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1. 发明授权

US08859272B2 Micro-device and methods for disrupting cells 有权
标题翻译：用于破坏细胞的微型装置和方法
公开(公告)号：US08859272B2
公开(公告)日：2014-10-14
申请号：US13275871
申请日：2011-10-18
申请人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
发明人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
IPC分类号： C12M1/33 , C12Q1/68
CPC分类号： C12Q1/6806 , C12M1/33 , C12M47/06
摘要： A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber
摘要翻译：用于破坏电池的微型装置包括其中电池被破坏的第一室，被加压和减压的第二室，分离第一室和第二室的柔性膜，并且通过对第二室进行加压和减压而振动，以及限制在第一室中的微单元，其中微单元破坏第一室中的单元

2. 发明申请

US20120309004A1 MICRO-DEVICE AND METHODS FOR DISRUPTING CELLS 有权
标题翻译：用于破坏细胞的微器件和方法
公开(公告)号：US20120309004A1
公开(公告)日：2012-12-06
申请号：US13492179
申请日：2012-06-08
申请人： Kyu-youn HWANG , Joon-ho KIM , Sung-hong KWON , Chin-sung PARK , Hee-kyun LIM , Sun-ok JUNG , Won-jong JUNG
发明人： Kyu-youn HWANG , Joon-ho KIM , Sung-hong KWON , Chin-sung PARK , Hee-kyun LIM , Sun-ok JUNG , Won-jong JUNG
IPC分类号： C12M1/40 , C12Q1/68 , G01N1/28
CPC分类号： C12M47/06 , B01L3/502753 , B01L2300/0816 , B01L2300/0867 , B01L2400/0481 , C12N1/06
摘要： A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber.
摘要翻译：用于破坏电池的微型装置包括其中电池被破坏的第一室，被加压和减压的第二室，分离第一室和第二室的柔性膜，并且通过对第二室进行加压和减压而振动，以及限制在第一室中的微单元，其中微单元破坏第一室中的单元。

3. 发明申请

US20120141999A1 GENE ANALYSIS APPARATUS AND GENE ANALYSIS METHOD USING THE SAME 有权
标题翻译：基因分析装置和使用该基因的基因分析方法
公开(公告)号：US20120141999A1
公开(公告)日：2012-06-07
申请号：US13176777
申请日：2011-07-06
申请人： Chin-sung PARK , Won-jong JUNG , Joon-ho KIM , Kak NAMKOONG , Kyu-youn HWANG , Won-seok CHUNG , Hee-kyun LIM , Sung-hong KWON , Sun-ok JUNG
发明人： Chin-sung PARK , Won-jong JUNG , Joon-ho KIM , Kak NAMKOONG , Kyu-youn HWANG , Won-seok CHUNG , Hee-kyun LIM , Sung-hong KWON , Sun-ok JUNG
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L7/52 , B01L3/502715 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0627 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/18 , B01L2400/0487 , B01L2400/06 , B01L2400/0655 , C12Q1/68 , G01N21/75
摘要： A gene analysis apparatus includes a sample preparation chip in which a polymerase chain reaction (“PCR”) sample is prepared, a PCR chip in which a PCR is performed on the PCR sample, and a package layer on which the sample preparation chip and the PCR chip are mounted. The package layer includes a channel through which a material flows from the sample preparation chip to the PCR chip. The sample preparation chip and the PCR chip are on a same side or on opposing sides of the package layer.
摘要翻译：基因分析装置包括准备了聚合酶链式反应（“PCR”）样品的样品制备芯片，对PCR样品进行PCR的PCR芯片，以及将样品制备芯片和 PCR芯片安装。封装层包括材料从样品制备芯片流向PCR芯片的通道。样品制备芯片和PCR芯片在封装层的相同侧或相对侧上。

4. 发明申请

US20100261615A9 ATOMIC FORCE MICROSCOPE AS AN ANALYZING TOOL FOR BIOCHIP 审中-公开
标题翻译：原子力显微镜作为生物技术分析工具
公开(公告)号：US20100261615A9
公开(公告)日：2010-10-14
申请号：US12140226
申请日：2008-06-16
申请人： Joon Won Park , Bong Jin Hong , Sung Hong Kwon
发明人： Joon Won Park , Bong Jin Hong , Sung Hong Kwon
IPC分类号： C40B30/10 , C40B60/12
CPC分类号： G01N33/6845 , G01Q60/42
摘要： The present application discloses a method for detecting a presence of target ligand in a fluid medium which includes the steps of: (i) contacting the fluid medium with a solid substrate that includes an array of dendrons on its surface, wherein each of the dendron includes a central atom, a probe that is attached to the central atom optionally through a linker, and a base portion attached to the central atom and having a plurality of termini that are attached to the surface of the solid support; and (ii) determining the presence of a probe-target ligand complex by measuring binding force between the bound ligand and detection molecule tethered to the tip of an atomic force microscope (“AFM”), which detection molecule has affinity for the ligand, wherein measurement of an increase in force between the probe-target ligand complex and the detection molecule by AFM indicates the presence of the probe-target ligand complex.
摘要翻译：本申请公开了一种用于检测流体介质中目标配体存在的方法，其包括以下步骤：（i）使流体介质与其表面上包含一系列树突的固体基质接触，其中每个树枝包括中心原子，任选地通过连接体连接到中心原子上的探针和连接到中心原子上并具有连接到固体载体的表面上的多个末端的基部; 和（ii）通过测量结合的配体和与原子力显微镜（“AFM”）的末端连接的检测分子之间的结合力来确定探针 - 靶配体复合物的存在，该检测分子对配体具有亲和性，其中通过AFM测量探针 - 靶配体复合物和检测分子之间的力的增加表明探针 - 靶配体复合物的存在。

5. 发明申请

US20090048120A1 ATOMIC FORCE MICROSCOPE AS AN ANALYZING TOOL FOR BIOCHIP 审中-公开
标题翻译：原子力显微镜作为生物技术分析工具
公开(公告)号：US20090048120A1
公开(公告)日：2009-02-19
申请号：US12140226
申请日：2008-06-16
申请人： Joon Won Park , Bong Jin Hong , Sung Hong Kwon
发明人： Joon Won Park , Bong Jin Hong , Sung Hong Kwon
IPC分类号： C40B30/10 , C40B60/12
CPC分类号： G01N33/6845 , G01Q60/42
摘要： The present application discloses a method for detecting a presence of target ligand in a fluid medium which includes the steps of: (i) contacting the fluid medium with a solid substrate that includes an array of dendrons on its surface, wherein each of the dendron includes a central atom, a probe that is attached to the central atom optionally through a linker, and a base portion attached to the central atom and having a plurality of termini that are attached to the surface of the solid support; and (ii) determining the presence of a probe-target ligand complex by measuring binding force between the bound ligand and detection molecule tethered to the tip of an atomic force microscope (“AFM”), which detection molecule has affinity for the ligand, wherein measurement of an increase in force between the probe-target ligand complex and the detection molecule by AFM indicates the presence of the probe-target ligand complex.
摘要翻译：本申请公开了一种用于检测流体介质中目标配体存在的方法，其包括以下步骤：（i）使流体介质与其表面上包含一系列树突的固体基质接触，其中每个树枝包括中心原子，任选地通过连接体连接到中心原子上的探针和连接到中心原子上并具有连接到固体载体的表面上的多个末端的基部; 和（ii）通过测量结合的配体和与原子力显微镜（“AFM”）的末端连接的检测分子之间的结合力来确定探针 - 靶配体复合物的存在，该检测分子对配体具有亲和性，其中通过AFM测量探针 - 靶配体复合物和检测分子之间的力的增加表明探针 - 靶配体复合物的存在。

6. 发明授权

US09044755B2 Gene analysis apparatus and gene analysis method using the same 有权
标题翻译：基因分析仪和基因分析方法采用相同的方法
公开(公告)号：US09044755B2
公开(公告)日：2015-06-02
申请号：US13176777
申请日：2011-07-06
申请人： Chin-sung Park , Won-jong Jung , Joon-ho Kim , Kak Namkoong , Kyu-youn Hwang , Won-seok Chung , Hee-kyun Lim , Sung-hong Kwon , Sun-ok Jung
发明人： Chin-sung Park , Won-jong Jung , Joon-ho Kim , Kak Namkoong , Kyu-youn Hwang , Won-seok Chung , Hee-kyun Lim , Sung-hong Kwon , Sun-ok Jung
IPC分类号： C12Q1/68 , G01N21/75 , B01L7/00 , B01L3/00
CPC分类号： B01L7/52 , B01L3/502715 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0627 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/18 , B01L2400/0487 , B01L2400/06 , B01L2400/0655 , C12Q1/68 , G01N21/75
摘要： A gene analysis apparatus includes a sample preparation chip in which a polymerase chain reaction (“PCR”) sample is prepared, a PCR chip in which a PCR is performed on the PCR sample, and a package layer on which the sample preparation chip and the PCR chip are mounted. The package layer includes a channel through which a material flows from the sample preparation chip to the PCR chip. The sample preparation chip and the PCR chip are on a same side or on opposing sides of the package layer.
摘要翻译：基因分析装置包括准备了聚合酶链式反应（“PCR”）样品的样品制备芯片，对PCR样品进行PCR的PCR芯片，以及将样品制备芯片和 PCR芯片安装。封装层包括材料从样品制备芯片流向PCR芯片的通道。样品制备芯片和PCR芯片在封装层的相同侧或相对侧上。

7. 发明授权

US08895297B2 Micro-device and methods for disrupting cells 有权
标题翻译：用于破坏细胞的微型装置和方法
公开(公告)号：US08895297B2
公开(公告)日：2014-11-25
申请号：US13492179
申请日：2012-06-08
申请人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
发明人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
IPC分类号： C12N1/06 , C12M1/00 , B01L3/00 , C12M1/33 , C12M3/08 , C12M3/00
CPC分类号： C12M47/06 , B01L3/502753 , B01L2300/0816 , B01L2300/0867 , B01L2400/0481 , C12N1/06
摘要： A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber.
摘要翻译：用于破坏电池的微型装置包括其中电池被破坏的第一室，被加压和减压的第二室，分离第一室和第二室的柔性膜，并且通过对第二室进行加压和减压而振动，以及限制在第一室中的微单元，其中微单元破坏第一室中的单元。

8. 发明授权

US08580506B2 Method and composition for enhancing efficiency and sensitivity in polymerase chain reaction 有权
标题翻译：用于提高聚合酶链反应的效率和灵敏度的方法和组合物
公开(公告)号：US08580506B2
公开(公告)日：2013-11-12
申请号：US13069969
申请日：2011-03-23
申请人： Sun-ok Jung , Hee-kyun Lim , Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon
发明人： Sun-ok Jung , Hee-kyun Lim , Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806 , C12Q1/686 , C12Q2527/125
摘要： Methods and compositions for enhancing reaction efficiency and sensitivity in polymerase chain reaction (PCR) are disclosed.
摘要翻译：公开了用于提高聚合酶链反应（PCR）中的反应效率和灵敏度的方法和组合物。

9. 发明申请

US20120107912A1 CELL LYSIS DEVICE AND METHODS OF LYSING CELLS OR VIRUSES 有权
标题翻译：细胞检测装置和遗传细胞或病毒的方法
公开(公告)号：US20120107912A1
公开(公告)日：2012-05-03
申请号：US13284364
申请日：2011-10-28
申请人： Kyu-youn HWANG , Joon-ho KIM , Sung-hong KWON , Chin-sung PARK , Hee-kyun LIM , Sun-ok JUNG , Won-jong JUNG
发明人： Kyu-youn HWANG , Joon-ho KIM , Sung-hong KWON , Chin-sung PARK , Hee-kyun LIM , Sun-ok JUNG , Won-jong JUNG
IPC分类号： C12M1/00 , C12N1/20 , C12N5/04 , C12N1/14 , C12N7/00 , C12N5/07
CPC分类号： C12M1/00 , C12M1/33 , C12M47/06
摘要： A method of lysing at least one of a cell and a virus, the method including: contacting a sample, which includes at least one of a cell and a virus, with a plurality of beads which are disposed in a first chamber to obtain a combination of the sample and the beads; and agitating the combination of the sample and the beads to lyse the at least one of the cell and the virus, wherein in the first chamber a liquid volume fraction is 0.6 or less, and wherein the liquid volume fraction is a value obtained by dividing a liquid volume of the first chamber by a pure void volume equivalent to a sum of the liquid volume of the first chamber and a void volume of the first chamber.
摘要翻译：一种裂解细胞和病毒中的至少一种的方法，所述方法包括：将包括细胞和病毒中的至少一种的样品与设置在第一室中的多个珠接触以获得组合的样品和珠粒; 并搅拌样品和珠的组合以裂解细胞和病毒中的至少一种，其中在第一室中液体体积分数为0.6或更小，并且其中液体体积分数是通过将第一室的液体体积相当于第一室的液体体积和第一室的空隙体积的总和的纯空隙体积。

10. 发明授权

US08986986B2 Cell lysis device and methods of lysing cells or viruses 有权
标题翻译：细胞裂解装置和裂解细胞或病毒的方法
公开(公告)号：US08986986B2
公开(公告)日：2015-03-24
申请号：US13284364
申请日：2011-10-28
申请人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
发明人： Kyu-youn Hwang , Joon-ho Kim , Sung-hong Kwon , Chin-sung Park , Hee-kyun Lim , Sun-ok Jung , Won-jong Jung
IPC分类号： C12M1/33 , C12M3/08 , C12Q1/68 , C12Q1/70 , C12M3/00 , C12M1/00
CPC分类号： C12M1/00 , C12M1/33 , C12M47/06
摘要： A method of lysing at least one of a cell and a virus, the method including: contacting a sample, which includes at least one of a cell and a virus, with a plurality of beads which are disposed in a first chamber to obtain a combination of the sample and the beads; and agitating the combination of the sample and the beads to lyse the at least one of the cell and the virus, wherein in the first chamber a liquid volume fraction is 0.6 or less, and wherein the liquid volume fraction is a value obtained by dividing a liquid volume of the first chamber by a pure void volume equivalent to a sum of the liquid volume of the first chamber and a void volume of the first chamber.
摘要翻译：一种裂解细胞和病毒中的至少一种的方法，所述方法包括：将包括细胞和病毒中的至少一种的样品与设置在第一室中的多个珠接触以获得组合的样品和珠粒; 并搅拌样品和珠的组合以裂解细胞和病毒中的至少一种，其中在第一室中液体体积分数为0.6或更小，并且其中液体体积分数是通过将第一室的液体体积相当于第一室的液体体积和第一室的空隙体积的总和的纯空隙体积。

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