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1. 发明专利

JP2010090172A Method for lowering serum glucose 审中-公开
标题翻译：降低血清葡萄糖的方法
公开(公告)号：JP2010090172A
公开(公告)日：2010-04-22
申请号：JP2010009197
申请日：2010-01-19
申请人： Genzyme Corp , ジェンザイムコーポレーション
发明人： BURKE STEVEN K , DONOVAN JOANNE M
IPC分类号： A61K31/785 , A61K31/78 , A61K31/787 , A61P3/00 , A61P3/10
CPC分类号： A61K31/787 , A61K31/785
摘要： PROBLEM TO BE SOLVED: To provide a method for lowering serum glucose, and to provide a composition for lowering serum glucose.
SOLUTION: The composition includes sevelamer or salts thereof for reducing serum glucose in a patient in need of reducing serum glucose.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供降低血清葡萄糖的方法，并提供降低血清葡萄糖的组合物。解决方案：组合物包含用于降低需要降低血清葡萄糖的患者中的血清葡萄糖的司维拉姆或其盐。版权所有（C）2010，JPO＆INPIT

2. 发明申请

WO2006050314A2 ONCE A DAY FORMULATION FOR PHOSPHATE BINDERS 审中-公开
标题翻译：一年一次的磷酸盐粘结剂配方
公开(公告)号：WO2006050314A2
公开(公告)日：2006-05-11
申请号：PCT/US2005039365
申请日：2005-11-01
申请人： GENZYME CORP , BURKE STEVEN K
发明人： BURKE STEVEN K
IPC分类号： A61K31/785 , A61K31/787 , A61K33/24 , A61P3/14 , A61P13/12 , A61P19/10 , A61P43/00
CPC分类号： A61K31/787 , A61K31/765 , A61K31/785 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： A method for reducing serum phosphate in a subject in need thereof comprising administering once per day to said subject a phosphate binder, wherein the phosphate binder has a phosphate binding capacity of at least 52 mmole.
摘要翻译：一种用于减少有需要的受试者的血清磷酸盐的方法，包括每天向所述受试者施用磷酸盐粘合剂，其中磷酸盐粘合剂具有至少52毫摩尔的磷酸盐结合能力。

3. 发明专利

DE60224052D1 未知
公开(公告)号：DE60224052D1
公开(公告)日：2008-01-24
申请号：DE60224052
申请日：2002-04-10
申请人： GENZYME CORP
发明人： HOLMES-FARLEY STEPHEN RANDALL , BURKE STEVEN K
IPC分类号： A61K31/785 , A61K45/00 , A61K31/519 , A61K31/78 , A61K31/787 , A61K45/06 , A61P3/00 , A61P13/02 , A61P13/12 , A61P19/06
摘要： A method for treating gout and/or reducing serum uric acid levels in a patient is disclosed that includes administering to the patient a therapeutically effective amount of an amine polymer, for example, an aliphatic amine polymer. In one embodiment, the polymer binds to uric acid or a precursor thereof. Examples of polymers useful in an embodiment of the invention include sevelamer hydrochloride and colesevelam. The invention includes the use of amine polymers such as a cross-linked polymer characterized by a repeat unit having the formula: and salts and copolymers thereof, where n is a positive integer and x is zero or an integer between 1 and about 4. Also described is a use, for the manufacture of a medicament, of a polymer that binds serum uric acid in a patient.

4. 发明专利

AU2002257147B9 Methods of treating syndrome X with aliphatic polyamines 未知
公开(公告)号：AU2002257147B9
公开(公告)日：2005-08-18
申请号：AU2002257147
申请日：2002-04-10
申请人： GENZYME CORP
发明人： DONOVAN JOANNE M , BURKE STEVEN K
IPC分类号： A61K45/00 , A61K31/015 , A61K31/355 , A61K31/375 , A61K31/4415 , A61K31/616 , A61K31/714 , A61K31/785 , A61K45/06 , A61P3/00 , A61P39/00 , A61K031/785 , A61P003/00
摘要： Disclosed is the use of colesevelam or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the purpose of treating Syndrome X in an individual in need thereof, under the proviso that the medicament does not contain a PTPase inhibitor. Also disclosed is the use of sevelamer or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the purpose of treating Syndrome X in an individual in need thereof. The invention also relates the administration of colesevelam or a pharmaceutically acceptable salt thereof, in combination with an antihyperlipidemic agent; a plasma HDL-raising agent; an antihypercholesterolemic agent; an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor; a cholesterol absorption inhibitor; a bile acid sequestrant anion exchange resin; LDL (low density lipoprotein) receptor inducer; fibrates; vitamin B 6 (also known as pyridoxine) or a pharmaceutically acceptable salts thereof; vitamin B 12 ; an anti-oxidant vitamin; an angiotensin II antagonist converting enzyme inhibitor; or a platelet aggregation inhibitor.

5. 发明专利

CY1119486T1 ΧΡΗΣΗ ΠΟΛΥΜΕΡΟΥΣ ΑΜΙΝΗΣ ΓΙΑ ΜΕΙΩΣΗ ΤΗΣ ΓΛΥΚΟΖΗΣ ΣΤΟΝ ΟΡΟ 未知
公开(公告)号：CY1119486T1
公开(公告)日：2018-03-07
申请号：CY171101019
申请日：2017-09-27
申请人： GENZYME CORP
发明人： BURKE STEVEN K
IPC分类号： A61K31/785 , A61K31/78 , A61K31/787 , A61P3/00 , A61P3/10
摘要： Αποκαλύπτεταιμιαμέθοδοςγιατηναγωγήτηςυπεργλυκαιμίαςκαι/ήτημείωσητωνεπιπέδωντηςγλυκόζηςστονορόσεένανασθενή, πουπεριλαμβάνειτηχορήγησηστονασθενήμιαςθεραπευτικάαποτελεσματικήςποσότηταςενόςπολυμερούςαμίνης. Σεμίαενσωμάτωση, τοπολυμερέςαμίνηςείναιαλειφατικό. Παραδείγματαπολυμερώνχρήσιμωνσεμιαενσωμάτωσητηςεφεύρεσηςπεριλαμβάνουνυδροχλωρικήσεβελαμέρηκαιχολησεβελάμη. Ηεφεύρεσηπεριλαμβάνειτηχρήσηπολυμερώναμίνηςόπωςέναδιασυνδεδεμένοπολυμερέςπουχαρακτηρίζεταιαπόμιαεπαναλαμβανόμενημονάδαπουέχειτοντύπο: καιάλατακαισυμπολυμερήαυτών, όπουτο n είναιέναςθετικόςακέραιοςκαιτο x είναιμηδένή έναςακέραιοςμεταξύ 1 καιπερίπου 4. Επίσηςπεριγράφεταιμιαχρήση, γιατηνπαρασκευήενόςφαρμάκου, ενόςπολυμερούςπουμειώνειτηγλυκόζηστονορό.

6. 发明专利

DE60225908T2 未知
公开(公告)号：DE60225908T2
公开(公告)日：2009-05-14
申请号：DE60225908
申请日：2002-04-10
申请人： GENZYME CORP
发明人： BURKE STEVEN K , JOANNE DONOVAN M
IPC分类号： A61K31/75 , A61K31/78 , A61K31/785 , A61K31/787 , A61P3/00 , A61P3/10
摘要： A method for treating hyperglycemia and/or reducing serum glucose levels in a patient that includes administering to the patient a therapeutically effective amount of an amine polymer is disclosed. In one embodiment, the amine polymer is aliphatic. Examples of polymers useful in an embodiment of the invention include sevelamer hydrogen chloride and colesevelam. The invention includes the use of amine polymers such as a cross-linked polymer characterized by a repeat unit having the formula: and salts and copolymers thereof, where n is a positive integer and x is zero or an integer between 1 and about 4. Also described is a use, for the manufacture of a medicament, of a polymer that lowers serum glucose.

7. 发明专利

MY125874A USE OF POLYALLYLAMINE POLYMERS FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING HYPERCHOLESTEROLEMIA 未知
公开(公告)号：MY125874A
公开(公告)日：2006-08-30
申请号：MYPI9802704
申请日：1998-06-17
申请人： GENZYME CORP
发明人： RANDALL HOLMES-FARLEY STEPHEN , HARRY MANDEVILLE III W , BURKE STEVEN K , GOLDBERG DENNIS I
IPC分类号： A61K31/785 , A61P3/06 , A61P9/10 , A61P43/00
摘要： A METHOD FOR REMOVING BILE SALTS FROM A PATIENT THAT INCLUDES ADMINISTERING TO THE PATIENT A THERAPEUTICALLY EFFECTIVE AMOUNT OF A NON-ABSORBABLE AMINE POLYMERS CHARACTERIZED BY A REPEAT UNIT HAVING THE FORMULA:(CH2-CH)N (CH2)X NH2 AND SALTS THEREOF, WHERE N IS A POSITIVE INTEGER AND X IS ZERO OR AN INTEGER BETWEEN 1 AND ABOUT 4. FIG 1.

8. 发明专利

AU2005302242A1 Once a day formulation for phosphate binders 未知
公开(公告)号：AU2005302242A1
公开(公告)日：2006-05-11
申请号：AU2005302242
申请日：2005-11-01
申请人： GENZYME CORP
发明人： BURKE STEVEN K
IPC分类号： A61K31/785 , A61K31/787 , A61K33/24 , A61P3/14 , A61P13/12 , A61P19/10 , A61P43/00
摘要： A method for reducing serum phosphate in a subject in need thereof comprising administering once per day to said subject a phosphate binder, wherein the phosphate binder has a phosphate binding capacity of at least 52 mmole.

9. 发明专利

AU2003263010A1 METHOD FOR REDUCING VASCULAR INFLAMMATION 未知
公开(公告)号：AU2003263010A1
公开(公告)日：2005-04-21
申请号：AU2003263010
申请日：2003-09-02
申请人： GENZYME CORP
发明人： BURKE STEVEN K
IPC分类号： A61K31/785 , A61K31/787 , A61P9/10 , A61P9/14

10. 发明专利

BR0209124A 未知
公开(公告)号：BR0209124A
公开(公告)日：2005-02-09
申请号：BR0209124
申请日：2002-04-10
申请人： GENZYME CORP
发明人： BURKE STEVEN K , DONOVAN JOANNE M
IPC分类号： A61K45/00 , A61K31/015 , A61K31/355 , A61K31/375 , A61K31/4415 , A61K31/616 , A61K31/714 , A61K31/785 , A61K45/06 , A61P3/00 , A61P39/00
摘要： Disclosed is the use of colesevelam or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the purpose of treating Syndrome X in an individual in need thereof, under the proviso that the medicament does not contain a PTPase inhibitor. Also disclosed is the use of sevelamer or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the purpose of treating Syndrome X in an individual in need thereof. The invention also relates the administration of colesevelam or a pharmaceutically acceptable salt thereof, in combination with an antihyperlipidemic agent; a plasma HDL-raising agent; an antihypercholesterolemic agent; an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor; a cholesterol absorption inhibitor; a bile acid sequestrant anion exchange resin; LDL (low density lipoprotein) receptor inducer; fibrates; vitamin B 6 (also known as pyridoxine) or a pharmaceutically acceptable salts thereof; vitamin B 12 ; an anti-oxidant vitamin; an angiotensin II antagonist converting enzyme inhibitor; or a platelet aggregation inhibitor.

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