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1. 发明授权

US06833153B1 Hemocompatible coatings on hydrophobic porous polymers 有权
标题翻译：疏水多孔聚合物上的血液相容性涂层
公开(公告)号：US06833153B1
公开(公告)日：2004-12-21
申请号：US09704212
申请日：2000-10-31
申请人： Wouter E. Roorda , Niraj Shah , Andrė-Jean Lundkvist
发明人： Wouter E. Roorda , Niraj Shah , Andrė-Jean Lundkvist
IPC分类号： B05D100
CPC分类号： A61L27/34 , A61L31/10
摘要： The present invention relates to coating a porous, hydrophobic polymer with a hemocompatible coating and to the materials produced thereby. One embodiment of the present invention relates to the coating of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible coating is dissolved in a mixture of solvents in which a first solvent wets the polymer to be coated and the second solvent enhances the solubility of the hemocompatible coating material in the solvent mixture. Typical first solvents wetting hydrophobic polymers include non-polar such as hydrocholorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation. An example is provided of coating heparin complex onto an endoluminal stent, typically consisting of coating DURAFLO onto an ePTFE stent covering material.
摘要翻译：本发明涉及用具有血液相容性涂层的多孔疏水性聚合物以及由此制备的材料。本发明的一个实施方案涉及用一种或多种肝素复合物涂覆膨胀的聚（四氟乙烯），其通常含有与疏水性抗衡离子组合的肝素。将血液相容性涂层溶解在其中第一溶剂润湿待涂覆的聚合物的溶剂混合物中，并且第二溶剂增强溶血混溶物中血液相容性涂料的溶解度。典型的第一溶剂润湿疏水性聚合物包括非极性如氢氯氟烃。典型的第二溶剂包括极性溶剂如有机醇和酮。在本发明的一些实施方案中使用第一溶剂中的第二溶剂的共沸混合物，尽管可以在小于0.1％至饱和的浓度范围内使用第二溶剂。提供了将肝素复合物涂覆在腔内支架上的实例，通常由将DURAFLO涂覆在ePTFE支架覆盖材料上。

2. 发明授权

US07807210B1 Hemocompatible polymers on hydrophobic porous polymers 有权
标题翻译：疏水多孔聚合物上的血液相容性聚合物
公开(公告)号：US07807210B1
公开(公告)日：2010-10-05
申请号：US10818927
申请日：2004-04-05
申请人： Wouter E. Roorda , Niraj Shah , André-Jean Lundkvist
发明人： Wouter E. Roorda , Niraj Shah , André-Jean Lundkvist
IPC分类号： A61L33/00 , A61L33/10 , A61F2/06
CPC分类号： A61L31/16 , A61L27/34 , A61L31/048 , A61L31/08 , A61L31/10 , A61L31/146 , A61L33/0011 , A61L2300/208 , A61L2300/236 , A61L2300/42 , C08L27/18
摘要： The present invention relates to providing a porous, hydrophobic polymer with a hemocompatible substance and to the materials produced thereby. One embodiment of the present invention relates to the providing of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible substance is dissolved in a mixture of solvents in which a first solvent wets the polymer to be coated and the second solvent enhances the solubility of the hemocompatible substance material in the solvent mixture. Typical first solvents wetting hydrophobic polymers include non-polar such as hydrochlorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation. A typical example providing a heparin complex to an endoluminal stent, consisting of coating DURAFLO onto an ePTFE stent-covering material.
摘要翻译：本发明涉及提供具有血液相容性物质的多孔疏水性聚合物及其制备的材料。本发明的一个实施方案涉及提供具有一种或多种肝素复合物的膨胀聚（四氟乙烯），其通常含有与疏水性抗衡离子组合的肝素。将血液相容性物质溶解在其中第一溶剂润湿待涂覆的聚合物的溶剂混合物中，并且第二溶剂增强溶血混合物中血液相容性物质物质的溶解度。典型的第一溶剂润湿疏水性聚合物包括非极性如氢氯氟烃。典型的第二溶剂包括极性溶剂如有机醇和酮。在本发明的一些实施方案中使用第一溶剂中的第二溶剂的共沸混合物，尽管可以在小于0.1％至饱和的浓度范围内使用第二溶剂。向肝内支架提供肝素复合物的典型例子包括将DURAFLO涂覆在ePTFE支架覆盖材料上。

3. 发明申请

US20080125857A1 HEMOCOMPATIBLE POLYMERS ON HYDROPHOBIC POROUS POLYMERS 审中-公开
标题翻译：疏水性多孔聚合物的可溶性聚合物
公开(公告)号：US20080125857A1
公开(公告)日：2008-05-29
申请号：US12021195
申请日：2008-01-28
申请人： Wouter E. Roorda , Niraj Shah , Andre-Jean Lundkvist
发明人： Wouter E. Roorda , Niraj Shah , Andre-Jean Lundkvist
IPC分类号： A61F2/82
CPC分类号： A61L31/16 , A61L27/34 , A61L31/048 , A61L31/08 , A61L31/10 , A61L31/146 , A61L33/0011 , A61L2300/208 , A61L2300/236 , A61L2300/42 , C08L27/18
摘要： Various embodiments of the present invention provide a medical device comprising at least one blood-contacting surface comprising a porous hydrophobic polymer substrate, wherein at least a portion of the at least one blood-contacting surface comprises a hemocompatible polymer substrate. One embodiment of the present invention relates to the providing of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible substance is dissolved in a mixture of solvents in which a first solvent wets the polymer substrate to be coated and the second solvent enhances the solubility of the hemocompatible substance material in the solvent mixture. Typical first solvents wetting a hydrophobic polymer substrate include non-polar such as hydrocholorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation.
摘要翻译：本发明的各种实施方案提供了一种医疗装置，其包括至少一个包含多孔疏水性聚合物基质的血液接触表面，其中所述至少一个接触血液的表面的至少一部分包含血液相容的聚合物底物。本发明的一个实施方案涉及提供具有一种或多种肝素复合物的膨胀聚（四氟乙烯），其通常含有与疏水性抗衡离子组合的肝素。将溶血性物质溶解在其中第一溶剂润湿待涂覆的聚合物基质的溶剂混合物中，并且第二溶剂增强溶血混合物中血液相容性物质物质的溶解度。润湿疏水性聚合物基质的典型的第一种溶剂包括非极性的，如氢氯氟烃。典型的第二溶剂包括极性溶剂如有机醇和酮。在本发明的一些实施方案中使用第一溶剂中的第二溶剂的共沸混合物，尽管可以在小于0.1％至饱和的浓度范围内使用第二溶剂。

4. 发明申请

US20080132592A1 HEMOCOMPATIBLE POLYMERS ON HYDROPHOBIC POROUS POLYMERS 审中-公开
标题翻译：疏水性多孔聚合物的可溶性聚合物
公开(公告)号：US20080132592A1
公开(公告)日：2008-06-05
申请号：US12021199
申请日：2008-01-28
申请人： WOUTER E. ROORDA , Niraj Shah , Andre-Jean Lundkvist
发明人： WOUTER E. ROORDA , Niraj Shah , Andre-Jean Lundkvist
IPC分类号： A61L27/56 , A61L27/16
CPC分类号： A61L31/16 , A61L27/34 , A61L31/048 , A61L31/08 , A61L31/10 , A61L31/146 , A61L33/0011 , A61L2300/208 , A61L2300/236 , A61L2300/42 , C08L27/18
摘要： The present invention relates to providing a porous, hydrophobic polymer substrate with a hemocompatible substance. One embodiment of the present invention relates to the providing of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible substance is dissolved in a mixture of solvents in which a first solvent wets the polymer substrate to be coated and the second solvent enhances the solubility of the hemocompatible substance material in the solvent mixture. Typical first solvents wetting a hydrophobic polymer substrate include non-polar such as hydrocholorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation.
摘要翻译：本发明涉及提供具有血液相容性物质的多孔疏水聚合物底物。本发明的一个实施方案涉及提供具有一种或多种肝素复合物的膨胀聚（四氟乙烯），其通常含有与疏水性抗衡离子组合的肝素。将溶血性物质溶解在其中第一溶剂润湿待涂覆的聚合物基质的溶剂混合物中，并且第二溶剂增强溶血混合物中血液相容性物质物质的溶解度。润湿疏水性聚合物基质的典型的第一种溶剂包括非极性的，如氢氯氟烃。典型的第二溶剂包括极性溶剂如有机醇和酮。在本发明的一些实施方案中使用第一溶剂中的第二溶剂的共沸混合物，尽管可以在小于0.1％至饱和的浓度范围内使用第二溶剂。

5. 发明申请

US20060248021A1 Verification system using public records 审中-公开
标题翻译：使用公开记录的验证系统
公开(公告)号：US20060248021A1
公开(公告)日：2006-11-02
申请号：US11285748
申请日：2005-11-22
申请人： Naveen Jain , John Arnold , Kevin Marcus , Niraj Shah
发明人： Naveen Jain , John Arnold , Kevin Marcus , Niraj Shah
IPC分类号： G06Q99/00
CPC分类号： G06Q10/10 , G06Q20/401
摘要： Public records are used to help in the detection and prevention of fraud as well as to verify a consumer. Public records are accessed in real-time and then used to determine if a consumer is who they claim to be or is a fraudster. Questions are generated using the public records based on an initial fraud score and a verification level associated with the entity requesting the fraud and verification services. Based on the response to the questions, the fraud score is updated and a confidence level is returned to the requestor to determine whether the user is legitimate or a fraudster. The questions may be presented online or offline. The verification can be different for every merchant.
摘要翻译：公共记录用于帮助检测和预防欺诈以及验证消费者。公共记录被实时访问，然后用于确定消费者是谁声称自己是或是欺诈者。使用基于初始欺诈分数的公开记录和与请求欺诈和验证服务的实体相关联的验证级别生成问题。基于对问题的响应，更新欺诈分数，并且向请求者返回置信水平以确定用户是合法的还是欺诈者。这些问题可能在线或离线显示。每个商家的验证可能不同。

6. 发明申请

US20060210630A1 Controlled release compositions of gamma-hydroxybutyrate 有权
公开(公告)号：US20060210630A1
公开(公告)日：2006-09-21
申请号：US11239638
申请日：2005-09-30
申请人： Likan Liang , Niraj Shah , Padmanabh Bhatt , Scott Ibrahim
发明人： Likan Liang , Niraj Shah , Padmanabh Bhatt , Scott Ibrahim
IPC分类号： A61K31/19 , A61K9/22
CPC分类号： A61K9/5031 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5073 , A61K9/5084 , A61K31/19
摘要： The present invention is directed to oral pulse-release pharmaceutical dosage form containing an immediate release component of gamma-hydroxybutyric acid, and one or more delayed/controlled release components of gamma-hydroxybutyric acid.

7. 发明授权

US07749532B2 Once daily formulations of tetracyclines 有权
标题翻译：每日一次四环素制剂
公开(公告)号：US07749532B2
公开(公告)日：2010-07-06
申请号：US10819620
申请日：2004-04-07
申请人： Rong-Kun Chang , Arash Raoufinia , Niraj Shah
发明人： Rong-Kun Chang , Arash Raoufinia , Niraj Shah
IPC分类号： A61K9/54
CPC分类号： A61K9/4808 , A61K9/167 , A61K9/2027 , A61K9/2054 , A61K9/209 , A61K9/5078 , A61K9/5084 , A61K31/65
摘要： Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis.
摘要翻译：公开了每天一次的含有四环素的制剂，特别是多西环素。这样的制剂可用于例如用于治疗胶原酶破坏性酶依赖性疾病，例如牙周病和痤疮，以及急性和慢性炎性疾病状态，例如酒渣鼻和关节炎。

8. 发明申请

US20090011006A1 Once daily formulations of tetracyclines 有权
标题翻译：每日一次四环素制剂
公开(公告)号：US20090011006A1
公开(公告)日：2009-01-08
申请号：US12155676
申请日：2008-06-06
申请人： Rong-Kun Chang , Arash Raoufinia , Niraj Shah
发明人： Rong-Kun Chang , Arash Raoufinia , Niraj Shah
IPC分类号： A61K9/48 , A61K31/65 , A61P29/00 , A61K9/14
CPC分类号： A61K9/4808 , A61K9/167 , A61K9/2027 , A61K9/2054 , A61K9/209 , A61K9/5078 , A61K9/5084 , A61K31/65
摘要： Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis.
摘要翻译：公开了每天一次的含有四环素的制剂，特别是多西环素。这样的制剂可用于例如用于治疗胶原酶破坏性酶依赖性疾病，例如牙周病和痤疮，以及急性和慢性炎性疾病状态，例如酒渣鼻和关节炎。

9. 发明申请

US20080046316A1 System and method for updating product pricing and advertising bids 失效
标题翻译：更新产品定价和广告投标的制度和方法
公开(公告)号：US20080046316A1
公开(公告)日：2008-02-21
申请号：US11507025
申请日：2006-08-21
申请人： Niraj Shah , Steven Conine
发明人： Niraj Shah , Steven Conine
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0244 , G06Q30/0247 , G06Q30/0275
摘要： A system and method maximize profits by determining the optimal combination of sale price for a product and bids for advertising. The system and method address the non-linear relationship between product pricing and advertising through an advertising bidding system. In particular, a seller sells a product at a plurality of sale prices and buys the at least one advertisement by submitting a plurality of bid prices to the at least one advertising venue, resulting in a combination of bid prices for the at least one advertisement at each of the plurality of sale prices. Data from advertising with each of the at least one advertisement is collected. Then, a non-linear model for pricing and bidding is determined from the collected data, and an optimal price for the product and an optimal advertising bid for each of the at least one advertisement is determined from the non-linear model.
摘要翻译：系统和方法通过确定产品的销售价格和广告出价的最佳组合来最大化利润。系统和方法通过广告投标系统解决产品定价与广告之间的非线性关系。特别地，卖方以多种销售价格出售产品，并通过向至少一个广告场地提交多个投标价格来购买至少一个广告，导致至少一个广告的投标价格的组合每个销售价格多。收集来自具有至少一个广告中的每一个的广告的数据。然后，从收集的数据确定定价和出价的非线性模型，并且从非线性模型确定产品的最优价格和对于至少一个广告中的每一个的最优广告出价。

10. 发明授权

US08808714B2 Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics 有权
标题翻译：使用两种或多种肠溶性物质的混合物来调节药物释放通过膜或基质进行全身治疗
公开(公告)号：US08808714B2
公开(公告)日：2014-08-19
申请号：US12929238
申请日：2011-01-10
申请人： Rong-Kun Chang , Niraj Shah
发明人： Rong-Kun Chang , Niraj Shah
IPC分类号： A61K9/00 , A61F13/00
CPC分类号： A61K31/65 , A61K9/2027 , A61K9/2054 , A61K9/5026 , A61K9/5042 , A61K9/5078
摘要： Disclosed are pharmaceutical compositions, particularly oral dosage forms, which comprise two or more enteric coating materials, either as a coating or as part of a matrix dosage form, and methods of making and using the same. The compositions are characterized by having a sustained release profile at lower pH and an accelerated dissolution profile at higher pH.
摘要翻译：公开了药物组合物，特别是口服剂型，其包含两种或多种肠溶包衣材料，作为包衣或基质剂型的一部分，以及制备和使用它们的方法。该组合物的特征在于在较低pH下具有持续释放曲线，并且在较高pH下具有加速的溶解曲线。

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