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1. 发明授权

US08089625B2 Time-resolved and wavelength-resolved spectroscopy for characterizing biological materials 失效
标题翻译：用于表征生物材料的时间分辨和波长分辨光谱
公开(公告)号：US08089625B2
公开(公告)日：2012-01-03
申请号：US12516341
申请日：2007-11-26
申请人： Laura Marcu , Javier A. Jo , Daniel Elson
发明人： Laura Marcu , Javier A. Jo , Daniel Elson
IPC分类号： G01J3/30
CPC分类号： G01N21/6408 , G01J3/02 , G01J3/0205 , G01J3/021 , G01J3/0218 , G01J3/0294 , G01J3/2889 , G01J3/4406 , G01N21/6402 , G01N21/6486 , G01N2021/6421 , G01N2021/6484
摘要： One embodiment of the present invention provides a system that characterizes a biological sample by analyzing light emissions from the biological sample in response to an excitation. The system first radiates the biological sample with a laser impulse to cause the biological sample to produce a responsive light emission. Next, the system uses a wavelength splitting device to split the responsive light emission into a set of spectral bands of different central wavelengths. The system applies temporal delays to the set of spectral bands so that each spectral band arrives at an optical detector at a different time, thereby allowing the optical detector to temporally resolve the responsive light emission for each spectral band separately. Next, the system captures the delayed spectral bands within a single detection window of the optical detector. The system then processes the captured spectral bands.
摘要翻译：本发明的一个实施方案提供了一种通过响应于激发分析来自生物样品的光发射来表征生物样品的系统。系统首先用激光脉冲辐射生物样品，使生物样品产生响应性发光。接下来，系统使用波长分离装置将响应光发射分成不同中心波长的一组光谱带。该系统将时间延迟应用于频谱带集合，使得每个频谱带在不同时间到达光学检测器，从而允许光学检测器分别时间地分辨每个频谱带的响应光发射。接下来，系统捕获在光学检测器的单个检测窗口内的延迟的光谱带。然后系统处理捕获的光谱带。

2. 发明申请

US20090203991A1 MULTIPLE IMAGING AND/OR SPECTROSCOPIC MODALITY PROBE 审中-公开
标题翻译：多成像和/或光谱模态探测
公开(公告)号：US20090203991A1
公开(公告)日：2009-08-13
申请号：US12297080
申请日：2006-04-21
申请人： Thanassis Papaioannou , Qiyin Fang , Javier A. Jo , Laura Marcu , K. Kirk Shung
发明人： Thanassis Papaioannou , Qiyin Fang , Javier A. Jo , Laura Marcu , K. Kirk Shung
IPC分类号： A61B5/055 , A61B1/00 , A61B8/14 , A61B6/00
CPC分类号： G01J3/02 , A61B5/0035 , A61B5/0066 , A61B5/0073 , A61B5/02007 , A61B5/6852 , A61B8/0833 , A61B8/12 , A61B8/4416 , A61B8/445 , A61B8/4461 , G01J3/0202 , G01J3/021 , G01J3/0218 , G01J3/024 , G01J3/0264 , G01J3/0286 , G01J3/0289 , G01J3/10
摘要： The apparatus and methods described herein enable an operator to simultaneously collect images and spectroscopic information from a region(s) of interest using a multiple modality imaging and/or spectroscopic probe, configured as a catheter, endoscope, microscope, or hand held probe. The device may incorporate, for example, an ultrasonic transducer and a fiber optic probe to translate images and spectra. The apparatus and methods may be used in any suitable cavity, for example, the vascular system of a mammal.
摘要翻译：本文描述的装置和方法使得操作者能够使用被配置为导管，内窥镜，显微镜或手持探针的多模式成像和/或光谱探针同时从感兴趣区域收集图像和光谱信息。该装置可以包括例如超声波换能器和光纤探针以翻转图像和光谱。该装置和方法可以用于任何合适的空腔，例如哺乳动物的血管系统。

3. 发明授权

US06272376B1 Time-resolved, laser-induced fluorescence for the characterization of organic material 有权
标题翻译：时间分辨，激光诱导的荧光用于表征有机材料
公开(公告)号：US06272376B1
公开(公告)日：2001-08-07
申请号：US09235710
申请日：1999-01-22
申请人： Laura Marcu , Warren S. Grundfest , Jean-Michel I. Maarek
发明人： Laura Marcu , Warren S. Grundfest , Jean-Michel I. Maarek
IPC分类号： A61B600
CPC分类号： G01N21/6408 , A61B5/0071 , A61B5/0075 , A61B5/0084 , G01N21/6402 , G01N21/6486 , G01N2021/6423
摘要： A method of analysis of organic matter, called Time-Resolved, Laser-Induced Fluorescence Spectroscopy (TR-LIFS), characterizes and discriminates certain matter, such as tissue, by investigating the fluoresence response of the protein and lipid fluorophore components in both the spectral domain and time domain. This method is more robust than prior methods as (1) can investigate the matter at muplitple wavelengths and even across an entire spectrum and (2) is more sensitive to picking up weaker fluorescence signals such as that from lipids. A detailed study of the use of TR-LIFs for the charaterization of arterial wall tisse is described. A system and instrumentation for practicing the novel method is also disclosed.
摘要翻译：通过研究蛋白质和脂质荧光团成分在光谱中的荧光响应，称为时间分辨，激光诱导荧光光谱（TR-LIFS）的分析方法，表征和鉴别某些物质，如组织域和时域。这种方法比以前的方法更为鲁棒，因为（1）可以检测波峰，甚至整个光谱的问题，（2）对于从脂质中获取较弱的荧光信号更敏感。描述了TR-LIF用于动脉壁的特征的详细研究。还公开了一种用于实践新方法的系统和仪器。

4. 发明授权

US07890157B2 Method for fluorescence lifetime imaging microscopy and spectroscopy 失效
标题翻译：荧光寿命成像显微镜和光谱学方法
公开(公告)号：US07890157B2
公开(公告)日：2011-02-15
申请号：US10567248
申请日：2004-08-19
申请人： Javier A. Jo , Laura Marcu , Qiyin Fang , Thanassis Papaioannou
发明人： Javier A. Jo , Laura Marcu , Qiyin Fang , Thanassis Papaioannou
IPC分类号： A61B6/00 , G01N21/64 , G01N31/00
CPC分类号： G01N21/6408 , A61B5/0059 , G01N21/6458
摘要： A method and system for analysis of fluorescence emission spectroscopy data and fluorescence lifetime imaging microscopy data are described. A unique Laguerre expansion can be found for fluorescence intensity decays of arbitrary form with convergence to a correct solution faster than with conventional methods. The Laguerre expansion technique includes expansion coefficients highly correlated with intrinsic fluorescence lifetimes, allowing direct characterization of fluorescence dynamics. For complex systems, conventional analysis of fluorescence intensity decay in terms of discrete exponential components can not readily provide a true representation of underlying fluorescence dynamics. Utilizing the Laguerre expansion technique, an alternative non-parametric method for analysis of time-resolved fluorescence data from various systems is described, facilitating characterization and discrimination of a sample. An ultra-fast method for analysis of fluorescence lifetime imaging is also described, facilitating real-time analysis of compositional and functional changes in samples, at a microscopic or macroscopic level.
摘要翻译：描述了用于分析荧光发射光谱数据和荧光寿命成像显微镜数据的方法和系统。对于任意形式的荧光强度衰减，可以发现独特的Laguerre扩展，与常规方法相比，可以更快地收敛到正确的解决方案。 Laguerre扩展技术包括与内在荧光寿命高度相关的扩增系数，允许直接表征荧光动力学。对于复杂系统，以离散指数分量为基础的荧光强度衰减的常规分析不能容易地提供底层荧光动力学的真实表示。使用Laguerre扩展技术，描述了用于分析来自各种系统的时间分辨荧光数据的替代非参数方法，有助于表征和鉴别样品。还描述了用于分析荧光寿命成像的超快速方法，便于在微观或宏观水平上实时分析样品中的组成和功能变化。

5. 发明申请

US20100067003A1 TIME-RESOLVED AND WAVELENGTH-RESOLVED SPECTROSCOPY FOR CHARACTERIZING BIOLOGICAL MATERIALS 失效
标题翻译：用于表征生物材料的时间分辨率和波长分辨光谱
公开(公告)号：US20100067003A1
公开(公告)日：2010-03-18
申请号：US12516341
申请日：2007-11-26
申请人： Laura Marcu , Javier A. Jo , Daniel Elson
发明人： Laura Marcu , Javier A. Jo , Daniel Elson
IPC分类号： G01J3/30
CPC分类号： G01N21/6408 , G01J3/02 , G01J3/0205 , G01J3/021 , G01J3/0218 , G01J3/0294 , G01J3/2889 , G01J3/4406 , G01N21/6402 , G01N21/6486 , G01N2021/6421 , G01N2021/6484
摘要： One embodiment of the present invention provides a system that characterizes a biological sample by analyzing light emissions from the biological sample in response to an excitation. The system first radiates the biological sample with a laser impulse to cause the biological sample to produce a responsive light emission. Next, the system uses a wavelength splitting device to split the responsive light emission into a set of spectral bands of different central wavelengths. The system applies temporal delays to the set of spectral bands so that each spectral band arrives at an optical detector at a different time, thereby allowing the optical detector to temporally resolve the responsive light emission for each spectral band separately. Next, the system captures the delayed spectral bands within a single detection window of the optical detector. The system then processes the captured spectral bands.
摘要翻译：本发明的一个实施方案提供了一种通过响应于激发分析来自生物样品的光发射来表征生物样品的系统。系统首先用激光脉冲辐射生物样品，使生物样品产生响应性发光。接下来，系统使用波长分离装置将响应光发射分成不同中心波长的一组光谱带。该系统将时间延迟应用于频谱带集合，使得每个频谱带在不同时间到达光学检测器，从而允许光学检测器分别时间地分辨每个频谱带的响应光发射。接下来，系统捕获在光学检测器的单个检测窗口内的延迟的光谱带。然后系统处理捕获的光谱带。

6. 发明申请

US20070197894A1 Method for fluorescence lifetime imaging microscopy and spectroscopy 失效
标题翻译：荧光寿命成像显微镜和光谱学方法
公开(公告)号：US20070197894A1
公开(公告)日：2007-08-23
申请号：US10567248
申请日：2004-08-19
申请人： Javier Jo , Laura Marcu , Qiyin Fang , Thanassis Papaioannou
发明人： Javier Jo , Laura Marcu , Qiyin Fang , Thanassis Papaioannou
IPC分类号： A61B5/05
CPC分类号： G01N21/6408 , A61B5/0059 , G01N21/6458
摘要： A method and system for analysis of fluorescence emission spectroscopy data and fluorescence lifetime imaging microscopy data are described. A unique Laguerre expansion can be found for fluorescence intensity decays of arbitrary form with convergence to a correct solution faster than with conventional methods. The Laguerre expansion technique includes expansion coefficients highly correlated with intrinsic fluorescence lifetimes, allowing direct characterization of fluorescence dynamics. For complex systems, conventional analysis of fluorescence intensity decay in terms of discrete exponential components can not readily provide a true representation of underlying fluorescence dynamics. Utilizing the Laguerre expansion technique, an alternative non-parametric method for analysis of time-resolved fluorescence data from various systems is described, facilitating characterization and discrimination of a sample. An ultra-fast method for analysis of fluorescence lifetime imaging is also described, facilitating real-time analysis of compositional and functional changes in samples, at a microscopic or macroscopic level.
摘要翻译：描述了用于分析荧光发射光谱数据和荧光寿命成像显微镜数据的方法和系统。对于任意形式的荧光强度衰减，可以发现独特的Laguerre扩展，与常规方法相比，可以更快地收敛到正确的解决方案。 Laguerre扩展技术包括与内在荧光寿命高度相关的扩增系数，允许直接表征荧光动力学。对于复杂系统，以离散指数分量为基础的荧光强度衰减的常规分析不能容易地提供底层荧光动力学的真实表示。使用Laguerre扩展技术，描述了用于分析来自各种系统的时间分辨荧光数据的替代非参数方法，有助于表征和鉴别样品。还描述了用于分析荧光寿命成像的超快速方法，便于在微观或宏观水平上实时分析样品中的组成和功能变化。

7. 发明申请

US20070048226A1 Biochemical marker detection device 审中-公开
标题翻译：生化标记检测装置
公开(公告)号：US20070048226A1
公开(公告)日：2007-03-01
申请号：US11350695
申请日：2006-02-08
申请人： Gerald Loeb , Laura Marcu , Sanmao Kang , Kuo-Chih Liao
发明人： Gerald Loeb , Laura Marcu , Sanmao Kang , Kuo-Chih Liao
IPC分类号： A61K49/00 , C12Q1/00
CPC分类号： G01N21/6428 , A61B5/0071 , A61B5/0084 , A61B5/4848 , A61K49/0021 , A61K49/0056 , G01N1/30 , G01N21/645 , G01N2021/6484 , G01N2510/00
摘要： A probe device for detecting chemotherapy effectiveness, and methods of use are disclosed. The device includes a fiber optic probe element that can be injected into a tumor. The probe element is connected to an external controlling/measurement element, which injects a reagent through the probe and into the tumor. The reagent reacts with biological markers indicative of chemotherapy effectiveness.
摘要翻译：公开了一种用于检测化疗效果的探针装置及其使用方法。该装置包括可注入肿瘤的光纤探针元件。探针元件连接到外部控制/测量元件，其通过探针注入试剂并进入肿瘤。试剂与指示化疗有效性的生物标志物反应。

8. 发明申请

US20070010726A1 Internal biochemical sensing device 审中-公开
标题翻译：内部生化检测装置
公开(公告)号：US20070010726A1
公开(公告)日：2007-01-11
申请号：US11351158
申请日：2006-02-08
申请人： Gerald Loeb , Thomas George , Cesar Blanco , Laura Marcu
发明人： Gerald Loeb , Thomas George , Cesar Blanco , Laura Marcu
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/14532 , A61B5/1459 , A61B5/415 , A61B5/418 , G01N21/7703 , G01N2021/7786
摘要： A biosensing device for detecting biological analytes, and methods of use and manufacture, are disclosed. The device includes a biosensing element that can remain implanted for extended periods of time. The biosensing element is connected to an optical fiber terminating outside of the body. The optical fiber is also connected to an information analyzer. The information analyzer receives light from the reaction of fluorescent molecules in the biosensing element. The biosensing device can be used to detect and analyze the effectiveness of chemotherapy agents and molecules associated with various diseases.
摘要翻译：公开了用于检测生物分析物的生物传感装置及其使用和制造方法。该装置包括可以长时间保持植入的生物传感元件。生物传感元件连接到终端外部的光纤。光纤也连接到信息分析仪。信息分析器从生物传感元件中的荧光分子的反应接收光。生物传感装置可用于检测和分析与各种疾病相关的化疗药物和分子的有效性。

9. 发明申请

US20060062074A1 Method for intracellular modifications within living cells using pulsed electric fields 审中-公开
公开(公告)号：US20060062074A1
公开(公告)日：2006-03-23
申请号：US11195135
申请日：2005-08-02
申请人： Martin Gundersen , Cheryl Craft , Laura Marcu , P. Vernier , Aimin Li , Xuemei Zhu
发明人： Martin Gundersen , Cheryl Craft , Laura Marcu , P. Vernier , Aimin Li , Xuemei Zhu
IPC分类号： G11C8/02
CPC分类号： A61N1/327 , A61B5/0059 , A61B5/417 , A61N1/306
摘要： The present invention is related to methods in which an electric field pulse is applied to cells and tissue. Several embodiments of the present invention relate to the application of electric field pulses to cells to regulate the physiology and biophysical properties of various cell types, including terminally differentiated and rapidly dividing cells. Methods of regulating transcription of a gene in a cell, marking a cell for diagnostic or therapeutic procedures, determining cellular tolerance to electroperturbation, selectively electroperturbing a population of cells, reducing proliferation of rapidly dividing cells in a patient, and facilitating entry of a diagnostic or therapeutic agent into a cell's intracellular structures are also provided.

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