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1. 发明授权

US06946153B2 Anti-fungal pharmaceutical compositions comprising an active ingredient prepared from Zingiber officinale 失效
标题翻译：抗真菌药物组合物，其包含由姜科药剂制备的活性成分
公开(公告)号：US06946153B2
公开(公告)日：2005-09-20
申请号：US10438233
申请日：2003-05-14
申请人： Tian-Shung Wu , Sheng-Chu Kuo , Che-Ming Teng , Feng-Nien Ko
发明人： Tian-Shung Wu , Sheng-Chu Kuo , Che-Ming Teng , Feng-Nien Ko
IPC分类号： A61K36/9066 , A61K35/78
CPC分类号： A61K36/9068 , A61K36/9066 , Y10S514/864
摘要： A method of treating a patient suffering a disease associated with Trichophyton mentagrophytes or Pityrosporum ovale by applying topically an anti-fungal pharmaceutical composition which is prepared from Zingiber officinale, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO2, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.
摘要翻译：通过局部施用由姜科药剂制备的抗真菌药物组合物治疗患有与毛癣菌相关的疾病的患者的方法包括以下步骤：通过用有机物提取从姜的根茎制备粗液体溶剂或超临界CO 2，或通过蒸汽蒸馏; 将粗液体引入反相色谱柱，并用水洗脱柱，第一洗脱液和第二洗脱液，其极性弱于第一洗脱液的极性，但比氯仿强烈，使得从洗脱产生的第一洗脱液的第一洗脱液和由第二洗脱液洗脱产生的第二洗脱液; 通过蒸发分别从第一洗脱液和第二洗脱液除去第一洗脱液和第二洗脱液，使得获得第一浓缩洗脱液和第二浓缩洗脱液作为有效提取物。

2. 发明授权

US06274177B1 Method of preparing an extract potent in anti-inflammation and anti-platelet aggregation from Zingiber officinale and pharmaceutical compositions containing said extract 失效
标题翻译：制备强效抗锌和抗血小板聚集的提取物的方法，所述提取物含有所述提取物
公开(公告)号：US06274177B1
公开(公告)日：2001-08-14
申请号：US09648662
申请日：2000-08-26
申请人： Tian-Shung Wu , Sheng-Chu Kuo , Che-Ming Teng , Feng-Nien Ko
发明人： Tian-Shung Wu , Sheng-Chu Kuo , Che-Ming Teng , Feng-Nien Ko
IPC分类号： A61K3578
CPC分类号： A61K36/9068
摘要： A method of preparing an extract from Zingiber officinale, which is potent in anti-inflammation and anti-platelet aggregation, includes the following steps: a) preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or by distillation with steam; b) introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; c) removing the first eluent from the first eluate by evaporation, so that a first concentrated eluate is obtained and is able to used as the potent extract; and d) removing the second eluent from the second eluate by evaporation, so that a second concentrated eluate is obtained and is able to used as the potent extract.
摘要翻译：一种制备抗炎和抗血小板聚集有效的姜科提取物的方法，包括以下步骤：a）通过用有机溶剂萃取或用蒸汽蒸馏，从姜的根茎制备粗液; b）将粗液引入反相层析柱，并用水洗脱柱，第一洗脱液和第二洗脱液的极性比第一洗脱液的极性弱，但比氯仿强烈，使得第一洗脱液得到从第一洗脱液的洗脱和第二洗脱液洗脱得到的第二洗脱液得到; c）通过蒸发从第一洗脱液中除去第一洗脱液，从而获得第一浓缩洗脱液并且能够用作有效提取物; 和d）通过蒸发从第二洗脱液中除去第二洗脱液，从而获得第二浓缩洗脱液并且能够用作有效提取物。

3. 发明授权

US08440692B2 Hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents 有权
标题翻译： 2-芳基-4-喹诺酮的亲水性衍生物作为抗癌剂
公开(公告)号：US08440692B2
公开(公告)日：2013-05-14
申请号：US12448088
申请日：2007-12-07
申请人： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
发明人： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
IPC分类号： A61K31/47 , C07F9/38
CPC分类号： C07F9/6561 , C07D215/233 , C07D421/04 , C07D491/056 , C07F9/60
摘要： 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
摘要翻译： 2-芳基-4-喹诺酮通过与焦磷酸四苄酯反应而形成磷酸盐，形成其二苄基磷酸酯，然后进行氢化，用H代替二苄基，然后与Amberlite IR-120（Na +形式）反应形成二钠盐。初步筛选结果表明，这些磷酸盐显示出显着的抗癌活性。还合成了一种新的中间体2-硒吩-4-喹诺酮和2-苯基-4-喹诺酮的λ/，λ/二烷基氨基烷基衍生物。这些新型中间体显示出显着的抗癌活性。

4. 发明申请

US20100168064A1 NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS 有权
标题翻译：作为抗原剂的2-亚芳基-4-喹啉酮的新型疏水衍生物
公开(公告)号：US20100168064A1
公开(公告)日：2010-07-01
申请号：US12448088
申请日：2007-12-07
申请人： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
发明人： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
IPC分类号： A61K31/675 , C07F9/09 , A61K31/47 , A61P35/00 , A61P35/02 , C07D421/04 , C07D215/233
CPC分类号： C07F9/6561 , C07D215/233 , C07D421/04 , C07D491/056 , C07F9/60
摘要： 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
摘要翻译： 2-芳基-4-喹诺酮通过与焦磷酸四苄酯反应而形成磷酸盐，形成其二苄基磷酸酯，然后进行氢化，用H代替二苄基，然后与Amberlite IR-120（Na +形式）反应形成二钠盐。初步筛选结果表明，这些磷酸盐显示出显着的抗癌活性。还合成2-苯基-4-喹诺酮的新型中间体2-硒吩-4-喹诺酮和Λ/，Λ/二烷基氨基烷基衍生物。这些新型中间体显示出显着的抗癌活性。

5. 发明授权

US07531519B2 Polygalatenosides and use thereof as an antidepressant agent 有权
标题翻译：聚天冬氨酸苷及其作为抗抑郁药的用途
公开(公告)号：US07531519B2
公开(公告)日：2009-05-12
申请号：US11524470
申请日：2006-09-21
申请人： Mo-Chi Cheng , Feng-Nien Ko , Tian-Shung Wu
发明人： Mo-Chi Cheng , Feng-Nien Ko , Tian-Shung Wu
IPC分类号： A61K31/70 , A01N43/04
CPC分类号： C07H13/02
摘要： A polygalatenoside useful as an antidepressant agent having the formula is disclosed: wherein R, R′ and R″ independently are H or R1, provided that R, R′ and R″ are not all H, wherein R1 is wherein R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen; or a pharmaceutically acceptable salt thereof. Preferably, R2 is H.
摘要翻译：公开了可用作具有下式的抗抑郁剂的聚天冬氨酸苷：其中R，R'和R“独立地为H或R 1，条件是R，R'和R”不全部为H，其中R 1为其中R 2为氢，C 1 -C 6烷基，C 1 -C 6烷氧基或卤素; 或其药学上可接受的盐。优选地，R2是H.

6. 发明申请

US20080076724A1 Novel polygalatenosides and use thereof as an antidepressant agent 有权
标题翻译：新型多羟基腺苷类及其作为抗抑郁剂的用途
公开(公告)号：US20080076724A1
公开(公告)日：2008-03-27
申请号：US11524470
申请日：2006-09-21
申请人： Mo-Chi Cheng , Feng-Nien Ko , Tian-Shung Wu
发明人： Mo-Chi Cheng , Feng-Nien Ko , Tian-Shung Wu
IPC分类号： A61K31/7024 , C07H13/02
CPC分类号： C07H13/02
摘要： A polygalatenoside useful as an antidepressant agent having the formula is disclosed: wherein R, R′ and R″ independently are H or R1, provided that R, R′ and R″ are not all H, wherein R1 is wherein R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen; or a pharmaceutically acceptable salt thereof. Preferably, R2 is H.
摘要翻译：公开了可用作具有下式的抗抑郁剂的聚天冬氨酸苷：其中R，R'和R“独立地为H或R 1，条件是R，R'和R”不全为H 其中R 1是其中R 2是氢，C 1 -C 6烷基，C 1 -C 6烷氧基或卤素; 或其药学上可接受的盐。优选地，R 2是H.

7. 发明授权

US5656274A Thromboxane A.sub.2 receptor antagonism and antioxidant action of cinnamophilin and its derivatives 失效
标题翻译：血栓素A2受体拮抗作用及其衍生物的抗氧化作用
公开(公告)号：US5656274A
公开(公告)日：1997-08-12
申请号：US394113
申请日：1995-02-24
申请人： Tian-Shung Wu , Che-Ming Teng , Sheu-Meei Yu
发明人： Tian-Shung Wu , Che-Ming Teng , Sheu-Meei Yu
IPC分类号： C07C43/23 , C07C59/64 , C07C69/017 , C07C69/734 , A01N65/00
CPC分类号： C07C59/64 , C07C43/23 , C07C69/017 , C07C69/734
摘要： The present invention discloses the method of isolation and purification of the bioactive constituents cinnamophilin from Cinnamomum philippinense (Merr.), the same as Machilus acuminatissima (Hayata). Pharmacological evaluation showed that these compounds possess the activity to inhibit platelet aggregation and to produce relaxing effects of aortic vascular constriction.
摘要翻译：本发明公开了与马蹄草（Hayata）相同的来自樟树（Merr。）的生物活性成分肌醇六肽的分离纯化方法。药理学评价表明，这些化合物具有抑制血小板聚集和产生主动脉夹层收缩的作用。

8. 发明授权

US5853731A Thromboxane A2 Receptor antagonism and antioxidant action of cinnamophilin and its derivatives, their pharmaceutical compositions and uses 失效
标题翻译：血栓素A2受体拮抗作用及其衍生物及其药物组合物及用途的抗氧化作用
公开(公告)号：US5853731A
公开(公告)日：1998-12-29
申请号：US841053
申请日：1997-04-29
申请人： Tian-Shung Wu , Che-Ming Teng , Sheu-Meei Yu
发明人： Tian-Shung Wu , Che-Ming Teng , Sheu-Meei Yu
IPC分类号： C07C43/23 , C07C59/64 , C07C69/017 , C07C69/734 , A01N65/00 , A61K35/78
CPC分类号： C07C59/64 , C07C43/23 , C07C69/017 , C07C69/734
摘要： A pharmaceutical composition which possesses vasorelaxing effect of aortic contraction, relaxing effect of tracheal contraction, and antioxidative properties, is disclosed. It contains a pharmaceutical acceptable vehicle and an effective amount of any compound selected from those compounds represented by the following formula: ##STR1## where R.sub.1 represents H, C.sub.1-8 alkyl, or --OCOR, R.sub.2 represents OH, or COO.sup.--, and R represents H, or C.sub.1-8 alkyl.
摘要翻译：公开了具有主动脉收缩的血管舒张作用，气管收缩的放松效果和抗氧化性质的药物组合物。它含有药物可接受的载体和有效量的选自下列化学式表示的那些化合物的任何化合物：其中R1代表H，C1-8烷基或-OCOR，R2代表OH或COO-，R 表示H或C 1-8烷基。

9. 发明授权

US08524740B2 Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives 有权
标题翻译：芳基和杂芳基 - 喹啉衍生物的合成和抗癌活性
公开(公告)号：US08524740B2
公开(公告)日：2013-09-03
申请号：US13181978
申请日：2011-07-13
申请人： Sheng-Chu Kuo , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Tian-Shung Wu , Tzong-Der Way , Jing-Gung Chung , Jai-Sing Yang , Chi-Hung Huang , Meng-Tung Tsai
发明人： Sheng-Chu Kuo , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Tian-Shung Wu , Tzong-Der Way , Jing-Gung Chung , Jai-Sing Yang , Chi-Hung Huang , Meng-Tung Tsai
IPC分类号： A61K31/04 , C07D215/04
CPC分类号： C07D493/04 , C07D215/22 , C07D215/233 , C07D215/38 , C07D401/04 , C07F9/60 , C07F9/65583 , C07F9/6561
摘要： A compound of Formula I is disclosed as follows: or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein R is hydrogen, P(═O)(OH)2, P(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, P(═O)(OH)(OM), P(═O)(OM)2, P═O(O2M), S(═O)(OH)2, S(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, S(═O)(OH)(OM), S(═O)(OM)2; M is a monovalent or divalent metal ion, or alkylammonium ion; W is (C6-C20)aryl, (C6-C20)heteroaryl, (C1-C18)alkyl(C6-C20)aryl, (C1-C18)alkyl(C6-C20)heteroaryl, hydroxy(C6-C20)aryl, hydroxy(C6-C20)heteroaryl, (C1-C18)alkoxy(C6-C20)aryl, (C1-C18)alkoxy(C6-C20)heteroaryl, (C1-C18)alkylenedioxy(C6-C20)aryl, (C1-C18)alkylenedioxy(C6-C20)heteroaryl, halo(C6-C20)aryl, halo(C6-C20)heteroaryl, (C1-C18)alkylamino(C6-C20)aryl, (C1-C18)alkylamino(C6-C20)heteroaryl, (C1-C18)cycloalkylamino(C6-C20)aryl, or (C1-C18)cycloalkylamino(C6-C20)heteroaryl, and their OR8 substutes; R5 is (C1-C18alkoxy, hydrogen, hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or OR8, or R5 and R6 are (C1-C18)dioxy provided that R7 is hydrogen; R6 is hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or OR8, (C1-C18)alkoxy, (C1-C18)alkylamino, or (C1-C18)cycloalkylamino, or R6 and R7 are (C1-C18)dioxy provided that R5 is hydrogen; R7 is hydrogen, halo or OR8, hydroxyl, or O—(C1-C18)alkyl(C6-C20)aryl; and R8 is P(═O)(OH)2, P(═O)(O(C1-C18)alkyl(C6-C20)aryl)2, P(═O)(OH)(OM), or P(═O)(OM)2, P═O(O2M).
摘要翻译：式I化合物公开如下：或其药学上可接受的盐，前药，溶剂合物或代谢物，其中R是氢，P（= O）（OH）2，P（= O）（O（C 1 -C 18））亚烷基（C 6 -C 20）芳基）2，P（= O）（OH）（OM），P（= O）（OM）2，P = O（O 2 M） S（= O）（O（C1-C18）亚烷基（C6-C20）芳基）2，S（= O）（OH）（OM），S（= O）（OM） M是一价或二价金属离子或烷基铵离子; W是（C 6 -C 20）芳基，（C 6 -C 20）杂芳基，（C 1 -C 18）烷基（C 6 -C 20）芳基，（C 1 -C 18）烷基（C 6 -C 20）羟基（C 6 -C 20）杂芳基，（C 1 -C 18）烷氧基（C 6 -C 20）芳基，（C 1 -C 18）烷氧基（C 6 -C 20）杂芳基，（C 1 -C 18）亚烷基二氧基 C 1 -C 20烷基氨基（C 6 -C 20）芳基，（C 1 -C 20）芳基，（C 1 -C 20）芳基，杂芳基，（C1-C18）环烷基氨基（C6-C20）芳基或（C1-C18）环烷基氨基（C6-C20）杂芳基及其OR8分子; R5是（C1-C18烷氧基，氢，羟基，O-（C1-C18）烷基（C6-C20）芳基，卤素或OR8或R5和R6是（C1-C18）二氧基，条件是R7是氢; R6是羟基，（C 1 -C 18）烷基（C 6 -C 20）芳基，卤素或OR 8，（C 1 -C 18）烷氧基，（C 1 -C 18）烷基氨基或（C 1 -C 18）环烷基氨基或R 6和R 7为（C 1 -C 18）烷基（C 6 -C 20）芳基; R 8为P（= O）（OH）2，P（= O） = O）（O（C 1 -C 18）烷基（C 6 -C 20）芳基）2，P（= O）（OH）（OM）或P（= O）（OM）2，P = O（O 2 M）。

10. 发明授权

US5571822A Antitumor compounds 失效
标题翻译：抗肿瘤化合物
公开(公告)号：US5571822A
公开(公告)日：1996-11-05
申请号：US316409
申请日：1994-09-30
申请人： Kuo-Hsiung Lee , Sheng-Chu Kuo , Tian-Shung Wu , Hui K. Wang , Leping Li
发明人： Kuo-Hsiung Lee , Sheng-Chu Kuo , Tian-Shung Wu , Hui K. Wang , Leping Li
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/5377 , C07D215/38 , C07D215/233
CPC分类号： C07D215/38 , A61K31/47 , A61K31/4709 , A61K31/5377
摘要： A method of inhibiting tumor-cell growth in a mammalian subject, by administering a therapeutically effective amount of a selected 2-phenyl-4-quinolone compound. The selected compound shows unexpectely high activity against a variety of solid tumor cells.
摘要翻译：一种通过施用治疗有效量的选择的2-苯基-4-喹诺酮化合物来抑制哺乳动物受试者的肿瘤细胞生长的方法。所选化合物对各种实体瘤细胞显示出非常高的活性。

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