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1. 发明申请

US20080076724A1 Novel polygalatenosides and use thereof as an antidepressant agent 有权
标题翻译：新型多羟基腺苷类及其作为抗抑郁剂的用途
公开(公告)号：US20080076724A1
公开(公告)日：2008-03-27
申请号：US11524470
申请日：2006-09-21
申请人： Mo-Chi Cheng , Feng-Nien Ko , Tian-Shung Wu
发明人： Mo-Chi Cheng , Feng-Nien Ko , Tian-Shung Wu
IPC分类号： A61K31/7024 , C07H13/02
CPC分类号： C07H13/02
摘要： A polygalatenoside useful as an antidepressant agent having the formula is disclosed: wherein R, R′ and R″ independently are H or R1, provided that R, R′ and R″ are not all H, wherein R1 is wherein R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen; or a pharmaceutically acceptable salt thereof. Preferably, R2 is H.
摘要翻译：公开了可用作具有下式的抗抑郁剂的聚天冬氨酸苷：其中R，R'和R“独立地为H或R 1，条件是R，R'和R”不全为H 其中R 1是其中R 2是氢，C 1 -C 6烷基，C 1 -C 6烷氧基或卤素; 或其药学上可接受的盐。优选地，R 2是H.

2. 发明申请

US20050250751A1 Neo-tanshinlactone and analogs as potent and selective anti-breast cancer agents 失效
标题翻译：新丹参内酯和类似物作为有效和选择性的抗乳腺癌药物
公开(公告)号：US20050250751A1
公开(公告)日：2005-11-10
申请号：US11075476
申请日：2005-03-09
申请人： Kuo-Hsiung Lee , Xihong Wang , Kenneth Bastow , Tian-Shung Wu
发明人： Kuo-Hsiung Lee , Xihong Wang , Kenneth Bastow , Tian-Shung Wu
IPC分类号： A61K31/343 , A61K31/366 , A61K31/381 , A61K31/407 , C07D491/052 , C07D493/04 , C07D495/04 , C07J1/00
CPC分类号： C07D307/77 , C07D493/04
摘要： Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmeutical formulations thereof.
摘要翻译：描述了式I-II的化合物，以及使用这些化合物治疗癌症的方法及其药物制剂。

3. 发明授权

US5656274A Thromboxane A.sub.2 receptor antagonism and antioxidant action of cinnamophilin and its derivatives 失效
标题翻译：血栓素A2受体拮抗作用及其衍生物的抗氧化作用
公开(公告)号：US5656274A
公开(公告)日：1997-08-12
申请号：US394113
申请日：1995-02-24
申请人： Tian-Shung Wu , Che-Ming Teng , Sheu-Meei Yu
发明人： Tian-Shung Wu , Che-Ming Teng , Sheu-Meei Yu
IPC分类号： C07C43/23 , C07C59/64 , C07C69/017 , C07C69/734 , A01N65/00
CPC分类号： C07C59/64 , C07C43/23 , C07C69/017 , C07C69/734
摘要： The present invention discloses the method of isolation and purification of the bioactive constituents cinnamophilin from Cinnamomum philippinense (Merr.), the same as Machilus acuminatissima (Hayata). Pharmacological evaluation showed that these compounds possess the activity to inhibit platelet aggregation and to produce relaxing effects of aortic vascular constriction.
摘要翻译：本发明公开了与马蹄草（Hayata）相同的来自樟树（Merr。）的生物活性成分肌醇六肽的分离纯化方法。药理学评价表明，这些化合物具有抑制血小板聚集和产生主动脉夹层收缩的作用。

4. 发明授权

US5340818A Methods and compositions for inhibiting tumor cell growth 失效
标题翻译：抑制肿瘤细胞生长的方法和组合物
公开(公告)号：US5340818A
公开(公告)日：1994-08-23
申请号：US16052
申请日：1993-02-10
申请人： Ting-Chao Chou , Tian-Shung Wu
发明人： Ting-Chao Chou , Tian-Shung Wu
IPC分类号： A61K31/435 , A61K31/44
CPC分类号： A61K31/435
摘要： The subject invention discloses methods of inhibiting growth of tumor cells which comprise contacting the cells with a growth inhibiting amount of a compound having one of following structures: ##STR1## wherein R.sup.1 is a hydroxyl or acetyl group; R.sup.2 is hydrogen, --CH.sub.2 --CH.dbd.C(CH.sub.3).sub.2 or a method group; R.sup.3 is a hydroxyl, methoxy or acetyl group; R.sup.4 is hydrogen, --CH.sub.2 --CH.dbd.C(CH.sub.3).sub.2 or a methoxy group; R.sup.5 is a hydroxyl, methoxy or acetyl group; is hydrogen or a hydroxyl, methoxy or acetyl group; and R.sup.10 is a methyl group, ##STR2## wherein R.sup.5 is hydrogen or --CH.sub.2 --CH.dbd.C(CH.sub.3).sub.2 ; R.sup.6 is a hydroxyl group; R.sup.10 is hydrogen or a hydroxyl group; R.sup.11 is a hydroxyl or methoxy group; and R.sup.12 is hydrogen or a methyl group. ##STR3##
摘要翻译：本发明公开了抑制肿瘤细胞生长的方法，其包括使细胞与生长抑制量的具有以下结构之一的化合物接触：其中R1是羟基或乙酰基; R2是氢，-CH2-CH = C（CH3）2或方法组; R3是羟基，甲氧基或乙酰基; R4是氢，-CH2-CH = C（CH3）2或甲氧基; R5是羟基，甲氧基或乙酰基; 是氢或羟基，甲氧基或乙酰基; 并且R 10是甲基，其中R 5是氢或-CH 2 -CH = C（CH 3）2; R6是羟基; R 10是氢或羟基; R11是羟基或甲氧基; R 12为氢或甲基。

5. 发明授权

US08524740B2 Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives 有权
标题翻译：芳基和杂芳基 - 喹啉衍生物的合成和抗癌活性
公开(公告)号：US08524740B2
公开(公告)日：2013-09-03
申请号：US13181978
申请日：2011-07-13
申请人： Sheng-Chu Kuo , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Tian-Shung Wu , Tzong-Der Way , Jing-Gung Chung , Jai-Sing Yang , Chi-Hung Huang , Meng-Tung Tsai
发明人： Sheng-Chu Kuo , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Tian-Shung Wu , Tzong-Der Way , Jing-Gung Chung , Jai-Sing Yang , Chi-Hung Huang , Meng-Tung Tsai
IPC分类号： A61K31/04 , C07D215/04
CPC分类号： C07D493/04 , C07D215/22 , C07D215/233 , C07D215/38 , C07D401/04 , C07F9/60 , C07F9/65583 , C07F9/6561
摘要： A compound of Formula I is disclosed as follows: or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein R is hydrogen, P(═O)(OH)2, P(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, P(═O)(OH)(OM), P(═O)(OM)2, P═O(O2M), S(═O)(OH)2, S(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, S(═O)(OH)(OM), S(═O)(OM)2; M is a monovalent or divalent metal ion, or alkylammonium ion; W is (C6-C20)aryl, (C6-C20)heteroaryl, (C1-C18)alkyl(C6-C20)aryl, (C1-C18)alkyl(C6-C20)heteroaryl, hydroxy(C6-C20)aryl, hydroxy(C6-C20)heteroaryl, (C1-C18)alkoxy(C6-C20)aryl, (C1-C18)alkoxy(C6-C20)heteroaryl, (C1-C18)alkylenedioxy(C6-C20)aryl, (C1-C18)alkylenedioxy(C6-C20)heteroaryl, halo(C6-C20)aryl, halo(C6-C20)heteroaryl, (C1-C18)alkylamino(C6-C20)aryl, (C1-C18)alkylamino(C6-C20)heteroaryl, (C1-C18)cycloalkylamino(C6-C20)aryl, or (C1-C18)cycloalkylamino(C6-C20)heteroaryl, and their OR8 substutes; R5 is (C1-C18alkoxy, hydrogen, hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or OR8, or R5 and R6 are (C1-C18)dioxy provided that R7 is hydrogen; R6 is hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or OR8, (C1-C18)alkoxy, (C1-C18)alkylamino, or (C1-C18)cycloalkylamino, or R6 and R7 are (C1-C18)dioxy provided that R5 is hydrogen; R7 is hydrogen, halo or OR8, hydroxyl, or O—(C1-C18)alkyl(C6-C20)aryl; and R8 is P(═O)(OH)2, P(═O)(O(C1-C18)alkyl(C6-C20)aryl)2, P(═O)(OH)(OM), or P(═O)(OM)2, P═O(O2M).
摘要翻译：式I化合物公开如下：或其药学上可接受的盐，前药，溶剂合物或代谢物，其中R是氢，P（= O）（OH）2，P（= O）（O（C 1 -C 18））亚烷基（C 6 -C 20）芳基）2，P（= O）（OH）（OM），P（= O）（OM）2，P = O（O 2 M） S（= O）（O（C1-C18）亚烷基（C6-C20）芳基）2，S（= O）（OH）（OM），S（= O）（OM） M是一价或二价金属离子或烷基铵离子; W是（C 6 -C 20）芳基，（C 6 -C 20）杂芳基，（C 1 -C 18）烷基（C 6 -C 20）芳基，（C 1 -C 18）烷基（C 6 -C 20）羟基（C 6 -C 20）杂芳基，（C 1 -C 18）烷氧基（C 6 -C 20）芳基，（C 1 -C 18）烷氧基（C 6 -C 20）杂芳基，（C 1 -C 18）亚烷基二氧基 C 1 -C 20烷基氨基（C 6 -C 20）芳基，（C 1 -C 20）芳基，（C 1 -C 20）芳基，杂芳基，（C1-C18）环烷基氨基（C6-C20）芳基或（C1-C18）环烷基氨基（C6-C20）杂芳基及其OR8分子; R5是（C1-C18烷氧基，氢，羟基，O-（C1-C18）烷基（C6-C20）芳基，卤素或OR8或R5和R6是（C1-C18）二氧基，条件是R7是氢; R6是羟基，（C 1 -C 18）烷基（C 6 -C 20）芳基，卤素或OR 8，（C 1 -C 18）烷氧基，（C 1 -C 18）烷基氨基或（C 1 -C 18）环烷基氨基或R 6和R 7为（C 1 -C 18）烷基（C 6 -C 20）芳基; R 8为P（= O）（OH）2，P（= O） = O）（O（C 1 -C 18）烷基（C 6 -C 20）芳基）2，P（= O）（OH）（OM）或P（= O）（OM）2，P = O（O 2 M）。

6. 发明申请

US20120196817A1 METHOD FOR ENHANCING NUTRIENT ABSORPTION WITH ASTRAGALOSIDES 审中-公开
公开(公告)号：US20120196817A1
公开(公告)日：2012-08-02
申请号：US13444770
申请日：2012-04-11
申请人： Hang-Ching Lin , Wen-Liang Chang , Tsu-Chung Chang , Hsiou-Yu Ding , Tian Shung Wu
发明人： Hang-Ching Lin , Wen-Liang Chang , Tsu-Chung Chang , Hsiou-Yu Ding , Tian Shung Wu
IPC分类号： A61K31/704 , A61P3/00
CPC分类号： A61K31/704 , A61K36/481 , Y10S514/909 , Y10S514/923
摘要： The present application relates to a method for enhancing absorption of a nutrient in a subject in need thereof with an effective amount of an isolated astragaloside compound.

7. 发明授权

US08197860B2 Method for enhancing nutrient absorption with astragalosides 有权
标题翻译：用黄芪药提高营养吸收的方法
公开(公告)号：US08197860B2
公开(公告)日：2012-06-12
申请号：US12424193
申请日：2009-04-15
申请人： Hang-Ching Lin , Wen-Liang Chang , Tsu-Chung Chang , Hsiou-Yu Ding , Tian Shung Wu
发明人： Hang-Ching Lin , Wen-Liang Chang , Tsu-Chung Chang , Hsiou-Yu Ding , Tian Shung Wu
IPC分类号： A61K36/00 , A61K36/481
CPC分类号： A61K31/704 , A61K36/481 , Y10S514/909 , Y10S514/923
摘要： The present application relates to a method for enhancing absorption of a nutrient in a subject in need thereof with an effective amount of an isolated astragaloside compound.
摘要翻译：本申请涉及一种用有效量的分离的黄芪甲苷化合物增强有需要的受试者的营养素吸收的方法。

8. 发明授权

US07795299B2 Neo-tanshinlactone and analogs as potent and selective anti-breast cancer agents 失效
标题翻译：新丹参内酯和类似物作为有效和选择性的抗乳腺癌药物
公开(公告)号：US07795299B2
公开(公告)日：2010-09-14
申请号：US12355309
申请日：2009-01-16
申请人： Kuo-Hsiung Lee , Xihong Wang , Kenneth F. Bastow , Tian-Shung Wu
发明人： Kuo-Hsiung Lee , Xihong Wang , Kenneth F. Bastow , Tian-Shung Wu
IPC分类号： A61K31/366 , C07D493/04
CPC分类号： C07D307/77 , C07D493/04
摘要： Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof.
摘要翻译：描述了式I-II的化合物以及使用这些化合物治疗癌症的方法及其药物制剂。

9. 发明申请

US20100099633A1 METHOD FOR ENHANCING NUTRIENT ABSORPTION WITH ASTRAGALOSIDES 有权
标题翻译：用于增强营养吸收的方法
公开(公告)号：US20100099633A1
公开(公告)日：2010-04-22
申请号：US12424193
申请日：2009-04-15
申请人： Hang-Ching Lin , Wen-Liang Chang , Tsu-Chung Chang , Hsiou-Yu Ding , Tian Shung Wu
发明人： Hang-Ching Lin , Wen-Liang Chang , Tsu-Chung Chang , Hsiou-Yu Ding , Tian Shung Wu
IPC分类号： A61K31/7048 , A61P1/00 , A61P3/02
CPC分类号： A61K31/704 , A61K36/481 , Y10S514/909 , Y10S514/923
摘要： The present application relates to a method for enhancing absorption of a nutrient in a subject in need thereof with an effective amount of an isolated astragaloside compound.
摘要翻译：本申请涉及一种用有效量的分离的黄芪甲苷化合物增强有需要的受试者的营养素吸收的方法。

10. 发明申请

US20090124914A1 ANALYSIS SYSTEM AND A METHOD FOR PULSE DIAGNOSIS IN CHINESE MEDICINE 审中-公开
标题翻译：分析系统和中国医学中脉搏诊断的方法
公开(公告)号：US20090124914A1
公开(公告)日：2009-05-14
申请号：US11937376
申请日：2007-11-08
申请人： Terry B. J. Kuo , Cheryl C. H. Yang , Hsin-Yo Chen , Tian-Shung Wu , Hsien-Chang Wu
发明人： Terry B. J. Kuo , Cheryl C. H. Yang , Hsin-Yo Chen , Tian-Shung Wu , Hsien-Chang Wu
IPC分类号： A61B5/021
CPC分类号： A61B5/0402 , A61B5/02116 , A61B5/022 , A61B5/7253 , A61B5/7257
摘要： The present invention relates to an analysis system and method for pulse diagnosis in Chinese medicine, which analyzes quantitatively the variances of pulse condition, and in particular analyzes the “pulse POSITION”, “pulse PACE”, “pulse FORM” and “pulse DYNAMICS” elements in pulse condition with remarkable increase in the accuracy of pulse diagnosis. The analysis system for pulse diagnosis of the present invention comprises a pulse signal collecting device to collect and generate blood pressure and electrocardiogram signals; and a signal process unit to receive and analyze the blood pressure signal series and electrocardiogram signal series. The execution of the signal process unit includes: establishing the position parameters based on measurement of the blood pressure signals, the heart rate parameters based on calculation of the blood pressure or electrocardiogram signals, the wave form parameters based on analysis of the blood pressure signals, the spectrum analysis parameters based on heart rate variability (HRV) and arterial pressure variability (APV), and the quantitative indexes of the elements in pulse condition of Chinese medicine based on the parameters mentioned above.
摘要翻译：本发明涉及一种中医脉搏诊断分析系统及方法，定量分析了脉搏情况的差异，特别分析了“脉搏位置”，“脉冲PACE”，“脉冲形式”，“脉搏动态” 脉冲条件下的元件显着提高了脉搏诊断的准确性。本发明的脉冲诊断用分析系统包括：收集并产生血压和心电图信号的脉冲信号采集装置; 以及用于接收和分析血压信号序列和心电图信号序列的信号处理单元。信号处理单元的执行包括：基于血压信号的测量建立位置参数，基于血压或心电图信号的计算的心率参数，基于血压信号分析的波形参数，基于心率变异性（HRV）和动脉压变异性（APV）的频谱分析参数，以及基于上述参数的中医脉搏状态元素的定量指标。

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