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1. 发明专利

AU2003268987B2 Enhancement of alcohol metabolism 未知
公开(公告)号：AU2003268987B2
公开(公告)日：2005-11-03
申请号：AU2003268987
申请日：2003-10-13
申请人： REMEDAL LTD
发明人： HEINO PEKKA
IPC分类号： A61K31/191 , A61P3/00 , A61P25/32 , A61K031/191 , A61P003/00 , A61P025/32
摘要： D-glyceric acid has been found to enhance alcohol metabolism and thereby prevent adverse effects of alcohol consumption. D-glyceric acid is administered concurrently with alcohol, to accelerate the elimination of the alcohol from the body. D-glyceric acid is converted into D-glyceraldehyde and further into glycerol in reactions catalysed by NADH-aldehyde dehydrogenase and NADH-alcohol dehydrogenase complexes, which are produced in excess during alcohol oxidation, in the cells of alcohol-metabolising tissues. In these reactions, the NADH complexes become NAD-aldehyde dehydrogenase and NAD-alcohol dehydrogenase complexes. These complexes in turn accelerate the oxidation of alcohol, which is paralleled by enhancement of acetaldehyde oxidation to metabolically harmless acetic acid. D-glyceric acid or its salt or ester is used for the manufacture of a pharmaceutical preparation for enhancing the metabolism of alcohol. A method of enhancing the metabolism of alcohol in a subject by administering said compounds an effective amount of D-glyceric acid or its salt or ester is disclosed. An oral or parenteral preparation comprising said compounds is also disclosed.

2. 发明专利

AU2002318969B2 A composition and uses therefor for combating hangover 未知
公开(公告)号：AU2002318969B2
公开(公告)日：2005-11-03
申请号：AU2002318969
申请日：2002-07-05
申请人： PENAM INVEST PTY LTD
发明人： MCGREGOR NEIL ROLAND
IPC分类号： A61K31/197 , A61K31/198 , A61K31/381 , A61K31/4188 , A61K31/51 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61P25/32 , A61P39/02 , A61K031/7004 , A61K031/7016 , A61K031/702 , A61P025/32
摘要： The present invention relates generally to a composition for use in the prophylaxis and/or treatment of one or more symptoms caused or exacerbated by consumption of alcohol which composition comprises: (1) fructose and (2) fructose-containing oligosaccharide.

3. 发明专利

AU2001226794B2 Substituted 1,2,3,4- tetrahydroquinoline-2-carboxylic acid derivatives 未知
公开(公告)号：AU2001226794B2
公开(公告)日：2005-06-02
申请号：AU2001226794
申请日：2001-01-19
申请人： GRUENENTHAL GMBH
发明人： JAGUSCH UTZ-PETER , MAUL CORINNA , BLOMS-FUNKE PETRA , REISSMULLER ELKE , ENGLBERGER WERNER , PRZEWOSNY MICHAEL , GERLACH MATTHIAS
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/473 , A61K31/4741 , A61K31/4743 , A61P1/04 , A61P1/12 , A61P3/10 , A61P9/00 , A61P11/00 , A61P11/14 , A61P13/02 , A61P19/10 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/34 , A61P25/36 , A61P27/06 , A61P27/16 , A61P29/00 , A61P37/08 , C07D215/48 , C07D221/16 , C07D221/18 , C07D221/22 , C07D405/04 , C07D491/04 , C07D491/048 , C07D495/04 , A61P025/32 , A61K031/47
摘要： A substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivative of formula Iand salts thereof with pharmaceutically acceptable acids. Also disclosed are methods for making the derivative, and pharmaceutical compositions comprising the derivative. Methods for treating pain, migraine, and various other diseases using the pharmaceutical composition are also disclosed.

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