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1. 发明授权

US06272376B1 Time-resolved, laser-induced fluorescence for the characterization of organic material 有权
标题翻译：时间分辨，激光诱导的荧光用于表征有机材料
公开(公告)号：US06272376B1
公开(公告)日：2001-08-07
申请号：US09235710
申请日：1999-01-22
申请人： Laura Marcu , Warren S. Grundfest , Jean-Michel I. Maarek
发明人： Laura Marcu , Warren S. Grundfest , Jean-Michel I. Maarek
IPC分类号： A61B600
CPC分类号： G01N21/6408 , A61B5/0071 , A61B5/0075 , A61B5/0084 , G01N21/6402 , G01N21/6486 , G01N2021/6423
摘要： A method of analysis of organic matter, called Time-Resolved, Laser-Induced Fluorescence Spectroscopy (TR-LIFS), characterizes and discriminates certain matter, such as tissue, by investigating the fluoresence response of the protein and lipid fluorophore components in both the spectral domain and time domain. This method is more robust than prior methods as (1) can investigate the matter at muplitple wavelengths and even across an entire spectrum and (2) is more sensitive to picking up weaker fluorescence signals such as that from lipids. A detailed study of the use of TR-LIFs for the charaterization of arterial wall tisse is described. A system and instrumentation for practicing the novel method is also disclosed.
摘要翻译：通过研究蛋白质和脂质荧光团成分在光谱中的荧光响应，称为时间分辨，激光诱导荧光光谱（TR-LIFS）的分析方法，表征和鉴别某些物质，如组织域和时域。这种方法比以前的方法更为鲁棒，因为（1）可以检测波峰，甚至整个光谱的问题，（2）对于从脂质中获取较弱的荧光信号更敏感。描述了TR-LIF用于动脉壁的特征的详细研究。还公开了一种用于实践新方法的系统和仪器。

2. 发明授权

US5701902A Spectroscopic burn injury evaluation apparatus and method 失效
标题翻译：光谱烧伤评估装置及方法
公开(公告)号：US5701902A
公开(公告)日：1997-12-30
申请号：US306118
申请日：1994-09-14
申请人： Sandor G. Vari , Jean-Michel I. Maarek
发明人： Sandor G. Vari , Jean-Michel I. Maarek
IPC分类号： G01N21/64 , A61B5/00 , A61B5/103 , G01N21/35
CPC分类号： A61B5/445 , A61B5/0059 , A61B5/0071 , A61B5/0075
摘要： A burn evaluation apparatus and related method, that allows a surgeon to make a quick evaluation of the extent and depth of a skin burn injury by employing induced ultraviolet or blue light fluorescence spectroscopy and visible and infrared reflectance spectroscopy. The apparatus monitors the condition of the structural and metabolic constituents in the injured skin. The apparatus includes a plurality of light sources, a sensor, a microprocessor, and several optical fiber bundles. The light sources emit excitation light at predetermined wavelengths, and when each is activated, the sensor measures the amount return light received within several wavelength bands of interest. A side fiber bundle spaced about a centimeter from a main fiber bundle assists in detecting tissue water below the burn area. By optically evaluating the skin at the burn site, the apparatus prevents the unnecessary removal of viable skin that will heal spontaneously within a few weeks, thereby reducing the amount of skin that must be surgically grafted.
摘要翻译：一种烧伤评估装置及相关方法，其允许外科医生通过使用诱导紫外或蓝光荧光光谱和可见光和红外反射光谱法快速评估皮肤烧伤的程度和深度。该装置监测受伤皮肤中结构和代谢成分的状况。该装置包括多个光源，传感器，微处理器和多个光纤束。光源发射预定波长的激发光，并且当激活光被激活时，传感器测量在感兴趣的几个波长带内接收的返回光量。与主纤维束间隔约一厘米的侧纤维束有助于检测烧伤区域以下的组织水。通过光刻评估烧伤部位的皮肤，该装置可防止不必要的去除在几周内自发愈合的活皮肤，从而减少必须手术移植的皮肤的量。

3. 发明申请

US20100022898A1 MEASUREMENT OF CARDIAC OUTPUT AND BLOOD VOLUME BY NON-INVASIVE DETECTION OF INDICATOR DILUTION 审中-公开
标题翻译：通过非侵入式检测指示剂浓度测量心脏输出量和血液体积
公开(公告)号：US20100022898A1
公开(公告)日：2010-01-28
申请号：US12564769
申请日：2009-09-22
申请人： Eduardo H. Rubinstein , Oscar U. Scremin , Daniel P. Holschneider , Jean-Michel I. Maarek
发明人： Eduardo H. Rubinstein , Oscar U. Scremin , Daniel P. Holschneider , Jean-Michel I. Maarek
IPC分类号： A61B5/02
CPC分类号： A61B5/029 , A61B5/0261 , A61B5/0275
摘要： A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection methods is disclosed. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health.
摘要翻译：公开了一种使用指示剂稀释和非侵入性或微创检测方法评估心血管系统参数的系统。刺激血管内指标，并检测排放模式，以计算心输出量，心脏指数，血容量和其他心血管健康指标。

4. 发明授权

US08449470B2 System for repetitive measurements of cardiac output in freely moving individuals 有权
标题翻译：用于重复测量自由移动个体心输出量的系统
公开(公告)号：US08449470B2
公开(公告)日：2013-05-28
申请号：US12544957
申请日：2009-08-20
申请人： Cesar Blanco , Frances Richmond , Daniel P. Holschneider , Jean-Michel I. Maarek
发明人： Cesar Blanco , Frances Richmond , Daniel P. Holschneider , Jean-Michel I. Maarek
IPC分类号： A61B5/02 , A61B6/00
CPC分类号： A61B5/0261 , A61B5/0275 , A61B2503/40 , A61B2560/0223
摘要： A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection and calibration methods are disclosed. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health.
摘要翻译：公开了一种使用指示剂稀释和非侵入性或微创检测和校准方法评估心血管系统参数的系统。刺激血管内指标，并检测排放模式，以计算心输出量，心脏指数，血容量和其他心血管健康指标。

5. 发明授权

US07611470B2 Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution 有权
公开(公告)号：US07611470B2
公开(公告)日：2009-11-03
申请号：US10865629
申请日：2004-06-10
申请人： Eduardo H. Rubinstein , Oscar U. Scremin , Daniel P. Holschneider , Jean-Michel I. Maarek
发明人： Eduardo H. Rubinstein , Oscar U. Scremin , Daniel P. Holschneider , Jean-Michel I. Maarek
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/029 , A61B5/0261 , A61B5/0275
摘要： A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection methods is disclosed. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health.

6. 发明授权

US08337444B2 Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution for hemodialysis 有权
标题翻译：通过非侵入性检测血液透析指标稀释度测量心输出量和血容量
公开(公告)号：US08337444B2
公开(公告)日：2012-12-25
申请号：US11744157
申请日：2007-05-03
申请人： Eduardo H. Rubinstein , Daniel P. Holschneider , Jean-Michel I. Maarek
发明人： Eduardo H. Rubinstein , Daniel P. Holschneider , Jean-Michel I. Maarek
IPC分类号： A61M37/00 , A61B6/00 , A61B5/02
CPC分类号： A61B5/0275 , A61B2503/40 , A61M1/16 , A61M1/3609 , A61M2230/04
摘要： A system and method of non-invasive or minimally invasive evaluating the cardiovascular system parameters to estimate the cardiac output and circulating blood volume of a patient undergoing hemodialysis. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health before and during hemodialysis.
摘要翻译：非侵入性或微创侵入性评估心血管系统参数以估计进行血液透析的患者的心输出量和循环血容量的系统和方法。刺激血管内指标，并检测血液透析前后心输出量，心脏指数，血容量和其他心血管健康指标的排放模式。

7. 发明申请

US20100099992A1 CARDIAC OUTPUT MONITOR WITH COMPENSATION FOR TISSUE PERFUSION 有权
标题翻译： CARDIAC输出监测器与组织灌注补偿
公开(公告)号：US20100099992A1
公开(公告)日：2010-04-22
申请号：US12574524
申请日：2009-10-06
申请人： Daniel P. Holschneider , Eduardo H. Rubinstein , Jean-Michel I. Maarek , Alan J. Eskovitz
发明人： Daniel P. Holschneider , Eduardo H. Rubinstein , Jean-Michel I. Maarek , Alan J. Eskovitz
IPC分类号： A61B8/06 , A61B5/02
CPC分类号： A61B5/0261 , A61B5/0275 , A61B5/029 , A61B2560/0223
摘要： A non-invasive system and method for determination of cardiac output and blood volume of a patient includes compensating for a change in the fluorescence of an indicator circulating in the bloodstream of a tissue or organ that is caused by a variation of the blood content at the site of the measurement.
摘要翻译：用于确定患者的心输出量和血液体积的非侵入性系统和方法包括补偿由在血液成分变化引起的组织或器官的血流中循环的指示物的荧光的变化现场测量。

8. 发明申请

US20100042007A1 SYSTEM FOR REPETITIVE MEASUREMENTS OF CARDIAC OUTPUT IN FREELY MOVING INDIVIDUALS 有权
标题翻译：自愿移动个体心脏输出重复测量系统
公开(公告)号：US20100042007A1
公开(公告)日：2010-02-18
申请号：US12544957
申请日：2009-08-20
申请人： Cesar Blanco , Frances Richmond , Daniel P. Holschneider , Jean-Michel I. Maarek
发明人： Cesar Blanco , Frances Richmond , Daniel P. Holschneider , Jean-Michel I. Maarek
IPC分类号： A61B5/026
CPC分类号： A61B5/0261 , A61B5/0275 , A61B2503/40 , A61B2560/0223
摘要： A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection and calibration methods are disclosed. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health.
摘要翻译：公开了一种使用指示剂稀释和非侵入性或微创检测和校准方法评估心血管系统参数的系统。刺激血管内指标，并检测排放模式，以计算心输出量，心脏指数，血容量和其他心血管健康指标。

9. 发明授权

US06757554B2 Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution 有权
标题翻译：通过非侵入性检测指标稀释度测量心输出量和血容量
公开(公告)号：US06757554B2
公开(公告)日：2004-06-29
申请号：US10153387
申请日：2002-05-21
申请人： Eduardo H. Rubinstein , Oscar V. Scremin , Daniel P. Holschneider , Jean-Michel I. Maarek
发明人： Eduardo H. Rubinstein , Oscar V. Scremin , Daniel P. Holschneider , Jean-Michel I. Maarek
IPC分类号： A61B500
CPC分类号： A61B5/029 , A61B5/0261 , A61B5/0275
摘要： A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection methods is disclosed. Intravascular indicators are stimulated, and emission patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health.
摘要翻译：公开了一种使用指示剂稀释和非侵入性或微创检测方法评估心血管系统参数的系统。血管内指标受到刺激，检测出心脏输出量，心脏指数，血容量等心血管健康指标的排放模式。

10. 发明授权

US08249697B2 Cardiac output monitor with compensation for tissue perfusion 有权
标题翻译：心脏输出监测器补偿组织灌注
公开(公告)号：US08249697B2
公开(公告)日：2012-08-21
申请号：US12574524
申请日：2009-10-06
申请人： Daniel P. Holschneider , Eduardo H. Rubinstein , Jean-Michel I. Maarek , Alan J. Eskovitz
发明人： Daniel P. Holschneider , Eduardo H. Rubinstein , Jean-Michel I. Maarek , Alan J. Eskovitz
IPC分类号： A61B6/00
CPC分类号： A61B5/0261 , A61B5/0275 , A61B5/029 , A61B2560/0223
摘要： A non-invasive system and method for determination of cardiac output and blood volume of a patient includes compensating for a change in the fluorescence of an indicator circulating in the bloodstream of a tissue or organ that is caused by a variation of the blood content at the site of the measurement.
摘要翻译：用于确定患者的心输出量和血液体积的非侵入性系统和方法包括补偿由在血液成分变化引起的组织或器官的血流中循环的指示物的荧光的变化现场测量。

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