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1. 发明授权

US5318023A Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle 失效
标题翻译：用于光敏剂的装置和方法增强基于荧光的活检针
公开(公告)号：US5318023A
公开(公告)日：1994-06-07
申请号：US679766
申请日：1991-04-03
申请人： Sandor G. Vari , Theodore Papazoglou , Warren S. Grundfest
发明人： Sandor G. Vari , Theodore Papazoglou , Warren S. Grundfest
IPC分类号： A61B5/00 , A61B10/00 , A61B10/02 , A61B17/22 , A61B18/20 , A61B18/22 , A61B19/00
CPC分类号： A61B10/0233 , A61B18/22 , A61B5/0059 , A61B5/415 , A61B5/418 , A61B2017/22087 , A61B2090/062
摘要： A method and apparatus is disclosed for the instant intraoperative detection and biopsy of metastatic cancer using fluorescence spectroscopy. A photosensitizing agent selectively retained by cancerous tissue is administered prior to surgery. A fiberoptic probe integrated with a biopsy device illuminates the examined tissue and causes fluorescence which is recorded by a spectrograph and plotted as a spectral curve. The intensity ratio (S1/S2) for the fluorescence from the photosensitizing agent (S1) and autofluorescence (S2) for the examined tissue is compared with the intensity ratio at the same wavelengths for primary tumor and normal tissue. Tissue that displays an intensity ratio different from that of normal tissue can immediately be analyzed for the depth of tumor involvement and then excised for histological examination using the biopsy device.
摘要翻译：公开了使用荧光光谱法进行的转移性癌症的即时术中检测和活检的方法和装置。在手术前给予由癌组织选择性保留的光敏剂。与活检装置集成的光纤探针照亮被检查的组织并引起荧光，其由光谱仪记录并绘制为光谱曲线。将来自光敏剂（S1）的荧光和检测组织的自发荧光（S2）的强度比（S1 / S2）与原发肿瘤和正常组织的相同波长的强度比进行比较。显示与正常组织不同的强度比的组织可以立即分析肿瘤深度，然后用活检装置进行组织学检查。

2. 发明授权

US5456252A Induced fluorescence spectroscopy blood perfusion and pH monitor and method 失效
标题翻译：诱导荧光光谱血液灌注和pH监测和方法
公开(公告)号：US5456252A
公开(公告)日：1995-10-10
申请号：US129406
申请日：1993-09-30
申请人： Sandor G. Vari , Theodore Papazoglou , Warren S. Grundfest
发明人： Sandor G. Vari , Theodore Papazoglou , Warren S. Grundfest
IPC分类号： A61B5/00 , G01N21/64 , A61B6/00
CPC分类号： G01N21/6486 , G01N2021/6417 , G01N2021/6484 , Y10S128/925
摘要： A medical monitor, and related method, determines a pre-existing physiological property of an organ of a patient by monitoring fluorescent light produced by constituents associated with the metabolic and structural condition of the organ. The monitor illuminates the organ with ultraviolet excitation light that induces some constituents of the organ to fluoresce, with the fluorescent light being monitored and processed to determine pre-existing physiological properties of the organ. A sensor monitors the return light, which includes fluorescent light produced by the fluorescent constituents of the organ, and generates first and second electrical signals indicative of the intensity of light at two wavelength. One wavelength is associated with the fluorescence of collagen, a constituent associated with organ's structural properties, and the other wavelength is a associated with the fluorescence of NADH, a constituent associated with the organ's metabolism. A processor then processes the first and second electrical signals to determine the localized pH of the organ. A fiber-optic waveguide is used to guide the excitation light from the laser light source to the organ and the return light from the organ to the sensor. In another aspect of the invention, the sensor generates a third electrical signal associated with the fluorescence of elastin, a constituent associated with the organ's structural properties. The processor processes the first, second and third electrical signals to determine the perfusion or oxygenation of the organ.
摘要翻译：医疗监视器和相关方法通过监测与器官的代谢和结构状况相关的成分产生的荧光，来确定患者器官的预先存在的生理特性。监视器用紫外线激发光照亮器官，诱导器官的一些成分发荧光，荧光被监测和处理以确定器官的先前存在的生理特性。传感器监测返回光，其包括由器官的荧光成分产生的荧光，并产生指示两个波长的光强度的第一和第二电信号。一个波长与胶原蛋白的荧光相关联，胶原蛋白是与器官结构特性相关的成分，另一个波长与NADH（与器官代谢相关的成分）的荧光相关。然后处理器处理第一和第二电信号以确定器官的局部pH。使用光纤波导将来自激光光源的激发光引导至器官，并将来自器官的返回光引导至传感器。在本发明的另一方面，传感器产生与弹性蛋白的荧光相关联的第三电信号，弹性蛋白是与器官结构特性相关的成分。处理器处理第一，第二和第三电信号以确定器官的灌注或氧合。

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