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1. 发明授权

US09000399B2 Fluorescence detecting optical system and multi-channel fluorescence detection apparatus including the same 有权
标题翻译：荧光检测光学系统和包括其的多通道荧光检测装置
公开(公告)号：US09000399B2
公开(公告)日：2015-04-07
申请号：US13271101
申请日：2011-10-11
申请人： Kyung-ho Kim , Joon-ho Kim , Kak Namkoong , Won-seok Chung
发明人： Kyung-ho Kim , Joon-ho Kim , Kak Namkoong , Won-seok Chung
IPC分类号： G01N21/64 , G01J3/44 , G01J3/02 , G01N21/05 , G01N21/03
CPC分类号： G01N21/645 , G01J3/0208 , G01J3/0229 , G01J3/0237 , G01J3/4406 , G01N21/05 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421 , G01N2021/6478 , G01N2201/0635
摘要： A fluorescence detection optical system detects fluorescence beams with two or more different wavelengths and maintains a focal position through an automatic focusing function. A multi-channel fluorescence detection apparatus includes the fluorescence detection optical system. The fluorescence detection optical system includes an automatic focusing unit which receives light reflected off a microfluidic device and determines a focal point by using an astigmatic method or a knife edge method, and an actuator which adjusts a position of an objective lens according to control of the automatic focusing unit. In addition, the fluorescence detection optical system may include a plurality of dual band pass filters, dichroic devices, etc., which provide light beams emitted from at least two light sources and transfer fluorescence generated from the microfluidic device to a photodetector.
摘要翻译：荧光检测光学系统检测具有两个或更多个不同波长的荧光束并通过自动聚焦功能保持焦点位置。多通道荧光检测装置包括荧光检测光学系统。荧光检测光学系统包括自动聚焦单元，其接收从微流体装置反射的光并且通过使用散光方法或刀刃方法确定焦点，以及致动器，其根据控制的方式调整物镜的位置自动对焦单元此外，荧光检测光学系统可以包括多个双带通滤波器，二向色装置等，其提供从至少两个光源发射的光束并将从微流体装置产生的荧光转移到光电检测器。

2. 发明授权

US08386191B2 Method for quantifying initial concentration of nucleic acid from real-time nucleic acid amplification data 有权
标题翻译：从实时核酸扩增数据定量核酸初始浓度的方法
公开(公告)号：US08386191B2
公开(公告)日：2013-02-26
申请号：US13161788
申请日：2011-06-16
申请人： Kak Namkoong , Jin-tae Kim , Young-sun Lee , Young-a Kim
发明人： Kak Namkoong , Jin-tae Kim , Young-sun Lee , Young-a Kim
IPC分类号： G01N33/48
CPC分类号： C12Q1/6851
摘要： Provided is a method for quantifying an initial concentration of a nucleic acid from a real-time nucleic acid amplification data. Nucleic acid (DNA or RNA) extracted from organism or virus is amplified using an enzyme. Then, the initial concentration of the nucleic acid is found by calculating the characteristic amplification cycle number or the characteristic amplification time at which the fluorescence intensity of the nucleic acid subtracted by the background fluorescence intensity of the nucleic acid has half of its maximum value, or the characteristic amplification cycle number or the characteristic amplification time at which the amplification efficiency has the maximum or the minimum value, or the prior-to-amplification fluorescence intensity of the nucleic acid subtracted by the background fluorescence intensity of the nucleic acid. Accordingly, the initial concentration of the nucleic acid can be calculated without differentiation or integration.
摘要翻译：提供了从实时核酸扩增数据定量核酸的初始浓度的方法。使用酶扩增从生物或病毒提取的核酸（DNA或RNA）。然后，通过计算由核酸的背景荧光强度减去的核酸的荧光强度具有其最大值的一半的特征扩增循环数或特异性扩增时间来发现核酸的初始浓度，或扩增效率具有由核酸的背景荧光强度减去的核酸的最大值或最小值或以前的扩增荧光强度的特征扩增循环数或特征扩增时间。因此，可以在不分化或整合的情况下计算核酸的初始浓度。

3. 发明申请

US20120305801A1 FLUORESCENCE DETECTING OPTICAL SYSTEM AND MULTI-CHANNEL FLUORESCENCE DETECTION APPARATUS HAVING THE SAME 有权
标题翻译：荧光检测光学系统及其多通道荧光检测装置
公开(公告)号：US20120305801A1
公开(公告)日：2012-12-06
申请号：US13421119
申请日：2012-03-15
申请人： Kyung-ho KIM , Joon-ho KIM , Kak NAMKOONG , Won-seok CHUNG
发明人： Kyung-ho KIM , Joon-ho KIM , Kak NAMKOONG , Won-seok CHUNG
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , G01N21/6445
摘要： A fluorescence detecting optical system, and a multi-channel fluorescence detection apparatus comprising same, comprising a light source that emits excitation light, a polarizer that transmits light having a predetermined polarization component, a polarizing beam splitter that transmits light having a predetermined polarization component and reflects light having a different polarization component than the predetermined polarization component, and a quarter-wave plate converting linearly polarized to circularly polarized light or vice versa.
摘要翻译：一种荧光检测光学系统和包括其的多通道荧光检测装置，包括发射激发光的光源，透射具有预定偏振分量的光的偏振器，透射具有预定偏振分量的光的偏振分束器和反射具有与预定偏振分量不同的偏振分量的光，以及将线偏振成圆偏振光的四分之一波片反射。

4. 发明申请

US20120280143A1 FLUORESCENCE DETECTING OPTICAL SYSTEM AND MULTI-CHANNEL FLUORESCENCE DETECTION APPARATUS INCLUDING THE SAME 有权
标题翻译：检测光学系统和多通道荧光检测装置的荧光检测装置
公开(公告)号：US20120280143A1
公开(公告)日：2012-11-08
申请号：US13271101
申请日：2011-10-11
申请人： Kyung-ho KIM , Joon-ho KIM , Kak NAMKOONG , Won-seok CHUNG
发明人： Kyung-ho KIM , Joon-ho KIM , Kak NAMKOONG , Won-seok CHUNG
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , G01J3/0208 , G01J3/0229 , G01J3/0237 , G01J3/4406 , G01N21/05 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421 , G01N2021/6478 , G01N2201/0635
摘要： A fluorescence detection optical system detects fluorescence beams with two or more different wavelengths and maintains a focal position through an automatic focusing function. A multi-channel fluorescence detection apparatus includes the fluorescence detection optical system. The fluorescence detection optical system includes an automatic focusing unit which receives light reflected off a microfluidic device and determines a focal point by using an astigmatic method or a knife edge method, and an actuator which adjusts a position of an objective lens according to control of the automatic focusing unit. In addition, the fluorescence detection optical system may include a plurality of dual band pass filters, dichroic devices, etc., which provide light beams emitted from at least two light sources and transfer fluorescence generated from the microfluidic device to a photodetector.
摘要翻译：荧光检测光学系统检测具有两个或更多个不同波长的荧光束并通过自动聚焦功能保持焦点位置。多通道荧光检测装置包括荧光检测光学系统。荧光检测光学系统包括自动聚焦单元，其接收从微流体装置反射的光并且通过使用散光方法或刀刃方法确定焦点，以及致动器，其根据控制的方式调整物镜的位置自动对焦单元此外，荧光检测光学系统可以包括多个双带通滤波器，二向色装置等，其提供从至少两个光源发射的光束并将从微流体装置产生的荧光转移到光电检测器。

5. 发明授权

US07838300B2 Method of reducing temperature difference between a pair of substrates 有权
标题翻译：降低一对基板之间的温度差的方法
公开(公告)号：US07838300B2
公开(公告)日：2010-11-23
申请号：US11689640
申请日：2007-03-22
申请人： Kak Namkoong , Su-hyeon Kim , Jin-tae Kim , Chin-sung Park , Young-sun Lee
发明人： Kak Namkoong , Su-hyeon Kim , Jin-tae Kim , Chin-sung Park , Young-sun Lee
IPC分类号： G01N25/20 , B01L3/02
CPC分类号： B81B3/0081 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00873 , B01L3/5027 , B01L7/5255 , B01L2200/14 , B01L2200/147 , B01L2300/1805 , B01L2300/1827 , B81B2201/051 , F28F21/02 , F28F2013/006
摘要： A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and the low-temperature substrate, wherein formation of an air layer can be at least substantially prevented between the high-temperature substrate and the heat transfer facilitating layer, and between the low-temperature substrate and the heat transfer facilitating layer.
摘要翻译：降低高温和低温基板之间的温度差的方法包括：介于热传导率高于空气的传热促进层，并且可以在基板之间保持颗粒，并且保持高温基板，传热促进层和低温基板，其中至少可以在高温基板和传热促进层之间以及在低温基板和热量之间基本上防止空气层的形成转移促进层。

6. 发明授权

US07799557B2 Polymerase chain reaction (PCR) module and multiple PCR system using the same 有权
标题翻译：聚合酶链反应（PCR）模块和多重PCR系统使用相同
公开(公告)号：US07799557B2
公开(公告)日：2010-09-21
申请号：US11080705
申请日：2005-03-15
申请人： Kwang-wook Oh , Jin-tae Kim , Kak Namkoong , Chin-sung Park , Yoon-kyoung Cho
发明人： Kwang-wook Oh , Jin-tae Kim , Kak Namkoong , Chin-sung Park , Yoon-kyoung Cho
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/6486 , B01L3/50851 , B01L7/52 , B01L2300/0627 , B01L2300/18 , G01N21/0332
摘要： Provided are a DNA PCR module and a multiple PCR system using the same. More particularly, provided are a DNA PCR module with a combined PCR thermal cycler and PCR product detector, and a multiple PCR system using the same.
摘要翻译：提供了DNA PCR模块和使用其的多重PCR系统。更具体地，提供了具有组合的PCR热循环仪和PCR产物检测器的DNA PCR模块，以及使用其的多重PCR系统。

7. 发明授权

US07790440B2 Sensing switch and detecting method using the same 有权
标题翻译：感应开关及使用其的检测方法
公开(公告)号：US07790440B2
公开(公告)日：2010-09-07
申请号：US12272183
申请日：2008-11-17
申请人： Kyu-tae Yoo , Joon-ho Kim , Jun-hong Min , Sung-ouk Jung , Ji-na Namgoong , Kui-hyun Kim , Jeo-young Shim , Kak Namkoong
发明人： Kyu-tae Yoo , Joon-ho Kim , Jun-hong Min , Sung-ouk Jung , Ji-na Namgoong , Kui-hyun Kim , Jeo-young Shim , Kak Namkoong
IPC分类号： C12M3/00
CPC分类号： G01N33/54373
摘要： Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.
摘要翻译：提供了一种感测开关和使用该感测开关的感测方法。感测开关包括：基板; 底物上的支撑物; 感测板，其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时，引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极，并且当感测板由于感测板的偏转而与基板接触时被连接。目标材料不需要标注，不需要使用分析装置的荧光或电检测信号的信号处理，并且可以通过确认电流是否流过开关直接解码信号。

8. 发明授权

US07736050B2 Fluid mixing device using cross channels 有权
标题翻译：流体混合装置使用交叉通道
公开(公告)号：US07736050B2
公开(公告)日：2010-06-15
申请号：US11433594
申请日：2006-05-12
申请人： Chin-sung Park , Joon-ho Kim , Kak Namkoong , Kwang-wook Oh
发明人： Chin-sung Park , Joon-ho Kim , Kak Namkoong , Kwang-wook Oh
IPC分类号： B01F5/00
CPC分类号： B01F13/1013 , B01F5/0475 , B01F5/0478 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F13/1019 , B01F15/0203 , B01F15/0404 , B01F2015/0221 , G01N1/38
摘要： Provided is a fluid mixing device which produces a series of solutions with a concentration gradient. The fluid mixing device includes: a plurality of first channels disposed parallel to each other on a layer, and into which an equal amount of diluent flows from its upstream; a plurality of second channels formed perpendicular to the first channels on an adjacent layer to the layer on which the first channels are formed, and into which an equal amount of sample solution flows from its upstream; and via holes formed at at least one intersection between each of the first channel and a plurality of second channels so that a predetermined amount of sample solution flows from the second channels into corresponding first channels, wherein a series of solutions with different concentrations is produced in the first channels depending on the amount of sample solution that flows into the first channels through the via holes. Thus, a series of solutions with different concentrations is output from the first channels.
摘要翻译：提供了一种流体混合装置，其产生具有浓度梯度的一系列溶液。流体混合装置包括：在层上彼此平行设置的多个第一通道，等量的稀释剂从其上游流入其中; 多个第二通道，其垂直于与形成有第一通道的层相邻的第一通道形成，并且等量的样品溶液从其上游流入其中; 以及形成在每个第一通道和多个第二通道之间的至少一个相交处的通孔，使得预定量的样品溶液从第二通道流入相应的第一通道，其中一系列具有不同浓度的溶液在第一通道取决于通过通孔流入第一通道的样品溶液的量。因此，从第一通道输出一系列具有不同浓度的溶液。

9. 发明授权

US07698072B2 Method for quantifying initial concentration of nucleic acid from real-time nucleic acid amplification data 有权
标题翻译：从实时核酸扩增数据定量核酸初始浓度的方法
公开(公告)号：US07698072B2
公开(公告)日：2010-04-13
申请号：US11217694
申请日：2005-09-01
申请人： Kak Namkoong , Jin-tae Kim , Young-sun Lee , Young-a Kim
发明人： Kak Namkoong , Jin-tae Kim , Young-sun Lee , Young-a Kim
IPC分类号： G06F19/00
CPC分类号： C12Q1/6851
摘要： Provided is a method for quantifying an initial concentration of a nucleic acid from a real-time nucleic acid amplification data. Nucleic acid (DNA or RNA) extracted from organism or virus is amplified using an enzyme. Then, the initial concentration of the nucleic acid is found by calculating the characteristic amplification cycle number or the characteristic amplification time at which the fluorescence intensity of the nucleic acid subtracted by the background fluorescence intensity of the nucleic acid has half of its maximum value, or the characteristic amplification cycle number or the characteristic amplification time at which the amplification efficiency has the maximum or the minimum value, or the prior-to-amplification fluorescence intensity of the nucleic acid subtracted by the background fluorescence intensity of the nucleic acid. Accordingly, the initial concentration of the nucleic acid can be calculated without differentiation or integration.
摘要翻译：提供了从实时核酸扩增数据定量核酸的初始浓度的方法。使用酶扩增从生物或病毒提取的核酸（DNA或RNA）。然后，通过计算由核酸的背景荧光强度减去的核酸的荧光强度具有其最大值的一半的特征扩增循环数或特异性扩增时间来发现核酸的初始浓度，或扩增效率具有由核酸的背景荧光强度减去的核酸的最大值或最小值或以前的扩增荧光强度的特征扩增循环数或特征扩增时间。因此，可以在不分化或整合的情况下计算核酸的初始浓度。

10. 发明授权

US07579172B2 Method and apparatus for amplifying nucleic acids 有权
标题翻译：扩增核酸的方法和装置
公开(公告)号：US07579172B2
公开(公告)日：2009-08-25
申请号：US11071383
申请日：2005-03-03
申请人： Yoon-kyoung Cho , Joon-ho Kim , Kak Namkoong , Geun-bae Lim , Jun-hong Min
发明人： Yoon-kyoung Cho , Joon-ho Kim , Kak Namkoong , Geun-bae Lim , Jun-hong Min
IPC分类号： C12Q1/66 , C12P19/34
CPC分类号： G01N35/08 , B01F5/0646 , B01F5/0647 , B01F5/0654 , B01F13/0071 , B01F2015/0221 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00873 , B01J2219/00891 , B01L3/5027 , B01L3/502715 , B01L2300/0809 , B01L2300/0861 , B01L2300/0883 , G01N2035/00366 , G01N2035/00514
摘要： An apparatus for amplifying nucleic acids includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate, wherein the reactant aqueous solution contacts the fluid to create a plurality of droplets surrounded by the fluid in the reaction vessel and the nucleic acids are amplified in the reactant aqueous solution droplets.
摘要翻译：用于放大核酸的装置包括：基板，形成在基板内部的反应容器，形成在基板内部的至少一个第一入口通道，与反应容器的端部连接，并且允许引入含有反应物的反应物水溶液，核酸扩增到反应容器中，形成在基底内的第二入口通道，连接到反应容器的末端，并允许引入与反应物水溶液相分离并且不参与扩增反应的流体反应容器和加热单元，其以与基底热接触并加热基底的方式安装在基底上，其中反应物水溶液接触流体以产生由反应容器中的流体包围的多个液滴，核酸在反应物水溶液液滴中被扩增。

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