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1. 发明申请

US20090227994A1 DEVICE AND METHOD FOR THE DELIVERY AND/OR ELIMINATION OF COMPOUNDS IN TISSUE 审中-公开
标题翻译：用于在组织中递送和/或消除化合物的装置和方法
公开(公告)号：US20090227994A1
公开(公告)日：2009-09-10
申请号：US11573422
申请日：2005-08-09
申请人： Warren S. Grundfest , Yaser M. Abdulraheem , Sze-Chun Chan , Margaret Chiang , Mario K. Furtado , Kevin Geary , Chih-Kang Lin
发明人： Warren S. Grundfest , Yaser M. Abdulraheem , Sze-Chun Chan , Margaret Chiang , Mario K. Furtado , Kevin Geary , Chih-Kang Lin
IPC分类号： A61B18/20 , A61B19/00
CPC分类号： A61B18/203 , A61B2017/00057 , A61B2017/00769 , A61B2018/00452 , A61B2018/0047 , A61M37/0076
摘要： A device for removing compounds in tissue such as, for example, tattoo pigment compounds in skin tissue includes a detector for detecting the peak optical absorption of the compound, a laser source, wherein the wavelength is tuned or selected based on the peak optical absorption of the compound in the skin. The device further includes a delivery member for delivering radiation from the laser source to the tissue. Compounds such as tattoo pigment compounds are removed by detecting the peak optical absorption of the tattoo pigments or photofragments thereof in tissue with the detector. The wavelength of the laser source is adjusted based on the peak optical absorption of the compound in the tissue, and delivers radiation at the adjusted (or non-adjusted) wavelength from the laser source to the compound in the tissue with the delivery member.
摘要翻译：用于去除组织中的化合物的装置，例如皮肤组织中的纹身颜料化合物包括用于检测化合物的峰值光吸收的检测器，激光源，其中基于峰值光吸收来调节或选择波长化合物在皮肤中。该装置还包括用于将来自激光源的辐射传送到组织的递送构件。通过用检测器检测组织中纹身颜料或其光片的峰值光吸收来除去纹身颜料化合物等化合物。基于组织中化合物的峰值光吸收来调整激光源的波长，并且将经调整（或未调节）的波长的辐射从激光源传送到具有递送构件的组织中的化合物。

2. 发明授权

US5701900A Ultrasonic transducer orientation sensing and display apparatus and method 失效
标题翻译：超声波换能器定向感应和显示装置及方法
公开(公告)号：US5701900A
公开(公告)日：1997-12-30
申请号：US433866
申请日：1995-05-01
申请人： Ramez E. Shehada , Warren S. Grundfest
发明人： Ramez E. Shehada , Warren S. Grundfest
IPC分类号： A61B8/12 , A61B8/00
CPC分类号： A61B8/12 , A61B8/4488
摘要： An ultrasonic transducer orientation sensing and display apparatus, and related method, for use in providing an accurate representation of the orientation of an ultrasonic transducer's imaging plane. The orientation sensing and display apparatus includes an ultrasonic transducer having an integral orientation sensor, a processor, and a display. The representation of the imaging plane as indicated on the display is based on electrical signals generated by the orientation sensor. The ultrasonic transducer, in accordance with one embodiment of the present invention, is integrated near the distal end or tip of an elongated tube of a laparoscopic instrument used for ultrasonic imaging. The orientation sensor is a biaxial gravitational sensor, composed of two orthogonal sensing toroids to sense rotation about any axis lying in a horizontal plane. Each sensing toroid has a hollow tubular shape that contains a gravity indicator that is free to move within the respective sensing toroid for measuring rotation about an axis through the toroid's center. Gravity causes each gravity indicator to migrate to the lowest portion of the respective toroid. The orientation also can include a permanent magnet thus providing a tri-axial sensor.
摘要翻译：一种用于提供超声波换能器成像平面的取向的精确表示的超声换能器定位感测和显示装置及相关方法。定向检测和显示装置包括具有整体定向传感器，处理器和显示器的超声换能器。显示器上指示的成像平面的表示基于由方位传感器产生的电信号。根据本发明的一个实施例的超声换能器集成在用于超声成像的腹腔镜仪器的细长管的远端或尖端附近。方向传感器是一个双轴重力传感器，由两个正交检测环形圈组成，用于检测围绕水平面的任何轴的旋转。每个感测环形线圈都具有中空的管状形状，其包含重力指示器，该重力指示器可以在相应的检测环形圈内自由移动，以便通过环形线圈的中心测量围绕轴的转动。重力使每个重力指示器迁移到相应环形体的最低部分。该方向还可以包括永磁体，从而提供三轴传感器。

3. 发明授权

US5318023A Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle 失效
标题翻译：用于光敏剂的装置和方法增强基于荧光的活检针
公开(公告)号：US5318023A
公开(公告)日：1994-06-07
申请号：US679766
申请日：1991-04-03
申请人： Sandor G. Vari , Theodore Papazoglou , Warren S. Grundfest
发明人： Sandor G. Vari , Theodore Papazoglou , Warren S. Grundfest
IPC分类号： A61B5/00 , A61B10/00 , A61B10/02 , A61B17/22 , A61B18/20 , A61B18/22 , A61B19/00
CPC分类号： A61B10/0233 , A61B18/22 , A61B5/0059 , A61B5/415 , A61B5/418 , A61B2017/22087 , A61B2090/062
摘要： A method and apparatus is disclosed for the instant intraoperative detection and biopsy of metastatic cancer using fluorescence spectroscopy. A photosensitizing agent selectively retained by cancerous tissue is administered prior to surgery. A fiberoptic probe integrated with a biopsy device illuminates the examined tissue and causes fluorescence which is recorded by a spectrograph and plotted as a spectral curve. The intensity ratio (S1/S2) for the fluorescence from the photosensitizing agent (S1) and autofluorescence (S2) for the examined tissue is compared with the intensity ratio at the same wavelengths for primary tumor and normal tissue. Tissue that displays an intensity ratio different from that of normal tissue can immediately be analyzed for the depth of tumor involvement and then excised for histological examination using the biopsy device.
摘要翻译：公开了使用荧光光谱法进行的转移性癌症的即时术中检测和活检的方法和装置。在手术前给予由癌组织选择性保留的光敏剂。与活检装置集成的光纤探针照亮被检查的组织并引起荧光，其由光谱仪记录并绘制为光谱曲线。将来自光敏剂（S1）的荧光和检测组织的自发荧光（S2）的强度比（S1 / S2）与原发肿瘤和正常组织的相同波长的强度比进行比较。显示与正常组织不同的强度比的组织可以立即分析肿瘤深度，然后用活检装置进行组织学检查。

4. 发明授权

US08690331B2 Corneal hydration sensing system 有权
标题翻译：角膜水合传感系统
公开(公告)号：US08690331B2
公开(公告)日：2014-04-08
申请号：US13597947
申请日：2012-08-29
申请人： Martin Culjat , Priyamvada Tewari , Jean L. Bourges , Jean P. Hubschman , Rahul S. Singh , Zachary Taylor , Warren S. Grundfest
发明人： Martin Culjat , Priyamvada Tewari , Jean L. Bourges , Jean P. Hubschman , Rahul S. Singh , Zachary Taylor , Warren S. Grundfest
IPC分类号： A61B3/10
CPC分类号： A61B3/0008 , A61B3/10
摘要： A corneal hydration sensing system includes an illumination system configured to provide an illumination beam of terahertz radiation, an optical system arranged in an optical path of the illumination system to relay and direct at least a portion of the illumination beam of terahertz radiation onto a cornea of a subject and to receive at least a portion of terahertz radiation reflected from the cornea to provide a return beam of terahertz radiation, and a detection system arranged in an optical path of the return beam of terahertz radiation. The detection system is configured to provide a detection signal from detecting at least a portion of the return beam of terahertz radiation. The corneal hydration sensing system also includes a signal processing system configured to communicate with the detection system to receive the detection signal. The signal processing system processes the detection signal to provide a measure of an amount of hydration sensed in the cornea of the subject.
摘要翻译：角膜水合感测系统包括被配置为提供太赫兹辐射的照明光束的照明系统，布置在照明系统的光路中的光学系统，以将太赫兹辐射的照明光束的至少一部分中的至少一部分引导到角膜并且接收从角膜反射的至少一部分太赫兹辐射以提供太赫兹辐射的返回光束，以及布置在太赫兹辐射的返回光束的光路中的检测系统。检测系统被配置为提供检测信号，以检测至少一部分太赫兹辐射的返回光束。角膜水合感测系统还包括被配置为与检测系统通信以接收检测信号的信号处理系统。信号处理系统处理检测信号以提供在受试者的角膜中感测到的水合量的量度。

5. 发明授权

US5456252A Induced fluorescence spectroscopy blood perfusion and pH monitor and method 失效
标题翻译：诱导荧光光谱血液灌注和pH监测和方法
公开(公告)号：US5456252A
公开(公告)日：1995-10-10
申请号：US129406
申请日：1993-09-30
申请人： Sandor G. Vari , Theodore Papazoglou , Warren S. Grundfest
发明人： Sandor G. Vari , Theodore Papazoglou , Warren S. Grundfest
IPC分类号： A61B5/00 , G01N21/64 , A61B6/00
CPC分类号： G01N21/6486 , G01N2021/6417 , G01N2021/6484 , Y10S128/925
摘要： A medical monitor, and related method, determines a pre-existing physiological property of an organ of a patient by monitoring fluorescent light produced by constituents associated with the metabolic and structural condition of the organ. The monitor illuminates the organ with ultraviolet excitation light that induces some constituents of the organ to fluoresce, with the fluorescent light being monitored and processed to determine pre-existing physiological properties of the organ. A sensor monitors the return light, which includes fluorescent light produced by the fluorescent constituents of the organ, and generates first and second electrical signals indicative of the intensity of light at two wavelength. One wavelength is associated with the fluorescence of collagen, a constituent associated with organ's structural properties, and the other wavelength is a associated with the fluorescence of NADH, a constituent associated with the organ's metabolism. A processor then processes the first and second electrical signals to determine the localized pH of the organ. A fiber-optic waveguide is used to guide the excitation light from the laser light source to the organ and the return light from the organ to the sensor. In another aspect of the invention, the sensor generates a third electrical signal associated with the fluorescence of elastin, a constituent associated with the organ's structural properties. The processor processes the first, second and third electrical signals to determine the perfusion or oxygenation of the organ.
摘要翻译：医疗监视器和相关方法通过监测与器官的代谢和结构状况相关的成分产生的荧光，来确定患者器官的预先存在的生理特性。监视器用紫外线激发光照亮器官，诱导器官的一些成分发荧光，荧光被监测和处理以确定器官的先前存在的生理特性。传感器监测返回光，其包括由器官的荧光成分产生的荧光，并产生指示两个波长的光强度的第一和第二电信号。一个波长与胶原蛋白的荧光相关联，胶原蛋白是与器官结构特性相关的成分，另一个波长与NADH（与器官代谢相关的成分）的荧光相关。然后处理器处理第一和第二电信号以确定器官的局部pH。使用光纤波导将来自激光光源的激发光引导至器官，并将来自器官的返回光引导至传感器。在本发明的另一方面，传感器产生与弹性蛋白的荧光相关联的第三电信号，弹性蛋白是与器官结构特性相关的成分。处理器处理第一，第二和第三电信号以确定器官的灌注或氧合。

6. 发明授权

US06697657B1 Method and devices for laser induced fluorescence attenuation spectroscopy (LIFAS) 失效
标题翻译：激光诱导荧光衰减光谱法（LIFAS）的方法和装置
公开(公告)号：US06697657B1
公开(公告)日：2004-02-24
申请号：US09605176
申请日：2000-06-28
申请人： Ramez E. N. Shehada , Vasilis Z. Marmarelis , Warren S. Grundfest
发明人： Ramez E. N. Shehada , Vasilis Z. Marmarelis , Warren S. Grundfest
IPC分类号： A61B500
CPC分类号： G01N21/6486 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1455 , A61B5/7267 , G01N21/49 , G01N21/6402 , G01N21/6428 , G01N2021/6484 , G01N2201/06193
摘要： Methods and devices for Laser Induced Fluorescence Attenuation Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) Spectrocopy, including, in particular, methods and devices for the detection of ischemia and hypoxia in biological tissue. The LIFAS method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.
摘要翻译：激光诱导荧光衰减激光诱导荧光衰减光谱法（LIFAS）的方法和装置，特别是用于检测生物组织缺血和缺氧的方法和装置。 LIFAS方法和装置优选地包括适于发射针对样品中的样品体积的辐射的源，以产生来自样品的返回光，这种返回光包括由样品的调制产生的调制的返回光，第一传感器，位移距离样品体积的第一距离，用于监测返回光并产生指示返回光强度的第一信号;第二传感器，与样品体积相距离第二距离，用于监测返回光，并产生指示的第二信号的返回光的强度，以及与第一传感器和第二传感器相关联的处理器并且适于处理第一和第二信号以便确定样本的调制的处理器。本发明的方法和装置特别适用于确定样品的波长相关衰减，并使用衰减来恢复样品的固有激光诱导荧光。反过来，衰减和固有的激光诱导荧光可用于确定感兴趣的特征，例如生物组织的缺血或缺氧状况。

7. 发明授权

US5363388A Continuously tunable solid state ultraviolet coherent light source 失效
标题翻译：连续可调固态紫外相干光源
公开(公告)号：US5363388A
公开(公告)日：1994-11-08
申请号：US781328
申请日：1991-10-18
申请人： Weiqiang Shi , Warren S. Grundfest
发明人： Weiqiang Shi , Warren S. Grundfest
IPC分类号： G02F1/35 , H01S3/108 , H01S3/16 , H01S3/10
CPC分类号： G02F1/3534 , H01S3/108 , G02F2001/3542 , H01S3/1625
摘要： A compact solid state source of coherent laser light in the range of about 298 nm through about 355 nm utilizes a Nd:YAG or Nd:YLF laser to pump a tunable Ti:Al.sub.2 O.sub.3 laser. The beam from the Nd:YAG/Nd:YLF laser is then combined in a nonlinear optical crystal with the tunable beam from the Ti:Al.sub.2 O.sub.3 laser to provide a continuously tunable laser beam in the range of about 298 nm through about 355 nm.
摘要翻译：在约298nm至约355nm的范围内的相干激光的紧凑的固态光源使用Nd：YAG或Nd：YLF激光器来泵浦可调Ti：Al 2 O 3激光器。然后将来自Nd：YAG / Nd：YLF激光器的光束在非线性光学晶体中与来自Ti：Al 2 O 3激光器的可调谐光束组合，以提供在约298nm至约355nm的范围内的连续可调激光束。

8. 发明授权

US5341805A Glucose fluorescence monitor and method 失效
标题翻译：葡萄糖荧光监测仪及方法
公开(公告)号：US5341805A
公开(公告)日：1994-08-30
申请号：US43580
申请日：1993-04-06
申请人： Marigo Stavridi , Warren S. Grundfest
发明人： Marigo Stavridi , Warren S. Grundfest
IPC分类号： G01N21/64 , A61B5/00 , A61B5/145 , A61B5/1455 , G01N21/76 , G01N21/78 , G01N33/66
CPC分类号： A61B5/1459 , A61B5/0071 , A61B5/0084 , A61B5/14532 , G01N21/6402 , G01N21/6486 , A61B5/0075 , A61B5/0088
摘要： A glucose monitor, and related method, determines the concentration of glucose in a sample by monitoring fluorescent light produced directly by any glucose present in the sample. The glucose monitor illuminates the sample with ultraviolet excitation light that induces any glucose present in the sample to fluoresce, with the fluorescent light being monitored and processed to determine the concentration of glucose in the sample. A sensor monitors the return light, which includes fluorescent light produced by any glucose in the sample, and generates first and second electrical signals indicative of the intensity of light in two wavelength bands. One wavelength band includes a characteristic spectral peak of glucose fluorescence, and the other wavelength band is a reference band having known spectral characteristics. A processor then processes the first and second electrical signals to determine the concentration of glucose in the sample. A fiber-optic waveguide is used to guide the excitation light from the laser light source to the sample and the return light from the sample to the sensor. The fiber-optic waveguide is housed in a catheter or probe that is adapted to monitor the concentration of glucose percutaneously in the oral cavity tissues of a person's mouth such as the gums.
摘要翻译：葡萄糖监测器和相关方法通过监测由样品中存在的任何葡萄糖直接产生的荧光，来确定样品中葡萄糖的浓度。葡萄糖监测器用紫外激发光照射样品，诱导样品中存在的任何葡萄糖发荧光，荧光被监测和处理以确定样品中葡萄糖的浓度。传感器监测返回光，其包括由样品中的任何葡萄糖产生的荧光，并且产生指示两个波长带中的光强度的第一和第二电信号。一个波长带包括葡萄糖荧光的特征光谱峰，而另一波长带是具有已知光谱特性的参考带。然后处理器处理第一和第二电信号以确定样品中葡萄糖的浓度。光纤波导用于将来自激光光源的激发光引导到样品以及从样品到传感器的返回光。光纤波导被容纳在导管或探针中，该导管或探针适合于监测人口的口腔组织（例如牙龈）经皮经皮葡萄糖的浓度。

9. 再颁专利

USRE39672E1 Method and devices for laser induced fluorescence attenuation spectroscopy 有权
标题翻译：激光诱导荧光衰减光谱法的方法和装置
公开(公告)号：USRE39672E1
公开(公告)日：2007-06-05
申请号：US10056335
申请日：2002-01-23
申请人： Ramez E. N. Shehada , Vasilis Z. Marmarelis , Warren S. Grundfest
发明人： Ramez E. N. Shehada , Vasilis Z. Marmarelis , Warren S. Grundfest
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1455 , A61B5/7267 , G01N21/49 , G01N21/6402 , G01N21/6428 , G01N2021/6484 , G01N2201/06193
摘要： The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.
摘要翻译：激光诱导荧光衰减光谱法（LIFAS）方法和装置优选地包括适于发射针对样品中的样品体积的辐射以产生来自样品的返回光的源，这种返回光包括由调制的调制的返回光样品，第一传感器，离开样品体积第一距离，用于监测返回光并产生指示返回光强度的第一信号;第二传感器，其从样品体积中移出第二距离，用于监测返回光并产生指示返回光强度的第二信号，以及与第一传感器和第二传感器相关联并适于处理第一和第二信号以便确定样本的调制的处理器。本发明的方法和装置特别适用于确定样品的波长相关衰减，并使用衰减来恢复样品的固有激光诱导荧光。反过来，衰减和固有的激光诱导荧光可用于确定感兴趣的特征，例如生物组织的缺血或缺氧状况。

10. 发明授权

US06272376B1 Time-resolved, laser-induced fluorescence for the characterization of organic material 有权
标题翻译：时间分辨，激光诱导的荧光用于表征有机材料
公开(公告)号：US06272376B1
公开(公告)日：2001-08-07
申请号：US09235710
申请日：1999-01-22
申请人： Laura Marcu , Warren S. Grundfest , Jean-Michel I. Maarek
发明人： Laura Marcu , Warren S. Grundfest , Jean-Michel I. Maarek
IPC分类号： A61B600
CPC分类号： G01N21/6408 , A61B5/0071 , A61B5/0075 , A61B5/0084 , G01N21/6402 , G01N21/6486 , G01N2021/6423
摘要： A method of analysis of organic matter, called Time-Resolved, Laser-Induced Fluorescence Spectroscopy (TR-LIFS), characterizes and discriminates certain matter, such as tissue, by investigating the fluoresence response of the protein and lipid fluorophore components in both the spectral domain and time domain. This method is more robust than prior methods as (1) can investigate the matter at muplitple wavelengths and even across an entire spectrum and (2) is more sensitive to picking up weaker fluorescence signals such as that from lipids. A detailed study of the use of TR-LIFs for the charaterization of arterial wall tisse is described. A system and instrumentation for practicing the novel method is also disclosed.
摘要翻译：通过研究蛋白质和脂质荧光团成分在光谱中的荧光响应，称为时间分辨，激光诱导荧光光谱（TR-LIFS）的分析方法，表征和鉴别某些物质，如组织域和时域。这种方法比以前的方法更为鲁棒，因为（1）可以检测波峰，甚至整个光谱的问题，（2）对于从脂质中获取较弱的荧光信号更敏感。描述了TR-LIF用于动脉壁的特征的详细研究。还公开了一种用于实践新方法的系统和仪器。

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