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1. 发明授权

US07318804B2 Methods and systems for measuring mechanical property of a vascular wall and method and system for determining health of a vascular structure 有权
标题翻译：用于测量血管壁的机械性能的方法和系统，以及用于确定血管结构健康的方法和系统
公开(公告)号：US07318804B2
公开(公告)日：2008-01-15
申请号：US10731302
申请日：2003-12-09
申请人： William F. Weitzel , Kang Kim , Matthew O'Donnell , Jonathan M. Rubin , Hua Xie , Xunchang Chen
发明人： William F. Weitzel , Kang Kim , Matthew O'Donnell , Jonathan M. Rubin , Hua Xie , Xunchang Chen
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B8/08
摘要： Methods and systems for measuring mechanical property of a vascular wall and a method and system for determining health of a vascular structure are provided wherein local deformation of a vessel wall resulting from physiologic pressures with altered transmural forces is measured. A non-invasive free-hand ultrasound scanning-procedure was performed to apply external force, comparable to the force generated in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. When the applied pressure matched the internal baseline diastolic pressure, strain and strain rate increased by a factor of 10 over a cardiac cycle. Radial arterial strain was assessed in the vessel wall over the entire deformation procedure using a phase-sensitive, two-dimensional speckle-tracking algorithm. An elastic modulus reconstruction procedure was developed to estimate the non-linear elastic properties of the vascular wall.
摘要翻译：提供了用于测量血管壁的机械性能的方法和系统以及用于确定血管结构健康的方法和系统，其中测量由具有改变的透壁力的生理压力引起的血管壁的局部变形。进行非侵入性自由手超声扫描程序以施加外力，与测量受试者血压时产生的力相当，以通过平衡内部动脉基线压力来实现更高的应变。当施加的压力与内部基线舒张压相匹配时，应变和应变率在心脏周期上增加10倍。使用相敏二维斑点跟踪算法，在整个变形过程的血管壁中评估径向动脉应变。开发弹性模量重建程序来估计血管壁的非线性弹性性质。

2. 发明授权

US08167804B2 Measurement of tissue elastic modulus 有权
标题翻译：组织弹性模量的测量
公开(公告)号：US08167804B2
公开(公告)日：2012-05-01
申请号：US11866000
申请日：2007-10-02
申请人： Kang Kim , William F. Weitzel , Jonathan M. Rubin , Congxian Jia , Matthew O'Donnell , Theodore J. Kolias
发明人： Kang Kim , William F. Weitzel , Jonathan M. Rubin , Congxian Jia , Matthew O'Donnell , Theodore J. Kolias
IPC分类号： A61B8/00
CPC分类号： A61B5/0285 , A61B8/06 , A61B8/08 , A61B8/485 , G01S7/52036 , G01S7/52042
摘要： An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.
摘要翻译：优化的弹性模量重建程序可以从壁内应变和脉搏波速度（PWV）测量中估计血管壁的非线性弹性特性。使用非侵入性自由手超声扫描程序来施加外力，与测量受试者血压的力相当，以通过平衡内部动脉基线压力来实现更高的应变。 PWV估计在测量壁内应变的相同位置。重建的弹性模量被优化，并且可以使用简单的双弹性模量重建程序来确定和监测动脉弹性模量。

3. 发明授权

US06709414B2 System for determining blood flow rate in a vessel using diverted flow measurements 失效
标题翻译：用于使用转向流量测量来确定血管中血流速度的系统
公开(公告)号：US06709414B2
公开(公告)日：2004-03-23
申请号：US10372470
申请日：2003-02-21
申请人： William F. Weitzel , Jonathan M. Rubin , Joseph M. Messana
发明人： William F. Weitzel , Jonathan M. Rubin , Joseph M. Messana
IPC分类号： A61M3700
CPC分类号： A61M1/3663 , A61M1/3658
摘要： A system and method are provided for determining the performance of a vessel, such as a hemodialysis access, which communicates blood between two locations of a patient. A conduit, such as an external dialysis circuit or an intravascular catheter, is provided in fluid communication with the vessel, and has a diversion point for diverting blood from the vessel into the conduit. The system further includes means for determining a flow rate of the diverted blood through the conduit. A first sensor in communication with the vessel generates at least one signal that is a function of a blood flow rate in the vessel downstream from the diversion point, wherein the downstream flow rate depends on the determined conduit flow rate and the performance of the vessel can be determined based on the signal. In addition, a processor can be provided in communication with the first sensor for determining a flow rate in the vessel upstream from the diversion point from the signal and the conduit flow rate. In a preferred embodiment, the first sensor is an ultrasonic sensor, and the at least one signal represents a time-averaged mean Doppler velocity of blood flow. Still further, additional sensors may be employed to provide a measure of the upstream flow rate as well as the conduit flow rate.
摘要翻译：提供了一种系统和方法，用于确定在患者的两个位置之间传送血液的血管的血液透析进入的血管的性能。提供与容器流体连通的导管，例如外部透析回路或血管内导管，并具有用于将血液从血管转移到导管中的转移点。该系统还包括用于确定通过导管的转运血液的流量的装置。与容器连通的第一传感器产生至少一个信号，该信号是从转向点下游的血管中的血液流速的函数，其中下游流速取决于确定的导管流速和容器的性能根据信号确定。此外，可以提供与第一传感器通信的处理器，用于从信号和导管流量确定从转向点上游的容器中的流量。在优选实施例中，第一传感器是超声波传感器，并且所述至少一个信号表示血流的时间平均平均多普勒速度。此外，可以使用附加的传感器来提供上游流量以及导管流量的量度。

4. 发明授权

US06575927B1 System and method for determining blood flow rate in a vessel 失效
标题翻译：用于确定血管中血流速度的系统和方法
公开(公告)号：US06575927B1
公开(公告)日：2003-06-10
申请号：US09310673
申请日：1999-05-12
申请人： William F. Weitzel , Jonathan M. Rubin , Joseph M. Messana
发明人： William F. Weitzel , Jonathan M. Rubin , Joseph M. Messana
IPC分类号： A61M500
CPC分类号： A61M1/3663 , A61M1/3658
摘要： A system and method are provided for determining the performance of a vessel, such as a hemodialysis access, which communicates blood between two locations of a patient. A conduit, such as an external dialysis circuit or an intravascular catheter, is provided in fluid communication with the vessel, and has a diversion point for diverting blood from the vessel into the conduit. The system further includes means for determining a flow rate of the diverted blood through the conduit. A first sensor in communication with the vessel generates at least one signal that is a function of a blood flow rate in the vessel downstream from the diversion point, wherein the downstream flow rate depends on the determined conduit flow rate and the performance of the vessel can be determined based on the signal. In addition, a processor can be provided in communication with the first sensor for determining a flow rate in the vessel upstream from the diversion point from the signal and the conduit flow rate. In a preferred embodiment, the first sensor is an ultrasonic sensor, and the at least one signal represents a time-averaged mean Doppler velocity of blood flow. Still further, additional sensors may be employed to provide a measure of the upstream flow rate as well as the conduit flow rate.
摘要翻译：提供了一种系统和方法，用于确定在患者的两个位置之间传送血液的血管的血液透析进入的血管的性能。提供与容器流体连通的导管，例如外部透析回路或血管内导管，并具有用于将血液从血管转移到导管中的转移点。该系统还包括用于确定通过导管的转运血液的流量的装置。与容器连通的第一传感器产生至少一个信号，该信号是从转向点下游的血管中的血液流速的函数，其中下游流速取决于确定的导管流速和容器的性能根据信号确定。此外，可以提供与第一传感器通信的处理器，用于从信号和导管流量确定从转向点上游的容器中的流量。在优选实施例中，第一传感器是超声波传感器，并且所述至少一个信号表示血流的时间平均平均多普勒速度。此外，可以使用附加的传感器来提供上游流量以及导管流量的量度。

5. 发明授权

US06167765A System and method for determining the flow rate of blood in a vessel using doppler frequency signals 有权
标题翻译：使用多普勒频率信号确定血管中血液流量的系统和方法
公开(公告)号：US06167765A
公开(公告)日：2001-01-02
申请号：US09160685
申请日：1998-09-25
申请人： William F. Weitzel
发明人： William F. Weitzel
IPC分类号： G01F120
CPC分类号： A61M1/3663 , A61M1/3658
摘要： A system and method are provided for determining the flow rate of blood in a vessel, such as a hemodialysis access. The system includes a conduit, such as an external dialysis circuit or an intravascular catheter, in communication with the blood in the vessel and having a diversion point for diverting the blood from the vessel into the conduit. As such, the vessel has a flow rate (QA) upstream from the diversion point and a flow rate (QD) downstream from the diversion point. A pump is connected to the conduit for diverting the blood into the conduit using a pump flow rate. An ultrasonic sensor is provided in communication with the blood in the vessel downstream from the diversion point. The ultrasonic sensor senses the downstream flow rate (QD) and generates at least two downstream Doppler frequency signals including a first downstream Doppler frequency signal when the pump has a first pump flow rate and a second downstream Doppler frequency signal when the pump has a second pump flow rate. A processor connected to the ultrasonic sensor and the pump then determines the upstream flow rate (QA) when the pump has a selected pump flow rate from the first and second downstream Doppler frequency signals and the selected pump flow rate.
摘要翻译：提供了一种系统和方法，用于确定血管中血液的流速，例如血液透析通路。该系统包括与容器中的血液连通的导管，例如外部透析回路或血管内导管，并具有用于将血液从血管转移到导管中的转移点。因此，容器具有从转向点上游的流量（QA）和从转向点下游的流量（QD）。泵连接到管道，以使用泵流量将血液转入管道。提供超声波传感器，其与转移点下游的血管中的血液连通。超声波传感器感测下游流量（QD）并且当泵具有第一泵流量时产生包括第一下游多普勒频率信号的至少两个下行多普勒频率信号，当泵具有第二下游多普勒频率信号时，该泵具有第二泵流量。连接到超声波传感器和泵的处理器随后确定当泵具有来自第一和第二下游多普勒频率信号的选定的泵流量和所选择的泵流量时的上游流量（QA）。

6. 发明申请

US20110237976A1 BIOPSY DEVICE HAVING HEMOSTATIC CONTROL 审中-公开
标题翻译：具有止血控制的生物装置
公开(公告)号：US20110237976A1
公开(公告)日：2011-09-29
申请号：US13131482
申请日：2009-12-03
申请人： William F. Weitzel , Anne E. Kirkpatrick , David A. Thompson , Todd Addis , Christopher M. Welch , Grant H. Kruger , Philip M. Wong , Panduranga S. Rao
发明人： William F. Weitzel , Anne E. Kirkpatrick , David A. Thompson , Todd Addis , Christopher M. Welch , Grant H. Kruger , Philip M. Wong , Panduranga S. Rao
IPC分类号： A61B10/02
CPC分类号： A61B10/0275 , A61B17/0057 , A61B2010/0208 , A61B2017/00654
摘要： A biopsy device assembly performs a biopsy of an anatomical tissue of a patient. The biopsy device assembly includes a housing and a biopsy device that extends out of the housing and that collects and cuts anatomical tissue from the patient. The biopsy device assembly further includes a hemostatic agent removably housed in the biopsy device. Moreover, the assembly includes an actuator assembly that moves the biopsy device relative to the housing from a first position to an extended position such that the biopsy device collects and cuts the anatomical tissue from the patient. The actuator assembly also retracts the biopsy device relative to the housing toward a retracted position. Furthermore, the assembly includes an ejection device that ejects the hemostatic agent from the biopsy device as the actuator assembly retracts the biopsy device toward the retracted position.
摘要翻译：活检装置组件执行患者的解剖组织的活组织检查。活检装置组件包括壳体和活检装置，其延伸出壳体并从患者收集和切割解剖组织。活检装置组件还包括可移除地容纳在活检装置中的止血剂。此外，组件包括致动器组件，其将活检装置相对于壳体从第一位置移动到延伸位置，使得活检装置从患者收集和切割解剖组织。致动器组件还使活检装置相对于壳体朝向缩回位置缩回。此外，该组件包括一个喷射装置，当致动器组件将活组织检查装置缩回到缩回位置时，其从活检装置喷射止血剂。

7. 发明申请

US20080108930A1 Methods and Systems for Determining Volume Flow in a Blood or Fluid Conduit, Motion, and Mechanical Properties of Structures Within the Body 审中-公开
标题翻译：用于确定体内血液或流体导管，运动和机械结构体积流量的方法和系统
公开(公告)号：US20080108930A1
公开(公告)日：2008-05-08
申请号：US11931439
申请日：2007-10-31
申请人： William F. Weitzel , Yogesh B. Gianchandani
发明人： William F. Weitzel , Yogesh B. Gianchandani
IPC分类号： A61M1/34 , B01D61/24
CPC分类号： A61M1/3639 , A61B5/02152 , A61B5/026 , A61M1/16 , A61M1/36 , A61M1/3607 , A61M1/3655 , A61M1/3656 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3375
摘要： The present invention provides a system for determining blood flow rate in a vessel which communicates blood between two locations of a patient, the system comprising: a conduit in fluid communication with the vessel; at least one sensor in communication with the vessel for determining differential blood pressure (? P) between two or more locations within the vessel; and a processor operably connected to the at least one sensor for processing the ? P to obtain blood flow rate within the vessel.A method for determining blood flow rate in a vessel which communicates blood between two locations of a patient, the method comprising: diverting blood from the vessel at a diversion point to obtain a flow of diverted blood in a conduit; determining differential blood pressure (? P) of the diverted blood through the conduit; and processing the ? P to obtain blood flow rate within the vessel.
摘要翻译：本发明提供了一种用于确定在患者的两个位置之间传送血液的血管中的血液流速的系统，所述系统包括：与血管流体连通的导管; 与血管连通的至少一个传感器，用于确定血管内两个或多个位置之间的差异血压（ΔP）; 以及可操作地连接到所述至少一个传感器的处理器， P以获得血管内血流量。一种用于确定在患者的两个位置之间传送血液的血管中的血液流速的方法，所述方法包括：在转移点处从血管转移血液以获得导管中转向的血液的流动; 通过导管确定转移的血液的差异血压（ΔP）; 并处理？ P以获得血管内血流量。

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