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1. 发明授权

US07049334B2 Enhancement of learning and memory and treatment of amnesia 有权
标题翻译：增强学习记忆和治疗失忆症
公开(公告)号：US07049334B2
公开(公告)日：2006-05-23
申请号：US10242826
申请日：2002-09-13
申请人： Wen-Mei Fu , Keng-Chen Liang , Wei-Lin Chien , Sheng-Chu Kuo , Fang-Yuan Lee , Che-Ming Teng
发明人： Wen-Mei Fu , Keng-Chen Liang , Wei-Lin Chien , Sheng-Chu Kuo , Fang-Yuan Lee , Che-Ming Teng
IPC分类号： A61K31/416
CPC分类号： A61K31/4162 , A61K31/416
摘要： A method for enhancing learning and memory or treating amnesia. The method includes administrating to a subject in need thereof a compound of the formula (I): A is H, R, or each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R1, R2, R3, R4, R5, and R6, independently, is H, nitro, halogen, R, OH, OR, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH2, C(O)NHR, C(O)NRR′, ROH, ROR′, RSH, RSR′, ROC(O)R′OH, NHR, NRR′, RNHR′, or RNR′R″; or R1 and R2 together, R3 and R4 together, or R5 and R6 together are ORO; wherein each of R, R′, and R″, independently is C1˜C6 alkyl; and n is 1, 2, or 3. The compound is in an effective amount for enhancing learning and memory or treating amnesia.
摘要翻译：一种增强学习记忆或治疗健忘症的方法。该方法包括向有需要的受试者施用式（I）化合物：A为H，R或Ar 1，Ar 2和Ar中的每一个独立地是苯基，噻吩基，呋喃基或吡咯基; R 1，R 2，R 3，R 4，R 5，和/或R 3中的每一个，和R 6独立地是H，硝基，卤素，R，OH，OR，C（O）OH，C（O）OR，C（O）SH，C（O） SR，C（O）NH 2，C（O）NHR，C（O）NRR'，ROH，ROR'，RSH，RSR'，ROC（O）R'OH，NHR，NRR '，RNHR'或RNR'R'; 或R 1和R 2共同在一起，R 3和R 4一起，或R 5， / SUB>和R 6一起是ORO; 其中R，R'和R“各自独立地是C 1 -C 6烷基; 并且n为1,2或3.化合物用于增强学习和记忆或治疗健忘症的有效量。

2. 发明授权

US07160916B2 Method of increasing bone density or treating osteoporosis 有权
标题翻译：增加骨密度或治疗骨质疏松症的方法
公开(公告)号：US07160916B2
公开(公告)日：2007-01-09
申请号：US10932323
申请日：2004-09-01
申请人： Wen-Mei Fu , Chih-Hsin Tang , Rong-Sen Yang , Che-Ming Teng , Sheng-Chu Kuo , Fang-Yu Lee
发明人： Wen-Mei Fu , Chih-Hsin Tang , Rong-Sen Yang , Che-Ming Teng , Sheng-Chu Kuo , Fang-Yu Lee
IPC分类号： A61K31/416 , A61K31/415 , A61K31/38 , A61K31/34 , A61K31/40
CPC分类号： A61K31/4162 , A61K31/416
摘要： This invention features a method for enhancing bone growth or inhibiting bone resportion. The method includes administering to a subject in need thereof a compound of the following formula: A is H, R, or each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R1, R2, R3, R4, R5, and R6, independently, is H, halogen, R, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH2, C(O)NHR, C(O)NRR′, ROH, ROR′, RSH, RSR′, NHR, NRR′, RNHR′, or RNR′R″; or R1 and R2 together, R3 and R4 together, or R5 and R6 together are ORO; wherein each of R, R′, and R″, independently is C1˜C6 alkyl; and n is 1, 2, or 3.
摘要翻译：本发明的特征在于增强骨生长或抑制骨重量的方法。所述方法包括向有需要的受试者施用下式的化合物：A为H，R或Ar 1，Ar 2和Ar _{3，独立地是苯基，噻吩基，呋喃基或吡咯基; R 1，R 2，R 3，R 4，R 5，和/或R 3中的每一个（O）OH，C（O）OR，C（O）SH，C（O）SR，C（O） NHR，NRR'，RNHR'或RNR'R“，其中R 1，R 2，R 2，或R 1和R 2共同在一起，R 3和R 4一起，或R 5， / SUB>和R 6一起是ORO; 其中R，R'和R“各自独立地是C 1 -C 6烷基; 且n为1,2或3。}

3. 发明申请

US20050131048A1 Enhancement of bone growth and inhibition of bone resorption 有权
标题翻译：增强骨生长和抑制骨吸收
公开(公告)号：US20050131048A1
公开(公告)日：2005-06-16
申请号：US10932323
申请日：2004-09-01
申请人： Wen-Mei Fu , Chih-Hsin Tang , Rong-Sen Yang , Che-Ming Teng , Sheng-Chu Kuo , Fang-Yu Lee
发明人： Wen-Mei Fu , Chih-Hsin Tang , Rong-Sen Yang , Che-Ming Teng , Sheng-Chu Kuo , Fang-Yu Lee
IPC分类号： C07D405/04 , A61K31/416 , A61K31/4162 , A61P19/08 , A61P19/10
CPC分类号： A61K31/4162 , A61K31/416
摘要： This invention features a method for enhancing bone growth or inhibiting bone resportion. The method includes administering to a subject in need thereof a compound of the following formula: A is H, R, or each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R1, R2, R3, R4, R5, and R6, independently, is H, halogen, R, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH2, C(O)NHR, C(O)NRR′, ROH, ROR′, RSH, RSR′, NHR, NRR′, RNHR′, or RNR′R″; or R1 and R2 together, R3 and R4 together, or R5 and R6 together are ORO; wherein each of R, R′, and R″, independently is C1˜C6 alkyl; and n is 1, 2, or 3.
摘要翻译：本发明的特征在于增强骨生长或抑制骨重量的方法。所述方法包括向有需要的受试者施用下式的化合物：A为H，R或Ar 1，Ar 2和Ar _{3，独立地是苯基，噻吩基，呋喃基或吡咯基; R 1，R 2，R 3，R 4，R 5，和/或R 3中的每一个（O）OH，C（O）OR，C（O）SH，C（O）SR，C（O） NHR，NRR'，RNHR'或RNR'R“，其中R 1，R 2，R 2，或R 1和R 2共同在一起，R 3和R 4一起，或R 5， / SUB>和R 6一起是ORO; 其中R，R'和R“各自独立地是C 1 -C 6烷基; 且n为1,2或3。}

4. 发明授权

US08440692B2 Hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents 有权
标题翻译： 2-芳基-4-喹诺酮的亲水性衍生物作为抗癌剂
公开(公告)号：US08440692B2
公开(公告)日：2013-05-14
申请号：US12448088
申请日：2007-12-07
申请人： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
发明人： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
IPC分类号： A61K31/47 , C07F9/38
CPC分类号： C07F9/6561 , C07D215/233 , C07D421/04 , C07D491/056 , C07F9/60
摘要： 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
摘要翻译： 2-芳基-4-喹诺酮通过与焦磷酸四苄酯反应而形成磷酸盐，形成其二苄基磷酸酯，然后进行氢化，用H代替二苄基，然后与Amberlite IR-120（Na +形式）反应形成二钠盐。初步筛选结果表明，这些磷酸盐显示出显着的抗癌活性。还合成了一种新的中间体2-硒吩-4-喹诺酮和2-苯基-4-喹诺酮的λ/，λ/二烷基氨基烷基衍生物。这些新型中间体显示出显着的抗癌活性。

5. 发明申请

US20100168064A1 NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS 有权
标题翻译：作为抗原剂的2-亚芳基-4-喹啉酮的新型疏水衍生物
公开(公告)号：US20100168064A1
公开(公告)日：2010-07-01
申请号：US12448088
申请日：2007-12-07
申请人： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
发明人： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
IPC分类号： A61K31/675 , C07F9/09 , A61K31/47 , A61P35/00 , A61P35/02 , C07D421/04 , C07D215/233
CPC分类号： C07F9/6561 , C07D215/233 , C07D421/04 , C07D491/056 , C07F9/60
摘要： 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
摘要翻译： 2-芳基-4-喹诺酮通过与焦磷酸四苄酯反应而形成磷酸盐，形成其二苄基磷酸酯，然后进行氢化，用H代替二苄基，然后与Amberlite IR-120（Na +形式）反应形成二钠盐。初步筛选结果表明，这些磷酸盐显示出显着的抗癌活性。还合成2-苯基-4-喹诺酮的新型中间体2-硒吩-4-喹诺酮和Λ/，Λ/二烷基氨基烷基衍生物。这些新型中间体显示出显着的抗癌活性。

6. 发明授权

US07176230B2 Synthesis of indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl) indazole (YC-1) as anti-platelet agents 有权
标题翻译： 1-苄基-3-（5'-羟甲基-2'-呋喃基）吲唑（YC-1）作为抗血小板剂的吲哚类似物的合成
公开(公告)号：US07176230B2
公开(公告)日：2007-02-13
申请号：US11274436
申请日：2005-11-15
申请人： Sheng-Chu Kuo , Fang-Yu Lee , Tsang-Miao Huang , Che-Ming Teng , On Lee , Chin-Yi Wu , Chrong-Shiong Hwang , Chi-Ying Hung
发明人： Sheng-Chu Kuo , Fang-Yu Lee , Tsang-Miao Huang , Che-Ming Teng , On Lee , Chin-Yi Wu , Chrong-Shiong Hwang , Chi-Ying Hung
IPC分类号： A61K31/405 , C07D209/04
CPC分类号： C07D209/12 , C07D405/04 , C07D409/04
摘要： The present invention synthesizes a series of novel indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole (YC-1), and their anti-platelet activity.
摘要翻译：本发明合成了一系列1-苄基-3-（5'-羟甲基-2'-呋喃基）吲唑（YC-1）的新吲哚类似物及其抗血小板活性。

7. 发明授权

US06946153B2 Anti-fungal pharmaceutical compositions comprising an active ingredient prepared from Zingiber officinale 失效
标题翻译：抗真菌药物组合物，其包含由姜科药剂制备的活性成分
公开(公告)号：US06946153B2
公开(公告)日：2005-09-20
申请号：US10438233
申请日：2003-05-14
申请人： Tian-Shung Wu , Sheng-Chu Kuo , Che-Ming Teng , Feng-Nien Ko
发明人： Tian-Shung Wu , Sheng-Chu Kuo , Che-Ming Teng , Feng-Nien Ko
IPC分类号： A61K36/9066 , A61K35/78
CPC分类号： A61K36/9068 , A61K36/9066 , Y10S514/864
摘要： A method of treating a patient suffering a disease associated with Trichophyton mentagrophytes or Pityrosporum ovale by applying topically an anti-fungal pharmaceutical composition which is prepared from Zingiber officinale, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO2, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.
摘要翻译：通过局部施用由姜科药剂制备的抗真菌药物组合物治疗患有与毛癣菌相关的疾病的患者的方法包括以下步骤：通过用有机物提取从姜的根茎制备粗液体溶剂或超临界CO 2，或通过蒸汽蒸馏; 将粗液体引入反相色谱柱，并用水洗脱柱，第一洗脱液和第二洗脱液，其极性弱于第一洗脱液的极性，但比氯仿强烈，使得从洗脱产生的第一洗脱液的第一洗脱液和由第二洗脱液洗脱产生的第二洗脱液; 通过蒸发分别从第一洗脱液和第二洗脱液除去第一洗脱液和第二洗脱液，使得获得第一浓缩洗脱液和第二浓缩洗脱液作为有效提取物。

8. 发明申请

US20050119278A1 Anti-angiogenesis methods 审中-公开
标题翻译：抗血管生成方法
公开(公告)号：US20050119278A1
公开(公告)日：2005-06-02
申请号：US10930065
申请日：2004-08-30
申请人： Che-Ming Teng , Sheng-Chu Kuo , Fang-Yu Lee , Shiow-Lin Pan , Jih-Hwa Guh
发明人： Che-Ming Teng , Sheng-Chu Kuo , Fang-Yu Lee , Shiow-Lin Pan , Jih-Hwa Guh
IPC分类号： A61K31/416 , A61K31/4745 , A61K31/519 , A61K31/4162 , A61K31/4439 , A61K31/506
CPC分类号： A61K31/4745 , A61K31/416 , A61K31/519
摘要： A method for inhibiting cell proliferation, cell migration, or tube formation induced by an angiogenic factor. The method includes administrating to a subject in need thereof an effective amount of a compound of the formula: wherein A is H or in which n is 0, 1, 2, or 3; each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, pyrrolyl, pyridinyl, or pyrimidinyl; each of R1, R2, R3, R4, R5, and R6, independently, is R, nitro, halogen, C(O)OR, C(O)SR, C(O)NRR′, (CH2)mOR, (CH2)mSR, (CH2)mNRR′, (CH2)mCN, (CH2)mC(O)OR, (CH2)mCHO, (CH2)mCH═NOR, or R1 and R2 together, R3 and R4 together, or R5 and R6 together are O(CH2)mO, in which each of R and R′, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; and m is 0, 1, 2, 3, 4, 5, or 6, and n is 0, 1, 2, or 3.
摘要翻译：一种抑制血管生成因子诱导的细胞增殖，细胞迁移或管形成的方法。该方法包括向有需要的受试者施用有效量的下式化合物：其中A为H或其中n为0,1,2或3; Ar 1，Ar 2和Ar 3各自独立地是苯基，噻吩基，呋喃基，吡咯基，吡啶基或嘧啶基; R 1，R 2，R 3，R 4，R 5，和/或R 3中的每一个 >和R 6独立地是R，硝基，卤素，C（O）OR，C（O）SR，C（O）NRR'，（CH 2）（CH 2）m，或（CH 2）m SR，（CH 2 2）m， C（O）OR（CH 2 CH 2）m C（O）OR（CH 2），（CH 2 CH 2）m CHO，（CH 2 CH 2）m CH或NOR，或R 1， 1个和R 2个在一起，R 3和R 4一起，或者R 5和R 5 一起是O（CH 2）2 O，其中R和R'各自独立地是H，烷基，芳基，杂芳基，环基或杂环基; m为0,1,2,3,4,5或6，n为0,1,2或3。

9. 发明申请

US20100179147A1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS 有权
标题翻译：苯并咪唑化合物及其作为反应剂的用途
公开(公告)号：US20100179147A1
公开(公告)日：2010-07-15
申请号：US12635206
申请日：2009-12-10
申请人： Chih-Shiang Chang , Jih-Hwa Guh , Che-Ming Teng , Shiow-Lin Pan , Wei-Ling Chang , Ju-Fang Liu , Kai-Wei Chang , Sheng-Chu Kuo
发明人： Chih-Shiang Chang , Jih-Hwa Guh , Che-Ming Teng , Shiow-Lin Pan , Wei-Ling Chang , Ju-Fang Liu , Kai-Wei Chang , Sheng-Chu Kuo
IPC分类号： A61K31/5377 , C07D235/18 , A61K31/4184 , C07D403/10 , C07D413/10 , C07D409/04 , C07D401/04 , A61K31/4439 , C07D405/14 , A61K31/454 , A61K31/496 , C07D403/06 , A61P35/00
CPC分类号： A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D235/06 , C07D235/10 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04
摘要： Benzimidazole compounds of formula (I): wherein R1, R2, R3, R4, R5, X, Y, Z1, and Z2 are defined herein. Also disclosed is a method for treating cancer with benzimidazole compounds.
摘要翻译：式（I）的苯并咪唑化合物：其中R1，R2，R3，R4，R5，X，Y，Z1和Z2如本文所定义。还公开了用苯并咪唑化合物治疗癌症的方法。

10. 发明授权

US07514465B2 Synthesis of N2-(substituted arylmethyl)-3-(substituted phenyl)indazoles as novel anti-angiogenic agents 失效
标题翻译：合成N2-（取代的芳基甲基）-3-（取代苯基）吲唑作为新的抗血管生成剂
公开(公告)号：US07514465B2
公开(公告)日：2009-04-07
申请号：US11274528
申请日：2005-11-15
申请人： Sheng-Chu Kuo , Li-Jiau Huang , Fang-Yu Lee , Che-Ming Teng , Mei-Ling Shih , Hua-Sin Chen
发明人： Sheng-Chu Kuo , Li-Jiau Huang , Fang-Yu Lee , Che-Ming Teng , Mei-Ling Shih , Hua-Sin Chen
IPC分类号： C07D231/56 , A61K31/4162
CPC分类号： C07D231/56 , C07D405/06
摘要： Novel compounds of 2-(substituted arylmethyl)-3-(substituted phenyl)-2H-indazoles and 1-(substituted arylmethyl)-3-(substituted phenyl)-1H-indazoles are synthesized, and useful as anti-angiogenic agents.
摘要翻译：合成2-（取代的芳基甲基）-3-（取代的苯基）-2H-吲唑和1-（取代的芳基甲基）-3-（取代的苯基）-1H-吲唑的新型化合物，可用作抗血管生成剂。

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