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1. 发明申请

US20060106041A1 Synthesis of indole analogs of 1-benzyl-3-(5'-hydroxymethy 1-2' -furyl) indazole (YC-1) as anti-platelet agents 有权
标题翻译： 1-苄基-3-（5'-羟基甲基-2' - 呋喃基）吲唑（YC-1）作为抗血小板剂的吲哚类似物的合成
公开(公告)号：US20060106041A1
公开(公告)日：2006-05-18
申请号：US11274436
申请日：2005-11-15
申请人： Sheng-Chu Kuo , Fang-Yu Lee , Tsang-Miao Huang , Che-Ming Teng , On Lee , Chin-Yi Wu , Chrong-Shiong Hwang , Chi-Ying Hung
发明人： Sheng-Chu Kuo , Fang-Yu Lee , Tsang-Miao Huang , Che-Ming Teng , On Lee , Chin-Yi Wu , Chrong-Shiong Hwang , Chi-Ying Hung
IPC分类号： A61K31/519 , A61K31/404 , C07D487/02 , C07D405/02 , C07D409/02
CPC分类号： C07D209/12 , C07D405/04 , C07D409/04
摘要： The present invention synthesizes a series of novel indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole (YC-1), and their anti-platelet activity.
摘要翻译：本发明合成了一系列1-苄基-3-（5'-羟甲基-2'-呋喃基）吲唑（YC-1）的新吲哚类似物及其抗血小板活性。

2. 发明授权

US07176230B2 Synthesis of indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl) indazole (YC-1) as anti-platelet agents 有权
标题翻译： 1-苄基-3-（5'-羟甲基-2'-呋喃基）吲唑（YC-1）作为抗血小板剂的吲哚类似物的合成
公开(公告)号：US07176230B2
公开(公告)日：2007-02-13
申请号：US11274436
申请日：2005-11-15
申请人： Sheng-Chu Kuo , Fang-Yu Lee , Tsang-Miao Huang , Che-Ming Teng , On Lee , Chin-Yi Wu , Chrong-Shiong Hwang , Chi-Ying Hung
发明人： Sheng-Chu Kuo , Fang-Yu Lee , Tsang-Miao Huang , Che-Ming Teng , On Lee , Chin-Yi Wu , Chrong-Shiong Hwang , Chi-Ying Hung
IPC分类号： A61K31/405 , C07D209/04
CPC分类号： C07D209/12 , C07D405/04 , C07D409/04
摘要： The present invention synthesizes a series of novel indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole (YC-1), and their anti-platelet activity.
摘要翻译：本发明合成了一系列1-苄基-3-（5'-羟甲基-2'-呋喃基）吲唑（YC-1）的新吲哚类似物及其抗血小板活性。

3. 发明申请

US20080125590A1 Azulene compounds 有权
标题翻译：薁类化合物
公开(公告)号：US20080125590A1
公开(公告)日：2008-05-29
申请号：US11980767
申请日：2007-10-31
申请人： On Lee , Chrong-Shiong Hwang , Chih-Hung Chen , Yuan-Jang Tsai , Chih Peng Liu , Ching-Huai Ko , Hsin-Hsin Shen , Ling-Mei Wang , Kuei-Tai Lai , Ying-Chu Shih , Ting-Shou Chen , Yen-Chun Chen , Lain-Tze Lee
发明人： On Lee , Chrong-Shiong Hwang , Chih-Hung Chen , Yuan-Jang Tsai , Chih Peng Liu , Ching-Huai Ko , Hsin-Hsin Shen , Ling-Mei Wang , Kuei-Tai Lai , Ying-Chu Shih , Ting-Shou Chen , Yen-Chun Chen , Lain-Tze Lee
IPC分类号： C07D403/12 , C07D209/34
CPC分类号： C07D209/34 , C07D401/12 , C07D403/06 , C07D405/06 , C07D471/04
摘要： An azulene compound is provided. The azulene compound has formula (I) shown below. Each variable in formula (I) is defined in the specification. One of R1, R2, R3, R4, R5, R6, R7, and R8 in formula (I) is a moiety of formula (II). The compound can be used to treat cancer.
摘要翻译：提供薁化合物。薁类化合物具有下述式（I）。式（I）中的每个变量在本说明书中定义。 R 1，R 2，R 3，R 4，R 5中的一个，式（I）中的R 6，R 7，R 8和R 8是式（II）的部分。该化合物可用于治疗癌症。

4. 发明授权

US07544666B2 NAP derivatives 有权
标题翻译： NAP衍生品
公开(公告)号：US07544666B2
公开(公告)日：2009-06-09
申请号：US11440174
申请日：2006-05-25
申请人： On Lee , Jenn-Tsang Hwang , Chrong-Shiong Hwang , Yuan-Jang Tsai , Chen-Yi Su , Tsan-Lin Hu , Shing Mein Wu , Chiu Hsing Lin
发明人： On Lee , Jenn-Tsang Hwang , Chrong-Shiong Hwang , Yuan-Jang Tsai , Chen-Yi Su , Tsan-Lin Hu , Shing Mein Wu , Chiu Hsing Lin
IPC分类号： A61K38/00 , A61K38/04 , A61K38/08 , C07K7/00
CPC分类号： C07K7/64 , A61K38/00 , C07K14/522
摘要： An oligopeptide comprises formulae (I) or (II) the oligopeptide derivative thereof, and a pharmaceutical composition comprising the same are provided.
摘要翻译：寡肽包含式（I）或（II）其寡肽衍生物，并且提供包含其的药物组合物。

5. 发明申请

US20070270454A1 Huperzine a compound for treatment of Alzheimer's disease 有权
标题翻译：石杉碱是治疗阿尔茨海默病的化合物
公开(公告)号：US20070270454A1
公开(公告)日：2007-11-22
申请号：US11798886
申请日：2007-05-17
申请人： On Lee , Jenn-Tsang Hwang , Chrong-Shiong Hwang , Wan-Hsu Yang , Chung Yao , Yuan-Jang Tsai , Chih Liu , Tsan Hu , Chia-Mu Tu , Pean-Jyy Jih
发明人： On Lee , Jenn-Tsang Hwang , Chrong-Shiong Hwang , Wan-Hsu Yang , Chung Yao , Yuan-Jang Tsai , Chih Liu , Tsan Hu , Chia-Mu Tu , Pean-Jyy Jih
IPC分类号： C07D221/22 , A61K31/473
CPC分类号： C07D221/22
摘要： A huperzine A compound is provided. The huperzine A compound has following formula: wherein X comprises O or S, Y comprises —O—, —S—, —CH(R4)—, —C(R4)(R5)—, —C(R4)═C(R5)—, —C≡C—, —NH— or —N(R4)—, n is 0, 1 or 2, R3 is C(═X)—(Y)n-R1 provided that R2 is H or R2 and R3 are combined to form ═CH—Ar, wherein R1, R4 and R5 independently comprise hydrogen, C1-C32 alkyl, C1-C32 alkenyl, C1-C32 alkynyl, C1-C32 aryl or C1-C32 heteroaryl, in which alkyl, alkenyl, alkynyl, aryl or heteroaryl with one or more substituents comprising halogen, hydroxyl, alkoxy, aryloxyl, amino, alkylamino, arylamino, dialkylamino, diarylamino, imino, alkylimino, arylimino, acylamido, diacylamido, acylimido, cyano, nitro, mercapto, carbamido, carbamoyl, carboxyl, thioureido, thiocyanato, sulfonamido, thio, sulfonyl or sulfinyl, and Ar comprises aryl or heteroaryl.
摘要翻译：提供一种石杉碱化合物。石杉碱A化合物具有下式：其中X包含O或S，Y包括-O - ， - S - ， - CH（R 4） - ， - C（R 4）（R 5） - ， - C（R 4） - C（R 5） - ， - C≡C-， -NH-或-N（R 4） - ，n为0,1或2，R 3为C（-X） - （Y）n 条件是R 2是H或R 2和R 3 3被组合成形式-CH-Ar，其中R 1，R 4和R 5独立地包含氢，C 1〜 C 32烷基，C 1 -C 32烯基，C 1 -C 32亚烷基炔基，C 1 -C 32芳基或C 1 -C 32杂芳基，其中烷基，烯基羟基，烷氧基，芳氧基，氨基，烷基氨基，芳基氨基，二烷基氨基，二芳基氨基，亚氨基，亚氨基亚氨基，芳基亚氨基，酰氨基，二酰氨基，酰基亚氨基，氰基，硝基，巯基，氨基甲酰基，羧基，硫脲基，硫氰基亚磺酰氨基，硫代，磺酰基或亚磺酰基，Ar包括芳基或杂芳基。

6. 发明申请

US20070142269A1 Oligopeptide, derivatives thereof, and pharmaceutical composition comprising the same 有权
标题翻译：寡肽，其衍生物和包含其的药物组合物
公开(公告)号：US20070142269A1
公开(公告)日：2007-06-21
申请号：US11440174
申请日：2006-05-25
申请人： On Lee , Jenn-Tsang Hwang , Chrong-Shiong Hwang , Yuan-Jang Tsai , Chen-Yi Su , Tsan-Lin Hu , Shing Mein Wu , Chiu Lin
发明人： On Lee , Jenn-Tsang Hwang , Chrong-Shiong Hwang , Yuan-Jang Tsai , Chen-Yi Su , Tsan-Lin Hu , Shing Mein Wu , Chiu Lin
IPC分类号： A61K38/12 , A61K38/10 , C07K7/64 , C07K7/08
CPC分类号： C07K7/64 , A61K38/00 , C07K14/522
摘要： An oligopeptide comprises formulae (I) or (II) the oligopeptide derivative thereof, and a pharmaceutical composition comprising the same are provided.
摘要翻译：寡肽包含式（I）或（II）其寡肽衍生物，并且提供包含其的药物组合物。

7. 发明授权

US07714146B2 Azulene-oxindole compounds as multiple-kinase inhibitors and useful as anticancer agents 有权
标题翻译：薁类羟吲哚化合物作为多重激酶抑制剂，可用作抗癌剂
公开(公告)号：US07714146B2
公开(公告)日：2010-05-11
申请号：US11980767
申请日：2007-10-31
申请人： On Lee , Chrong-Shiong Hwang , Chih-Hung Chen , Yuan-Jang Tsai , Chih-Peng Liu , Ching-Huai Ko , Hsin-Hsin Shen , Ling-Mei Wang , Kuei-Tai Lai , Ying-Chu Shih , Ting-Shou Chen , Yen-Chun Chen , Lain-Tze Lee
发明人： On Lee , Chrong-Shiong Hwang , Chih-Hung Chen , Yuan-Jang Tsai , Chih-Peng Liu , Ching-Huai Ko , Hsin-Hsin Shen , Ling-Mei Wang , Kuei-Tai Lai , Ying-Chu Shih , Ting-Shou Chen , Yen-Chun Chen , Lain-Tze Lee
IPC分类号： C07D209/34
CPC分类号： C07D209/34 , C07D401/12 , C07D403/06 , C07D405/06 , C07D471/04
摘要： The invention is related to novel azulene-oxindole compounds having formula (I) shown below, wherein one of R1, R2 and R3 represents a moiety of formula (II), each of A1 and A2 independently is nitrogen, oxygen or sulfur, each of the others of R1, R2, R3, R1, R5, R6, R7, R8, R9, R10, R11, R12, R13, and R14 is as recited in the specification. The novel compound potentially inhibits multiple kinases and thus can be used to treat some disease like cancer or inflammatory.
摘要翻译：本发明涉及下述式（I）的新的薁 - 羟吲哚化合物，其中R 1，R 2和R 3中的一个表示式（II）的部分，A1和A2各自独立地为氮，氧或硫，其中R 1，R 2，R 3，R 1，R 5，R 6，R 7，R 8，R 9，R 10，R 11，R 12，R 13和R 14如说明书所述。新型化合物潜在地抑制多种激酶，因此可用于治疗某些疾病如癌症或炎症。

8. 发明授权

US07288545B2 Piperazinedione compounds 失效
公开(公告)号：US07288545B2
公开(公告)日：2007-10-30
申请号：US10689865
申请日：2003-10-20
申请人： Che-Ming Teng , Hui-Po Wang , Eric I. C. Li , On Lee , Jih-Hwa Guh , Huei-Ting Chen , Ya-Bing Fan , Ya-Lan Chen
发明人： Che-Ming Teng , Hui-Po Wang , Eric I. C. Li , On Lee , Jih-Hwa Guh , Huei-Ting Chen , Ya-Bing Fan , Ya-Lan Chen
IPC分类号： A61K31/496 , C07D405/14
CPC分类号： C07D401/06 , C07D409/14
摘要： This invention relates to a method for treating an angiogenesis-related disease. The method includes administering to a subject in need thereof an effective amount of a piperazinedione compound having the formula: In the above formula, each of and , independently, is a single bond or a double bond; A is H or CH(RaRb) when is a single bond, or C(RaRb) when is a double bond; Z is CH(RcRd) when is a single bond, or C(RcRd) when is a double bond; each of R1 and R2, independently, is H, C(O)Re, C(O)ORe, C(O)NReRf, or SO2Re; and each of Ra, Rb, Rc, Rd, Re, and Rf, independently, is H, C1-C6 alkyl, aryl, heteroaryl, C3-C8 cycloalkyl, or C3-C8 heterocycloalkyl; or Ra and Rb taken together are C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, or heteroaryl; or R1 and Ra or R1 and Rb taken together are C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, or heteroaryl; provided that one of Rc and Rd is aryl or heteroaryl.

9. 发明授权

US06635649B2 Piperazinedione compounds 失效
标题翻译：哌嗪二酮化合物
公开(公告)号：US06635649B2
公开(公告)日：2003-10-21
申请号：US09851077
申请日：2001-05-08
申请人： Che-Ming Teng , Hui-Po Wang , Eric I. C. Li , On Lee , Jih-Hwa Guh , Huei-Ting Chen , Ya-Bing Fan , Ya-Lan Chen
发明人： Che-Ming Teng , Hui-Po Wang , Eric I. C. Li , On Lee , Jih-Hwa Guh , Huei-Ting Chen , Ya-Bing Fan , Ya-Lan Chen
IPC分类号： A61K31496
CPC分类号： C07D401/06 , C07D409/14
摘要： Piperazinedione compounds of the formula: Each of and and independently, is a single bond or a double bond; A is H or CH(RaRb) when is a single bond, or C(RaRb) when is a double bond; Z is R3O—(Ar)—B, in which B is CH(Rc) when is a single bond, or C(Rc) when is a double bond; Ar is heteroaryl; and R3 is H, alkyl, aryl, heteroaryl, C(O)Rd, C(O)ORd, C(O)NRdRe, or SO2Rd; each of R1 and R2, independently, is H, C(O)Rd, C(O)ORd, C(O)NRdRe, or SO2Rd; and each of Ra, Rb, Rc, Rd, and Re, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl. Optionally, Ra and Rb taken together are cyclyl or heterocyclyl; and, also optionally, R1 and Ra or R1 and Rb taken together are cyclyl or heterocyclyl. Also disclosed is a method for treating tumor with the above described piperazinedione compounds.
摘要翻译：哌嗪二酮化合物，分别为：＆lt; CUSTOM-CHARACTER FILE =“US06635649-20031021-P00900.TIF”ALT =“custom character”HE =“20”WI =“20”ID =“CUSTOM-CHARACTER-00001”/ >和或双键; 当是单键，或C（R a R b）当为双键时; 当是单键或C（R ）”ALT =“自定义字符”HE =“20”WI =“20”ID =“CUSTOM-CHARACTER-00005”/>是双键; Ar是杂芳基; 且R 3为H，烷基，芳基，杂芳基，C（O）R d，C（O）OR d，C（O）NR d R e或SO 2 R d; R 1和R 2各自独立地是H，C（O）R d，C（O）OR d，C（O）NR d R e或SO 2 R ; R a，R b，R c，R d和R e各自独立地是H，烷基，芳基，杂芳基，环基或杂环基。任选地，R 5和R b一起是环基或杂环基; 并且还可任选地，R 1和R 5'或R 1和R b一起是环基或杂环基。还公开了用上述哌嗪二酮化合物治疗肿瘤的方法。

10. 发明授权

US08242282B2 Histone deacetylase inhibitors 有权
标题翻译：组蛋白脱乙酰酶抑制剂
公开(公告)号：US08242282B2
公开(公告)日：2012-08-14
申请号：US12781979
申请日：2010-05-18
申请人： Hui-po Wang , On Lee , Yu-Wen Cheng , Chun-li Wang , Feng-Shuo Chang , Hsiao Che-Chih
发明人： Hui-po Wang , On Lee , Yu-Wen Cheng , Chun-li Wang , Feng-Shuo Chang , Hsiao Che-Chih
IPC分类号： C07D213/00 , A61K31/44
CPC分类号： C07D213/65
摘要： This invention relates to compounds of the following general formula: The variables are defined herein. Also disclosed is a method for treating mucositis or cancer using these compounds.
摘要翻译：本发明涉及以下通式的化合物：这些变量在本文中定义。还公开了一种使用这些化合物治疗粘膜炎或癌症的方法。

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