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1. 发明授权

US09044751B2 Gene analysis device 有权
标题翻译：基因分析装置
公开(公告)号：US09044751B2
公开(公告)日：2015-06-02
申请号：US13608533
申请日：2012-09-10
申请人： Won-jong Jung , Sun-ok Jung , Won-seok Chung , Chin-sung Park , Joon-ho Kim , Kak Namkoong
发明人： Won-jong Jung , Sun-ok Jung , Won-seok Chung , Chin-sung Park , Joon-ho Kim , Kak Namkoong
IPC分类号： C12M1/34 , C12M3/00 , B01L3/00 , G01N21/64 , G01N21/03 , G01N21/05
CPC分类号： B01L3/502715 , B01L2300/0654 , B01L2300/0816 , G01N21/6452 , G01N2021/0314 , G01N2021/0325 , G01N2021/058 , G01N2021/6463
摘要： A gene analysis device including an illumination optical system radiating exciting light onto a sample solution; a microfluidic device for forming a bio-reaction space of the sample solution and including at least one micro-chamber in which a reflection pattern is formed; and a detection optical system for detecting a fluorescence signal generated by a bio-reaction in the micro-chamber and comprising a photodetector.
摘要翻译：一种基因分析装置，包括将激发光照射到样品溶液上的照明光学系统; 微流体装置，用于形成样品溶液的生物反应空间，并且包括至少一个其中形成有反射图案的微室; 以及检测光学系统，用于检测由微室中的生物反应产生的荧光信号，并包括光电检测器。

2. 发明授权

US09044755B2 Gene analysis apparatus and gene analysis method using the same 有权
标题翻译：基因分析仪和基因分析方法采用相同的方法
公开(公告)号：US09044755B2
公开(公告)日：2015-06-02
申请号：US13176777
申请日：2011-07-06
申请人： Chin-sung Park , Won-jong Jung , Joon-ho Kim , Kak Namkoong , Kyu-youn Hwang , Won-seok Chung , Hee-kyun Lim , Sung-hong Kwon , Sun-ok Jung
发明人： Chin-sung Park , Won-jong Jung , Joon-ho Kim , Kak Namkoong , Kyu-youn Hwang , Won-seok Chung , Hee-kyun Lim , Sung-hong Kwon , Sun-ok Jung
IPC分类号： C12Q1/68 , G01N21/75 , B01L7/00 , B01L3/00
CPC分类号： B01L7/52 , B01L3/502715 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0627 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/18 , B01L2400/0487 , B01L2400/06 , B01L2400/0655 , C12Q1/68 , G01N21/75
摘要： A gene analysis apparatus includes a sample preparation chip in which a polymerase chain reaction (“PCR”) sample is prepared, a PCR chip in which a PCR is performed on the PCR sample, and a package layer on which the sample preparation chip and the PCR chip are mounted. The package layer includes a channel through which a material flows from the sample preparation chip to the PCR chip. The sample preparation chip and the PCR chip are on a same side or on opposing sides of the package layer.
摘要翻译：基因分析装置包括准备了聚合酶链式反应（“PCR”）样品的样品制备芯片，对PCR样品进行PCR的PCR芯片，以及将样品制备芯片和 PCR芯片安装。封装层包括材料从样品制备芯片流向PCR芯片的通道。样品制备芯片和PCR芯片在封装层的相同侧或相对侧上。

3. 发明授权

US08945484B2 Microfluidic device including microvalve 有权
标题翻译：微流控器件包括微型阀
公开(公告)号：US08945484B2
公开(公告)日：2015-02-03
申请号：US13188075
申请日：2011-07-21
申请人： Kak Namkoong , Joon-ho Kim , Won-jong Jung , Chin-sung Park
发明人： Kak Namkoong , Joon-ho Kim , Won-jong Jung , Chin-sung Park
IPC分类号： F16K3/00 , B01L3/00 , F16K99/00
CPC分类号： B01L3/502738 , B01L2300/0816 , B01L2300/123 , B01L2400/0655 , F16K37/0066 , F16K99/0015 , F16K99/0057 , F16K99/0059 , F16K2099/0084
摘要： A microfluidic device including at least one microvalve which controls a flow of a fluid, where the at least one microvalve includes: a pneumatic layer, a fluidic layer disposed opposite to the pneumatic layer; an elastomer membrane disposed between the pneumatic layer and the fluidic layer; and an asymmetric valve seat protruding from a surface of the fluidic layer toward a surface of the elastomer membrane and asymmetrically dividing a space between the fluidic layer and the elastomer membrane.
摘要翻译：一种微流体装置，包括控制流体流动的至少一个微型阀，其中所述至少一个微型阀包括：气动层，与所述气动层相对设置的流体层; 设置在气动层和流体层之间的弹性体膜; 以及从流体层的表面朝向弹性体膜的表面突出的不对称的阀座，并且不对称地划分流体层和弹性体膜之间的空间。

4. 发明授权

US08778282B2 Microfluidic device having microvalve 有权
标题翻译：具有微型阀的微流体装置
公开(公告)号：US08778282B2
公开(公告)日：2014-07-15
申请号：US12957900
申请日：2010-12-01
申请人： Won-jong Jung , Chin-sung Park , Kak Namkoong , Joon-ho Kim , Hyung-sok Yeo
发明人： Won-jong Jung , Chin-sung Park , Kak Namkoong , Joon-ho Kim , Hyung-sok Yeo
IPC分类号： F16K1/00 , B01L99/00 , F16K99/00
CPC分类号： F16K99/0026 , B01L3/502738 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , F16K99/0015 , F16K99/0059 , F16K2099/008 , F16K2099/0084
摘要： A microfluidic device including a microvalve includes a first substrate, a second substrate facing the first substrate, an elastic film between the first and second substrates, a microfluidic channel on the second substrate, a valve seat of the second substrate protruding in the microfluidic channel, and a fine structure on a surface of the elastic film, facing the valve seat and which contacts the valve seat when the microvalve is operated.
摘要翻译：包括微阀的微流体装置包括第一基板，面向第一基板的第二基板，第一和第二基板之间的弹性膜，第二基板上的微流体通道，突出于微流体通道中的第二基板的阀座，以及在弹性膜的面向阀座的表面上的精细结构，并且当微型阀被操作时与该阀座接触。

5. 发明授权

US07736050B2 Fluid mixing device using cross channels 有权
标题翻译：流体混合装置使用交叉通道
公开(公告)号：US07736050B2
公开(公告)日：2010-06-15
申请号：US11433594
申请日：2006-05-12
申请人： Chin-sung Park , Joon-ho Kim , Kak Namkoong , Kwang-wook Oh
发明人： Chin-sung Park , Joon-ho Kim , Kak Namkoong , Kwang-wook Oh
IPC分类号： B01F5/00
CPC分类号： B01F13/1013 , B01F5/0475 , B01F5/0478 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F13/1019 , B01F15/0203 , B01F15/0404 , B01F2015/0221 , G01N1/38
摘要： Provided is a fluid mixing device which produces a series of solutions with a concentration gradient. The fluid mixing device includes: a plurality of first channels disposed parallel to each other on a layer, and into which an equal amount of diluent flows from its upstream; a plurality of second channels formed perpendicular to the first channels on an adjacent layer to the layer on which the first channels are formed, and into which an equal amount of sample solution flows from its upstream; and via holes formed at at least one intersection between each of the first channel and a plurality of second channels so that a predetermined amount of sample solution flows from the second channels into corresponding first channels, wherein a series of solutions with different concentrations is produced in the first channels depending on the amount of sample solution that flows into the first channels through the via holes. Thus, a series of solutions with different concentrations is output from the first channels.
摘要翻译：提供了一种流体混合装置，其产生具有浓度梯度的一系列溶液。流体混合装置包括：在层上彼此平行设置的多个第一通道，等量的稀释剂从其上游流入其中; 多个第二通道，其垂直于与形成有第一通道的层相邻的第一通道形成，并且等量的样品溶液从其上游流入其中; 以及形成在每个第一通道和多个第二通道之间的至少一个相交处的通孔，使得预定量的样品溶液从第二通道流入相应的第一通道，其中一系列具有不同浓度的溶液在第一通道取决于通过通孔流入第一通道的样品溶液的量。因此，从第一通道输出一系列具有不同浓度的溶液。

6. 发明申请

US20060234379A1 Cell separation method using hydrophobic solid supports 审中-公开
标题翻译：使用疏水性固体支持物的细胞分离方法
公开(公告)号：US20060234379A1
公开(公告)日：2006-10-19
申请号：US11405106
申请日：2006-04-17
申请人： Hee-kyun Lim , Kyu-youn Hwang , Joon-ho Kim , Kak Namkoong , Chin-sung Park
发明人： Hee-kyun Lim , Kyu-youn Hwang , Joon-ho Kim , Kak Namkoong , Chin-sung Park
IPC分类号： C12N5/02 , C12N5/00
CPC分类号： B01L3/502753 , B01L3/502746 , B01L2300/0681 , B01L2400/086 , B82Y30/00 , B82Y40/00 , C12M47/02
摘要： Provided is a method of separating cells using a hydrophobic solid support. The method comprises contacting a solution containing cells with a hydrophobic solid support having a water contact angle between 70 and 90 degrees. By allowing cells to be adsorbed to the hydrophobic solid substrate, the cells can be separated. Thus, the cell separation efficiency can be rapidly and simply increased.
摘要翻译：提供了使用疏水性固体支持物分离细胞的方法。该方法包括将含有细胞的溶液与70-90度的水接触角的疏水性固体支持物接触。通过使细胞被吸附到疏水性固体底物上，可以分离细胞。因此，可以快速且简单地增加细胞分离效率。

7. 发明申请

US20060262642A1 Fluid mixing device using cross channels 有权
标题翻译：流体混合装置使用交叉通道
公开(公告)号：US20060262642A1
公开(公告)日：2006-11-23
申请号：US11433594
申请日：2006-05-12
申请人： Chin-sung Park , Joon-ho Kim , Kak Namkoong , Kwang-wook Oh
发明人： Chin-sung Park , Joon-ho Kim , Kak Namkoong , Kwang-wook Oh
IPC分类号： B01F5/06
CPC分类号： B01F13/1013 , B01F5/0475 , B01F5/0478 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F13/1019 , B01F15/0203 , B01F15/0404 , B01F2015/0221 , G01N1/38
摘要： Provided is a fluid mixing device which produces a series of solutions with a concentration gradient. The fluid mixing device includes: a plurality of first channels disposed parallel to each other on a layer, and into which an equal amount of diluent flows from its upstream; a plurality of second channels formed perpendicular to the first channels on an adjacent layer to the layer on which the first channels are formed, and into which an equal amount of sample solution flows from its upstream; and via holes formed at at least one intersection between each of the first channel and a plurality of second channels so that a predetermined amount of sample solution flows from the second channels into corresponding first channels, wherein a series of solutions with different concentrations is produced in the first channels depending on the amount of sample solution that flows into the first channels through the via holes. Thus, a series of solutions with different concentrations is output from the first channels.
摘要翻译：提供了一种流体混合装置，其产生具有浓度梯度的一系列溶液。流体混合装置包括：在层上彼此平行设置的多个第一通道，等量的稀释剂从其上游流入其中; 多个第二通道，其垂直于与形成有第一通道的层相邻的第一通道形成，并且等量的样品溶液从其上游流入其中; 以及形成在每个第一通道和多个第二通道之间的至少一个相交处的通孔，使得预定量的样品溶液从第二通道流入相应的第一通道，其中一系列具有不同浓度的溶液在第一通道取决于通过通孔流入第一通道的样品溶液的量。因此，从第一通道输出一系列具有不同浓度的溶液。

8. 发明授权

US08859272B2 Micro-device and methods for disrupting cells 有权
标题翻译：用于破坏细胞的微型装置和方法
公开(公告)号：US08859272B2
公开(公告)日：2014-10-14
申请号：US13275871
申请日：2011-10-18
申请人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
发明人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
IPC分类号： C12M1/33 , C12Q1/68
CPC分类号： C12Q1/6806 , C12M1/33 , C12M47/06
摘要： A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber
摘要翻译：用于破坏电池的微型装置包括其中电池被破坏的第一室，被加压和减压的第二室，分离第一室和第二室的柔性膜，并且通过对第二室进行加压和减压而振动，以及限制在第一室中的微单元，其中微单元破坏第一室中的单元

9. 发明授权

US09061277B2 Micro-fluid supplying device having gas bubble trapping function 有权
标题翻译：具有气泡捕集功能的微流体供给装置
公开(公告)号：US09061277B2
公开(公告)日：2015-06-23
申请号：US13298482
申请日：2011-11-17
申请人： Won-jong Jung , Chin-sung Park , Joon-ho Kim , Joon-sub Shim
发明人： Won-jong Jung , Chin-sung Park , Joon-ho Kim , Joon-sub Shim
IPC分类号： C12M3/00 , B01L3/00
CPC分类号： B01L3/502 , B01L3/502723 , B01L2200/0673 , B01L2200/0684
摘要： A micro-fluid supplying device having a gas bubble trapping function. The micro-fluid supplying device includes: a fluid supplier including a fluid having a biomaterial; a trap chamber in which a gas bubble is removed from the fluid supplied from the fluid supplier; and a fluid discharger which externally discharges a material supplied from the trap chamber. Material properties of a side wall and a bottom of an inside of the trap chamber are different from each other. The side wall has a better property of wetting with respect to the fluid supplied from the fluid supplier than the bottom.
摘要翻译：具有气泡捕获功能的微流体供给装置。微流体供应装置包括：流体供应器，其包括具有生物材料的流体; 捕集室，其中气体从流体供应器供应的流体中移除; 以及从所述收集室供给的材料外部排出的流体排出器。捕集室的侧壁和底部的材料性质彼此不同。相对于从流体供应者供应的流体而言，侧壁具有比底部更好的润湿性能。

10. 发明授权

US09267618B2 Microvalve device and method of manufacturing the same 有权
标题翻译：微阀装置及其制造方法
公开(公告)号：US09267618B2
公开(公告)日：2016-02-23
申请号：US13110452
申请日：2011-05-18
申请人： Chin-sung Park , Won-jong Jung , Jae-young Kim , Joon-ho Kim
发明人： Chin-sung Park , Won-jong Jung , Jae-young Kim , Joon-ho Kim
IPC分类号： B01L99/00 , F16K99/00 , B01L3/00
CPC分类号： F16K99/0059 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0638 , F16K99/0001 , F16K99/0015 , F16K2099/008 , F16K2099/0084
摘要： A microvalve device comprises: a first substrate having a first surface, where at least one fluidic channel is formed into the first surface of the first substrate; and at least one valve seat is formed in the fluidic channel; a second substrate having a second surface, the second substrate comprising at least one air channel and at least one air chamber formed on the second surface of the second substrate, where the air chamber is connected to the air channel; and an elastic film interposed between the first substrate and the second substrate, where an upper portion of the valve seat is lower than the first surface of the first substrate.
摘要翻译：微阀装置包括：具有第一表面的第一基板，其中至少一个流体通道形成在第一基板的第一表面中; 并且至少一个阀座形成在流体通道中; 具有第二表面的第二基板，所述第二基板包括至少一个空气通道和形成在所述第二基板的第二表面上的至少一个空气室，其中所述空气室连接到所述空气通道; 以及插入在第一基板和第二基板之间的弹性膜，其中阀座的上部比第一基板的第一表面低。

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