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1. 发明授权

US06663880B1 Permeabilizing reagents to increase drug delivery and a method of local delivery 有权
标题翻译：渗透力试剂以增加药物输送和局部递送的方法
公开(公告)号：US06663880B1
公开(公告)日：2003-12-16
申请号：US09997706
申请日：2001-11-30
申请人： Wouter E. Roorda , Vinayak D. Bhat , Paul M. Consigny
发明人： Wouter E. Roorda , Vinayak D. Bhat , Paul M. Consigny
IPC分类号： A61F202
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0067 , A61L2300/606
摘要： A composition and a method for increasing the permeability of membrane junctions or cell membranes for delivery of a drug to target tissues are disclosed. Also disclosed are methods and devices for local drug delivery.
摘要翻译：公开了用于增加用于将药物递送至靶组织的膜结或细胞膜的渗透性的组合物和方法。还公开了用于局部药物递送的方法和装置。

2. 发明授权

US07014861B2 Permeabilizing reagents to increase drug delivery and a method of local delivery 失效
公开(公告)号：US07014861B2
公开(公告)日：2006-03-21
申请号：US10693047
申请日：2003-10-24
申请人： Wouter E. Roorda , Vinayak D. Bhat , Paul M. Consigny
发明人： Wouter E. Roorda , Vinayak D. Bhat , Paul M. Consigny
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0067 , A61L2300/606
摘要： A composition and a method for increasing the permeability of membrane junctions or cell membranes for delivery of a drug to target tissues are disclosed. Also disclosed are methods and devices for local drug delivery.

3. 发明授权

US07651695B2 Medicated stents for the treatment of vascular disease 失效
标题翻译：用于治疗血管疾病的药物支架
公开(公告)号：US07651695B2
公开(公告)日：2010-01-26
申请号：US09860384
申请日：2001-05-18
申请人： Wouter E. Roorda , Vinayak D. Bhat , Steven L. Mouw , Syed F. A. Hossainy , Steven Z. Wu , Deborra Sanders Millare
发明人： Wouter E. Roorda , Vinayak D. Bhat , Steven L. Mouw , Syed F. A. Hossainy , Steven Z. Wu , Deborra Sanders Millare
IPC分类号： A61F2/00 , A61F2/06
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/606 , C08L29/04
摘要： The invention provides bioactive compositions and methods of delivery for ameliorating a vascular diseased state, particularly for the management of stenosis or restenosis following a vascular trauma or disease.
摘要翻译：本发明提供用于改善血管疾病状态的生物活性组合物和递送方法，特别是用于在血管创伤或疾病之后管理狭窄或再狭窄。

4. 发明授权

US06706013B1 Variable length drug delivery catheter 有权
标题翻译：可变长度药物输送导管
公开(公告)号：US06706013B1
公开(公告)日：2004-03-16
申请号：US09896328
申请日：2001-06-29
申请人： Vinayak D. Bhat , Steven B. Choi , Paul M. Consigny , Syed F. A. Hossainy
发明人： Vinayak D. Bhat , Steven B. Choi , Paul M. Consigny , Syed F. A. Hossainy
IPC分类号： A61M2900
CPC分类号： A61M25/1011 , A61M2025/1015 , A61M2025/1068
摘要： A catheter for insertion in a physiological lumen is provided which includes two balloons, wherein the distance between the balloons can be adjusted. The catheter can be used for the delivery of a therapeutic substance for the treatment of conditions such as restenosis.
摘要翻译：提供用于插入生理腔的导管，其包括两个气囊，其中可以调节气囊之间的距离。导管可用于递送用于治疗诸如再狭窄的病症的治疗物质。

5. 发明授权

US09937280B2 Luminal prostheses and methods for coating thereof 有权
公开(公告)号：US09937280B2
公开(公告)日：2018-04-10
申请号：US12426598
申请日：2009-04-20
申请人： John Yan , Howard Huang , Vinayak D. Bhat
发明人： John Yan , Howard Huang , Vinayak D. Bhat
IPC分类号： A61F2/86 , A61L27/34 , A61F2/91 , A61F2/915 , A61L27/54 , A61L29/08 , A61L29/16
CPC分类号： A61L27/34 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2230/0054 , A61F2250/0067 , A61L27/54 , A61L29/085 , A61L29/16 , A61L2300/606 , A61L2430/16
摘要： Luminal prostheses comprise scaffolds having coatings adhered to at least a portion of their outer surfaces. The surfaces are modified to enhance binding of the coatings. For example, the surfaces may be microblasted, laser treated, chemically etched, exposed to plasma, or exposed to a corona discharge, allowing a polymeric coating to adhere to the scaffold more tightly than in the absence of the surface modification. The coatings can be used to deliver therapeutic or other agents dispersed therein.

6. 发明申请

US20110097364A1 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 审中-公开
标题翻译： MACROCYCLIC LACTONE化合物及其使用方法
公开(公告)号：US20110097364A1
公开(公告)日：2011-04-28
申请号：US12959153
申请日：2010-12-02
申请人： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
发明人： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
IPC分类号： A61K31/436 , A61K9/00 , A61K31/675 , A61P35/00 , A61P37/06 , A61P31/10 , A61M31/00
CPC分类号： A61K31/787 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6 and R8 are each independently a member selected from the group consisting of H, C1-6 alkyl and OH; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites and prodrugs thereof.
摘要翻译：本发明提供包含药学上可接受的赋形剂和下式化合物的药物组合物：其中R 1，R 2，R 3，R 5，R 6和R 8各自独立地选自H，C 1-6烷基和OH ; R 4，R 7和R 9各自独立地选自C 1-6烷氧基和OH; R 10是选自H，-OH，-OP（O）Me 2，-O-（CH 2）n -OH和-O-（CH 2）m -O-（CH 2）o -CH 3的成员，其中下标n和m各自独立地为2至8，下标o为1至6; L1和L4中的每一个独立地选自以下各项：L2和L3各自独立地选自：和其盐，水合物，异构体，代谢物和前药。

7. 发明申请

US20090228094A1 LUMINAL PROSTHESES AND METHODS FOR COATING THEREOF 有权
标题翻译：发光材料及其涂层方法
公开(公告)号：US20090228094A1
公开(公告)日：2009-09-10
申请号：US12426598
申请日：2009-04-20
申请人： John Yan , Howard Huang , Vinayak D. Bhat
发明人： John Yan , Howard Huang , Vinayak D. Bhat
IPC分类号： A61F2/06
CPC分类号： A61L27/34 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2230/0054 , A61F2250/0067 , A61L27/54 , A61L29/085 , A61L29/16 , A61L2300/606 , A61L2430/16
摘要： Luminal prostheses comprise scaffolds having coatings adhered to at least a portion of their outer surfaces. The surfaces are modified to enhance binding of the coatings. For example, the surfaces may be microblasted, laser treated, chemically etched, exposed to plasma, or exposed to a corona discharge, allowing a polymeric coating to adhere to the scaffold more tightly than in the absence of the surface modification. The coatings can be used to deliver therapeutic or other agents dispersed therein.
摘要翻译：假体假体包括具有粘附在其外表面的至少一部分上的涂层的支架。修饰表面以增强涂层的粘结。例如，表面可以被微粉碎，激光处理，化学蚀刻，暴露于等离子体，或暴露于电晕放电，使得聚合物涂层比没有表面改性更牢固地粘附到支架上。涂层可用于递送分散在其中的治疗剂或其它试剂。

8. 发明授权

US06625486B2 Method and apparatus for intracellular delivery of an agent 有权
公开(公告)号：US06625486B2
公开(公告)日：2003-09-23
申请号：US09833149
申请日：2001-04-11
申请人： Andre-Jean S. Lundkvist , Elisa J. Aldridge , Vinayak D. Bhat , Renee C. Slater
发明人： Andre-Jean S. Lundkvist , Elisa J. Aldridge , Vinayak D. Bhat , Renee C. Slater
IPC分类号： A61N130
CPC分类号： A61N1/325 , A61M2025/0087 , A61N1/306
摘要： A method and an apparatus for electropermeabilization-mediated intracellular delivery of an agent are provided.

9. 发明授权

US07709019B2 Method for treatment directed to agent retention in biological tissues 失效
标题翻译：用于治疗生物组织中药物滞留的方法
公开(公告)号：US07709019B2
公开(公告)日：2010-05-04
申请号：US10777444
申请日：2004-02-11
申请人： Vinayak D. Bhat
发明人： Vinayak D. Bhat
IPC分类号： A61F2/02
CPC分类号： A61K47/34 , A61L31/16 , A61L2300/40 , A61L2300/604
摘要： An increase in agent residence time at a tissue site is provided for by the presence of a barrier. The barrier is a separate entity from the agent when introduced to the tissue. A binding member is included in the barrier for coupling the barrier to the surface of the tissue. In one embodiment, agent is introduced to the tissue prior to attachment of the barrier to the tissue. In another embodiment, agent is presented after the barrier is positioned on the tissue surface. A delivery vehicle may be used to administer the agent and barrier to a patient.
摘要翻译：通过存在屏障提供了在组织部位的药剂停留时间的增加。当导入组织时，屏障是与药剂分开的实体。在屏障中包括粘合构件，用于将屏障耦合到组织的表面。在一个实施方案中，在将屏障附着到组织之前将试剂引入组织。在另一个实施方案中，在屏障定位在组织表面上之后呈现试剂。递送载体可以用于给患者施用药剂和屏障。

10. 发明申请

US20080234309A1 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 有权
标题翻译： MACROCYCLIC LACTONE化合物及其使用方法
公开(公告)号：US20080234309A1
公开(公告)日：2008-09-25
申请号：US12046024
申请日：2008-03-11
申请人： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
发明人： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
IPC分类号： A61K31/4525 , A61P27/02 , C07D491/052
CPC分类号： A61K31/436 , A61K9/0004 , A61K31/439 , A61K31/4525 , A61K45/06
摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.
摘要翻译：本发明提供一种药物组合物，其包含药学上可接受的赋形剂和下式化合物：其中R 1，R 2，R 3， R 5，R 6，R 8，M 1，M 2， M 3，M 4，M 5，M 6和M 7均为各自独立地是选自H，C 1-6烷基，OH和C 1-6 1-6羟基烷基的成员; R 4，R 7和R 9各自独立地选自C 1-6 - 烷氧基和OH; R 10是选自H，-OH，-OP（O）Me 2，-O - （CH 2/2）， OH）和-O-（CH 2 CH 2）m -O - （CH 2 CH 2）其中下标n和m各自独立地为2至8，下标o为1至6; L 1和L 4中的每一个独立地选自：其中每个M 8独立地是选自以下的成员：的C 1-6烷基，OH和C 1-6烷基羟基烷基; L 2和L 3中的每一个独立地选自：其盐，水合物，异构体，代谢物，N-氧化物和前药。

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