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1. 发明专利

AU2001249072B2 Lipase-containing composition and methods of use thereof 未知
公开(公告)号：AU2001249072B2
公开(公告)日：2004-09-30
申请号：AU2001249072
申请日：2001-02-23
申请人： LILLY CO ELI
发明人： MARGOLIN ALEX , SHENOY BHAMI
IPC分类号： A61K38/46 , A61K38/47 , A61K38/48 , A61P1/14 , A61P1/18 , C12N9/20 , C12N9/26 , C12N9/50 , C12N9/96 , A61K038/46 , A61K038/47 , A61K038/48 , A61P001/00 , A61P003/00 , C12N009/96

2. 发明专利

AU2004100062B4 Composition and method 未知
公开(公告)号：AU2004100062B4
公开(公告)日：2004-05-20
申请号：AU2004100062
申请日：2004-02-02
申请人： LIVESTOCK NUTRITION TECH PTY LTD
发明人： POLLOCK DOUGLAS MALCOLM
IPC分类号： A23K1/16 , A61K31/7016 , A61P43/00 , A61K031/7016 , A23K001/00 , A23K001/16 , A61P003/00 , A61P043/00

3. 发明专利

AU2002214029B2 isothiazoles 未知
公开(公告)号：AU2002214029B2
公开(公告)日：2004-12-23
申请号：AU2002214029
申请日：2001-10-26
申请人： HOFFMANN LA ROCHE
发明人： AEBI JOHANNES , ACKERMANN JEAN , DEHMLOW HENRIETTA , MAERKI HANS-PETER , MORAND OLIVIER
IPC分类号： A61K31/381 , A61K31/397 , A61K31/428 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P31/10 , A61P33/00 , A61P35/00 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12 , C07D417/12 , C07D521/00 , A61P003/00 , A61K031/381
摘要： The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

4. 发明专利

AU2002252632B2 Low salt forms of polyallylamine 未知
公开(公告)号：AU2002252632B2
公开(公告)日：2004-09-23
申请号：AU2002252632
申请日：2002-04-10
申请人： GENZYME CORP
发明人： BURKE STEVEN KEITH , HOLMES-FARLEY STEPHEN RANDALL , PETERSEN JOHN S
IPC分类号： A61K31/765 , A61K31/785 , A61P3/00 , A61P13/12 , A61P43/00 , A61K031/785 , C08F026/00 , A61P003/00
摘要： Disclosed is a pharmaceutical composition comprising a stable polyallylamine hydrochloride polymer in which between about 4% to about 12% by weight of the polymer is a chloride anion and a pharmaceutically acceptable carrier or diluent.

5. 发明专利

AU2001274195B2 Use of riluzole or its salts for preventing and treating adrenoleukodystrophy 未知
公开(公告)号：AU2001274195B2
公开(公告)日：2005-12-01
申请号：AU2001274195
申请日：2001-06-05
申请人： AVENTIS PHARMA SA , INST NAT SANTE RECH MED
发明人： DIB MICHEL , STUTZMANN JEAN-MARIE , AUBOURG PATRICK
IPC分类号： C07D277/82 , A61K31/428 , A61P13/12 , A61P25/00 , A61K031/425 , A61P003/00

6. 发明专利

AU2001284284B2 The hydrochloride salt of 5-(4-(2-(N-methyl-N-(2-pyridyl)amino)ethoxy)benzyl) thiazolidine-2,4-dione 未知
公开(公告)号：AU2001284284B2
公开(公告)日：2005-08-04
申请号：AU2001284284
申请日：2001-09-05
申请人： SMITHKLINE BEECHAM PLC
发明人： MILLAN MICHAEL , CRAIG ANDREW SIMON
IPC分类号： A61K31/44 , A61K31/4439 , A61P1/14 , A61P3/00 , A61P3/04 , A61P3/10 , A61P5/50 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , C07D417/12 , A61P003/00 , A61K031/44
摘要： A novel pharmaceutical compound 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrochloride, a process for preparing such a compound, a pharmaceutical composition comprising such a compound and the use of such a compound in medicine

7. 发明专利

AU2001248809B2 Novel insulin/IGF/relaxin family polypeptides and DNAs thereof 未知
公开(公告)号：AU2001248809B2
公开(公告)日：2005-05-19
申请号：AU2001248809
申请日：2001-04-20
申请人： TAKEDA PHARMACEUTICALS CO
发明人： OGI KAZUHIRO , HARADA MASATAKA , KIZAWA HIDEKI , NISHI KAZUNORI , SUZUKI NOBUHIRO , ITOH YASUAKI
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K38/22 , A61K38/27 , A61K38/28 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/16 , A61P3/00 , A61P5/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/00 , A61P19/00 , A61P25/00 , A61P37/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/575 , C07K14/62 , C07K14/64 , C07K14/65 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/74 , C12N015/09 , G01N033/15 , G01N033/50 , A61P017/00 , A61P011/00 , A61P001/16 , A61P037/00 , A61P025/00 , A61P005/00 , A61P009/00 , A61P019/00 , A61P003/00 , A61P043/00 , A61K045/00 , A61K039/395 , A61K038/30 , A61K038/28 , A61K038/17 , C12P021/08 , C12P021/02 , C12Q001/68 , C12N005/00 , C12N001/21 , C12N001/19 , C12N001/15 , C07K016/26 , C07K014/65
摘要： The present invention relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:8 (B chain), (3) a polypeptide wherein the A and B chains are bonded to each other via disulfide bonds (2 chains) or its salt, (4) DNAs encoding the same, etc. These polypeptides and DNAs encoding the same can be used for the diagnosis, treatment, prevention, etc. for diseases, including abnormalities (e.g., diabetes mellitus, etc.) in metabolic regulation (sugar metabolism, lipid metabolism, etc.) of energy sources such as carbohydrates.

8. 发明专利

AU2003268987B2 Enhancement of alcohol metabolism 未知
公开(公告)号：AU2003268987B2
公开(公告)日：2005-11-03
申请号：AU2003268987
申请日：2003-10-13
申请人： REMEDAL LTD
发明人： HEINO PEKKA
IPC分类号： A61K31/191 , A61P3/00 , A61P25/32 , A61K031/191 , A61P003/00 , A61P025/32
摘要： D-glyceric acid has been found to enhance alcohol metabolism and thereby prevent adverse effects of alcohol consumption. D-glyceric acid is administered concurrently with alcohol, to accelerate the elimination of the alcohol from the body. D-glyceric acid is converted into D-glyceraldehyde and further into glycerol in reactions catalysed by NADH-aldehyde dehydrogenase and NADH-alcohol dehydrogenase complexes, which are produced in excess during alcohol oxidation, in the cells of alcohol-metabolising tissues. In these reactions, the NADH complexes become NAD-aldehyde dehydrogenase and NAD-alcohol dehydrogenase complexes. These complexes in turn accelerate the oxidation of alcohol, which is paralleled by enhancement of acetaldehyde oxidation to metabolically harmless acetic acid. D-glyceric acid or its salt or ester is used for the manufacture of a pharmaceutical preparation for enhancing the metabolism of alcohol. A method of enhancing the metabolism of alcohol in a subject by administering said compounds an effective amount of D-glyceric acid or its salt or ester is disclosed. An oral or parenteral preparation comprising said compounds is also disclosed.

9. 发明专利

AU2002257147B9 Methods of treating syndrome X with aliphatic polyamines 未知
公开(公告)号：AU2002257147B9
公开(公告)日：2005-08-18
申请号：AU2002257147
申请日：2002-04-10
申请人： GENZYME CORP
发明人： DONOVAN JOANNE M , BURKE STEVEN K
IPC分类号： A61K45/00 , A61K31/015 , A61K31/355 , A61K31/375 , A61K31/4415 , A61K31/616 , A61K31/714 , A61K31/785 , A61K45/06 , A61P3/00 , A61P39/00 , A61K031/785 , A61P003/00
摘要： Disclosed is the use of colesevelam or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the purpose of treating Syndrome X in an individual in need thereof, under the proviso that the medicament does not contain a PTPase inhibitor. Also disclosed is the use of sevelamer or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the purpose of treating Syndrome X in an individual in need thereof. The invention also relates the administration of colesevelam or a pharmaceutically acceptable salt thereof, in combination with an antihyperlipidemic agent; a plasma HDL-raising agent; an antihypercholesterolemic agent; an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor; a cholesterol absorption inhibitor; a bile acid sequestrant anion exchange resin; LDL (low density lipoprotein) receptor inducer; fibrates; vitamin B 6 (also known as pyridoxine) or a pharmaceutically acceptable salts thereof; vitamin B 12 ; an anti-oxidant vitamin; an angiotensin II antagonist converting enzyme inhibitor; or a platelet aggregation inhibitor.

10. 发明专利

AU2001259592B2 Tetrahydroisoquinoline analogs useful as growth hormone secretagogues 未知
公开(公告)号：AU2001259592B2
公开(公告)日：2005-02-24
申请号：AU2001259592
申请日：2001-05-07
申请人： BRISTOL MYERS SQUIBB CO
发明人： TINO JOSEPH A , LI JAMES J
IPC分类号： A61K31/472 , A61K31/4725 , A61K38/00 , A61K45/00 , A61P1/14 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P13/12 , A61P17/02 , A61P19/02 , A61P19/10 , A61P21/00 , A61P25/20 , A61P25/24 , A61P31/18 , A61P37/04 , C07D209/44 , C07D217/26 , C07D223/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/08 , C07K5/065 , A61K031/472 , C07K005/06 , A61P003/00
摘要： Tetrahydroisoquinoline analogs are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.The tetrahdroisoquinoline analogs thereof have the structurewherein R1, R2, R3, R3a, X1, X2, X3, X4, m and n are as described herein.

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