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1. 发明授权

US08778282B2 Microfluidic device having microvalve 有权
标题翻译：具有微型阀的微流体装置
公开(公告)号：US08778282B2
公开(公告)日：2014-07-15
申请号：US12957900
申请日：2010-12-01
申请人： Won-jong Jung , Chin-sung Park , Kak Namkoong , Joon-ho Kim , Hyung-sok Yeo
发明人： Won-jong Jung , Chin-sung Park , Kak Namkoong , Joon-ho Kim , Hyung-sok Yeo
IPC分类号： F16K1/00 , B01L99/00 , F16K99/00
CPC分类号： F16K99/0026 , B01L3/502738 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , F16K99/0015 , F16K99/0059 , F16K2099/008 , F16K2099/0084
摘要： A microfluidic device including a microvalve includes a first substrate, a second substrate facing the first substrate, an elastic film between the first and second substrates, a microfluidic channel on the second substrate, a valve seat of the second substrate protruding in the microfluidic channel, and a fine structure on a surface of the elastic film, facing the valve seat and which contacts the valve seat when the microvalve is operated.
摘要翻译：包括微阀的微流体装置包括第一基板，面向第一基板的第二基板，第一和第二基板之间的弹性膜，第二基板上的微流体通道，突出于微流体通道中的第二基板的阀座，以及在弹性膜的面向阀座的表面上的精细结构，并且当微型阀被操作时与该阀座接触。

2. 发明授权

US09044751B2 Gene analysis device 有权
标题翻译：基因分析装置
公开(公告)号：US09044751B2
公开(公告)日：2015-06-02
申请号：US13608533
申请日：2012-09-10
申请人： Won-jong Jung , Sun-ok Jung , Won-seok Chung , Chin-sung Park , Joon-ho Kim , Kak Namkoong
发明人： Won-jong Jung , Sun-ok Jung , Won-seok Chung , Chin-sung Park , Joon-ho Kim , Kak Namkoong
IPC分类号： C12M1/34 , C12M3/00 , B01L3/00 , G01N21/64 , G01N21/03 , G01N21/05
CPC分类号： B01L3/502715 , B01L2300/0654 , B01L2300/0816 , G01N21/6452 , G01N2021/0314 , G01N2021/0325 , G01N2021/058 , G01N2021/6463
摘要： A gene analysis device including an illumination optical system radiating exciting light onto a sample solution; a microfluidic device for forming a bio-reaction space of the sample solution and including at least one micro-chamber in which a reflection pattern is formed; and a detection optical system for detecting a fluorescence signal generated by a bio-reaction in the micro-chamber and comprising a photodetector.
摘要翻译：一种基因分析装置，包括将激发光照射到样品溶液上的照明光学系统; 微流体装置，用于形成样品溶液的生物反应空间，并且包括至少一个其中形成有反射图案的微室; 以及检测光学系统，用于检测由微室中的生物反应产生的荧光信号，并包括光电检测器。

3. 发明授权

US09044755B2 Gene analysis apparatus and gene analysis method using the same 有权
标题翻译：基因分析仪和基因分析方法采用相同的方法
公开(公告)号：US09044755B2
公开(公告)日：2015-06-02
申请号：US13176777
申请日：2011-07-06
申请人： Chin-sung Park , Won-jong Jung , Joon-ho Kim , Kak Namkoong , Kyu-youn Hwang , Won-seok Chung , Hee-kyun Lim , Sung-hong Kwon , Sun-ok Jung
发明人： Chin-sung Park , Won-jong Jung , Joon-ho Kim , Kak Namkoong , Kyu-youn Hwang , Won-seok Chung , Hee-kyun Lim , Sung-hong Kwon , Sun-ok Jung
IPC分类号： C12Q1/68 , G01N21/75 , B01L7/00 , B01L3/00
CPC分类号： B01L7/52 , B01L3/502715 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0627 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/18 , B01L2400/0487 , B01L2400/06 , B01L2400/0655 , C12Q1/68 , G01N21/75
摘要： A gene analysis apparatus includes a sample preparation chip in which a polymerase chain reaction (“PCR”) sample is prepared, a PCR chip in which a PCR is performed on the PCR sample, and a package layer on which the sample preparation chip and the PCR chip are mounted. The package layer includes a channel through which a material flows from the sample preparation chip to the PCR chip. The sample preparation chip and the PCR chip are on a same side or on opposing sides of the package layer.
摘要翻译：基因分析装置包括准备了聚合酶链式反应（“PCR”）样品的样品制备芯片，对PCR样品进行PCR的PCR芯片，以及将样品制备芯片和 PCR芯片安装。封装层包括材料从样品制备芯片流向PCR芯片的通道。样品制备芯片和PCR芯片在封装层的相同侧或相对侧上。

4. 发明授权

US08945484B2 Microfluidic device including microvalve 有权
标题翻译：微流控器件包括微型阀
公开(公告)号：US08945484B2
公开(公告)日：2015-02-03
申请号：US13188075
申请日：2011-07-21
申请人： Kak Namkoong , Joon-ho Kim , Won-jong Jung , Chin-sung Park
发明人： Kak Namkoong , Joon-ho Kim , Won-jong Jung , Chin-sung Park
IPC分类号： F16K3/00 , B01L3/00 , F16K99/00
CPC分类号： B01L3/502738 , B01L2300/0816 , B01L2300/123 , B01L2400/0655 , F16K37/0066 , F16K99/0015 , F16K99/0057 , F16K99/0059 , F16K2099/0084
摘要： A microfluidic device including at least one microvalve which controls a flow of a fluid, where the at least one microvalve includes: a pneumatic layer, a fluidic layer disposed opposite to the pneumatic layer; an elastomer membrane disposed between the pneumatic layer and the fluidic layer; and an asymmetric valve seat protruding from a surface of the fluidic layer toward a surface of the elastomer membrane and asymmetrically dividing a space between the fluidic layer and the elastomer membrane.
摘要翻译：一种微流体装置，包括控制流体流动的至少一个微型阀，其中所述至少一个微型阀包括：气动层，与所述气动层相对设置的流体层; 设置在气动层和流体层之间的弹性体膜; 以及从流体层的表面朝向弹性体膜的表面突出的不对称的阀座，并且不对称地划分流体层和弹性体膜之间的空间。

5. 发明授权

US09267618B2 Microvalve device and method of manufacturing the same 有权
标题翻译：微阀装置及其制造方法
公开(公告)号：US09267618B2
公开(公告)日：2016-02-23
申请号：US13110452
申请日：2011-05-18
申请人： Chin-sung Park , Won-jong Jung , Jae-young Kim , Joon-ho Kim
发明人： Chin-sung Park , Won-jong Jung , Jae-young Kim , Joon-ho Kim
IPC分类号： B01L99/00 , F16K99/00 , B01L3/00
CPC分类号： F16K99/0059 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0638 , F16K99/0001 , F16K99/0015 , F16K2099/008 , F16K2099/0084
摘要： A microvalve device comprises: a first substrate having a first surface, where at least one fluidic channel is formed into the first surface of the first substrate; and at least one valve seat is formed in the fluidic channel; a second substrate having a second surface, the second substrate comprising at least one air channel and at least one air chamber formed on the second surface of the second substrate, where the air chamber is connected to the air channel; and an elastic film interposed between the first substrate and the second substrate, where an upper portion of the valve seat is lower than the first surface of the first substrate.
摘要翻译：微阀装置包括：具有第一表面的第一基板，其中至少一个流体通道形成在第一基板的第一表面中; 并且至少一个阀座形成在流体通道中; 具有第二表面的第二基板，所述第二基板包括至少一个空气通道和形成在所述第二基板的第二表面上的至少一个空气室，其中所述空气室连接到所述空气通道; 以及插入在第一基板和第二基板之间的弹性膜，其中阀座的上部比第一基板的第一表面低。

6. 发明授权

US08986986B2 Cell lysis device and methods of lysing cells or viruses 有权
标题翻译：细胞裂解装置和裂解细胞或病毒的方法
公开(公告)号：US08986986B2
公开(公告)日：2015-03-24
申请号：US13284364
申请日：2011-10-28
申请人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
发明人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
IPC分类号： C12M1/33 , C12M3/08 , C12Q1/68 , C12Q1/70 , C12M3/00 , C12M1/00
CPC分类号： C12M1/00 , C12M1/33 , C12M47/06
摘要： A method of lysing at least one of a cell and a virus, the method including: contacting a sample, which includes at least one of a cell and a virus, with a plurality of beads which are disposed in a first chamber to obtain a combination of the sample and the beads; and agitating the combination of the sample and the beads to lyse the at least one of the cell and the virus, wherein in the first chamber a liquid volume fraction is 0.6 or less, and wherein the liquid volume fraction is a value obtained by dividing a liquid volume of the first chamber by a pure void volume equivalent to a sum of the liquid volume of the first chamber and a void volume of the first chamber.
摘要翻译：一种裂解细胞和病毒中的至少一种的方法，所述方法包括：将包括细胞和病毒中的至少一种的样品与设置在第一室中的多个珠接触以获得组合的样品和珠粒; 并搅拌样品和珠的组合以裂解细胞和病毒中的至少一种，其中在第一室中液体体积分数为0.6或更小，并且其中液体体积分数是通过将第一室的液体体积相当于第一室的液体体积和第一室的空隙体积的总和的纯空隙体积。

7. 发明授权

US08859272B2 Micro-device and methods for disrupting cells 有权
标题翻译：用于破坏细胞的微型装置和方法
公开(公告)号：US08859272B2
公开(公告)日：2014-10-14
申请号：US13275871
申请日：2011-10-18
申请人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
发明人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
IPC分类号： C12M1/33 , C12Q1/68
CPC分类号： C12Q1/6806 , C12M1/33 , C12M47/06
摘要： A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber
摘要翻译：用于破坏电池的微型装置包括其中电池被破坏的第一室，被加压和减压的第二室，分离第一室和第二室的柔性膜，并且通过对第二室进行加压和减压而振动，以及限制在第一室中的微单元，其中微单元破坏第一室中的单元

8. 发明授权

US09061277B2 Micro-fluid supplying device having gas bubble trapping function 有权
标题翻译：具有气泡捕集功能的微流体供给装置
公开(公告)号：US09061277B2
公开(公告)日：2015-06-23
申请号：US13298482
申请日：2011-11-17
申请人： Won-jong Jung , Chin-sung Park , Joon-ho Kim , Joon-sub Shim
发明人： Won-jong Jung , Chin-sung Park , Joon-ho Kim , Joon-sub Shim
IPC分类号： C12M3/00 , B01L3/00
CPC分类号： B01L3/502 , B01L3/502723 , B01L2200/0673 , B01L2200/0684
摘要： A micro-fluid supplying device having a gas bubble trapping function. The micro-fluid supplying device includes: a fluid supplier including a fluid having a biomaterial; a trap chamber in which a gas bubble is removed from the fluid supplied from the fluid supplier; and a fluid discharger which externally discharges a material supplied from the trap chamber. Material properties of a side wall and a bottom of an inside of the trap chamber are different from each other. The side wall has a better property of wetting with respect to the fluid supplied from the fluid supplier than the bottom.
摘要翻译：具有气泡捕获功能的微流体供给装置。微流体供应装置包括：流体供应器，其包括具有生物材料的流体; 捕集室，其中气体从流体供应器供应的流体中移除; 以及从所述收集室供给的材料外部排出的流体排出器。捕集室的侧壁和底部的材料性质彼此不同。相对于从流体供应者供应的流体而言，侧壁具有比底部更好的润湿性能。

9. 发明授权

US08895297B2 Micro-device and methods for disrupting cells 有权
标题翻译：用于破坏细胞的微型装置和方法
公开(公告)号：US08895297B2
公开(公告)日：2014-11-25
申请号：US13492179
申请日：2012-06-08
申请人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
发明人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
IPC分类号： C12N1/06 , C12M1/00 , B01L3/00 , C12M1/33 , C12M3/08 , C12M3/00
CPC分类号： C12M47/06 , B01L3/502753 , B01L2300/0816 , B01L2300/0867 , B01L2400/0481 , C12N1/06
摘要： A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber.
摘要翻译：用于破坏电池的微型装置包括其中电池被破坏的第一室，被加压和减压的第二室，分离第一室和第二室的柔性膜，并且通过对第二室进行加压和减压而振动，以及限制在第一室中的微单元，其中微单元破坏第一室中的单元。

10. 发明授权

US08411277B2 Method and apparatus for controlling quality of a microfluidic device 有权
标题翻译：用于控制微流体装置质量的方法和装置
公开(公告)号：US08411277B2
公开(公告)日：2013-04-02
申请号：US12765956
申请日：2010-04-23
申请人： Won-jong Jung , Jae-young Kim
发明人： Won-jong Jung , Jae-young Kim
IPC分类号： G01N21/84 , G01N21/55
CPC分类号： G01N21/95607
摘要： A method for determining the quality of a microfluidic device, the method including placing a microfluidic device including a valve on a stage; radiating light on the valve of the microfluidic device; detecting light reflected from the valve using a photodetector; opening the valve of the microfluidic device; and comparing a change of the light reflected from the valve when the valve is opened with previously-stored reference data to evaluate a quality of the microfluidic device, wherein the valve of the microfluidic device includes a valve seat, which protrudes into a microfluidic path, and a polymer film, which opens and closes the valve.
摘要翻译：一种用于确定微流体装置的质量的方法，所述方法包括将包括阀的微流体装置放置在载物台上; 在微流体装置的阀上照射光; 使用光电检测器检测从所述阀反射的光; 打开微流体装置的阀门; 以及比较当阀打开时从阀反射的光的变化与预先存储的参考数据进行比较，以评估微流体装置的质量，其中微流体装置的阀包括突出到微流体路径中的阀座，以及打开和关闭阀的聚合物膜。

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