应模块的反应容器的内部容积为10n至20.000ml。反应模块包括加热和/或冷却装置和/或微波。反应容器包括封闭物，当将产生各种放射化学化合物所需的物质引入反应容器或将反应混合物或反应混合物的一部分从反应容器中排出时，封闭物打开。在确定物质的供应或清除后，开口关闭。当将产生各种放射化学化合物所需的物质引入反应容器或反应混合物或反应混合物的一部分从反应容器中散出时，剂量单位封闭开口。移液头可在x，y方向或x，y和z方向上移动。该装置包括剂量单元，其从供应模块中除去粉末状物质以运输反应模块，并且经由开口将粉末状物质引入反应容器，和/或另外的剂量单元将液体物质从供给模块中除去运输反应模块，并通过开口将液体物质引入反应容器。剂量单元包括用于从反应容器供应和除去液体和气体物质的通道（23）。包括用于使用装置生产放射化学化合物的方法的独立权利要求。

8. 发明公开

EP2543434A1 Catalytic reaction process using microchannel technology 有权
标题翻译： Katalysator-Reaktionsverfahren unter Verwendung der Mikrokanal-Technologie
公开(公告)号：EP2543434A1
公开(公告)日：2013-01-09
申请号：EP12153890.4
申请日：2006-06-30
申请人： Velocys Inc.
发明人： Tonkovich, Anna Lee , Jarosch, Kai Tod Paul , Sullivan, Timothy J. , Mazanec, Terry , Fitzgerald, Sean Patrick , Fanelli, Maddalena
IPC分类号： B01J19/00 , B01J23/889 , C10G2/00
CPC分类号： B01J23/8896 , B01J19/0093 , B01J35/023 , B01J2219/00783 , B01J2219/00788 , B01J2219/00835 , B01J2219/00873 , B01J2219/00889 , B01J2219/00984 , C10G2/32 , C10G2/33 , C10G29/205 , C10G45/02 , C10G47/02 , C10G50/00 , C10G2300/301 , C10G2300/302 , C10G2300/4018 , C10G2300/4025 , C10G2300/802 , C10G2300/805 , C10G2300/807 , C10G2400/04 , C10G2400/10 , C10L1/08
摘要： The disclosed technology relates to a process for conducting a chemical reaction between at least one liquid reactant and at least one gaseous reactant in a process microchannel containing at least one catalyst, the catalyst comprising a solid phase catalyst or a homogeneous catalyst immobilized on a solid. In one embodiment, the process microchannel comprises a processing zone containing one or more structures for disrupting fluid flow and a reaction zone containing one or more structures for contacting and/or supporting the catalyst, the one or more structures for contacting and/or supporting the catalyst containing openings to permit the reactants to flow through the one or more structures and contact the catalyst. The process comprises: forming a reactant mixture comprising at least one liquid reactant and the at least one gaseous reactant; flowing the reactant mixture in the processing zone in contact with the one or more structures for disrupting fluid flow to enhance mixing of the liquid reactant and the gaseous reactant; flowing the reactant mixture in openings in the one or more structures for contacting and/or supporting the catalyst in contact with catalyst; and reacting the at least one liquid reactant with the at least one gaseous reactant to form at least one product. In one embodiment, the process relates to a process for conducting a Fischer-Tropsch synthesis in a process microchannel containing at least one Fischer-Tropsch synthesis catalyst, the catalyst comprising a solid phase catalyst or a homogeneous catalyst immobilized on a solid, the process comprising: flowing reactants comprising H 2 and CO in the process microchannel, the inlet superficial velocity of the reactants being at least about 0.1 m/s; contacting the Fischer-Tropsch synthesis catalyst with the reactants; and reacting the reactants in the presence of the catalyst to form at least one product.
摘要翻译：所公开的技术涉及在含有至少一种催化剂的工艺微通道中的至少一种液体反应物与至少一种气体反应物之间进行化学反应的方法，所述催化剂包含固相催化剂或固相在固体上的均相催化剂。在一个实施方案中，工艺微通道包括含有用于破坏流体流动的一种或多种结构的处理区和含有用于接触和/或支撑催化剂的一种或多种结构的反应区，用于接触和/或支撑催化剂的一种或多种结构催化剂含有开口以允许反应物流过一个或多个结构并与催化剂接触。该方法包括：形成包含至少一种液体反应物和至少一种气态反应物的反应物混合物; 使处理区中的反应物混合物与一个或多个结构接触以破坏流体流动，以增强液体反应物和气态反应物的混合; 使反应物混合物在一个或多个结构中的开口中流动，用于接触和/或支撑与催化剂接触的催化剂; 以及使所述至少一种液体反应物与所述至少一种气体反应物反应以形成至少一种产物。在一个实施方案中，该方法涉及在含有至少一种费 - 托合成催化剂的工艺微通道中进行费 - 托合成的方法，该催化剂包含固相在固体上的固相催化剂或均相催化剂，该方法包括：在工艺微通道中包含H 2和CO的流动反应物，反应物的入口空塔速度为至少约0.1m / s; 使费 - 托合成催化剂与反应物接触; 并在催化剂存在下使反应物反应以形成至少一种产物。

9. 发明公开

EP2539066A2 HONEYCOMB BODY INTERDIGITATED MIXERS AND METHODS FOR PRODUCING 审中-公开
标题翻译： BY蜂窝体纠缠在一起旋转法的用于生产
公开(公告)号：EP2539066A2
公开(公告)日：2013-01-02
申请号：EP11710065.1
申请日：2011-02-28
申请人： Corning Incorporated
发明人： BHOPTE, Siddharth , SUTHERLAND, James, S.
IPC分类号： B01J19/00 , B01J19/24 , B01F5/06 , B28B11/12
CPC分类号： B01F5/0644 , B01J19/0093 , B01J19/2485 , B01J2219/00085 , B01J2219/00092 , B01J2219/00788 , B01J2219/00824 , B01J2219/00831 , B01J2219/00873 , B01J2219/00889 , B28B11/12 , F28F13/06 , F28F2250/108 , Y10T29/49826 , Y10T428/24149
摘要： Honeycomb body interdigitating mixers are disclosed along with methods for producing them, the honeycomb body having parallel cells extending along a common direction, the mixer comprising a first fluid path extending within the honeycomb body along a first path direction perpendicular to the common direction, the first fluid path defined within a first plurality of said cells, at least a high aspect ratio portion of the first fluid path having an aspect ratio of height in the common direction to width perpendicular to the common direction and to the first path direction of at least 3:1, and a second fluid path extending within the honeycomb body along a second path direction perpendicular to the common direction, the second fluid path defined within a second plurality of said cells, at least a high aspect ratio portion of the second fluid path having an aspect ratio of height in the common direction to width perpendicular to the common direction and to the second path direction of at least 3:1, wherein the first fluid path is fluidically connected to the second fluid path within their respective high aspect ratio portions via a group of apertures, the group extending in the common direction, the group of apertures taken together having a ratio of height in the common direction to width perpendicular to the common direction of at least 3:1.

10. 发明公开

EP2386562A4 HALOGEN-SUBSTITUTED SACCHARIDE, METHOD FOR PRODUCING SAME, REACTION COMPOSITION OF SAME AND DEVICE FOR PRODUCING SAME 审中-公开
标题翻译：卤素取代糖，METHOD FOR ITS，反应其组成和生产器用于其
公开(公告)号：EP2386562A4
公开(公告)日：2012-08-08
申请号：EP09837468
申请日：2009-12-25
申请人： NAT INST OF ADVANCED IND SCIEN
发明人： SATO MASAHIRO , KAWANAMI HAJIME , MIZUKAMI FUJIO
IPC分类号： C07H1/00 , A61K51/04 , B01J3/00 , B01J19/00 , B81B1/00 , C07B59/00 , C07B63/00 , C07H5/02
CPC分类号： C07H5/02 , A61K51/0491 , B01J19/0093 , B01J2219/00788 , B01J2219/00891 , C07B63/00 , C07H1/00 , Y02P20/544

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