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    • 4. 发明授权
    • Enhancement of learning and memory and treatment of amnesia
    • 增强学习记忆和治疗失忆症
    • US07049334B2
    • 2006-05-23
    • US10242826
    • 2002-09-13
    • Wen-Mei FuKeng-Chen LiangWei-Lin ChienSheng-Chu KuoFang-Yuan LeeChe-Ming Teng
    • Wen-Mei FuKeng-Chen LiangWei-Lin ChienSheng-Chu KuoFang-Yuan LeeChe-Ming Teng
    • A61K31/416
    • A61K31/4162A61K31/416
    • A method for enhancing learning and memory or treating amnesia. The method includes administrating to a subject in need thereof a compound of the formula (I): A is H, R, or  each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R1, R2, R3, R4, R5, and R6, independently, is H, nitro, halogen, R, OH, OR, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH2, C(O)NHR, C(O)NRR′, ROH, ROR′, RSH, RSR′, ROC(O)R′OH, NHR, NRR′, RNHR′, or RNR′R″; or R1 and R2 together, R3 and R4 together, or R5 and R6 together are ORO; wherein each of R, R′, and R″, independently is C1˜C6 alkyl; and n is 1, 2, or 3. The compound is in an effective amount for enhancing learning and memory or treating amnesia.
    • 一种增强学习记忆或治疗健忘症的方法。 该方法包括向有需要的受试者施用式(I)化合物:A为H,R或Ar 1,Ar 2和Ar中的每一个 独立地是苯基,噻吩基,呋喃基或吡咯基; R 1,R 2,R 3,R 4,R 5,和/或R 3中的每一个 ,和R 6独立地是H,硝基,卤素,R,OH,OR,C(O)OH,C(O)OR,C(O)SH,C(O) SR,C(O)NH 2,C(O)NHR,C(O)NRR',ROH,ROR',RSH,RSR',ROC(O)R'OH,NHR,NRR ',RNHR'或RNR'R'; 或R 1和R 2共同在一起,R 3和R 4一起,或R 5, / SUB>和R 6一起是ORO; 其中R,R'和R“各自独立地是C 1 -C 6烷基; 并且n为1,2或3.化合物用于增强学习和记忆或治疗健忘症的有效量。