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1. 发明申请

US20010048918A1 FOOD PRODUCTS CONTAINING BACTERIA WITH CHOLESTEROL LOWERING ACTIVITY 无效
标题翻译：含有胆固醇降低活性的细菌的食品
公开(公告)号：US20010048918A1
公开(公告)日：2001-12-06
申请号：US08804874
申请日：1997-02-24
发明人： LOURUS CORNELIS LIEVENSE , JOHN M. E. FLETCHER , INGRID DE SMET
IPC分类号： A23K001/00 , A23K003/00 , A23L001/00 , A23B007/10 , A01N063/00
CPC分类号： C12R1/01 , A23D7/0056 , A23L29/065 , A23Y2220/00 , A23Y2300/00
摘要： The invention concerns bacteria having byle salt hydrolysis activity and optionally and preferably also bile salt polymerisation activity. Food products comprising such bacteria have been found to be capable to reduce the blood cholesterol level in the human blood. The effect is obtained by interference with the cholesterol and/or bile salt metabolism and is based on BSH activity of the bacteria. Food products which, on the basis of their normal daily intake provide a daily-BSH-intake of 0.3 micro-mol/min/kg bodyweight, are preferred, and even more preferred are food products providing at least a daily-BSH-intake of 0.6 micro-mol/min/kg bodyweight. In a further preferred embodiment a BSH activity of at least 0.8 micro-mol/min/1e10 cfu is obtained by the common, daily intake of food products comprising the bacteria. Further preferred are food products comprising fat, wherein at least 40% of the fat are poly unsaturated fatty acids.
摘要翻译：本发明涉及具有副盐水解活性和任选且优选也是胆盐聚合活性的细菌。已经发现包含这种细菌的食品能够降低人血液中的血液胆固醇水平。通过干扰胆固醇和/或胆汁盐代谢而获得的效果是基于细菌的BSH活性。以每日正常摄入量为基础的食品，优选为0.3微摩尔/分/公斤体重的日常BSH摄入量，更优选的是至少提供每日BSH摄入量的BSH摄入量 0.6微mol / min / kg体重。在另一个优选的实施方案中，通过每天摄入含有细菌的食品，获得至少0.8微摩尔/分钟/ 1e10cfu的BSH活性。进一步优选的是包含脂肪的食品，其中至少40％的脂肪是多不饱和脂肪酸。

2. 发明申请

US20020119514A1 Process for producing a bran pickless flavoring solution 失效
标题翻译：生产无麸皮调味溶液的方法
公开(公告)号：US20020119514A1
公开(公告)日：2002-08-29
申请号：US10062777
申请日：2002-02-05
发明人： Chiaki Saitoh , Atsushi Yashiro , Chikara Tokunaga , Kyoto Ozawa , Atsuko Yokoi , Nobuo Ogata , Hiroshi Katahira , Keiko Ochiai , Katsuhiko Ando
IPC分类号： C12P001/00 , A23B007/10
CPC分类号： C12R1/15 , A23B7/10 , A23L27/24 , C12P17/04 , Y10S435/843
摘要： The present invention relates to a novel flavoring solution for making pickles having a flavor of foods pickled in rice bran paste (hereinafter referred to as a bran pickles flavoring solution), a clear bran pickles flavoring solution, processes for producing said solutions, a novel microorganism belonging to the genus Corynebacterium used for the production of said flavoring solutions, and a process for producing a solution containing a lactone wherein the lactone is selectively extracted from a culture of a lactone-producing microorganism. The present invention also relates to a novel bacterium of the genus Corynebacterium which has the ability to produce null-dodecalactone and/or null-dodecelactone and is useful for the production of said bran pickles flavoring solutions.
摘要翻译：本发明涉及一种新鲜的调味溶液，其用于制备腌米糠糊食品（以下称为麸皮酱调味剂）的咸菜，澄清麸酱调味剂溶液，生产所述溶液的方法，新型微生物属于用于生产所述调味溶液的棒状杆菌属的制造方法，以及含有内酯的溶液的制造方法，其中内酯从内酯生产微生物的培养物中选择性提取。本发明还涉及具有产生γ-十二烷内酯和/或γ-二糖内酯的能力的棒状杆菌属的新型细菌，并且可用于生产所述麸皮调味剂溶液。

3. 发明申请

US20020037830A1 ADDITIVE FOR USE IN ANY ENERGY SUPPLEMENTATION, USE OF A PROTEIN HYDROLYSATE TO THE PREPARATION OF ENERGY SUPPLEMENTATION AND AN ENERGY SUPPLEMENT CONTAINING SUCH AN ADDITIVE 无效
标题翻译：在任何能源补充中使用的补充剂，使用蛋白质水解产物来制备能量补充剂和包含这些添加剂的能量补充剂
公开(公告)号：US20020037830A1
公开(公告)日：2002-03-28
申请号：US09171202
申请日：1999-03-05
发明人： JORN HAVSKOV BERTHELSEN , SVEN FROKJAER , BENGT SALTIN
IPC分类号： A23J001/14 , A61K035/80 , A61K035/78 , C07K017/00 , C07K016/00 , C07K014/00 , C07K001/00 , C12P021/06 , A23K003/00 , A23L001/00 , A23B007/10 , A23F003/00 , A23L001/22 , A23K001/00 , A01N037/18 , A61K038/00 , A61K031/70 , A01N043/04 , A23L001/20
CPC分类号： A23L2/66 , A23L33/18
摘要： Additive for use in any energy supplementation or metabolic nutrient in the form of a beverage or other nutrient for athletes or other persons in need of increased glycogen level, use of a protein hydrolysate to the preparation of such an energy supplementation and an energy supplement containing such an additive. The protein hydrolysate can be of animal or vegetable origin.
摘要翻译：用于运动员或需要增加糖原水平的其他人的饮料或其他营养物形式的任何能量补充或代谢营养物质的添加剂，使用蛋白质水解产物来制备这种能量补充剂和含有这种能量补充剂的能量补充剂一种添加剂。蛋白质水解物可以是动物或植物来源的。

4. 发明申请

US20040248280A1 Animal feed containing polypeptides 失效
标题翻译：含多肽的动物饲料
公开(公告)号：US20040248280A1
公开(公告)日：2004-12-09
申请号：US10730323
申请日：2003-12-08
发明人： Robert I. Bolla , Joseph E. Zahner , Monty S. Kerley
IPC分类号： C12N001/18 , A23B007/10
CPC分类号： C12N15/81 , A23K10/30 , A23K20/147 , A23K50/30
摘要： The present invention relates to an animal feed made of an amount of cereal grain and a peptide or polypeptide expressed by a transformed organism, whereby the transformed organism can be included in the animal feed composition. The present invention also relates to a method for forming the animal feed wherein the method includes forming a transformed organism by transforming a yeast cell by inserting a nucleic acid molecule which will express a polypeptide desired for use in the animal feed.
摘要翻译：本发明涉及由一定量的谷物颗粒和由转化生物表达的肽或多肽制成的动物饲料，其中转化的生物体可以包含在动物饲料组合物中。本发明还涉及形成动物饲料的方法，其中所述方法包括通过插入将表达所需用于动物饲料中的多肽的核酸分子来转化酵母细胞形成转化的生物体。

5. 发明申请

US20040091578A1 Stabilization of hypoallergenic, hyperdigestible previously reduced proteins 审中-公开
公开(公告)号：US20040091578A1
公开(公告)日：2004-05-13
申请号：US10698824
申请日：2003-10-30
申请人： The Regents of University of California
发明人： Bob B. Buchanan , Susumu Morigasaki , Gregorio del Val , Oscar L. Frick
IPC分类号： C12P021/06 , A23B007/10
CPC分类号： A21D2/26 , A21D2/264 , A21D2/265 , A21D2/266 , A21D2/36 , A21D8/04 , A21D13/064 , A23C9/1209 , A23C9/1213 , A23C9/152 , A23J1/12 , A23J1/14 , A23J3/08 , A23J3/18 , A23K20/147 , A23L5/27 , A23L7/109 , A23L11/34 , A23L13/48 , A23L33/17 , A61K38/00 , A61K39/35 , A61K2035/122 , C07K1/1133 , C07K14/415 , C07K14/43504 , C07K14/46 , C07K14/76 , C07K14/811 , C12N9/0036 , C12N9/20 , C12P21/02 , C12Q1/26 , C12Q1/34 , C12Y108/01008 , C12Y108/01009
摘要： Disulfide proteins showed mitigated allergenicity and increased digestibility by pepsin following reduction by thioredoxin. The sulfhydryl groups newly formed on reduction by thioredoxin (at 4null C.) or dithiothreitol (DTT) (at 55null C.) were blocked with a physiological disulfide, such as cystamine or oxidized glutathione (GSSG) to obtain stable forms of the disarmed allergen. When derivatized with cystamine, BLG was separated from its oxidized and reduced forms on non-reducing SDS-PAGE and appeared to lack sulfhydryl groups. Although less effective GSSG, gave similar results. Allergenicity of the two derivatives was compared with that of the oxidized, reduced and reoxidized forms of BLG by skin testing dogs from a colony sensitized to cow's milk. Both the cystamine and GSSG derivatized BLG showed decreased allergenicity and increased sensitivity to pepsin as compared to controls. The reoxidized form resembled the derivatives in having lower allergenicity. The thioredoxin- and DTT-reduced forms showed hypoallergenic, hyperdigestible properties, most effectively when the reduced proteins were heated at 55null C. Whole milk subjected to these procedures showed results similar to those obtained with pure BLG. Other proteins are similarly stabilized. Stable forms of such disarmed, hypoallergenic and hyperdigestible disulfide protein allergens or just hypoallergenic or just hyperdigestible protein allergens are useful in foods as well as clinical preparations.

6. 发明申请

US20040161448A1 Use of acid stable protease in animal feed 有权
标题翻译：在动物饲料中使用酸稳定蛋白酶
公开(公告)号：US20040161448A1
公开(公告)日：2004-08-19
申请号：US10713394
申请日：2003-11-14
申请人： F. Hoffman-La Roche AG
发明人： Carsten Sjoeholm , Peter Rahbek Oestergaard
IPC分类号： A23B007/10 , A23K001/165 , A23K001/17
CPC分类号： A23J3/16 , A23J3/346 , A23K10/30 , A23K20/189 , A23K50/30 , C12N9/52
摘要： The present invention relates to acid-stable proteases homologous to those derived from strains of the genus Nocardiopsis, their use in animal feed, feed-additives and feed compositions containing such proteases, and methods for the treatment of vegetable proteins using such proteases.
摘要翻译：本发明涉及与诺卡氏菌属的菌株同源的酸稳定蛋白酶，它们在动物饲料中的用途，含有这种蛋白酶的饲料添加剂和饲料组合物，以及使用这种蛋白酶处理植物蛋白质的方法。

7. 发明申请

US20030228995A1 Multiply-substituted protease variants with altered net charge for use in detergents 有权
公开(公告)号：US20030228995A1
公开(公告)日：2003-12-11
申请号：US10423649
申请日：2003-04-25
发明人： Ayrookaran J. Poulose , Volker Schellenberger , James T. Kellis JR. , Christian Paech , Joanne Nadherny , Donald P. Naki , Katherine D. Collier , Robert M. Caldwell
IPC分类号： C11D003/386 , C07H021/04 , A23B007/10 , C12N009/56 , C12N001/21 , C12P021/02 , C12N015/74
CPC分类号： A23G4/123 , A61K8/66 , A61K2800/86 , A61Q11/00 , C11D3/386 , C12N9/54 , C12Y304/21062
摘要： Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Protease variants are provided that contain substitutions of the amino acids at one or more residue positions so that the substitution alters the charge at that position to make the charge more negative or less positive compared to a precursor protease and thus the protease variant is more effective in a low detergent concentration system than a precursor protease. Also provided are protease variants containing substitutions of the amino acids at one or more residue positions so that the substitution alters the charge at that position to make the charge more positive or less negative compared to a precursor protease and thus the protease variant is more effective in a high detergent concentration system than a precursor protease. Protease variants are provided that contain substitutions of the amino acids at one or more residue positions so that the substitution alters the charge at that position to make the charge more negative or less positive compared to a precursor protease and thus the protease variant is more effective in a medium detergent concentration system than a precursor protease. Also provided are protease variants containing substitutions of the amino acids at one or more residue positions so that the substitution alters the charge at that position to make the charge more positive or less negative compared to a precursor protease and thus the protease variant is more effective in a medium detergent concentration system than a precursor protease. Further provided is a method of producing a protease variant that is more effective in a low detergent concentration system, medium detergent concentration system and high detergent concentration system than a precursor protease.

8. 发明申请

US20030186417A1 Amino acid sequence 审中-公开
标题翻译：氨基酸序列
公开(公告)号：US20030186417A1
公开(公告)日：2003-10-02
申请号：US10372947
申请日：2003-02-26
申请人： DANISCO A/S
发明人： Janne Brunstedt , Tove Martel Ida Else Christensen
IPC分类号： A23L001/05 , A23B007/10 , C07H021/04 , C12P019/00 , C12P019/04 , C12N009/16
CPC分类号： C12N9/18 , A23C9/1542 , A23L29/231 , C07K14/00 , C12Y301/01011
摘要： An amino acid sequence is described that affects PME activity. The amino acid has the formula (1): A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22nullnull(I)
摘要翻译：描述了影响PME活性的氨基酸序列。氨基酸具有式（1）：A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20- A21-A22（I）

9. 发明申请

US20030000234A1 Method for controlling operation of kimchi storage device 有权
公开(公告)号：US20030000234A1
公开(公告)日：2003-01-02
申请号：US10155431
申请日：2002-05-24
发明人： Wan-Suck Seo
IPC分类号： A23K001/00 , A23L001/22 , A23F003/00 , A23B007/10 , G05D023/32 , G01N033/02 , A01K043/00 , A01J011/00 , A23B004/00
CPC分类号： A23L3/001 , A23B7/00 , A23B7/10 , F25D2400/02 , G05D23/19
摘要： Disclosed is a method for controlling operation of a kimchi storage device. A compressor operates immediately if the condition to operate the compressor is met, and a heater operates after a predetermined time delay if the condition to operate the heater has been met, whereby the variation in the temperature of a storage chamber caused by the immediate sensing of low temperature and the operation of the heater thereby can be reduced, so the flavor and freshness of the kimchi can be enhanced.

10. 发明申请

US20040208956A1 Microorganism for biological detoxification of mycotoxins, namely ochratoxins and/or zearalenons, as well as method and use thereof 审中-公开
标题翻译：用于生物解毒真菌毒素的微生物，即赭曲霉毒素和/或玉米赤霉烯，以及其方法和用途
公开(公告)号：US20040208956A1
公开(公告)日：2004-10-21
申请号：US10843305
申请日：2004-05-12
发明人： Gerd Schatzmayr , Dian Heidler , Elisabeth Fuchs , Eva-Maria Binder
IPC分类号： A23B007/10 , C12N001/20 , C12N001/18
CPC分类号： A23K10/18 , A23L5/28 , A23L7/104 , A23L29/065 , C12N1/14 , C12N1/20
摘要： A microorganism for the biological inactivation or detoxification of mycotoxins, in particular ochratoxins, which is selected from bacteria and/or yeasts, which cleaves the phenylalanine group of the mycotoxins, in particular ochratoxins, as well as a method for biologically inactivating or detoxifying mycotoxins, in particular ochratoxins, in food products and animal feeds by the aid of a microorganism, and the use of the microorganism(s).
摘要翻译：一种微生物，用于生物灭活或解毒霉菌毒素，特别是赭曲霉毒素，其选自细菌和/或酵母，其切割真菌毒素的苯丙氨酸，特别是赭曲霉毒素，以及用于生物灭活或解毒真菌毒素的方法，特别是赭曲霉毒素，在微生物的帮助下在食品和动物饲料中，以及使用微生物。

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