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1. 再颁专利

USRE39672E1 Method and devices for laser induced fluorescence attenuation spectroscopy 有权
标题翻译：激光诱导荧光衰减光谱法的方法和装置
公开(公告)号：USRE39672E1
公开(公告)日：2007-06-05
申请号：US10056335
申请日：2002-01-23
申请人： Ramez E. N. Shehada , Vasilis Z. Marmarelis , Warren S. Grundfest
发明人： Ramez E. N. Shehada , Vasilis Z. Marmarelis , Warren S. Grundfest
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1455 , A61B5/7267 , G01N21/49 , G01N21/6402 , G01N21/6428 , G01N2021/6484 , G01N2201/06193
摘要： The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.
摘要翻译：激光诱导荧光衰减光谱法（LIFAS）方法和装置优选地包括适于发射针对样品中的样品体积的辐射以产生来自样品的返回光的源，这种返回光包括由调制的调制的返回光样品，第一传感器，离开样品体积第一距离，用于监测返回光并产生指示返回光强度的第一信号;第二传感器，其从样品体积中移出第二距离，用于监测返回光并产生指示返回光强度的第二信号，以及与第一传感器和第二传感器相关联并适于处理第一和第二信号以便确定样本的调制的处理器。本发明的方法和装置特别适用于确定样品的波长相关衰减，并使用衰减来恢复样品的固有激光诱导荧光。反过来，衰减和固有的激光诱导荧光可用于确定感兴趣的特征，例如生物组织的缺血或缺氧状况。

2. 发明授权

US6124597A Method and devices for laser induced fluorescence attenuation spectroscopy 失效
标题翻译：激光诱导荧光衰减光谱法的方法和装置
公开(公告)号：US6124597A
公开(公告)日：2000-09-26
申请号：US889017
申请日：1997-07-07
申请人： Ramez E. N. Shehada , Vasilis Z. Marmarelis , Warren S. Grundfest
发明人： Ramez E. N. Shehada , Vasilis Z. Marmarelis , Warren S. Grundfest
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B10/00 , G01N21/27 , G01N21/49 , G01N21/64
CPC分类号： G01N21/6486 , A61B5/0075 , A61B5/0084 , G01N21/49 , G01N21/6402 , G01N21/6428 , A61B5/0071 , A61B5/0086 , A61B5/1455 , A61B5/7267 , G01N2021/6484 , G01N2201/06193
摘要： The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.
摘要翻译：激光诱导荧光衰减光谱法（LIFAS）方法和装置优选地包括适于发射针对样品中的样品体积的辐射以产生来自样品的返回光的源，这种返回光包括由调制的调制的返回光样品，第一传感器，离开样品体积第一距离，用于监测返回光并产生指示返回光强度的第一信号;第二传感器，其从样品体积中移出第二距离，用于监测返回光并产生指示返回光强度的第二信号，以及与第一传感器和第二传感器相关联并适于处理第一和第二信号以便确定样本的调制的处理器。本发明的方法和装置特别适用于确定样品的波长相关衰减，并使用衰减来恢复样品的固有激光诱导荧光。反过来，衰减和固有的激光诱导荧光可用于确定感兴趣的特征，例如生物组织的缺血或缺氧状况。

3. 发明授权

US06697657B1 Method and devices for laser induced fluorescence attenuation spectroscopy (LIFAS) 失效
标题翻译：激光诱导荧光衰减光谱法（LIFAS）的方法和装置
公开(公告)号：US06697657B1
公开(公告)日：2004-02-24
申请号：US09605176
申请日：2000-06-28
申请人： Ramez E. N. Shehada , Vasilis Z. Marmarelis , Warren S. Grundfest
发明人： Ramez E. N. Shehada , Vasilis Z. Marmarelis , Warren S. Grundfest
IPC分类号： A61B500
CPC分类号： G01N21/6486 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1455 , A61B5/7267 , G01N21/49 , G01N21/6402 , G01N21/6428 , G01N2021/6484 , G01N2201/06193
摘要： Methods and devices for Laser Induced Fluorescence Attenuation Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) Spectrocopy, including, in particular, methods and devices for the detection of ischemia and hypoxia in biological tissue. The LIFAS method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.
摘要翻译：激光诱导荧光衰减激光诱导荧光衰减光谱法（LIFAS）的方法和装置，特别是用于检测生物组织缺血和缺氧的方法和装置。 LIFAS方法和装置优选地包括适于发射针对样品中的样品体积的辐射的源，以产生来自样品的返回光，这种返回光包括由样品的调制产生的调制的返回光，第一传感器，位移距离样品体积的第一距离，用于监测返回光并产生指示返回光强度的第一信号;第二传感器，与样品体积相距离第二距离，用于监测返回光，并产生指示的第二信号的返回光的强度，以及与第一传感器和第二传感器相关联的处理器并且适于处理第一和第二信号以便确定样本的调制的处理器。本发明的方法和装置特别适用于确定样品的波长相关衰减，并使用衰减来恢复样品的固有激光诱导荧光。反过来，衰减和固有的激光诱导荧光可用于确定感兴趣的特征，例如生物组织的缺血或缺氧状况。

4. 发明授权

US6044336A Method and apparatus for situationally adaptive processing in echo-location systems operating in non-Gaussian environments 失效
标题翻译：在非高斯环境中运行的回波定位系统中的情境自适应处理方法和装置
公开(公告)号：US6044336A
公开(公告)日：2000-03-28
申请号：US114563
申请日：1998-07-13
申请人： Vasilis Z. Marmarelis , Chrysostomos L. Nikias , Dae Cheol Shin
发明人： Vasilis Z. Marmarelis , Chrysostomos L. Nikias , Dae Cheol Shin
IPC分类号： G01S7/292 , G01S7/487 , G01S7/527 , G01S15/00 , G04B1/10
CPC分类号： G01S7/292 , G01S7/487 , G01S7/527
摘要： A signal processing method for use in echo-location systems (radar, sonar, laser radar) to obtain accurate estimates of the target reflectivity sequence in a random (non-Gaussian) noise environment, including ambient noise, reverberation, and clutter. The method derives the statistical characteristics of the random background environments and then constructs and maximizes the corresponding approximate likelihood function using iterative methods. The approximate maximum likelihood estimates are generated on the basis of an approximation of the ideal likelihood function which is maximized using computationally efficient algorithms.
摘要翻译：一种用于回波定位系统（雷达，声纳，激光雷达）中的信号处理方法，用于获得随机（非高斯）噪声环境中的目标反射率序列的准确估计，包括环境噪声，混响和杂波。该方法得出随机背景环境的统计特征，然后使用迭代法构建和最大化对应的近似似然函数。基于使用计算有效算法最大化的理想似然函数的近似来生成近似最大似然估计。

5. 发明申请

US20140278285A1 Method for Quantitative Diagnosis of Cerebrovascular, Neurovascular and Neurodegenerative Diseases via Computation of a CO2 Vasomotor Reactivity Index based on a Nonlinear Predictive Model 审中-公开
标题翻译：基于非线性预测模型计算CO2血管运动反应性指数的脑血管，神经血管和神经变性疾病的定量诊断方法
公开(公告)号：US20140278285A1
公开(公告)日：2014-09-18
申请号：US13801426
申请日：2013-03-13
申请人： Vasilis Z. Marmarelis , Melissa Emily Orme-Marmarelis , Dae C. Shin
发明人： Vasilis Z. Marmarelis , Melissa Emily Orme-Marmarelis , Dae C. Shin
IPC分类号： G06F19/00
CPC分类号： G16H50/30 , G16H50/50
摘要： The present invention relates generally to a method for computer-aided quantitative diagnosis of cerebrovascular and neurodegenerative diseases (such as Alzheimer's, vascular dementia, mild cognitive impairment, transient ischemia, stroke etc.) via a vasomotor reactivity index (VMRI) which is computed on the basis of a computational model of the dynamic nonlinear inter-relationships between beat-to-beat time-series measurements of cerebral blood flow velocity, arterial blood pressure and end-tidal CO2. This model is obtained by means of a method pioneered by the inventors and may incorporate additional physiological measurements from human subjects. Its purpose is to provide useful information to physicians involved in the diagnosis and treatment of cerebrovascular and neurodegenerative diseases with a significant neurovascular component by offering quantitative means of assessment of the effects of the disease or medication on cerebral vasomotor reactivity. Initial results from clinical data have corroborated the diagnostic potential of this approach.
摘要翻译：本发明一般涉及通过血管运动反应性指数（VMRI）计算机辅助定量诊断脑血管和神经变性疾病（如阿尔茨海默病，血管性痴呆，轻度认知障碍，短暂性脑缺血，中风等）的方法，脑血流速度，动脉血压和尾气CO2的搏动时间序列测量之间的动态非线性相互关系的计算模型的基础。该模型通过本发明人先驱的方法获得，并且可以包括来自人类受试者的额外的生理测量。其目的是通过提供评估疾病或药物对脑血管运动反应性的影响的定量方法，为涉及诊断和治疗脑血管和神经变性疾病的医生提供有用的信息，具有显着的神经血管成分。临床数据的初步结果证实了这种方法的诊断潜力。

6. 发明授权

US08463582B2 Modeling nonlinear systems 有权
标题翻译：建模非线性系统
公开(公告)号：US08463582B2
公开(公告)日：2013-06-11
申请号：US12135904
申请日：2008-06-09
申请人： Dong Song , Vasilis Z. Marmarelis , Theodore W. Berger
发明人： Dong Song , Vasilis Z. Marmarelis , Theodore W. Berger
IPC分类号： G06F17/10
CPC分类号： G06F17/50 , G05B13/04
摘要： Systems and techniques, including machine-readable instructions, for modeling of nonlinear systems. In one aspect, an apparatus includes a collection of two or more inputs configured and arranged to receive input signals, a collection of two or more outputs configured and arranged to output output signals, a processing unit configured to transform the input signals into the output signals, wherein the transformation is non-linear and treats the non-linear system as a collection of multiple input, single output non-linear systems, and a data storage that stores characteristics of the transformation.
摘要翻译：用于非线性系统建模的系统和技术，包括机器可读指令。在一个方面，一种装置包括两个或更多个输入的集合，所述两个或多个输入被配置和布置为接收输入信号，被配置和布置为输出输出信号的两个或更多个输出的集合;处理单元，被配置为将输入信号变换成输出信号，其中所述变换是非线性的，并且将所述非线性系统视为多个输入单输出非线性系统的集合，以及存储所述转换特征的数据存储器。

7. 发明申请

US20090089022A1 Modeling Nonlinear Systems 有权
标题翻译：非线性系统建模
公开(公告)号：US20090089022A1
公开(公告)日：2009-04-02
申请号：US12135904
申请日：2008-06-09
申请人： Dong Song , Vasilis Z. Marmarelis , Theodore W. Berger
发明人： Dong Song , Vasilis Z. Marmarelis , Theodore W. Berger
IPC分类号： G06F17/10
CPC分类号： G06F17/50 , G05B13/04
摘要： Systems and techniques, including machine-readable instructions, for modeling of nonlinear systems. In one aspect, an apparatus includes a collection of two or more inputs configured and arranged to receive input signals, a collection of two or more outputs configured and arranged to output output signals, a processing unit configured to transform the input signals into the output signals, wherein the transformation is non-linear and treats the non-linear system as a collection of multiple input, single output non-linear systems, and a data storage that stores characteristics of the transformation.
摘要翻译：用于非线性系统建模的系统和技术，包括机器可读指令。在一个方面，一种装置包括两个或更多个输入的集合，所述两个或多个输入被配置和布置为接收输入信号，被配置和布置为输出输出信号的两个或更多个输出的集合;处理单元，被配置为将输入信号变换成输出信号，其中所述变换是非线性的，并且将所述非线性系统视为多个输入单输出非线性系统的集合，以及存储所述转换特征的数据存储器。

8. 发明授权

US5760732A Method and apparatus for enhanced resolution of range estimates in echo location for detection and imaging systems 失效
标题翻译：用于增强检测和成像系统回波位置范围估计分辨率的方法和装置
公开(公告)号：US5760732A
公开(公告)日：1998-06-02
申请号：US641346
申请日：1996-05-01
申请人： Vasilis Z. Marmarelis , Chrysostomos L. Nikias , David Sheby
发明人： Vasilis Z. Marmarelis , Chrysostomos L. Nikias , David Sheby
IPC分类号： G01S7/288 , G01S7/32 , G01S13/28 , G01S13/90 , G01S13/06
CPC分类号： G01S13/9035 , G01S7/32 , G01S13/282 , G01S13/9011 , G01S13/9017 , G01S2007/2883 , Y10S367/905
摘要： A method and apparatus for enhancing resolution of range estimates in all echo location systems and, specifically, such systems as Radar, Sonar, and Synthetic Aperture Radar (SAR), for example. The invention utilizes high order signal processing to "sharpen" or contract the main lobe of the processing system ambiguity function and suppress its side lobes, for a given transmission pulse bandwidth. The method and apparatus may be implemented in the frequency domain or time domain. Enhanced resolution is achieved by using a filter (MSC filter), according to this invention, in the echo location data processing system so that the received echo data is processed by the MSC filter to produce a signal that exhibits enhanced range resolution. The MSC filter output, H(.omega.), which is specific to the transmitted pulse waveform, is the ratio of a high-order manipulation of the transmitted signal with its modified spectral profile.
摘要翻译：例如，用于增强所有回波定位系统中的范围估计的分辨率的方法和装置，具体地，例如雷达，声纳和合成孔径雷达（SAR）等系统。本发明利用高阶信号处理对于给定的传输脉冲带宽来“锐化”或收缩处理系统模糊函数的主瓣并抑制其旁瓣。该方法和装置可以在频域或时域中实现。通过使用根据本发明的滤波器（MSC滤波器）在回波位置数据处理系统中实现增强的分辨率，使得接收的回波数据由MSC滤波器处理以产生展现出增强的距离分辨率的信号。特定于发送脉冲波形的MSC滤波器输出H（ω）是传输信号的高阶操纵与其修改的频谱分布的比率。

9. 发明授权

US07094205B2 High-resolution 3D ultrasonic transmission imaging 有权
标题翻译：高分辨率3D超声波传输成像
公开(公告)号：US07094205B2
公开(公告)日：2006-08-22
申请号：US10117763
申请日：2002-04-05
申请人： Vasilis Z. Marmarelis
发明人： Vasilis Z. Marmarelis
IPC分类号： A61B8/02
CPC分类号： A61B8/0825 , A61B8/406 , A61B8/483 , A61B90/17
摘要： A system for providing high resolution imaging of objects having sub-millimeter dimensions comprised of at least one transmitter, at least one receiver, a coupling chamber, and a processor for recording attenuation and time of flight profiles of the transmitted signals. The signals are conditioned in a manner to provide high signal-to-noise ration (SNR) and minimal crosstalk and multipath effects at the receiver.
摘要翻译：一种用于提供具有亚毫米尺寸的物体的高分辨率成像的系统，其包括至少一个发射器，至少一个接收器，耦合室和用于记录发射信号的衰减和飞行时间的处理器。这些信号的调理方式是在接收机上提供高信噪比（SNR）和最小的串扰和多路径效应。

10. 发明授权

US06776760B2 Multi-mode processing for ultrasonic imaging 有权
标题翻译：超声波成像多模式处理
公开(公告)号：US06776760B2
公开(公告)日：2004-08-17
申请号：US10382235
申请日：2003-03-05
申请人： Vasilis Z. Marmarelis
发明人： Vasilis Z. Marmarelis
IPC分类号： A61B802
CPC分类号： A61B8/0858 , A61B8/06 , A61B8/0825 , A61B8/0866 , A61B8/15 , G06F19/00 , G06F19/321 , G06F19/324 , G16H15/00
摘要： Systems and methods for obtaining images of body organs or other tissue for each of their multiple characterizing aspects, and for classifying different tissue types within the images according to their characterizing aspects, are disclosed herein. The tissue may be irradiated with an ultrasonic signal, and an interaction signal received in return. Sinogram data may be constructed from the received interaction signal, and multiple characterizing data extracted therefrom. The multiple characterizing data representing multiple characterizing aspects may then be matched to tissue type within a database containing information correlating characterizing multi-aspect data with tissue type. Images of the tissue may then be presented with identifiers associating tissue portions with their matched tissue types.
摘要翻译：本文公开了用于获得其多个特征方面中的每一个的身体器官或其他组织的图像的系统和方法，并且根据其特征方面对图像内的不同组织类型进行分类。可以用超声波信号照射组织，并且作为回报而接收到相互作用信号。 Sinogram数据可以从接收的交互信号构成，并从中提取多个特征数据。然后可以将表示多个特征方面的多个特征化数据与包含与表征多方面数据与组织类型相关的信息的数据库内的组织类型进行匹配。然后可以呈现与组织部分与其匹配的组织类型相关联的标识符的组织的图像。

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