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1. 发明申请

US20080125857A1 HEMOCOMPATIBLE POLYMERS ON HYDROPHOBIC POROUS POLYMERS 审中-公开
标题翻译：疏水性多孔聚合物的可溶性聚合物
公开(公告)号：US20080125857A1
公开(公告)日：2008-05-29
申请号：US12021195
申请日：2008-01-28
申请人： Wouter E. Roorda , Niraj Shah , Andre-Jean Lundkvist
发明人： Wouter E. Roorda , Niraj Shah , Andre-Jean Lundkvist
IPC分类号： A61F2/82
CPC分类号： A61L31/16 , A61L27/34 , A61L31/048 , A61L31/08 , A61L31/10 , A61L31/146 , A61L33/0011 , A61L2300/208 , A61L2300/236 , A61L2300/42 , C08L27/18
摘要： Various embodiments of the present invention provide a medical device comprising at least one blood-contacting surface comprising a porous hydrophobic polymer substrate, wherein at least a portion of the at least one blood-contacting surface comprises a hemocompatible polymer substrate. One embodiment of the present invention relates to the providing of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible substance is dissolved in a mixture of solvents in which a first solvent wets the polymer substrate to be coated and the second solvent enhances the solubility of the hemocompatible substance material in the solvent mixture. Typical first solvents wetting a hydrophobic polymer substrate include non-polar such as hydrocholorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation.
摘要翻译：本发明的各种实施方案提供了一种医疗装置，其包括至少一个包含多孔疏水性聚合物基质的血液接触表面，其中所述至少一个接触血液的表面的至少一部分包含血液相容的聚合物底物。本发明的一个实施方案涉及提供具有一种或多种肝素复合物的膨胀聚（四氟乙烯），其通常含有与疏水性抗衡离子组合的肝素。将溶血性物质溶解在其中第一溶剂润湿待涂覆的聚合物基质的溶剂混合物中，并且第二溶剂增强溶血混合物中血液相容性物质物质的溶解度。润湿疏水性聚合物基质的典型的第一种溶剂包括非极性的，如氢氯氟烃。典型的第二溶剂包括极性溶剂如有机醇和酮。在本发明的一些实施方案中使用第一溶剂中的第二溶剂的共沸混合物，尽管可以在小于0.1％至饱和的浓度范围内使用第二溶剂。

2. 发明授权

US07807210B1 Hemocompatible polymers on hydrophobic porous polymers 有权
标题翻译：疏水多孔聚合物上的血液相容性聚合物
公开(公告)号：US07807210B1
公开(公告)日：2010-10-05
申请号：US10818927
申请日：2004-04-05
申请人： Wouter E. Roorda , Niraj Shah , André-Jean Lundkvist
发明人： Wouter E. Roorda , Niraj Shah , André-Jean Lundkvist
IPC分类号： A61L33/00 , A61L33/10 , A61F2/06
CPC分类号： A61L31/16 , A61L27/34 , A61L31/048 , A61L31/08 , A61L31/10 , A61L31/146 , A61L33/0011 , A61L2300/208 , A61L2300/236 , A61L2300/42 , C08L27/18
摘要： The present invention relates to providing a porous, hydrophobic polymer with a hemocompatible substance and to the materials produced thereby. One embodiment of the present invention relates to the providing of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible substance is dissolved in a mixture of solvents in which a first solvent wets the polymer to be coated and the second solvent enhances the solubility of the hemocompatible substance material in the solvent mixture. Typical first solvents wetting hydrophobic polymers include non-polar such as hydrochlorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation. A typical example providing a heparin complex to an endoluminal stent, consisting of coating DURAFLO onto an ePTFE stent-covering material.
摘要翻译：本发明涉及提供具有血液相容性物质的多孔疏水性聚合物及其制备的材料。本发明的一个实施方案涉及提供具有一种或多种肝素复合物的膨胀聚（四氟乙烯），其通常含有与疏水性抗衡离子组合的肝素。将血液相容性物质溶解在其中第一溶剂润湿待涂覆的聚合物的溶剂混合物中，并且第二溶剂增强溶血混合物中血液相容性物质物质的溶解度。典型的第一溶剂润湿疏水性聚合物包括非极性如氢氯氟烃。典型的第二溶剂包括极性溶剂如有机醇和酮。在本发明的一些实施方案中使用第一溶剂中的第二溶剂的共沸混合物，尽管可以在小于0.1％至饱和的浓度范围内使用第二溶剂。向肝内支架提供肝素复合物的典型例子包括将DURAFLO涂覆在ePTFE支架覆盖材料上。

3. 发明授权

US06833153B1 Hemocompatible coatings on hydrophobic porous polymers 有权
标题翻译：疏水多孔聚合物上的血液相容性涂层
公开(公告)号：US06833153B1
公开(公告)日：2004-12-21
申请号：US09704212
申请日：2000-10-31
申请人： Wouter E. Roorda , Niraj Shah , Andrė-Jean Lundkvist
发明人： Wouter E. Roorda , Niraj Shah , Andrė-Jean Lundkvist
IPC分类号： B05D100
CPC分类号： A61L27/34 , A61L31/10
摘要： The present invention relates to coating a porous, hydrophobic polymer with a hemocompatible coating and to the materials produced thereby. One embodiment of the present invention relates to the coating of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible coating is dissolved in a mixture of solvents in which a first solvent wets the polymer to be coated and the second solvent enhances the solubility of the hemocompatible coating material in the solvent mixture. Typical first solvents wetting hydrophobic polymers include non-polar such as hydrocholorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation. An example is provided of coating heparin complex onto an endoluminal stent, typically consisting of coating DURAFLO onto an ePTFE stent covering material.
摘要翻译：本发明涉及用具有血液相容性涂层的多孔疏水性聚合物以及由此制备的材料。本发明的一个实施方案涉及用一种或多种肝素复合物涂覆膨胀的聚（四氟乙烯），其通常含有与疏水性抗衡离子组合的肝素。将血液相容性涂层溶解在其中第一溶剂润湿待涂覆的聚合物的溶剂混合物中，并且第二溶剂增强溶血混溶物中血液相容性涂料的溶解度。典型的第一溶剂润湿疏水性聚合物包括非极性如氢氯氟烃。典型的第二溶剂包括极性溶剂如有机醇和酮。在本发明的一些实施方案中使用第一溶剂中的第二溶剂的共沸混合物，尽管可以在小于0.1％至饱和的浓度范围内使用第二溶剂。提供了将肝素复合物涂覆在腔内支架上的实例，通常由将DURAFLO涂覆在ePTFE支架覆盖材料上。

4. 发明授权

US08852220B2 Thrombus penetrating devices, systems, and methods 有权
标题翻译：血栓穿透装置，系统和方法
公开(公告)号：US08852220B2
公开(公告)日：2014-10-07
申请号：US13227071
申请日：2011-09-07
申请人： Wouter E. Roorda , Aaron M. Fortson
发明人： Wouter E. Roorda , Aaron M. Fortson
IPC分类号： A61B17/22 , A61B17/3207 , A61B18/04 , A61B17/00
CPC分类号： A61B17/320725 , A61B18/04 , A61B2017/00867 , A61B2017/22094
摘要： A device for penetrating occlusive material in a body lumen is provided that may include an outer tube, an intermediate tube, and an inner tube. At least a portion of the intermediate tube may be moveably disposed within the outer tube. At least a portion of the inner tube may be moveably disposed within the intermediate tube. A first dynamic member may be operably connected to the intermediate tube and the inner tube. The first dynamic member may be configured to penetrate the occlusive material and to anchor the first dynamic member within the occlusive material. A second dynamic member may be operably connected to the outer tube and the intermediate tube. The second dynamic member may be configured to penetrate the occlusive material and to anchor the second dynamic member within the occlusive material and to support movement of the first dynamic member.
摘要翻译：提供一种用于穿透体腔内的封闭材料的装置，其可以包括外管，中间管和内管。中间管的至少一部分可以可移动地设置在外管内。内管的至少一部分可以可移动地设置在中间管内。第一动态构件可以可操作地连接到中间管和内管。第一动态构件可以构造成穿透封闭材料并将第一动态构件锚定在封闭材料内。第二动态构件可以可操作地连接到外管和中间管。第二动态构件可以构造成穿透封闭材料并将第二动态构件锚定在封闭材料内并且支撑第一动态构件的移动。

5. 发明申请

US20140074124A1 NEEDLE HARVESTING DEVICES, SYSTEMS AND METHODS 有权
标题翻译：针刺收集装置，系统和方法
公开(公告)号：US20140074124A1
公开(公告)日：2014-03-13
申请号：US13610602
申请日：2012-09-11
申请人： Laveille Kao Voss , Stephanie Henze , Kristopher M. Konawalik , Leah M. Davis , Wouter E. Roorda
发明人： Laveille Kao Voss , Stephanie Henze , Kristopher M. Konawalik , Leah M. Davis , Wouter E. Roorda
IPC分类号： A61B17/06 , A61B17/04
CPC分类号： A61B17/06161 , A61B17/0057 , A61B17/0469 , A61B17/0491 , A61B17/06061 , A61B17/062 , A61B50/3001 , A61B50/362 , A61B2017/00663 , A61B2017/047 , A61B2017/0472 , A61B2017/06142 , A61B2050/364 , A61B2090/0807 , A61M5/3278 , A61M2005/3284
摘要： A needle removal device is provided for removing needles from suturing devices and/or systems. In an embodiment, the needle removal device may be intended for use with a suturing device having one or more needle lumens. The needle removal device may include a first member having a first plurality of needle receptacles extending therethrough. The first needle receptacles may be configured and positioned to correspond to one or more of the one or more needle lumens of the suturing device. The needle removal device may also include a second member having a second plurality of needle receptacles extending therethrough. At least one of the first member or the second member may be moveable between a first position, wherein the first needle receptacles and the second needle receptacles are substantially aligned, and a second position, wherein the first needle receptacles and the second needle receptacles substantially unaligned.
摘要翻译：提供针去除装置用于从缝合装置和/或系统中去除针。在一个实施例中，针去除装置可以用于具有一个或多个针管的缝合装置。针去除装置可以包括具有延伸穿过其中的第一多个针插座的第一构件。可以将第一针插槽配置和定位成对应于缝合装置的一个或多个针管腔中的一个或多个。针去除装置还可以包括具有延伸穿过其中的第二多个针插座的第二构件。第一构件或第二构件中的至少一个可以在第一位置和第二位置之间移动，第一位置和第二针座基本上对准，其中第一针座和第二针座基本上对准，其中第一针座和第二针座基本上不对齐。

6. 发明授权

US08603116B2 Closure device with long tines 有权
标题翻译：闭合器具长齿
公开(公告)号：US08603116B2
公开(公告)日：2013-12-10
申请号：US12850242
申请日：2010-08-04
申请人： Wouter E. Roorda
发明人： Wouter E. Roorda
IPC分类号： A61B17/08 , A61D1/00
CPC分类号： A61B17/064 , A61B2017/00668 , A61B2017/0641
摘要： A device for engaging tissue may include a generally annular-shaped body defining a plane and disposed about a central axis extending substantially normal to the plane. The body may be movable from a substantially planar configuration lying generally in the plane towards a transverse configuration extending out of the plane. The body may include a plurality of looped elements including alternating inner and outer curved regions. The inner curved regions may define an inner periphery of the body and the outer curved regions may define an outer periphery of the body in the planar configuration. A plurality of tines may extend from the outer curved regions. The tines may be oriented generally towards the central axis in the planar configuration and generally parallel to the central axis in the transverse configuration. The tines may extend beyond the central axis without passing through the central axis so as to collectively form a central lumen about the central axis in the planar configuration.
摘要翻译：用于接合组织的装置可以包括限定平面的大致环形的主体，并围绕基本上垂直于该平面延伸的中心轴设置。主体可以从通常在平面中的基本上平面的构造移动到横向延伸出平面的横向构型。主体可以包括多个环形元件，包括交替的内部和外部弯曲区域。内弯曲区域可以限定主体的内周边，并且外弯曲区域可以在平面构型中限定主体的外周。多个齿可以从外部弯曲区域延伸。尖齿可以在平面构造中大致朝向中心轴定向，并且在横向构型中大致平行于中心轴线。齿可以延伸超过中心轴线而不穿过中心轴线，以便在平面构型中围绕中心轴线共同形成中心腔。

7. 发明申请

US20110311632A1 STABLE CHITOSAN HEMOSTATIC EXTERNAL PATCH AND METHODS OF MANUFACTURE 审中-公开
标题翻译：稳定的CHITOSAN HEMOSTATIC EXTERNAL PATCH AND METHODS OF MANUFACTURE
公开(公告)号：US20110311632A1
公开(公告)日：2011-12-22
申请号：US12817005
申请日：2010-06-16
申请人： Wouter E. Roorda , Jill A. McCoy , Laveille Kao Voss , Richard Seto
发明人： Wouter E. Roorda , Jill A. McCoy , Laveille Kao Voss , Richard Seto
IPC分类号： A61K31/722 , B32B37/02 , B32B37/10 , A61K9/14 , A61P17/02
CPC分类号： A61K31/722 , Y10T156/10
摘要： Hemostatic products with improved stability are prepared from crosslinked chitosan hemostatic compositions. The crosslinked chitosan hemostatic compositions have improved stability and can be prepared into a variety of medical devices in various shapes and sizes so as to be usable for inhibiting blood flow and ooze from substantially any type of bleeding site. For example, the chitosan compositions can be prepared into hemostatic gauze pads, bandages, wrappings, wound dressings, wound coverings, wound dressings, incision dressings, sealers, sheets, rolls, combinations thereof, and the like.
摘要翻译：具有改善的稳定性的止血产品由交联的壳聚糖止血组合物制备。交联的壳聚糖止血组合物具有改进的稳定性，并且可以制备成各种形状和尺寸的各种医疗装置，以便可用于抑制基本上任何类型的出血部位的血液流动和渗出。例如，可以将壳聚糖组合物制备成止血纱布垫，绷带，包衣，伤口敷料，伤口覆盖物，伤口敷料，切口敷料，密封剂，片材，卷筒及其组合等。

8. 发明申请

US20110311608A1 STABLE CHITOSAN HEMOSTATIC IMPLANT AND METHODS OF MANUFACTURE 失效
标题翻译：稳定的CHITOSAN HEMOSTATIC IMPLANT AND METHODS OF MANUFACTURE
公开(公告)号：US20110311608A1
公开(公告)日：2011-12-22
申请号：US12816997
申请日：2010-06-16
申请人： Wouter E. Roorda , Jill A. McCoy , Richard Seto , Eugene T. Michal
发明人： Wouter E. Roorda , Jill A. McCoy , Richard Seto , Eugene T. Michal
IPC分类号： A61K9/00 , A61K9/14 , A61P17/02 , A61K31/722
CPC分类号： A61K31/738 , A61L15/28 , A61L24/0021 , A61L24/08 , A61L26/0023 , A61L26/0071 , A61L27/20 , A61L2400/04 , C08L5/08
摘要： Implantable hemostatic products with improved stability are prepared from crosslinked chitosan hemostatic compositions. The crosslinked chitosan hemostatic compositions have improved stability and can be prepared into a variety of implantable medical devices in various shapes and sizes so as to be usable for inhibiting blood flow and ooze from substantially any type of internal bleeding site. For example, the chitosan compositions can be prepared into hemostatic gauze pads, bandages, dressings, wound plugs, incision plugs, arteriotomy plugs, tissue fillers, sealers, sheets, rolls, combinations thereof, and the like.
摘要翻译：由交联的壳聚糖止血组合物制备具有改善的稳定性的植入式止血产品。交联的壳聚糖止血组合物具有改进的稳定性，并且可以制备成各种形状和尺寸的各种可植入医疗装置，以便可用于抑制基本上任何类型的内部出血部位的血液流动和渗出。例如，可以将壳聚糖组合物制备成止血纱布垫，绷带，敷料，伤口塞，切口塞，动脉切断术栓塞，组织填充剂，密封剂，片材，卷筒及其组合等。

9. 发明授权

US07014861B2 Permeabilizing reagents to increase drug delivery and a method of local delivery 失效
公开(公告)号：US07014861B2
公开(公告)日：2006-03-21
申请号：US10693047
申请日：2003-10-24
申请人： Wouter E. Roorda , Vinayak D. Bhat , Paul M. Consigny
发明人： Wouter E. Roorda , Vinayak D. Bhat , Paul M. Consigny
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0067 , A61L2300/606
摘要： A composition and a method for increasing the permeability of membrane junctions or cell membranes for delivery of a drug to target tissues are disclosed. Also disclosed are methods and devices for local drug delivery.

10. 发明授权

US06544543B1 Periodic constriction of vessels to treat ischemic tissue 失效
标题翻译：定期收缩血管以治疗缺血组织
公开(公告)号：US06544543B1
公开(公告)日：2003-04-08
申请号：US09752399
申请日：2000-12-27
申请人： Evgenia Mandrusov , Christopher J. Buchko , Wouter E. Roorda
发明人： Evgenia Mandrusov , Christopher J. Buchko , Wouter E. Roorda
IPC分类号： A61F1300
CPC分类号： B82Y5/00 , A61F2/82 , A61F2250/0068 , A61K9/0009 , A61K9/1271 , A61K9/1647 , A61K9/1658 , A61K47/643 , A61K47/665 , A61K47/6911 , A61K47/6925 , A61L24/0015 , A61L24/0031 , A61L27/34 , A61L27/52 , A61L27/54 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/40 , A61L2300/622 , A61M37/0092
摘要： Brief periods of occlusion of blood flow in an otherwise open target vessel adjacent to vessels supplying blood to an ischemic region are caused by periodic administration of a therapeutically effective amount of a vasoconstrictor. It is anticipated these brief periods of occlusion will induce the enlargement of collateral vessels, causing increased blood flow to the ischemic region.
摘要翻译：通过定期施用治疗有效量的血管收缩剂引起在与供血到缺血区域的血管相邻的另外开放的目标血管中血流阻塞的简单时期。预计这些短暂的闭塞期将导致侧支血管扩大，导致血液流向缺血区域。

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