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1. 发明公开

EP4353359A1 A LIQUID HANDLING DEVICE, AND USE OF A HOLLOW PLUNGER 审中-公开
公开(公告)号：EP4353359A1
公开(公告)日：2024-04-17
申请号：EP22201369.0
申请日：2022-10-13
申请人： Sartorius Biohit Liquid Handling Oy
发明人： VIHINEN, Pasi
IPC分类号： B01L3/02 , G01N35/10
CPC分类号： B01L3/0231 , B01L3/021 , B01L2200/02320130101 , B01L2400/063320130101 , G01N35/1016
摘要： According to an example aspect of the present invention, there is provided a liquid handling device based on air displacement principle, comprising a cavity comprising a first chamber and a second chamber, a plunger movable inside the cavity, to apply a vacuum or pressure inside the cavity, wherein the first chamber is configured to provide a first dosing volume range, wherein the second chamber together with the first chamber is configured to provide a second dosing volume range, which is larger than the first dosing volume range, wherein said first chamber and said second chamber are connected by a closable fluid connection, and wherein said fluid connection is provided through said plunger.

2. 发明公开

EP1635948A2 DUAL RESOLUTION SYRINGE 审中-公开
标题翻译：与双倍分辨率SPLASH
公开(公告)号：EP1635948A2
公开(公告)日：2006-03-22
申请号：EP04753042.3
申请日：2004-05-24
申请人： Schwartz, Donald H.
发明人： SCHWARTZ, Donald, H. , SABIN, Douglas, G.
IPC分类号： B01L3/02
CPC分类号： G01F11/027 , B01L3/022 , B01L3/0231 , G01F11/023
摘要： A syringe for accurately metering small volumes of fluid samples is provided with dual resolution capabilities. The syringe permits the aspiration of a tiny sample and also the dilution of a tiny sample with a much larger volume of reagent with the same syringe. The syringe also allows the aspiration of a minute fluid sample and the touchless transfer off the fluid sample from the tip of the syringe. The present invention allows the aspiration resolution to differ from the dispensing resolution. The dual resolution capabilities also permits the present invention to be implemented into existing conventional syringe drive system. The syringe may include a housing, a piston within the housing, and a plunger extending from the housing. A chamber is formed in the housing between the plunger and a sealing means and between the piston and the inner surface of the housing. The chamber may further include first and second portions, where the volume change of the fluid in the first and second portions corresponds to the dual resolution capabilities.

3. 发明公开

EP1065001A1 APPARATUS FOR INTEGRATING PROCESSING OF MAGNETIC PARTICLES, AND METHOD OF CONTROLLING THE SAME 有权
标题翻译：装置ZUR集成VON MAGNETTEILCHEN - VERARBEITUNG UND STEUERUNGSVERFAHREN
公开(公告)号：EP1065001A1
公开(公告)日：2001-01-03
申请号：EP99909237.2
申请日：1999-03-18
申请人： Precision System Science Co., Ltd.
发明人： TAJIMA, H., Precision System Science Co., Ltd.
IPC分类号： B03C1/00 , C12M1/00
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00286 , B01J2219/0029 , B01J2219/00292 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/00369 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00686 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01L3/0231 , B01L3/5025 , B01L2300/0829 , B03C1/025 , B03C1/033 , B03C1/035 , B03C1/284 , B03C1/288 , B03C2201/18 , B03C2201/26 , C40B40/06 , C40B60/14 , G01N35/0098 , G01N35/028 , G01N35/1065 , G01N35/1074 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： The present invention relates to an apparatus for an integrated process of magnetic particles and a method of controlling the same, for executing a process for magnetic particles incorporated in a fluid in an integrated state. The present invention aims to provide an apparatus for an integrated process of magnetic particles and a method of controlling the same, that can promptly and efficiently process all together in high precision, with the process of magnetic particles integrated.
The apparatus for an integrated process of magnetic particles comprises a reservoir body provided with plural pit-like reservoirs for storing a drawn liquid arranged in a matrix, a sliding body with jutting plural sliding projections sliding through the reservoirs and capable of moving vertically to and from the reservoir body, plural nozzles attached to the lower parts of the reservoirs and capable of passing the liquid therethrough, a magnetic force device capable of magnetization and demagnetization having plural through sections in which is inserted each nozzle and having a wall part in contact with or near the outer side surface of the nozzle, with the nozzles inserted thereinto, wherein each wall part has two divided wall parts being apart from one another in such a manner that the divided wall parts have opposite polarities by magnetization, respectively.
摘要翻译：本发明涉及一种用于磁性颗粒的集成过程的装置及其控制方法，用于执行一体化状态下结合在流体中的磁性颗粒的过程。本发明的目的在于提供一种磁性粒子的集成方法的装置及其控制方法，其可以将磁性粒子整合的过程以高精度快速高效地一起处理。用于磁性颗粒的集成过程的装置包括储存器主体，其设置有多个凹坑状储存器，用于储存以矩阵形式布置的拉伸液体，滑动体具有突出的多个滑动突起，其滑动通过储存器并且能够垂直移动和移出储存器本体，附接到储存器的下部并且能够使液体通过的多个喷嘴，能够进行磁化和退磁的磁力装置，其具有插入每个喷嘴的多个贯穿部分，并且具有壁部分接触或在喷嘴的外侧表面附近，喷嘴插入其中，其中每个壁部分分别具有两个分开的壁部分，以使分隔的壁部分分别具有相对的磁化极性。

4. 发明公开

EP0544814A4 EP0544814A4 - 失效
标题翻译： EP0544814A4 - Google专利
公开(公告)号：EP0544814A4
公开(公告)日：1994-02-09
申请号：EP91916796
申请日：1991-08-22
申请人： DRD DILUTER CORPORATION
发明人： QURESHI, HUMAYUN , SCHWARTZ, DONALD
IPC分类号： B01L3/02 , G01N1/14
CPC分类号： B01L3/0231 , Y10T436/2575
摘要： A pipette (10) has a first and second piston (13, 14) to provide for a precise dose measurement and delivery and a second dose which can be an air blowout to fully expel the precise measured first dose. Preferably, two pistons are used of different diameter with a difference in diameters permitting precise measurement of small doses of, for example, 10 microleters or less.
摘要翻译：移液管（10）具有第一和第二活塞（13,14）以提供精确的剂量测量和输送以及第二剂量，其可以是空气吹出以完全排出精确测量的第一剂量。优选地，使用两个直径不同的活塞，以允许精确测量例如10微米或更小的小剂量。

5. 发明公开

EP0544814A1 PIPETTE 失效
公开(公告)号：EP0544814A1
公开(公告)日：1993-06-09
申请号：EP91916796.0
申请日：1991-08-22
申请人： DRD DILUTER CORPORATION
发明人： QURESHI, Humayun , SCHWARTZ, Donald
IPC分类号： B01L3
CPC分类号： B01L3/0231 , Y10T436/2575
摘要： Une pipette (10) possède des premier et second pistons (13, 14) pour effectuer un dosage précis et une seconde dose qui peut être de l'air soufflé afin d'expulser entièrement le premier dosage mesuré avec précision. De préférence, deux pistons de diamètres différents sont utilisés, la différence des diamètres permettant d'effectuer une mesure précise de petites doses, par exemple de l'ordre de 10 microlitres ou moins.
摘要翻译：移液管（10）具有用于精确定量的第一和第二活塞（13,14）以及可以是膨化空气以完全排出第一精确测量的测定的第二剂量。优选地，使用两个不同直径的活塞，这些直径的差异使得可以执行小剂量的准确测量，例如约10微升或更少。

6. 发明授权

EP3129145B1 SYSTÈME DE PIPETAGE MULTICANAUX COMPRENANT DEUX CHAMBRES D'ASPIRATION IMBRIQUÉES L'UNE DANS L'AUTRE 有权
标题翻译：多通道管道系统包括两个单吸气室
公开(公告)号：EP3129145B1
公开(公告)日：2018-03-14
申请号：EP15714834.7
申请日：2015-04-09
申请人： GILSON SAS
发明人： DUDEK, Bruno
IPC分类号： B01L3/02
CPC分类号： B01L3/0231 , B01L2300/0861 , B01L2400/0478

7. 发明公开

EP3159397A1 HEAD DEVICE FOR MOUNTING DISPENSING TIP THEREON, AND MOVEMENT DEVICE USING SAME 有权
标题翻译：用于安装分配头的头部装置以及使用该头部装置的运动装置
公开(公告)号：EP3159397A1
公开(公告)日：2017-04-26
申请号：EP14895175.9
申请日：2014-06-17
申请人： Yamaha Hatsudoki Kabushiki Kaisha
发明人： ITO, Saburo , OSADA, Yukimasa , IZUME, Yohei
IPC分类号： C12M1/26 , B01L3/02 , G01N1/00
CPC分类号： G01N35/1011 , B01L3/02 , B01L3/0227 , B01L3/0231 , B01L3/0279 , B01L2200/026 , B01L2400/0478 , B01L2400/082 , G01N1/14 , G01N35/1081 , G01N2035/103
摘要： A head device for mounting a dispensing tip includes a piston member, a first shaft member engaging with the piston member to move the piston member in an up-down direction, a tubular rod including a tubular space having a cylinder space in which the piston member is housed to move in the up-down direction and including, at a lower end thereof, a tip mounting portion into which a base end portion of the dispensing tip is fitted, a first frame equipped with the first shaft member and the tubular rod, a second shaft member engaging with the first frame to move the first frame in the up-down direction, a second frame equipped with the second shaft member and including a guide portion configured to guide movement of the tubular rod in the up-down direction in association with the movement of the first frame in the up-down direction, and a shaft controller configured to control operation of the first and second shaft members.
摘要翻译：一种用于安装分配尖端的头部装置，包括：活塞构件;第一轴构件，该第一轴构件与活塞构件接合以使活塞构件沿上下方向移动;管状杆，其包括具有缸空间的管状空间，活塞构件被容纳以沿上下方向移动，并且在其下端包括：尖端安装部分，所述分配尖端的基端部分装配到所述尖端安装部分中;第一框架，所述第一框架配备有所述第一轴部件和所述管状杆，第二轴构件，与第一框架接合以使第一框架在上下方向上移动;第二框架，配备有第二轴构件并且包括引导部分，该引导部分构造成引导管状杆在上下方向上的运动与第一框架在上下方向上的移动相关联;以及轴控制器，配置成控制第一轴构件和第二轴构件的操作。

8. 发明公开

EP2945744A1 LIQUID END ASSEMBLY FOR A MULTICHANNEL AIR DISPLACEMENT PIPETTE 有权转让
标题翻译： FLÜSSIGKEITSENDMONTAGEFÜREINE MEHRKANAL-LUFTVERDRÄNGUNGSPIPETTE
公开(公告)号：EP2945744A1
公开(公告)日：2015-11-25
申请号：EP14702385.7
申请日：2014-01-13
申请人： Rainin Instrument LLC.
发明人： MORIARTY, Kent, Gordon , ELGINSMITH, Christopher, Brian , HUSMANN, Brian, Matthew
IPC分类号： B01L3/02
CPC分类号： B01L3/0231 , B01L3/0217 , B01L3/0279 , B01L2200/025
摘要： A handheld multichannel air displacement pipette is modular in construction and includes compliant joints and molded plastic components in place of various machined metal, glass, and ceramic components found in traditional multichannel pipettes. These improvements are made without sacrificing performance in channel-to-channel consistency, accuracy, and precision. The multichannel pipette is inexpensive to manufacture, lightweight, reliable, and easy to assemble and service.
摘要翻译：手持式多通道空气置换移液器是模块化的结构，包括柔性接头和模制塑料部件，代替传统多通道移液器中的各种加工金属，玻璃和陶瓷部件。这些改进是在不影响通道间通道一致性，精度和精度方面的性能的。多通道移液器制造便宜，重量轻，可靠，易于组装和维修。

9. 发明公开

EP2323765A1 APPARATUS, SYSTEM AND METHOD FOR FILTERING LIQUID SAMPLES 有权
标题翻译：系统和方法过滤液体样品
公开(公告)号：EP2323765A1
公开(公告)日：2011-05-25
申请号：EP09784167.0
申请日：2009-09-01
申请人： WALLAC OY
发明人： LEHTINEN, Kauko , KORPI, Jarmo
IPC分类号： B01L3/00 , B01L3/02 , G01N35/10
CPC分类号： B01L3/50255 , B01L3/0231 , B01L3/565 , B01L2300/0829 , B01L2400/0478
摘要： The present invention relates to an apparatus and a system for filtering a liquid sample in a sample well (310) by transferring the liquid out of the sample well (310) through a filter member (320) situated at a bottom part of the sample well (310). The apparatus and the system comprise a syringe (100), and a seal member (200) arranged around a nozzle (140) of the syringe (100) in such a way that the syringe (100) is adjustable in connection with an upper part of the sample well (310) in a substantially airtight manner. The invention also concerns a method for filtering a liquid sample and use of the system for filtering eluted blood.

10. 发明公开

EP1065001A4 APPARATUS FOR INTEGRATING PROCESSING OF MAGNETIC PARTICLES, AND METHOD OF CONTROLLING THE SAME 有权
标题翻译：设备整合磁 - 处理和控制方法
公开(公告)号：EP1065001A4
公开(公告)日：2004-04-14
申请号：EP99909237
申请日：1999-03-18
申请人： PREC SYSTEM SCIENCE CO LTD
发明人： TAJIMA H
IPC分类号： B01J19/00 , B01L3/00 , B03C1/025 , B03C1/035 , C40B40/06 , C40B60/14 , G01N35/00 , G01N35/02 , G01N35/10 , B03C1/00 , C12M1/00
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00286 , B01J2219/0029 , B01J2219/00292 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/00369 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00686 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01L3/0231 , B01L3/5025 , B01L2300/0829 , B03C1/025 , B03C1/033 , B03C1/035 , B03C1/284 , B03C1/288 , B03C2201/18 , B03C2201/26 , C40B40/06 , C40B60/14 , G01N35/0098 , G01N35/028 , G01N35/1065 , G01N35/1074 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A method for making any combined substances in carriers by arbitrarily combining with plural elements of substances, comprising the steps of: dispensing each liquid incorporating each element of substances into one or more groups of containing parts arranged by plural containing parts in a matrix in which the containing parts accommodating said carriers are arranged in rows or columns having a predetermined number width in a way so as to be included in said matrix, according to the structure of the specified combined substances or the utilized kinds of containing parts, and mixing the dispensed elements of substances into the group of the containing parts accommodating the carriers, with the elements of substances arranged in rows or columns having a predetermined number width, in such a manner that row-like or column-like arrangements of the dispensed elements of substances are positioned against row-like or column-like arrangements of the elements of substances in a state of transposition or non-transposition.

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