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1. 发明专利

AU2001243342B2 Modulation of pleiotrophin signaling by receptor-type protein tyrosine phosphatase beta/zeta 未知
公开(公告)号：AU2001243342B2
公开(公告)日：2005-06-23
申请号：AU2001243342
申请日：2001-02-28
申请人： BARNES JEWISH HOSPITAL
发明人： DEUEL THOMAS
IPC分类号： C12N15/02 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P35/04 , C07K14/475 , C07K14/49 , C07K16/40 , C12N9/12 , C12N9/16 , C12Q1/42 , G01N33/574 , G01N33/74 , C12Q001/42 , C07K001/00 , C07H021/04 , C07H021/02 , C12N015/00 , C12N001/20 , C12N009/16 , C12N009/12 , C12P021/06
摘要： The mechanism by which pleiotrophin binds to the receptor protein tyrosine phosphatase beta/zeta(RPTP beta/zeta) is disclosed along with methods of modulating both pleiotrophin expression and signaling to treat, prevent and inhibit abnormal cell growth states. Specifically provided are methods of inhibiting tumor growth, promotion, metastasis, invasiveness and angiogenesis as well as methods of preventing or inhibiting cell adhesion.

2. 发明专利

AU2002320649B2 Methods for the Preparation of Retroviral Particles and Cell Lines Deficient in the Alpha-Galactosyl Epitope 未知
公开(公告)号：AU2002320649B2
公开(公告)日：2005-03-10
申请号：AU2002320649
申请日：2002-12-19
申请人： ALEXION PHARMA INC
发明人： SPRINGHORN JEREMY P , FODOR WILLIAM L , ROLLINS SCOTT A , ROTHER RUSSELL P
IPC分类号： A61K39/21 , C07H21/04 , C12P7/04 , C12P15/00 , C12P21/06 , C12P021/06 , A61K039/21 , C07H021/04

4. 发明专利

AU2001261771B2 In vitro evolution of nucleic acids and encoded polypeptide 未知
公开(公告)号：AU2001261771B2
公开(公告)日：2005-06-09
申请号：AU2001261771
申请日：2001-05-18
申请人： WILLIAMS RICHARD B
发明人： WILLIAMS RICHARD B
IPC分类号： G01N33/53 , C12N15/09 , C12N15/10 , C12Q1/68 , G01N33/566 , C12Q001/68 , C07H021/02 , C07H021/04 , C12P015/00 , C12P021/02 , C12P021/06 , C12Q001/70

5. 发明专利

AU2002211665B2 Human Ect2 and methods of use 未知
公开(公告)号：AU2002211665B2
公开(公告)日：2005-10-20
申请号：AU2002211665
申请日：2001-10-12
申请人： EXELIXIS INC
发明人： KEEGAN KEVIN PATRICK , MATTHEWS DAVID , JOLY ALISON , STOUT THOMAS J , OLLMANN MICHAEL MARTIN
IPC分类号： G01N33/50 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K014/00 , C12P021/06 , G01N033/53
摘要： Human Ect2 polypeptide, fragments and derivatives, along with vectors and host cells for expression and production of Ect2 polypeptide are provided. Various methods of screening for agents that modulate interaction of Ect2 with an Ect2 binding agent, including high throughput methods, are also provided.

6. 发明专利

AU2001275458B2 Chimeric human papillomavirus (HPV) L1 molecules and uses therefor 未知
公开(公告)号：AU2001275458B2
公开(公告)日：2004-08-19
申请号：AU2001275458
申请日：2001-06-12
申请人： MEDIMMUNE LLC
发明人： MULLIKIN BRIAN , SUZICH JOANN A , WHITE WENDY , WILSON SUSAN
IPC分类号： A61K39/00 , A61P31/12 , C07K14/025 , C07K16/08 , C12N7/04 , A61K039/12 , C12N007/00 , C12P021/06 , A61K039/00
摘要： Disclosed are chimeric HPV L1 proteins and virus like particles comprising the same which are capable of generating high titer neutralizing antibody responses against at least two HPV types. The disclosed chimeric HPV L1 proteins and VLPs are useful as therapeutic and prophylactic reagents, as well as reagents for diagnosing papillomavirus infection.

7. 发明申请

US20040265950A1 Process for natural recycling of protein waste 有权
标题翻译：蛋白质废物自然回收的工艺
公开(公告)号：US20040265950A1
公开(公告)日：2004-12-30
申请号：US10607690
申请日：2003-06-30
发明人： Jonathan Scott Darling , Don Scott Darling
IPC分类号： C12P021/06 , C12P013/04
CPC分类号： A23J1/10 , A23K10/14 , A23K10/26 , A23K40/20 , A23K40/25 , Y10S426/807
摘要： An apparatus and process for naturally recycling poultry carcasses for use as a nutritional supplement, the apparatus generally consists of four modules: an enzymatic digest medium mixing assembly that self adjusts for pH; a mobile grinding assembly mounted on a truck trailer; a digesting and emulsifying assembly which includes a heated tank and separator; and a drying system. Carcasses are loaded into the grinder, and the ground carcasses are pumped into a storage tank with the enzymatic digest medium to produce a protein soluble mixture. The particle size of this mixture is then further reduced, and transported to a centralized and stationary processing plant for digesting and emulsifying. The remaining emulsified proteins are then dried. The resulting pellet-like pieces are uniformly sized for packaging.
摘要翻译：用于自然回收用作营养补充剂的家禽屠体的装置和方法，该装置通常由四个模块组成：酶自动调节pH值的酶消化介质混合组件; 安装在卡车拖车上的移动研磨组件; 包括加热罐和分离器的消化乳化组件; 和干燥系统。将胴体装载到研磨机中，将研磨的胴体用酶消化介质泵送到储罐中以产生蛋白质可溶性混合物。然后将该混合物的粒径进一步降低，并运送到中央和固定的加工厂进行消化和乳化。然后将剩余的乳化蛋白质干燥。所得的颗粒状件的尺寸均匀以进行包装。

8. 发明申请

US20040259193A1 Regulation of target protein activity through modifier proteins 审中-公开
标题翻译：通过修饰蛋白调节靶蛋白活性
公开(公告)号：US20040259193A1
公开(公告)日：2004-12-23
申请号：US10723475
申请日：2003-11-25
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Svetlana A. Lyapina , Rati Verma , Raymond Deshaies , Greg Cope
IPC分类号： C12P021/06 , A61K038/48
CPC分类号： C12N9/16 , A61K38/00 , C07K14/705 , C12N9/48 , C12N9/6489 , C12Q1/37 , G01N2500/02
摘要： The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
摘要翻译：本发明基于以下发现：含有JAB亚基或JAM结构域的多肽具有肽酶活性，例如肽酶活性。本发明提供含有JAM结构域的多肽和结晶多肽以及使用这些多肽筛选能够影响多肽的肽酶活性的试剂的方法。本发明还提供了使用JAM结构域进行合理药物设计或鉴定能够影响JAM结构域的肽酶活性的试剂的方法。

9. 发明申请

US20040259150A1 Method of enhancing of binding activity of antibody composition to Fcgamma receptor IIIa 审中-公开
标题翻译：增强抗体组合物与Fcγ受体IIIa的结合活性的方法
公开(公告)号：US20040259150A1
公开(公告)日：2004-12-23
申请号：US10409611
申请日：2003-04-09
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Kazuyasu Nakamura , Kenya Shitara
IPC分类号： G01N033/53 , C12P021/06
CPC分类号： C12P21/02 , A61K39/395 , C07K16/22 , C07K16/283 , C07K16/2866 , C07K16/3084 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2319/30
摘要： A method for enhancing a binding activity of an antibody composition to Fcnull receptor IIIa, which comprises modifying a complex N-glycoside-linked sugar chain which is bound to the Fc region of an antibody molecule; a method for enhancing an antibody-dependent cell-mediated cytotoxic activity of an antibody composition; a process for producing an antibody composition having an enhanced binding activity to Fcnull receptor IIIa; a method for detecting the ratio of a sugar chain in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chain among total complex N-glycoside-linked sugar chains bound to the Fc region in an antibody composition; an Fc fusion protein composition produced by using a cell resistant to a lectin which recognizes a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through null-bond in a complex N-glycoside-linked sugar chain; and a process for producing the same.
摘要翻译：一种用于增强抗体组合物与Fcγ受体IIIa的结合活性的方法，其包括修饰与抗体分子的Fc区结合的复合N-糖苷连接的糖链; 用于增强抗体依赖性细胞介导的抗体组合物的细胞毒活性的方法; 制备对Fcγ受体IIIa具有增强的结合活性的抗体组合物的方法; 在抗体组合物中与Fc区结合的总复合N-糖苷连接的糖链中，检测糖链与还原末端中的岩藻糖不与N-乙酰葡糖胺结合的糖链的比例的方法; 通过使用对凝集素有抗性的细胞产生的Fc融合蛋白组合物，所述细胞通过复合N-糖苷中的α键识别糖链的1-位与还原末端的N-乙酰葡糖胺的6-位结合的糖链链糖链及其制造方法。

10. 发明申请

US20040241180A1 Notch 失效
标题翻译：缺口
公开(公告)号：US20040241180A1
公开(公告)日：2004-12-02
申请号：US10877563
申请日：2004-06-25
发明人： Jonathan Robert Lamb , Margaret Jane Dallman , Gerard Francis Hoyne
IPC分类号： A61K039/00 , C12P021/06 , C07K014/705 , C12N005/08
CPC分类号： C07K14/705 , A61K38/00 , A61K2039/5154 , C07K2319/00 , C12N2799/027 , G01N33/505 , Y02A50/412 , Y10S424/81
摘要： The present invention relates to the use of therapeutic compounds in the modification of T-cell, T-cell-antigen presenting cell (APC) interactions and the interactions between pathogenic organisms and immunocompetent cells of a host. In particular it relates to the use of these compounds in the modulation of the interaction between Notch proteins and their ligands and to the use of such compounds in the therapy of conditions such as graft rejection, autoimmunity, allergy, and asthma and infectious diseases.
摘要翻译：本发明涉及治疗性化合物在T细胞，T细胞抗原呈递细胞（APC）相互作用的修饰中的应用以及宿主的病原体和免疫活性细胞之间的相互作用。特别地，它涉及这些化合物在调节Notch蛋白质及其配体之间的相互作用以及在治疗诸如移植排斥反应，自身免疫，变态反应，哮喘和感染性疾病等病症中的用途。

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