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1. 发明授权

US07807210B1 Hemocompatible polymers on hydrophobic porous polymers 有权
标题翻译：疏水多孔聚合物上的血液相容性聚合物
公开(公告)号：US07807210B1
公开(公告)日：2010-10-05
申请号：US10818927
申请日：2004-04-05
申请人： Wouter E. Roorda , Niraj Shah , André-Jean Lundkvist
发明人： Wouter E. Roorda , Niraj Shah , André-Jean Lundkvist
IPC分类号： A61L33/00 , A61L33/10 , A61F2/06
CPC分类号： A61L31/16 , A61L27/34 , A61L31/048 , A61L31/08 , A61L31/10 , A61L31/146 , A61L33/0011 , A61L2300/208 , A61L2300/236 , A61L2300/42 , C08L27/18
摘要： The present invention relates to providing a porous, hydrophobic polymer with a hemocompatible substance and to the materials produced thereby. One embodiment of the present invention relates to the providing of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible substance is dissolved in a mixture of solvents in which a first solvent wets the polymer to be coated and the second solvent enhances the solubility of the hemocompatible substance material in the solvent mixture. Typical first solvents wetting hydrophobic polymers include non-polar such as hydrochlorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation. A typical example providing a heparin complex to an endoluminal stent, consisting of coating DURAFLO onto an ePTFE stent-covering material.
摘要翻译：本发明涉及提供具有血液相容性物质的多孔疏水性聚合物及其制备的材料。本发明的一个实施方案涉及提供具有一种或多种肝素复合物的膨胀聚（四氟乙烯），其通常含有与疏水性抗衡离子组合的肝素。将血液相容性物质溶解在其中第一溶剂润湿待涂覆的聚合物的溶剂混合物中，并且第二溶剂增强溶血混合物中血液相容性物质物质的溶解度。典型的第一溶剂润湿疏水性聚合物包括非极性如氢氯氟烃。典型的第二溶剂包括极性溶剂如有机醇和酮。在本发明的一些实施方案中使用第一溶剂中的第二溶剂的共沸混合物，尽管可以在小于0.1％至饱和的浓度范围内使用第二溶剂。向肝内支架提供肝素复合物的典型例子包括将DURAFLO涂覆在ePTFE支架覆盖材料上。

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