基本信息:
- 专利标题： INTERPENETRATING POLYMER NETWORK HYDROGEL CONTACT LENSES
- 专利标题（中）：INTERPENETRATING聚合物网络HYDROGEL接触镜
- 申请号：PCT/US2006047170 申请日：2006-12-08
- 公开(公告)号：WO2007108842A3 公开(公告)日：2008-02-28
- 发明人： MYUNG DAVID , NOOLANDI JAAN , TA CHRISTOPHER , FRANK CURTIS W
- 申请人： BOARD TRUSTEES OF THE LELAND S , MYUNG DAVID , NOOLANDI JAAN , TA CHRISTOPHER , FRANK CURTIS W
- 专利权人： BOARD TRUSTEES OF THE LELAND S,MYUNG DAVID,NOOLANDI JAAN,TA CHRISTOPHER,FRANK CURTIS W
- 当前专利权人： BOARD TRUSTEES OF THE LELAND S,MYUNG DAVID,NOOLANDI JAAN,TA CHRISTOPHER,FRANK CURTIS W
- 优先权： US78330706 2006-03-17; US40921806 2006-04-20; US84394206 2006-09-11; US63611406 2006-12-07
- 主分类号： G02C7/04
- IPC分类号： G02C7/04
摘要：
The present invention, provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.
摘要（中）：
本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网络水凝胶。 水凝胶包括两个互穿聚合物网络。 第一个聚合物网络是基于亲水的遥爪大分子单体。 第二聚合物网络基于亲水性单体。 在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。 遥爪大分子单体的分子量优选为约575Da至约20,000Da。 也可以使用分子量的混合物。 在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。 该材料被设计成用作隐形眼镜。