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1. 发明授权

US06709414B2 System for determining blood flow rate in a vessel using diverted flow measurements 失效
标题翻译：用于使用转向流量测量来确定血管中血流速度的系统
公开(公告)号：US06709414B2
公开(公告)日：2004-03-23
申请号：US10372470
申请日：2003-02-21
申请人： William F. Weitzel , Jonathan M. Rubin , Joseph M. Messana
发明人： William F. Weitzel , Jonathan M. Rubin , Joseph M. Messana
IPC分类号： A61M3700
CPC分类号： A61M1/3663 , A61M1/3658
摘要： A system and method are provided for determining the performance of a vessel, such as a hemodialysis access, which communicates blood between two locations of a patient. A conduit, such as an external dialysis circuit or an intravascular catheter, is provided in fluid communication with the vessel, and has a diversion point for diverting blood from the vessel into the conduit. The system further includes means for determining a flow rate of the diverted blood through the conduit. A first sensor in communication with the vessel generates at least one signal that is a function of a blood flow rate in the vessel downstream from the diversion point, wherein the downstream flow rate depends on the determined conduit flow rate and the performance of the vessel can be determined based on the signal. In addition, a processor can be provided in communication with the first sensor for determining a flow rate in the vessel upstream from the diversion point from the signal and the conduit flow rate. In a preferred embodiment, the first sensor is an ultrasonic sensor, and the at least one signal represents a time-averaged mean Doppler velocity of blood flow. Still further, additional sensors may be employed to provide a measure of the upstream flow rate as well as the conduit flow rate.
摘要翻译：提供了一种系统和方法，用于确定在患者的两个位置之间传送血液的血管的血液透析进入的血管的性能。提供与容器流体连通的导管，例如外部透析回路或血管内导管，并具有用于将血液从血管转移到导管中的转移点。该系统还包括用于确定通过导管的转运血液的流量的装置。与容器连通的第一传感器产生至少一个信号，该信号是从转向点下游的血管中的血液流速的函数，其中下游流速取决于确定的导管流速和容器的性能根据信号确定。此外，可以提供与第一传感器通信的处理器，用于从信号和导管流量确定从转向点上游的容器中的流量。在优选实施例中，第一传感器是超声波传感器，并且所述至少一个信号表示血流的时间平均平均多普勒速度。此外，可以使用附加的传感器来提供上游流量以及导管流量的量度。

2. 发明授权

US06575927B1 System and method for determining blood flow rate in a vessel 失效
标题翻译：用于确定血管中血流速度的系统和方法
公开(公告)号：US06575927B1
公开(公告)日：2003-06-10
申请号：US09310673
申请日：1999-05-12
申请人： William F. Weitzel , Jonathan M. Rubin , Joseph M. Messana
发明人： William F. Weitzel , Jonathan M. Rubin , Joseph M. Messana
IPC分类号： A61M500
CPC分类号： A61M1/3663 , A61M1/3658
摘要： A system and method are provided for determining the performance of a vessel, such as a hemodialysis access, which communicates blood between two locations of a patient. A conduit, such as an external dialysis circuit or an intravascular catheter, is provided in fluid communication with the vessel, and has a diversion point for diverting blood from the vessel into the conduit. The system further includes means for determining a flow rate of the diverted blood through the conduit. A first sensor in communication with the vessel generates at least one signal that is a function of a blood flow rate in the vessel downstream from the diversion point, wherein the downstream flow rate depends on the determined conduit flow rate and the performance of the vessel can be determined based on the signal. In addition, a processor can be provided in communication with the first sensor for determining a flow rate in the vessel upstream from the diversion point from the signal and the conduit flow rate. In a preferred embodiment, the first sensor is an ultrasonic sensor, and the at least one signal represents a time-averaged mean Doppler velocity of blood flow. Still further, additional sensors may be employed to provide a measure of the upstream flow rate as well as the conduit flow rate.
摘要翻译：提供了一种系统和方法，用于确定在患者的两个位置之间传送血液的血管的血液透析进入的血管的性能。提供与容器流体连通的导管，例如外部透析回路或血管内导管，并具有用于将血液从血管转移到导管中的转移点。该系统还包括用于确定通过导管的转运血液的流量的装置。与容器连通的第一传感器产生至少一个信号，该信号是从转向点下游的血管中的血液流速的函数，其中下游流速取决于确定的导管流速和容器的性能根据信号确定。此外，可以提供与第一传感器通信的处理器，用于从信号和导管流量确定从转向点上游的容器中的流量。在优选实施例中，第一传感器是超声波传感器，并且所述至少一个信号表示血流的时间平均平均多普勒速度。此外，可以使用附加的传感器来提供上游流量以及导管流量的量度。

3. 发明授权

US07318804B2 Methods and systems for measuring mechanical property of a vascular wall and method and system for determining health of a vascular structure 有权
标题翻译：用于测量血管壁的机械性能的方法和系统，以及用于确定血管结构健康的方法和系统
公开(公告)号：US07318804B2
公开(公告)日：2008-01-15
申请号：US10731302
申请日：2003-12-09
申请人： William F. Weitzel , Kang Kim , Matthew O'Donnell , Jonathan M. Rubin , Hua Xie , Xunchang Chen
发明人： William F. Weitzel , Kang Kim , Matthew O'Donnell , Jonathan M. Rubin , Hua Xie , Xunchang Chen
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B8/08
摘要： Methods and systems for measuring mechanical property of a vascular wall and a method and system for determining health of a vascular structure are provided wherein local deformation of a vessel wall resulting from physiologic pressures with altered transmural forces is measured. A non-invasive free-hand ultrasound scanning-procedure was performed to apply external force, comparable to the force generated in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. When the applied pressure matched the internal baseline diastolic pressure, strain and strain rate increased by a factor of 10 over a cardiac cycle. Radial arterial strain was assessed in the vessel wall over the entire deformation procedure using a phase-sensitive, two-dimensional speckle-tracking algorithm. An elastic modulus reconstruction procedure was developed to estimate the non-linear elastic properties of the vascular wall.
摘要翻译：提供了用于测量血管壁的机械性能的方法和系统以及用于确定血管结构健康的方法和系统，其中测量由具有改变的透壁力的生理压力引起的血管壁的局部变形。进行非侵入性自由手超声扫描程序以施加外力，与测量受试者血压时产生的力相当，以通过平衡内部动脉基线压力来实现更高的应变。当施加的压力与内部基线舒张压相匹配时，应变和应变率在心脏周期上增加10倍。使用相敏二维斑点跟踪算法，在整个变形过程的血管壁中评估径向动脉应变。开发弹性模量重建程序来估计血管壁的非线性弹性性质。

4. 发明授权

US08167804B2 Measurement of tissue elastic modulus 有权
标题翻译：组织弹性模量的测量
公开(公告)号：US08167804B2
公开(公告)日：2012-05-01
申请号：US11866000
申请日：2007-10-02
申请人： Kang Kim , William F. Weitzel , Jonathan M. Rubin , Congxian Jia , Matthew O'Donnell , Theodore J. Kolias
发明人： Kang Kim , William F. Weitzel , Jonathan M. Rubin , Congxian Jia , Matthew O'Donnell , Theodore J. Kolias
IPC分类号： A61B8/00
CPC分类号： A61B5/0285 , A61B8/06 , A61B8/08 , A61B8/485 , G01S7/52036 , G01S7/52042
摘要： An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.
摘要翻译：优化的弹性模量重建程序可以从壁内应变和脉搏波速度（PWV）测量中估计血管壁的非线性弹性特性。使用非侵入性自由手超声扫描程序来施加外力，与测量受试者血压的力相当，以通过平衡内部动脉基线压力来实现更高的应变。 PWV估计在测量壁内应变的相同位置。重建的弹性模量被优化，并且可以使用简单的双弹性模量重建程序来确定和监测动脉弹性模量。

5. 发明授权

US07542544B2 Ultrasound gating of cardiac CT scans 失效
标题翻译：超声门控心脏CT扫描
公开(公告)号：US07542544B2
公开(公告)日：2009-06-02
申请号：US11029773
申请日：2005-01-05
申请人： Jonathan M. Rubin , Jeffrey Brian Fowlkes , Charles R. Meyer , Srini Tridandapani
发明人： Jonathan M. Rubin , Jeffrey Brian Fowlkes , Charles R. Meyer , Srini Tridandapani
IPC分类号： G01N23/04 , A61B6/00 , A61B5/05
CPC分类号： A61B6/488 , A61B6/503 , A61B6/504 , A61B6/541 , A61B8/02
摘要： An ultrasonic imaging system acquires echo signals from an object being imaged such as a moving coronary artery and the cross-correlation between echo signals is employed as an objective measure of relative object location. The method is used in a prescan procedure to determine an optimal gating window to acquire image data during a cardiac gated scan, and it is used during the scan as a real time gating signal.
摘要翻译：超声成像系统从诸如移动冠状动脉的成像对象获取回波信号，并且采用回波信号之间的互相关作为相对物体位置的客观测量。该方法以预扫描程序用于确定在心脏门控扫描期间获取图像数据的最佳门控窗口，并且其在扫描期间被用作实时门控信号。

6. 发明授权

US07154987B2 Projection gating of x-ray CT scan 有权
标题翻译： x射线CT扫描的投射门控
公开(公告)号：US07154987B2
公开(公告)日：2006-12-26
申请号：US11222105
申请日：2005-09-08
申请人： Jonathan M. Rubin , Benoit Desjardins , J. Brian Fowlkes , Srini Tridandapani
发明人： Jonathan M. Rubin , Benoit Desjardins , J. Brian Fowlkes , Srini Tridandapani
IPC分类号： G01N23/083
CPC分类号： A61B6/5264 , A61B6/027 , A61B6/032 , A61B6/503 , A61B6/5217 , A61B6/541 , G06T11/005 , G06T2211/412
摘要： An x-ray CT system performs a scan by acquiring projection views from which an image is reconstructed. In a prospective embodiment, the correlation of adjacent views is calculated as the scan is performed and is used to detect subject motion as the scan is being performed. In a retrospective embodiment, the correlation of adjacent views is calculated and is used to detect subject motion after the scan is completed. In the first embodiment substitute projection views are acquired by continuing the scan and in the second embodiment redundant projection views acquired during the scan are substituted until the best possible image is produced.
摘要翻译： X射线CT系统通过获取重建图像的投影视图来执行扫描。在预期实施例中，当执行扫描时计算相邻视图的相关性，并且当扫描正在执行时用于检测对象运动。在回顾性实施例中，计算相邻视图的相关性并且用于在扫描完成之后检测被摄体动作。在第一实施例中，通过继续扫描来获取替代投影视图，并且在第二实施例中，在扫描期间获取的冗余投影视图被代替，直到产生最佳可能的图像为止。

7. 发明申请

US20140094702A1 METHODS AND APPARATUSES FOR MEASURING TISSUE STIFFNESS CHANGES USING ULTRASOUND ELASTICITY IMAGING 有权
标题翻译：使用超声波弹性成像测量组织变形的方法和装置
公开(公告)号：US20140094702A1
公开(公告)日：2014-04-03
申请号：US14119050
申请日：2012-05-23
申请人： Kang Kim , Jingping Xu , Jonathan M. Rubin
发明人： Kang Kim , Jingping Xu , Jonathan M. Rubin
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/485 , A61B8/08 , A61B8/085 , A61B8/0858 , A61B8/4281 , A61B8/4483 , A61B8/461 , A61B8/5223 , G01N29/0654 , G01N29/07 , G01N2291/02475 , G01N2291/0422
摘要： A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.
摘要翻译：评估目标区域的组织刚度的方法包括将超声弹性成像装置定位在所述目标区域所在的组织区域的表面附近，并向组织施加动态范围的力。可以将多个超声波束指向组织，并且可以从目标区域中的应变组织获取多个超声波回波，以计算目标区域内产生的应变量。

8. 发明授权

US6059727A Method and apparatus for composition and display of three-dimensional image from two-dimensional ultrasound scan data 失效
标题翻译：用于从二维超声扫描数据组合和显示三维图像的方法和装置
公开(公告)号：US6059727A
公开(公告)日：2000-05-09
申请号：US981058
申请日：1998-04-13
申请人： J. Brian Fowlkes , Paul L. Carson , Aaron Moskalik , Jian-Feng Chen , Jonathan M. Rubin
发明人： J. Brian Fowlkes , Paul L. Carson , Aaron Moskalik , Jian-Feng Chen , Jonathan M. Rubin
IPC分类号： A61B8/00 , A61B8/08 , A61B8/14 , G06T1/00 , G06T11/00
CPC分类号： A61B8/08 , G01S15/8993 , G06T7/0026 , A61B8/14 , G01S15/8936 , G06T2207/10132 , G06T2207/20021 , G06T2207/30004 , Y10S128/916
摘要： A 3D image data set representing a volume of material such as human tissue is created using speckle decorrelation techniques to process successive 2D data slices from a moving, standard 1D or 1.5D ultrasound transducer. This permits the use of standard ultrasound machinery, without the use of additional slice-position hardware, to create 3D images without having to modify the machinery or its operation. Similar techniques can be used for special data processing within the imaging system as well to expedite the image acquisition process. Optionally, the image quality of 2D images can be enhanced through the use of multiple 3D data sets derived using the method.
摘要翻译： PCT No.PCT / US96 / 10189 Sec。 371日期：1998年4月13日 102（e）1998年4月13日PCT PCT 1996年6月14日PCT公布。公开号WO97 / 00482 日期1997年1月3日使用斑点去相关技术来创建表示诸如人体组织的材料体积的3D图像数据集，以从移动的标准1D或1.5D超声换能器处理连续的2D数据切片。这允许使用标准超声机器，而不需要使用附加的切片位置硬件来创建3D图像，而不必修改机器或其操作。类似的技术可用于成像系统内的特殊数据处理，并且可以加快图像采集过程。可选地，可以通过使用使用该方法导出的多个3D数据集来增强2D图像的图像质量。

9. 发明授权

US09554777B2 Methods and apparatuses for measuring tissue stiffness changes using ultrasound elasticity imaging 有权
标题翻译：使用超声弹性成像测量组织刚度变化的方法和装置
公开(公告)号：US09554777B2
公开(公告)日：2017-01-31
申请号：US14119050
申请日：2012-05-23
申请人： Kang Kim , Jingping Xu , Jonathan M. Rubin
发明人： Kang Kim , Jingping Xu , Jonathan M. Rubin
IPC分类号： A61B8/08 , G01N29/06 , G01N29/07 , A61B8/00
CPC分类号： A61B8/485 , A61B8/08 , A61B8/085 , A61B8/0858 , A61B8/4281 , A61B8/4483 , A61B8/461 , A61B8/5223 , G01N29/0654 , G01N29/07 , G01N2291/02475 , G01N2291/0422
摘要： A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.
摘要翻译：评估目标区域的组织刚度的方法包括将超声弹性成像装置定位在所述目标区域所在的组织区域的表面附近，并向组织施加动态范围的力。可以将多个超声波束指向组织，并且可以从目标区域中的应变组织获取多个超声波回波，以计算目标区域内产生的应变量。

10. 发明授权

US06535835B1 Angle independent ultrasound volume flow measurement 有权
标题翻译：角独立超声体积流量测量
公开(公告)号：US06535835B1
公开(公告)日：2003-03-18
申请号：US09495231
申请日：2000-01-31
申请人： Jonathan M. Rubin , Jeffrey Brian Fowlkes , Theresa Ann Tuthill , Anne Lindsey Hall
发明人： Jonathan M. Rubin , Jeffrey Brian Fowlkes , Theresa Ann Tuthill , Anne Lindsey Hall
IPC分类号： G01B1102
CPC分类号： G01S15/8959 , A61B8/06 , A61B8/13 , G01S15/8961 , G01S15/8984
摘要： The volume of fluid flow within a vessel (VE) is measured by an ultrasound system. Ultrasound waves backscattered from the fluid within the vessel generate data from which velocity values representing components of velocity (Vx and Vy) of the fluid flow in the scan plane (IP) are calculated. Grayscale data is correlated and the rate of decorrelation (D) of the data is calculated. The volume flow of the fluid (F) is estimated in response to the velocity signals and the rate of decorrelation (D).
摘要翻译：容器（VE）内的流体流量由超声系统测量。从容器内的流体反向散射的超声波产生数据，从中计算表示扫描平面（IP）中的流体流速度（Vx和Vy）的分量的速度值。灰度数据相关，并计算数据的去相关（D）的速率。流体（F）的体积流量是根据速度信号和去相关速率（D）来估计的。

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