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1. 发明授权

US07154987B2 Projection gating of x-ray CT scan 有权
标题翻译： x射线CT扫描的投射门控
公开(公告)号：US07154987B2
公开(公告)日：2006-12-26
申请号：US11222105
申请日：2005-09-08
申请人： Jonathan M. Rubin , Benoit Desjardins , J. Brian Fowlkes , Srini Tridandapani
发明人： Jonathan M. Rubin , Benoit Desjardins , J. Brian Fowlkes , Srini Tridandapani
IPC分类号： G01N23/083
CPC分类号： A61B6/5264 , A61B6/027 , A61B6/032 , A61B6/503 , A61B6/5217 , A61B6/541 , G06T11/005 , G06T2211/412
摘要： An x-ray CT system performs a scan by acquiring projection views from which an image is reconstructed. In a prospective embodiment, the correlation of adjacent views is calculated as the scan is performed and is used to detect subject motion as the scan is being performed. In a retrospective embodiment, the correlation of adjacent views is calculated and is used to detect subject motion after the scan is completed. In the first embodiment substitute projection views are acquired by continuing the scan and in the second embodiment redundant projection views acquired during the scan are substituted until the best possible image is produced.
摘要翻译： X射线CT系统通过获取重建图像的投影视图来执行扫描。在预期实施例中，当执行扫描时计算相邻视图的相关性，并且当扫描正在执行时用于检测对象运动。在回顾性实施例中，计算相邻视图的相关性并且用于在扫描完成之后检测被摄体动作。在第一实施例中，通过继续扫描来获取替代投影视图，并且在第二实施例中，在扫描期间获取的冗余投影视图被代替，直到产生最佳可能的图像为止。

2. 发明授权

US5860929A Fractional moving blood volume estimation with power doppler ultrasound 失效
标题翻译：动力多普勒超声的分数移动血容量估计
公开(公告)号：US5860929A
公开(公告)日：1999-01-19
申请号：US657897
申请日：1996-06-07
申请人： Jonathan M. Rubin , Ronald S. Adler , J. Brian Fowlkes , Ray Steven Spratt
发明人： Jonathan M. Rubin , Ronald S. Adler , J. Brian Fowlkes , Ray Steven Spratt
IPC分类号： A61B8/06
CPC分类号： A61B8/463 , A61B8/06
摘要： A method for quantitatively estimating the amount of tissue that contains moving blood using power Doppler ultrasound. A region of interest is identified from a frozen image (i.e., a snapshot screen display created by displaying the last real-time image for a given scan). The region of interest is specified by using a pointing device (e.g., a mouse). An object that contains one hundred percent blood flow and is located at the same depth as the region of interest, but not necessarily inside the region of interest, is identified and the corresponding power noted and designated as the reference power level. The display is adjusted to show the one hundred percent blood flow vessel in a designated color (such as, for example, green) and all other power levels are normalized to the reference power level. The fractional blood volume is quantitatively estimated by summing the normalized Doppler power levels in a region of interest and dividing the sum by the number of pixels in region of interest. The numerical result for the specified region of interest may be shown on the display of the ultrasound scanner.
摘要翻译：一种使用功率多普勒超声波定量估计含有移动血液的组织量的方法。从冻结图像识别感兴趣区域（即，通过显示给定扫描的最后一个实时图像而创建的快照屏幕显示）。通过使用指示设备（例如，鼠标）来指定感兴趣的区域。识别出含有百分之一百血液流量并且位于与感兴趣区域相同的深度但不一定在感兴趣区域内的物体，并且将相应的功率标记并指定为参考功率水平。调整显示器以指定颜色（例如，绿色）显示百分之一百的血流容器，并将所有其它功率电平归一化为参考功率电平。通过将感兴趣区域中的归一化多普勒功率电平相加并将该和除以感兴趣区域中的像素数量来定量估计分数血容量。指定感兴趣区域的数值结果可以显示在超声波扫描仪的显示器上。

3. 发明授权

US6059727A Method and apparatus for composition and display of three-dimensional image from two-dimensional ultrasound scan data 失效
标题翻译：用于从二维超声扫描数据组合和显示三维图像的方法和装置
公开(公告)号：US6059727A
公开(公告)日：2000-05-09
申请号：US981058
申请日：1998-04-13
申请人： J. Brian Fowlkes , Paul L. Carson , Aaron Moskalik , Jian-Feng Chen , Jonathan M. Rubin
发明人： J. Brian Fowlkes , Paul L. Carson , Aaron Moskalik , Jian-Feng Chen , Jonathan M. Rubin
IPC分类号： A61B8/00 , A61B8/08 , A61B8/14 , G06T1/00 , G06T11/00
CPC分类号： A61B8/08 , G01S15/8993 , G06T7/0026 , A61B8/14 , G01S15/8936 , G06T2207/10132 , G06T2207/20021 , G06T2207/30004 , Y10S128/916
摘要： A 3D image data set representing a volume of material such as human tissue is created using speckle decorrelation techniques to process successive 2D data slices from a moving, standard 1D or 1.5D ultrasound transducer. This permits the use of standard ultrasound machinery, without the use of additional slice-position hardware, to create 3D images without having to modify the machinery or its operation. Similar techniques can be used for special data processing within the imaging system as well to expedite the image acquisition process. Optionally, the image quality of 2D images can be enhanced through the use of multiple 3D data sets derived using the method.
摘要翻译： PCT No.PCT / US96 / 10189 Sec。 371日期：1998年4月13日 102（e）1998年4月13日PCT PCT 1996年6月14日PCT公布。公开号WO97 / 00482 日期1997年1月3日使用斑点去相关技术来创建表示诸如人体组织的材料体积的3D图像数据集，以从移动的标准1D或1.5D超声换能器处理连续的2D数据切片。这允许使用标准超声机器，而不需要使用附加的切片位置硬件来创建3D图像，而不必修改机器或其操作。类似的技术可用于成像系统内的特殊数据处理，并且可以加快图像采集过程。可选地，可以通过使用使用该方法导出的多个3D数据集来增强2D图像的图像质量。

4. 发明申请

US20110054315A1 MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS 有权
标题翻译：用于治疗和成像超声波传感器的微机控制器
公开(公告)号：US20110054315A1
公开(公告)日：2011-03-03
申请号：US12868768
申请日：2010-08-26
申请人： WILLIAM W. ROBERTS , Timothy L. Hall , Charles A. Cain , J. Brian Fowlkes , Zhen Xu , Michael Thomas Kusner, JR. , Dejan Teofilovic
发明人： WILLIAM W. ROBERTS , Timothy L. Hall , Charles A. Cain , J. Brian Fowlkes , Zhen Xu , Michael Thomas Kusner, JR. , Dejan Teofilovic
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/02 , A61B8/12 , A61B8/4218 , A61B34/72 , A61B90/50 , A61B2017/22008 , A61B2090/378
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.
摘要翻译：提供了可以包括许多特征中的任何一个的医学成像和治疗装置。该装置的一个特点是可以对目标组织体积进行成像，并将超声能量应用于目标组织体积。在一些实施例中，医疗成像和治疗装置被配置为可控制地将超声能量施加到前列腺中，通过维持由成像系统产生的前列腺图像内的超声治疗系统产生的空泡气泡云。医学成像和治疗装置可用于治疗应用，例如组织切除术，碎石术和HIFU。还涉及与使用医学成像和治疗装置相关的方法。

5. 发明授权

US09642634B2 Pulsed cavitational ultrasound therapy 有权
公开(公告)号：US09642634B2
公开(公告)日：2017-05-09
申请号：US13241076
申请日：2011-09-22
申请人： Charles A. Cain , Zhen Xu , J. Brian Fowlkes , Timothy L. Hall , William W. Roberts
发明人： Charles A. Cain , Zhen Xu , J. Brian Fowlkes , Timothy L. Hall , William W. Roberts
IPC分类号： A61H1/00 , A61B17/22 , A61M37/00 , A61B5/053 , A61B5/055 , A61B8/00 , A61B8/08 , A61B17/225 , A61B17/00 , A61B90/00
CPC分类号： A61B17/22004 , A61B5/0536 , A61B5/055 , A61B8/00 , A61B8/08 , A61B8/4272 , A61B8/485 , A61B17/225 , A61B2017/00154 , A61B2017/00172 , A61B2017/22008 , A61B2017/22088 , A61B2017/22089 , A61B2090/378 , A61M37/0092
摘要： Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial-temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and/or the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.

6. 发明授权

US06309355B1 Method and assembly for performing ultrasound surgery using cavitation 有权
标题翻译：使用气穴进行超声手术的方法和装配
公开(公告)号：US06309355B1
公开(公告)日：2001-10-30
申请号：US09218310
申请日：1998-12-22
申请人： Charles A. Cain , J. Brian Fowlkes
发明人： Charles A. Cain , J. Brian Fowlkes
IPC分类号： A61B1722
CPC分类号： A61B17/22004 , A61B2017/22008 , A61B2017/22089 , A61M37/0092
摘要： A method and assembly are provided which use cavitation induced by an ultrasound beam for creating a controlled surgical lesion in a selected treatment volume of a patient. First, a plurality of microbubbles are provided in the treatment volume. Preferably, the threshold for cavitation of microbubbles in the treatment volume is lowered compared with the threshold for cavitation in surrounding tissues. The expected location of the surgical lesion within the treatment volume may be previewed, and then the microbubbles in the treatment volume are cavitated with the ultrasound beam to create the controlled surgical lesion. Preferably, the creation of the surgical lesion at the expected lesion location is then verified. Using the method and assembly of the present invention, the cavitation threshold within the treatment volume is made predictable, and a low frequency ultrasound beam may be used to cavitate the microbubbles within the treatment volume without causing damage to surrounding tissues.
摘要翻译：提供了一种方法和组件，其使用由超声波束引起的空化，以在患者的所选择的治疗体积中产生受控手术病变。首先，在处理容积中设置多个微泡。优选地，与周围组织中的空化阈值相比，治疗体积中的微泡气蚀阈值降低。手术病变在治疗体积内的预期位置可以预览，然后治疗体积中的微泡被超声波束气蚀，以产生受控的手术病变。优选地，验证在预期的病变位置处的手术损伤的产生。使用本发明的方法和装配，可以预测处理体积内的气蚀阈值，并且可以使用低频超声波束来对治疗体积内的微泡进行空化，而不会对周围组织造成损伤。

7. 发明授权

US09901753B2 Ultrasound lithotripsy and histotripsy for using controlled bubble cloud cavitation in fractionating urinary stones 有权
$Ultrasound lithotripsy and histotripsy for using controlled bubble cloud cavitation in fractionating urinary stones$
公开(公告)号：US09901753B2
公开(公告)日：2018-02-27
申请号：US12868775
申请日：2010-08-26
申请人： Charles A. Cain , Timothy L. Hall , William W. Roberts , Zhen Xu , J. Brian Fowlkes , Thomas W. Davison
发明人： Charles A. Cain , Timothy L. Hall , William W. Roberts , Zhen Xu , J. Brian Fowlkes , Thomas W. Davison
IPC分类号： A61N7/00 , A61B17/225 , A61B8/00 , A61B17/00 , A61B17/22 , A61B90/00
CPC分类号： A61N7/00 , A61B8/00 , A61B17/225 , A61B17/2256 , A61B2017/00172 , A61B2017/22008 , A61B2090/378
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.

8. 发明申请

US20130303906A1 Devices and Methods for Using Controlled Bubble Cloud Cavitation in Fractionating Urinary Stones 审中-公开
标题翻译：在分泌尿路中使用受控气泡云气蚀的装置和方法
公开(公告)号：US20130303906A1
公开(公告)日：2013-11-14
申请号：US13943621
申请日：2013-07-16
申请人： Charles A. Cain , Timothy L. Hall , William W. Roberts , Zhen Xu , J. Brian Fowlkes , Thomas W. Davison
发明人： Charles A. Cain , Timothy L. Hall , William W. Roberts , Zhen Xu , J. Brian Fowlkes , Thomas W. Davison
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/00 , A61B8/00 , A61B17/225 , A61B17/2256 , A61B2017/00172 , A61B2017/22008 , A61B2090/378
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.
摘要翻译：提供了可以包括许多特征中的任何一个的医学成像和治疗装置。该装置的一个特征是它可以向病人提供Lithotripsy治疗，以便分泌尿石。该装置的另一个特征是可以将Histotripsy治疗方法提供给患者，以便侵蚀尿石。在一些实施例中，医学成像和治疗装置被配置为在治疗期间靶向和跟踪患者的尿石。还涉及与使用医学成像和治疗装置相关的方法。

9. 发明申请

US20100069797A1 PULSED CAVITATIONAL ULTRASOUND THERAPY 审中-公开
标题翻译：脉冲超声治疗
公开(公告)号：US20100069797A1
公开(公告)日：2010-03-18
申请号：US12569061
申请日：2009-09-29
申请人： Charles A. Cain , J. Brian Fowlkes , Zhen Xu , Timothy L. Hall
发明人： Charles A. Cain , J. Brian Fowlkes , Zhen Xu , Timothy L. Hall
IPC分类号： A61N7/00
CPC分类号： A61M37/0092 , A61B8/00 , A61B8/485 , A61B17/22004 , A61B2017/22088 , A61B2017/22089
摘要： Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial-temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.
摘要翻译：使用脉冲空化超声治疗的治疗方法可以包括组织过程的起始，维持，治疗和反馈的子过程，其涉及创建和维护微泡组合以及反馈的使用，以便基于观察到的空间来优化过程 - 时空泡云动力学。该方法提供了组织的细分或侵蚀，组织的液化以及增强的治疗剂的递送。各种反馈机制允许超声参数的变化并且提供对脉冲空化过程的控制，允许该过程针对多个应用进行调整。这样的应用可以包括特定的组织侵蚀，本体组织均质化和跨越障碍物的治疗剂的递送。

10. 发明授权

US09943708B2 Automated control of micromanipulator arm for histotripsy prostate therapy while imaging via ultrasound transducers in real time 有权
公开(公告)号：US09943708B2
公开(公告)日：2018-04-17
申请号：US12868768
申请日：2010-08-26
申请人： William W. Roberts , Timothy L. Hall , Charles A. Cain , J. Brian Fowlkes , Zhen Xu , Michael Thomas Kusner, Jr. , Dejan Teofilovic
发明人： William W. Roberts , Timothy L. Hall , Charles A. Cain , J. Brian Fowlkes , Zhen Xu , Michael Thomas Kusner, Jr. , Dejan Teofilovic
IPC分类号： A61B8/00 , A61N7/00 , A61N7/02 , A61B8/12 , A61B34/00 , A61B17/22 , A61B90/50 , A61B90/00
CPC分类号： A61N7/02 , A61B8/12 , A61B8/4218 , A61B34/72 , A61B90/50 , A61B2017/22008 , A61B2090/378
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

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