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1. 发明申请

US20080125857A1 HEMOCOMPATIBLE POLYMERS ON HYDROPHOBIC POROUS POLYMERS 审中-公开
标题翻译：疏水性多孔聚合物的可溶性聚合物
公开(公告)号：US20080125857A1
公开(公告)日：2008-05-29
申请号：US12021195
申请日：2008-01-28
申请人： Wouter E. Roorda , Niraj Shah , Andre-Jean Lundkvist
发明人： Wouter E. Roorda , Niraj Shah , Andre-Jean Lundkvist
IPC分类号： A61F2/82
CPC分类号： A61L31/16 , A61L27/34 , A61L31/048 , A61L31/08 , A61L31/10 , A61L31/146 , A61L33/0011 , A61L2300/208 , A61L2300/236 , A61L2300/42 , C08L27/18
摘要： Various embodiments of the present invention provide a medical device comprising at least one blood-contacting surface comprising a porous hydrophobic polymer substrate, wherein at least a portion of the at least one blood-contacting surface comprises a hemocompatible polymer substrate. One embodiment of the present invention relates to the providing of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible substance is dissolved in a mixture of solvents in which a first solvent wets the polymer substrate to be coated and the second solvent enhances the solubility of the hemocompatible substance material in the solvent mixture. Typical first solvents wetting a hydrophobic polymer substrate include non-polar such as hydrocholorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation.
摘要翻译：本发明的各种实施方案提供了一种医疗装置，其包括至少一个包含多孔疏水性聚合物基质的血液接触表面，其中所述至少一个接触血液的表面的至少一部分包含血液相容的聚合物底物。本发明的一个实施方案涉及提供具有一种或多种肝素复合物的膨胀聚（四氟乙烯），其通常含有与疏水性抗衡离子组合的肝素。将溶血性物质溶解在其中第一溶剂润湿待涂覆的聚合物基质的溶剂混合物中，并且第二溶剂增强溶血混合物中血液相容性物质物质的溶解度。润湿疏水性聚合物基质的典型的第一种溶剂包括非极性的，如氢氯氟烃。典型的第二溶剂包括极性溶剂如有机醇和酮。在本发明的一些实施方案中使用第一溶剂中的第二溶剂的共沸混合物，尽管可以在小于0.1％至饱和的浓度范围内使用第二溶剂。

2. 发明申请

US20080132592A1 HEMOCOMPATIBLE POLYMERS ON HYDROPHOBIC POROUS POLYMERS 审中-公开
标题翻译：疏水性多孔聚合物的可溶性聚合物
公开(公告)号：US20080132592A1
公开(公告)日：2008-06-05
申请号：US12021199
申请日：2008-01-28
申请人： WOUTER E. ROORDA , Niraj Shah , Andre-Jean Lundkvist
发明人： WOUTER E. ROORDA , Niraj Shah , Andre-Jean Lundkvist
IPC分类号： A61L27/56 , A61L27/16
CPC分类号： A61L31/16 , A61L27/34 , A61L31/048 , A61L31/08 , A61L31/10 , A61L31/146 , A61L33/0011 , A61L2300/208 , A61L2300/236 , A61L2300/42 , C08L27/18
摘要： The present invention relates to providing a porous, hydrophobic polymer substrate with a hemocompatible substance. One embodiment of the present invention relates to the providing of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible substance is dissolved in a mixture of solvents in which a first solvent wets the polymer substrate to be coated and the second solvent enhances the solubility of the hemocompatible substance material in the solvent mixture. Typical first solvents wetting a hydrophobic polymer substrate include non-polar such as hydrocholorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation.
摘要翻译：本发明涉及提供具有血液相容性物质的多孔疏水聚合物底物。本发明的一个实施方案涉及提供具有一种或多种肝素复合物的膨胀聚（四氟乙烯），其通常含有与疏水性抗衡离子组合的肝素。将溶血性物质溶解在其中第一溶剂润湿待涂覆的聚合物基质的溶剂混合物中，并且第二溶剂增强溶血混合物中血液相容性物质物质的溶解度。润湿疏水性聚合物基质的典型的第一种溶剂包括非极性的，如氢氯氟烃。典型的第二溶剂包括极性溶剂如有机醇和酮。在本发明的一些实施方案中使用第一溶剂中的第二溶剂的共沸混合物，尽管可以在小于0.1％至饱和的浓度范围内使用第二溶剂。

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